11 completed, 9 unknown, 5 recruiting, 4 active not recruiting. 36 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 36 | Completed 11, Unknown 9, Recruiting 5, Active not recruiting 4, Not yet recruiting 3, Terminated 3, Withdrawn 1 |
Follow Mitral Valve Disease: new trials by email Literature Review of Mitral Valve Disease trials Research Report on Mitral Valve Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY Mitral valve repair with creation of an 8 mm inter-atrial shunt - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Ottawa Heart Institute Research Corporation | 50 | 2026-09-30 | 2026-05-06 |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study Septal Scoring Along Midline Endocardium - Hypertrophic Cardiomyopathy, Left Ventricular Septal Hypertrophy | Not applicable | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2024-12-18 | 2025-12-18 |
| EXPLORE MRace (BR): Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve Disease | Not applicable | Recruiting | Polares Medical SA | 10 | 2024-04-08 | 2026-09-01 |
| Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer CO/CI/SVR - Coronary Artery Disease, Aortic Valve Disease | Not applicable | Unknown | George Papanicolaou Hospital | 50 | 2024-01-01 | 2024-01-17 |
| Munich Transcatheter Mitral Valve Safety and Effectiveness MUNICH TRANSCATHETER MITRAL VALVE REPLACEMENT SYSTEM - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | P+F Products + Features GmbH | 60 | 2023-07-30 | 2023-07-11 |
| The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy 360-degree Virtual Reality Patient Tour, State Trait Anxiety Inventory, Amsterdam Preoperative Anxiety and Information Scale - Cardiac Valve Disease, Aortic Valve Disease | Not applicable | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 100 | 2023-07-01 | 2024-07-10 |
| Clinical Investigation for the Foldax Tria Mitral Valve- India Mitral Valve Replacement - Mitral Valve Disease, Mitral Regurgitation | Not applicable | Unknown | Foldax, Inc | 70 | 2023-03-01 | 2024-01-05 |
| EXPLORE MRace (GE): Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve Disease | Not applicable | Recruiting | Polares Medical SA | 100 | 2022-05-23 | 2026-09-01 |
| Prospective Multicenter Study on Mitral Annular Disjunction diagnostic flow - Mitral Valve Disease | Not applicable | Active not recruiting | University Hospital of Ferrara | 249 | 2021-06-03 | 2025-07-15 |
| Transcatheter Mitral Valve InterventiOn Single Center Registry in CHinese Patients With Mitral Valve Disease (TORCH-M) transcatheter mitral valve repair/transcatheter mitral valve replacement - Mitral Valve Disease | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2000 | 2021-05-01 | 2021-07-08 |
| The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves). Transseptal ViMAC - Mitral Annular Calcification, Mitral Stenosis | Not applicable | Recruiting | Mayra Guerrero | 210 | 2021-03-08 | 2026-01-13 |
| Early Feasibility Study for the Foldax TRIA Mitral Heart Valve Replacement Foldax TRIA Mitral Valve - Mitral Valve Disease, Mitral Valve Stenosis | Not applicable | Unknown | Foldax, Inc | 15 | 2021-02-01 | 2023-09-13 |
| VIenna Pilot Study for Automated Annular Suturing Technology automated annular suturing - Aortic Valve Disease, Mitral Valve Disease | Not applicable | Unknown | Medical University of Vienna | 30 | 2021-01-01 | 2020-12-09 |
| SATURN Transcatheter Mitral Valve Replacement for Functional Mitral Regurgitation SATURN TA System - Mitral Regurgitation, Valve Heart Disease | Not applicable | Unknown | InnovHeart | 20 | 2020-08-19 | 2024-05-22 |
