Craniofacial Abnormalities: Clinical Trials

266 completed, 92 unknown, 85 recruiting, 32 terminated. 225 Not applicable, 60 Phase 2, 39 Phase 1, 25 Phase 3, 12 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	225	Completed 98, Unknown 55, Recruiting 27, Not yet recruiting 15, Terminated 11, Enrolling by invitation 8, Withdrawn 7, Active not recruiting 4
Phase 2	60	Completed 31, Terminated 8, Recruiting 7, Unknown 6, Withdrawn 4, Active not recruiting 3, Enrolling by invitation 1
Phase 1	39	Completed 22, Unknown 5, Recruiting 4, Terminated 4, Active not recruiting 2, Enrolling by invitation 1, Withdrawn 1
Phase 3	25	Completed 13, Unknown 4, Recruiting 3, Active not recruiting 2, Not yet recruiting 1, Suspended 1, Terminated 1
Phase 4	12	Completed 4, Recruiting 3, Terminated 2, Withdrawn 2, Active not recruiting 1
Early Phase 1	1	Completed 1

Follow Craniofacial Abnormalities: new trials by email Literature Review of Craniofacial Abnormalities trials Research Report on Craniofacial Abnormalities

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy	Phase 3	Not yet recruiting	Carelon Research	25	2027-08-01	2026-09-14
Clinical Genetics Branch Eligibility Screening Survey Melanoma, Li-Fraumeni Syndrome		Not yet recruiting	National Cancer Institute (NCI)	1000	2026-11-04	2026-10-30
Multimodal Mechanical, Tissue, Architectural, and Histological Evaluation of the Bone and Sutures of the Parietal Bone in an Infant With Craniosynostosis. Biological sample, bones sample and questionaires. - Craniostenosis		Not yet recruiting	Hospices Civils de Lyon	80	2026-11-01	2026-10-26
Effects of Tummy Time Associated With Therapeutic Positioning in Premature Newborns With Cranial Asymmetry Tummy Time Protocol - Premature Newborns, Cranial Asymmetry	Not applicable	Not yet recruiting	Hospital de Clinicas de Porto Alegre	300	2026-10-01	2026-09-18
Comparing 3D-Printed and Milled Titanium Plates in Jaw Surgery (Le Fort I): Accuracy and Operative Time 3D-Printed Patient-Specific Titanium Plates, Milled Patient-Specific Titanium Plates - Malocclusion, Angle Class II, Malocclusion, Angle Class III	Not applicable	Recruiting	Future University in Egypt	12	2026-10-01	2026-09-25
Frontal Reconstruction Without Orbital Advancement for Moderate Metopic Craniosynostosis Frontal vault remodelling without orbital advancement - Metopic Craniosynostosis, Craniosynostosis	Not applicable	Not yet recruiting	Assiut University	15	2026-10-01	2026-09-23
Furlow With Buccinator and Fistula Formation furlow with buccinator, two flap palatoplasty - Cleft Palate	Not applicable	Not yet recruiting	Fayoum University	20	2026-09-25	2026-09-25
Clinical and Radiographic Evaluation of Low Sagittal Medial Ramus Osteotomy for Treatment of Skeletal Class II and Class III Malocclusion Low Sagittal Medial Ramus Osteotomy - Skeletal Class II Malocclusion, Skeletal Class III Malocclusion	Not applicable	Not yet recruiting	Al-Azhar University	11	2026-09-01	2026-08-05
Treatment for "Asymmetric Crying Facies" Botulinium toxin type A injection - Hemifacial Microsomia, Facial Nerve Paralysis	Not applicable	Recruiting	Xiaolei Jin	60	2026-08-07	2026-09-28
