36 completed, 7 unknown, 4 terminated, 1 not yet recruiting. 19 Not applicable, 16 Phase 4, 8 Phase 3, 3 Phase 2, 1 Early Phase 1.
Follow HES 130-0.4: new trials by email Literature Review of HES 130-0.4 trials Research Report on HES 130-0.4
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula Burn Navigator, Resuscitation (Voluven) - Resuscitation, Burn | Phase 4 | Not yet recruiting | Alnas Hospital | 62 | 2026-01-01 | 2025-12-29 |
| Re-bleeding in Giant Meningioma and Intraoperative Hydroxyethyl Starch (HES) Fluid Therapy exposure to Hydroxyethyl Starch (HES) Voluven® or Volulyte® 130/0.4 - Meningioma of Brain, Meningioma Surgery | Completed | Chiang Mai University | 300 | 2025-03-01 | 2026-03-17 | |
| Cardiac Output in Preeclamptic 1000 mL of ringer's acetate solution, 250 mL 6% hydroxyethyl starch (Voluven) then 500 mL of ringer's acetate solution then 250 mL of 6% hydroxyethyl starch (Voluven) - Echocardiography | Not applicable | Completed | Mansoura University | 34 | 2022-08-17 | 2026-02-17 |
| The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning Hydroxyethyl Starch 130-0.4 60 MG/ML [Voluven], Hydrocortisone, Placebo - Potential Therapeutic Role | Not applicable | Completed | Tanta University | 60 | 2020-07-15 | 2024-05-01 |
| Different Preloads for Prevention of Hypotension in Patients Undergoing Elective CS Under Intrathecal Anesthesia Ringer, Voluven - Hypotension Drug-Induced | Early Phase 1 | Unknown | Assiut University | 60 | 2018-03-01 | 2018-03-15 |
| Fluid Optimization With Crystalloids and Colloids in Neurosurgery Sterofundin (Bolus of crystalloids), Voluven (Bolus of colloids) - Postoperative Complications | Not applicable | Completed | University Medical Centre Ljubljana | 80 | 2017-01-01 | 2021-09-16 |
| Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery Non balanced Hydroxyethyl starch 130/0.4 (Voluven®, Fresenius), Sodium Chloride 0.9% (Fresenius) - Extracorporeal Circulation, Cardiac Surgery | Phase 3 | Completed | Hospices Civils de Lyon | 30 | 2016-12-06 | 2025-08-06 |
| Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia hydroxyethyl starch (6% 130/0.4), Hyperbaric bupivacaine, Morphine - Coagulation Defect; Bleeding | Phase 2 | Completed | Assiut University | 60 | 2016-01-01 | 2016-11-08 |
| Disinvestment in Hydroxyl-ethyl Starches (HES) for Cardiac Surgery 6% hydroxyethyl starch - Cardiac Surgical Procedures | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 2000 | 2015-05-01 | 2018-11-06 | |
| Colloid Preload Versus Colloid Coload During Cesarean Deliveries hydroxyethyl starch (% 6 HES 130/0.4) (Voluven®), hydroxyethyl starch (%6 HES 130/0.4) (Voluven®) - Anesthesia; Adverse Effect, Spinal and Epidural, Hypotension | Phase 4 | Unknown | Sifa University | 200 | 2015-03-01 | 2015-11-17 |
| Use of 6% Hydroxyethylstarch (130/0.4) in Cardiac Surgical Patients human albumin 5%, HES 130/0.4 (Voluven) - Postoperative Kidney Injury | Phase 3 | Completed | The Cleveland Clinic | 149 | 2015-03-01 | 2023-02-14 |
| Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial Intravenous colloid bolus with Voluven - Supratentorial Neoplasms, Brain Tumor, Primary | Not applicable | Unknown | National Taiwan University Hospital | 80 | 2014-04-01 | 2014-12-03 |
| Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients Phenylephrine, Epinephrine, Albumin - Intracranial Aneurysm, Brain Edema | Not applicable | Completed | NYU Langone Health | 66 | 2014-03-01 | 2019-08-28 |
| Comparison of Priming Constituents in Patients Undergoing CPB Assisted Cardiac Surgery: HES 130/0.4 or Albumin 5% prime crystalloid, Human Albumin, Voluven - Coronary Artery Disease, Aortic Valve Disease | Not applicable | Withdrawn | University of Saskatchewan | 2013-11-01 | 2019-05-03 | |
