31 completed, 18 unknown, 17 recruiting, 5 active not recruiting. 36 Not applicable, 5 Phase 4, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 36 | Completed 11, Unknown 9, Recruiting 5, Active not recruiting 4, Not yet recruiting 3, Terminated 3, Withdrawn 1 |
| Phase 4 | 5 | Completed 4, Unknown 1 |
| Phase 2 | 1 | Completed 1 |
Follow Mitral Valve Disease: new trials by email Literature Review of Mitral Valve Disease trials Research Report on Mitral Valve Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDY Mitral valve repair with creation of an 8 mm inter-atrial shunt - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Ottawa Heart Institute Research Corporation | 50 | 2026-09-30 | 2026-05-06 |
| MitrAl Valve Calcium aSsEssmEnt With TrueVue Trans-illumination 3D Rendering. Mitral Annular Calcification, Mitral Valve Disease | Recruiting | Centro Cardiologico Monzino | 100 | 2025-12-17 | 2026-09-17 | |
| Abbott Cephea Mitral Valve Disease Registry Mitral Regurgitation, Mitral Stenosis | Recruiting | Abbott Medical Devices | 1000 | 2025-08-13 | 2026-09-10 | |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
| Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease Heart Valve Disease, Mitral Valve (MV) Regurgitation | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10000 | 2025-06-01 | 2025-12-05 | |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study Septal Scoring Along Midline Endocardium - Hypertrophic Cardiomyopathy, Left Ventricular Septal Hypertrophy | Not applicable | Terminated | National Heart, Lung, and Blood Institute (NHLBI) | 1 | 2024-12-18 | 2025-12-18 |
| Safety and Efficacy of the CoolCryo System for Cardiac Cryoablation in the Treatment of Atrial Fibrillation Atrial Fibrillation, Paroxysmal or Persistent, Mitral Valve Disease | Recruiting | Medinice S.A. | 20 | 2024-07-03 | 2025-09-23 | |
| EXPLORE MRace (BR): Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve Disease | Not applicable | Recruiting | Polares Medical SA | 10 | 2024-04-08 | 2026-09-01 |
| European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study Intervention not provided - Heart Valve Diseases, Multiple Valve Disease, Unspecified | Recruiting | Assistance Publique - Hôpitaux de Paris | 1500 | 2024-02-07 | 2024-06-03 | |
| Non-invasive Prediction of Fluid and Noradrenaline Responsiveness Using the Carotid Wave Intensity. Shock, Aortic Valve Disease | Completed | Catharina Ziekenhuis Eindhoven | 120 | 2024-01-15 | 2025-02-18 | |
| Cardiac Index, SVR/SVRI During Weaning From ECC- Data Obtained From Femoral and Radial Artery Transducer CO/CI/SVR - Coronary Artery Disease, Aortic Valve Disease | Not applicable | Unknown | George Papanicolaou Hospital | 50 | 2024-01-01 | 2024-01-17 |
| Retrospective Clinical Data Collection on Carbomedics OptiForm Mitral Heart Valve Mitral Valve Replacement - Mitral Valve Disease | Unknown | Corcym S.r.l | 400 | 2023-11-23 | 2024-03-07 | |
| PROMISE: Percutaneous peRipheral cannulatiOn for Minimally-InvaSive Heart Valve surgEry Heart Valve Diseases, Mitral Valve Disease | Unknown | Universitätsklinikum Hamburg-Eppendorf | 1000 | 2023-08-01 | 2024-05-17 | |
| Munich Transcatheter Mitral Valve Safety and Effectiveness MUNICH TRANSCATHETER MITRAL VALVE REPLACEMENT SYSTEM - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | P+F Products + Features GmbH | 60 | 2023-07-30 | 2023-07-11 |
| The Effects of 360-degree Virtual Reality on Pre-procedural Anxiety in Patients Awaiting Elective Cardiac Surgery Involving a Sternotomy 360-degree Virtual Reality Patient Tour, State Trait Anxiety Inventory, Amsterdam Preoperative Anxiety and Information Scale - Cardiac Valve Disease, Aortic Valve Disease | Not applicable | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 100 | 2023-07-01 | 2024-07-10 |