Palatoplasty Techniques Using PRF and Gentamicin-Loaded PRF in Cleft Palate Standard palatoplasty ( control), Platelet _ Rich Fibrin ( PRF), gentamicin_ loaded PRF - Cleft Palate, Unilateral Cleft Palate	Not applicable	Recruiting	Al-Thawra Modern General Hospital	90	2026-08-01	2026-08-07
Speech Intervention Frameworks in Cantonese-speaking Children and Adolescences With Cleft Palate +/- Lip Non-linear based phonological speech intervention, Linear-based speech intervention - Cleft Palate +/- Lip	Not applicable	Enrolling by invitation	Chinese University of Hong Kong	12	2026-07-24	2026-07-09
Safety, Tolerability, and Pharmacokinetics of SVG103 (Paxalisib) in Focal Cortical Dysplasia Type II (FCD-II), Tuberous Sclerosis Complex (TSC) or Hemimegalencephaly (HME) SVG103 - Focal Cortical Dysplasia, Tuberous Sclerosis Complex (TSC)	Phase 1 / Phase 2	Recruiting	Sovargen	12	2026-07-14	2026-08-10
Perioperative Respiratory Adverse Events in Cleft Lip and Palate Surgery: Incidence, Risk Factors, and Clinical Scoring Standard General Anesthesia per Institutional Protocol - Cleft Palate, Cleft Lip		Not yet recruiting	Marmara University Pendik Training and Research Hospital	150	2026-06-27	2026-06-16
Futibatinib (TAS-120) in Patients With Advanced Biliary Tract Cancer Futibatinib, Zimberelimab, Durvalumab - Biliary Tract Cancer	Phase 3	Recruiting	Taiho Pharmaceutical Co., Ltd.	784	2026-06-24	2026-07-17
Changes in Depression and Esthetic Perception After Orthognathic Surgery Dentofacial Deformities, Malocclusions		Recruiting	Kırıkkale University	18	2026-06-20	2026-07-16
MRI Assessment of Velopharyngeal Anatomy After Modified Furlow-Buccinator Flap in Late Primary Palate Repair Modified Furlow Palatoplasty combined with buccinator myomucosal flap - Cleft Palate, Cleft Palate, Unilateral, Complete	Not applicable	Not yet recruiting	Cairo University	10	2026-06-01	2026-04-07
Using Chin Bone Rings for Sinus Lifting and Dental Implants in One Surgery Bone Ring Technique (BRT) - Maxillary Deficiency, Bone Resorption	Not applicable	Recruiting	Damascus University	10	2026-05-31	2026-09-01
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD) Hematopoietic stem cell transplant (HSCT) - Common Variable Immunodeficiency (CVID), Primary Immune Regulatory Disorder	Phase 2	Recruiting	Paul Szabolcs	25	2026-05-04	2026-05-15
Research on Deep Learning-Based Intelligent Diagnosis and Treatment Malocclusion, Craniofacial Morphology		Not yet recruiting	Xi'an Jiaotong University	2000	2026-05-01	2026-04-27
Clinical Evaluation of Patient-Specific 3D-Printed Titanium Implants for Facial Reconstruction. Patient-specific titanium implants for facial reconstruction - Hemifacial Microsomia, Mucormycosis	Not applicable	Recruiting	Latakia University	30	2026-04-26	2026-06-17

Showing 20 of 557. Sign in to see all of them.

Narrower conditions

Cleft Palate (114)  ·  Retrognathia (58)  ·  Cleft Lip (49)  ·  Craniosynostoses (49)  ·  Noonan Syndrome (49)  ·  DiGeorge Syndrome (46)  ·  Dentofacial Deformities (39)  ·  Acrocephalosyndactylia (33)  ·  Micrognathism (26)  ·  Microcephaly (22)  ·  Maxillofacial Abnormalities (21)  ·  Congenital Abnormalities (17)  ·  Malocclusion (17)  ·  Plagiocephaly, Nonsynostotic (17)