| Colloids in Pediatric Cardiac Surgery: Comparison Between a Balanced and a Non-balanced Colloid Hydroxyethyl starch 130/0.4 in an isotonic electrolyte solution, Hydroxyethyl starch 130/0.4 in 0.9% sodium chloride - Cardiac Surgery, Cardiopulmonary Bypass | Phase 3 | Completed | Queen Fabiola Children's University Hospital | 88 | 2013-02-15 | 2020-11-09 |
| Stroke Volume Variation and Pulse Pressure Variation as Predictors of Fluid Responsiveness During Kidney Transplantation Fluid loading - Kidney Transplantation | Not applicable | Completed | Samsung Medical Center | 42 | 2012-12-01 | 2015-06-02 |
| Pulse Pressure Variation for Prediction of Fluid Responsiveness in Coronary Artery Disease Patients With Diastolic Dysfunction Fluid loading (Voluven) - Fluid Responsiveness Predictability | Not applicable | Completed | Yonsei University | 66 | 2012-01-01 | 2014-02-19 |
| Hydroxyethyl Starch and Renal Function After Radical Prostatectomy Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9 mg/ml - Prostate Cancer | Phase 4 | Completed | Regional Hospital Holstebro | 40 | 2012-01-01 | 2013-09-17 |
| Rotational Thromboelstometry (ROTEM) change_colloid_total Hip Replacement Arthroplasty Pentaspan, voluven, volulyte - Avascular Necrosis of Hip, Total Hip Replacement Arthroplasty | Not applicable | Completed | Seoul National University Bundang Hospital | 75 | 2012-01-01 | 2014-01-28 |
| Hydroxyethyl Starch and Renal Function After Hip Replacement Surgery Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9 mg/ml - Osteoarthritis | Phase 4 | Completed | Regional Hospital Holstebro | 42 | 2012-01-01 | 2013-05-29 |
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Hypotension (7) · Ischemia (3) · Postoperative Complications (3) · Sepsis (3) · Coronary Artery Disease (2) · Hemorrhage (2) · Shock, Septic (2) · Angina Pectoris (1) · Angina, Unstable (1) · Aortic Valve Disease (1) · Brain Edema (1) · Brain Neoplasms (1) · Burns (1) · Coronary Disease (1) · Critical Illness (1)
Fresenius Kabi (4) · Regional Hospital Holstebro (3) · Sangart (3) · Assiut University (2) · Hospices Civils de Lyon (2) · Seoul National University Hospital (2) · The Cleveland Clinic (2) · Alnas Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Biopure Corporation (1) · Chiang Mai University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Innogene Kalbiotech Pte. Ltd (1) · K. C. Rasmussen (1) · Karolinska Institutet (1)
South Korea (6) · Sweden (6) · Belgium (5) · Denmark (5) · Egypt (5) · France (4) · Austria (3) · Netherlands (3) · United States (3) · Canada (2) · Czechia (2) · Germany (2) · Poland (2) · Argentina (1) · Brazil (1)
Anne Sophie P. Kancir, MD PhD (3) · Andra Duncan, M.D. (1) · Andrea Kurz, MD (1) · Arnaldo Dubin, MD (1) · Aysun Afife Kar, MD (1) · Bertrand Guidet, Prof., MD (1) · Christian Loubert, MD, FRCPC (1) · Christina I. Olofsson, MD, PhD (1) · Chun-Yu Wu, MD (1) · Cindy E Boom, PhD, MD (1) · Erzsebet Bartha, M.D (1) · Eva M Base, MD (1) · Frederic Mercier, Professor (1) · Gaab Soo Kim, M.D, Ph.D. (1) · Hans Gombotz, Professor (1)
PMID 11273919, PMID 11810123, PMID 14750917, PMID 15758080, PMID 16127110, PMID 18633018, PMID 19608488, PMID 20813485, PMID 21317165, PMID 21455059, PMID 21924634, PMID 22624531, PMID 23047301, PMID 23303244, PMID 23718743, PMID 23837606, PMID 24100337, PMID 24570753, PMID 24970272, PMID 25572383, PMID 25627076, PMID 26261748, PMID 26475802, PMID 26635088, PMID 26994228, PMID 27413488, PMID 28981592, PMID 30411246, PMID 31138465, PMID 32072617, PMID 32619039, PMID 32753064, PMID 33744114, PMID 33957864, PMID 33966019, PMID 34127830, PMID 34406128, PMID 35677840, PMID 35710188, PMID 35884768
2009 (1)