| Clinical Investigation for the Foldax Tria Mitral Valve- India Mitral Valve Replacement - Mitral Valve Disease, Mitral Regurgitation | Not applicable | Unknown | Foldax, Inc | 70 | 2023-03-01 | 2024-01-05 |
| Evaluation of Mitral Valve Insufficiency Under General Anesthesia Mitral Regurgitation, Mitral Valve Disease | Unknown | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 50 | 2023-02-13 | 2023-07-24 | |
| Bleeding and Blood Transfusion in MVR Mitral valve replacement - Mitral Valve Disease | Unknown | Assiut University | 40 | 2022-12-01 | 2022-10-26 | |
| Respired Gases in Patients Post Cardiac Surgery Data collection using the Optical Gas Analyser - Critically Ill, Cardiac Disease | Completed | University of Oxford | 25 | 2022-10-30 | 2025-03-30 |
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Aortic Valve Disease (23) · Mitral Valve Insufficiency (23) · Heart Valve Diseases (14) · Coronary Artery Disease (13) · Mitral Valve Stenosis (9) · Aortic Valve Stenosis (8) · Heart Failure (8) · Atrial Fibrillation (5) · Cardiovascular Diseases (5) · Aortic Valve Insufficiency (4) · Heart Diseases (4) · Mitral Valve Prolapse (3) · Tricuspid Valve Insufficiency (3) · Disease (2) · Gastroesophageal Reflux (2)
Cardiovascular Diseases (53) · Heart Diseases (52) · Heart Valve Diseases (37) · Vascular Diseases (17) · Pathological Conditions, Signs and Symptoms (15) · Arterial Occlusive Diseases (13) · Arteriosclerosis (13) · Coronary Disease (13) · Myocardial Ischemia (13) · Pathologic Processes (13) · Ventricular Outflow Obstruction (8) · Aortic Valve Disease (4) · Arrhythmias, Cardiac (4) · Heart Valve Prolapse (3) · Signs and Symptoms (3)
Acetaminophen (2) · Anesthesia, General (2) · Cardiac Surgical Procedures (2) · Oxycodone (2) · Aminolevulinic Acid (1) · Anesthesia, Local (1) · Breathing Exercises (1) · Cardioplegic Solutions (1) · Continuous Positive Airway Pressure (1) · Drug Delivery Systems (1) · Echocardiography (1) · Enoxaparin (1) · HES 130-0.4 (1) · Intermittent Positive-Pressure Breathing (1) · Passive Cutaneous Anaphylaxis (1)
Abbott Medical Devices (4) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (3) · Polares Medical SA (3) · Universitätsklinikum Hamburg-Eppendorf (3) · Assiut University (2) · Catharina Ziekenhuis Eindhoven (2) · Edwards Lifesciences (2) · Foldax, Inc (2) · Mayra Guerrero (2) · Medical University of Lublin (2) · Michele De Bonis (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · University Hospital of Ferrara (2) · University of Oxford (2) · AHEPA University Hospital (1)
United States (18) · Italy (11) · Germany (7) · Netherlands (6) · United Kingdom (6) · Canada (5) · France (5) · Greece (5) · Switzerland (5) · China (4) · Poland (4) · Australia (3) · Brazil (3) · Egypt (3) · Austria (2)
Mayra Guerrero, MD (2) · Sebastian Ludwig, MD (2) · Alan Zajarias, MD (1) · Alberto Cremonesi (1) · Alexander Bogachev-Prokofiev, MD, PhD (1) · Alexey Evtushenko, MD, PhD (1) · Amar Krishnaswamy, MD (1) · Andres Beiras Fernandez, MD PhD (1) · Andrew Wang, M.D. (1) · Arash Yavari, DPhil MRCP (1) · Arthur Bouwman, MD PhD (1) · Ayman M Saleh, MD (1) · Bojan Biocina, M.D., Ph.D. (1)
PMID 11603594, PMID 11899956, PMID 14670881, PMID 14771796, PMID 15464329, PMID 16275007, PMID 25231271, PMID 29116972, PMID 29200066, PMID 29574443, PMID 29699609, PMID 31794742, PMID 32106812, PMID 32220010, PMID 33888229, PMID 33888230, PMID 33888231, PMID 33888232, PMID 34600872, PMID 34782683, PMID 35274222, PMID 35731506, PMID 36266153, PMID 37194288, PMID 37758379, PMID 39034924, PMID 39049480, PMID 39068298, PMID 39091640, PMID 39243262, PMID 39966045, PMID 40329826, PMID 40589299, PMID 41126360, PMID 41635678, PMID 41840772, PMID 42118099, PMID 42575577
2018 (1), 2019 (1), R01HL133667 (1)