Broader conditions

Congenital, Hereditary, and Neonatal Diseases and Abnormalities (556)  ·  Musculoskeletal Abnormalities (556)  ·  Musculoskeletal Diseases (555)  ·  Congenital Abnormalities (540)  ·  Stomatognathic Diseases (277)  ·  Stomatognathic System Abnormalities (270)  ·  Maxillofacial Abnormalities (247)  ·  Jaw Diseases (218)  ·  Jaw Abnormalities (204)  ·  Bone Diseases (128)  ·  Mouth Diseases (126)  ·  Bone Diseases, Developmental (123)  ·  Mouth Abnormalities (118)  ·  Cardiovascular Diseases (116)

Interventions

Orthognathic Surgery (11)  ·  Saline Solution (9)  ·  Human Growth Hormone (8)  ·  Blood Specimen Collection (6)  ·  Tranexamic Acid (6)  ·  pemigatinib (6)  ·  Bupivacaine (5)  ·  Sodium Chloride (5)  ·  Dexmedetomidine (4)  ·  Health Records, Personal (4)  ·  Masks (4)  ·  Surveys and Questionnaires (4)  ·  Acetaminophen (3)  ·  Glucose Tolerance Test (3)  ·  Melatonin (3)

Sponsors

Cairo University (19)  ·  Assistance Publique - Hôpitaux de Paris (10)  ·  Assiut University (10)  ·  National Human Genome Research Institute (NHGRI) (9)  ·  Hospices Civils de Lyon (8)  ·  Novo Nordisk A/S (8)  ·  Al-Azhar University (7)  ·  Fayoum University (7)  ·  Fondazione Policlinico Universitario Agostino Gemelli IRCCS (7)  ·  Incyte Corporation (7)  ·  Sumitomo Pharma Switzerland GmbH (7)  ·  University Hospital, Montpellier (7)  ·  Institut National de la Santé Et de la Recherche Médicale, France (6)  ·  University Hospital, Bordeaux (6)  ·  Alexandria University (5)

Countries

United States (172)  ·  France (79)  ·  Egypt (55)  ·  Italy (37)  ·  Turkey (Türkiye) (34)  ·  Spain (29)  ·  Brazil (25)  ·  Belgium (22)  ·  Canada (22)  ·  Germany (22)  ·  United Kingdom (18)  ·  China (16)  ·  Japan (16)  ·  South Korea (16)  ·  Switzerland (16)

Top investigators

M. Louise Markert, MD, PhD (5)  ·  Chiara Leoni, MD, PhD (3)  ·  Cuneyt M Alper, MD (2)  ·  Ekaterine Asatiani, MD (2)  ·  Fabianne MG Furtado, PhD (2)  ·  Gabriela PR Prado, MS (2)  ·  Jeff Murray, M.D. (2)  ·  Johan Abeloos, MD (2)  ·  Lydia M Ferreira, PhD (2)

Results publications

PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 20236866, PMID 17284531, PMID 15100156, PMID 18155964, PMID 20978268, PMID 23607606, PMID 26494722, PMID 41285480, PMID 10371309, PMID 10417280, PMID 10883694, PMID 11381256, PMID 12642839, PMID 12702512, PMID 12820840, PMID 14707617, PMID 1472517, PMID 15100681, PMID 16001919, PMID 16122596, PMID 16203673, PMID 16282778, PMID 16428493, PMID 16448254, PMID 16526927, PMID 16563165, PMID 16814942, PMID 17186250, PMID 17218256, PMID 17343269, PMID 17440368, PMID 17760493, PMID 17763894, PMID 17899471, PMID 17945777, PMID 18297062, PMID 18333898, PMID 18452361, PMID 18459881, PMID 18513295, PMID 18635960, PMID 18754893, PMID 18797362, PMID 18980518, PMID 19699898, PMID 19761925

NIH funding

K12HD043494 (7), R01AI047040 (7), R01AI054843 (6), 2016 (4), R56AI047040 (4), 2019 (3), 2008 (2), 2018 (2), R21DC017553 (2), 2005 (1), 2014 (1), 2015 (1), 2017 (1), 2023 (1), 268201000048C-5-0-1 (1)