4 completed, 1 enrolling by invitation, 1 not yet recruiting, 1 recruiting. 4 Not applicable, 2 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 2, Enrolling by invitation 1, Recruiting 1 |
| Early Phase 1 | 2 | Completed 1, Withdrawn 1 |
| Phase 2 | 1 | Not yet recruiting 1 |
Follow Microstomia: new trials by email Literature Review of Microstomia trials Research Report on Microstomia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Allogenic Cultured Adipose-derived Mesenchymal Stromal Cell Injections on MoUth Fibrosis and Handicap in Patients With Systemic sclEroderma AdMSC, Placebo - Systemic Scleroderma | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 50 | 2026-01-01 | 2026-01-08 |
| Clinical Effectiveness of a Patient-tailored Orthosis Based on 3-dimensional (3D) Scanner Modeling and 3D Printing Technology for Microstomia Caused by Burns : Pilot Study patient's tailored mouthpiece fitting - Burn, 3D Printing | Not applicable | Enrolling by invitation | Hangang Sacred Heart Hospital | 10 | 2025-07-05 | 2025-12-04 |
| Efficacy of 3D-Printed Mouth Splints Splint - Microstomia | Not applicable | Recruiting | Wake Forest University Health Sciences | 10 | 2025-02-21 | 2025-12-17 |
| Hyaluronidase Via LADD Scleroderma-induced Microstomia Hyaluronidase, CO2 laser - Microstomia, Scleroderma | Early Phase 1 | Completed | University of Nebraska | 3 | 2024-03-01 | 2026-04-15 |
| GlideScope Videolaryngoscopy in Patients With Reduced Mouth Opening Intubation;Difficult, Videolaryngoscopy | Completed | Universitätsklinikum Hamburg-Eppendorf | 30 | 2021-01-20 | 2021-11-24 | |
| Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease hyaluronidase injected intradermally - Microstomia, Scleroderma | Early Phase 1 | Withdrawn | Brigham and Women's Hospital | 2020-01-01 | 2021-01-14 | |
| The Effect of a Home-based Orofacial Exercise Program on Oral Aperture of Systemic Sclerosis Patients orofacial exercise program - Microstomia, Systemic Sclerosis | Not applicable | Completed | Cukurova University | 60 | 2017-03-01 | 2020-04-29 |
| A Comparison Between Two Educational Methods in the Rehabilitation of the Microstomia in Systemic Sclerosis Brochure and DVD plus nursing training, Brochure and DVD only - Scleroderma, Systemic | Not applicable | Completed | IRCSS Istituto Dermopatico dell'Immacolata, Fondazione Luigi Maria Monti | 39 | 2013-02-01 | 2018-12-06 |
Scleroderma, Systemic (3) · Scleroderma, Diffuse (2) · Burns (1) · CREST Syndrome (1) · Cleft Lip (1) · Freeman-Sheldon syndrome (1) · Motor Activity (1) · Scleroderma, Localized (1) · Scleromyxedema (1)
Congenital Abnormalities (8) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Mouth Abnormalities (8) · Mouth Diseases (8) · Stomatognathic Diseases (8) · Stomatognathic System Abnormalities (8) · Connective Tissue Diseases (5) · Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Scleroderma, Systemic (2) · Behavior (1) · Calcinosis (1) · Calcium Metabolism Disorders (1) · Cardiovascular Diseases (1) · Deglutition Disorders (1)
Chondroitinases and Chondroitin Lyases (1) · Hyaluronoglucosaminidase (1) · Lasers, Gas (1) · Splints (1)
Brigham and Women's Hospital (1) · Cukurova University (1) · Hangang Sacred Heart Hospital (1) · IRCSS Istituto Dermopatico dell'Immacolata, Fondazione Luigi Maria Monti (1) · University Hospital, Toulouse (1) · University of Nebraska (1) · Universitätsklinikum Hamburg-Eppendorf (1) · Wake Forest University Health Sciences (1)
United States (2) · France (1) · Germany (1) · South Korea (1) · Turkey (Türkiye) (1)
Christopher Runyan, MD, PhD (1) · Damiano DC Abeni, MD, MPH (1) · Nihan Cuzdan, MD (1) · Sarah L Lonowski, MD (1)