| Effect of Early Mobilization on Length of Stay, Recovery and Readmission Rate of Patients After CABG or AVR/MVR Surgery Intensive early mobilization techniques - Coronary Artery Disease, Aortic Valve Disease | Not applicable | Completed | Dimitris Chatzitheodorou | 40 | 2020-06-03 | 2021-01-05 |
| A Feasibility Study of the Millipede Transcatheter Annuloplasty Ring System in Patients With Functional Mitral Regurgitation Millipede Transcatheter Annuloplasty Ring System (Millipede System) - Mitral Regurgitation Functional, Mitral Valve Disease | Not applicable | Active not recruiting | Boston Scientific Corporation | 4 | 2019-11-13 | 2026-10-23 |
| The Conveyor Study Mitral valve-in-valve - Mitral Valve Insufficiency, Mitral Valve Disease | Not applicable | Unknown | Synecor, LLC | 10 | 2019-04-01 | 2019-04-05 |
| Enhanced Recovery After Cardiac Surgery Pre-operative Carbohydrate PreLoad drink, Oral Gabapentin pre-op, Oral Lansoprazole pre-op - Cardiac Surgery, Coronary Artery Disease | Not applicable | Unknown | James Cook University Hospital | 80 | 2018-12-17 | 2019-09-27 |
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Mitral Valve Insufficiency (13) · Aortic Valve Disease (12) · Coronary Artery Disease (8) · Heart Failure (7) · Heart Valve Diseases (6) · Cardiovascular Diseases (5) · Mitral Valve Stenosis (5) · Aortic Valve Stenosis (2) · Atrial Fibrillation (2) · Disease (2) · Heart Diseases (2) · Aortic Aneurysm (1) · Aortic Valve Insufficiency (1) · Cardiomyopathies (1) · Cardiomyopathy, Hypertrophic (1)
Heart Diseases (26) · Cardiovascular Diseases (24) · Heart Valve Diseases (21) · Vascular Diseases (9) · Arterial Occlusive Diseases (8) · Arteriosclerosis (8) · Coronary Disease (8) · Myocardial Ischemia (8) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Arrhythmias, Cardiac (2) · Ventricular Outflow Obstruction (2) · Aneurysm (1) · Aortic Diseases (1) · Aortic Stenosis, Subvalvular (1)
Anesthesia, Local (1) · Breathing Exercises (1) · Continuous Positive Airway Pressure (1) · Drug Delivery Systems (1) · HES 130-0.4 (1) · Intermittent Positive-Pressure Breathing (1) · Physical Therapy Modalities (1) · Plasmalyte A (1) · Radiofrequency Ablation (1) · Ringer's Lactate (1) · Serum Albumin, Human (1) · Sodium Chloride (1) · normosol R (1) · zidovudine 5'-monophosphate-mannose-albumin conjugate (1)
Abbott Medical Devices (3) · Edwards Lifesciences (2) · Foldax, Inc (2) · Mayra Guerrero (2) · Polares Medical SA (2) · University Hospital of Ferrara (2) · AHEPA University Hospital (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ain Shams University (1) · Boston Scientific Corporation (1) · Caisson Interventional LLC (1) · Cardiovalve Ltd. (1) · Dimitris Chatzitheodorou (1) · Emory University (1) · George Papanicolaou Hospital (1)
United States (11) · Italy (4) · Brazil (3) · Canada (3) · Greece (3) · Australia (2) · China (2) · Germany (2) · Netherlands (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Belgium (1) · Chile (1) · Denmark (1)
Mayra Guerrero, MD (2) · Alan Zajarias, MD (1) · Alberto Cremonesi (1) · Amar Krishnaswamy, MD (1) · Chris S. Malaisrie, MD (1) · Elisabetta Tonet, MD (1) · Frank Shannon, MD (1) · Georg Nickenig (1) · Gianluca Campo (1) · Guy Vandenplas, MD (1) · James McCabe, MD (1) · Jian'an Wang, PhD, MD (1) · Jim C Coates, MBBS (1) · Jiri Barta, MD (1) · Jo-Anne E Marcocoux, M. Sc. (1)
PMID 11603594, PMID 11899956, PMID 14670881, PMID 15464329, PMID 16275007, PMID 29574443, PMID 29699609, PMID 33888229, PMID 33888230, PMID 33888231, PMID 33888232, PMID 35731506, PMID 37758379, PMID 39034924, PMID 39049480, PMID 40589299
R01HL133667 (1)