1902 completed. 1902 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 1902 | Completed 1902 |
Follow Mental Disorders: new trials by email Literature Review of Mental Disorders trials Research Report on Mental Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Psoriasis With Depression and/or Anxiety With Methotrexate vs Combined Methotrexate and Antidepressant Combination of methotrexate and escitalopram in treatment of psoriasis patients with depression and/or anxiety, Methotrexate - Depression, Anxiety | Phase 4 | Completed | Cairo University | 40 | 2026-02-01 | 2026-10-05 |
| Health Benefits of Nutraceutical Supplementation in Older Adults. Powder containing whey isolate and herbal extracts (30g sachet) - Age-related Functional Decline, Mild Cognitive Impairment | Phase 4 | Completed | GPLIFE HEALTHCARE PRIVATE LIMITED | 23 | 2025-12-24 | 2026-04-16 |
| Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients Dexmedetomidine, Dexmedetomidine-esketamine combination - Older Patients, Postoperative Care | Phase 4 | Completed | Peking University First Hospital | 100 | 2025-10-21 | 2026-06-30 |
| Efficacy of Bacillus Coagulans in Alleviating Anxiety and Depression in Patients With Functional Dyspepsia Bacillus coagulans, placebo - Functional Dyspepsia, Probiotics | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 181 | 2025-09-18 | 2026-10-13 |
| Mexidol® Efficacy and Safety in Treatment of VCIND in Older Adults Mexidol, Standard Therapy - Vascular Cognitive Impairment no Dementia | Phase 4 | Completed | Pharmasoft | 120 | 2025-09-14 | 2026-07-14 |
| EFFECT OF ZOLPIDEM ON SLEEP QUALITY AND OPIOID CONSUMPTION FOLLOWING PRIMARY TOTAL KNEE ARTHROPLASTY: A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL Zolpidem 10 mg tablets, Avocado-soybean unsaponifiables 300 mg - Postoperative Pain Management in Total Knee Arthroplasty | Phase 4 | Completed | Sanatorio Allende | 54 | 2025-08-05 | 2026-09-03 |
| A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression Esketamine 56 mg, Esketamine 84 mg - Depressive Disorder, Treatment-Resistant | Phase 4 | Completed | Janssen Korea, Ltd., Korea | 47 | 2025-06-09 | 2026-08-03 |
| Association Between Diastolic Dysfunction and Erectile Dysfunction and the Effect of Tadalafil and SGLT2 Inhibitors on Them in Men With Metabolic Syndrome Tadalafil 5 mg, SGLT-2 inhibitor, Tadalafil plus SGLT2 inhibitors - Erectile Dysfunction, Left Ventricular Diastolic Dysfunction | Phase 4 | Completed | Kafrelsheikh University | 60 | 2025-05-05 | 2026-05-04 |
| Efficacy of Transcutaneous Electrical Neural Stimulation and Tadalafil in Men With Erectile Dysfunction: A Randomized, Double-Blind, Bi-centric, Placebo- and Sham-Controlled Trial Placabo, Tadalafil 5 mg, Sham stimulation - Erectile Dysfunction | Phase 4 | Completed | Menoufia University | 185 | 2025-05-01 | 2026-09-02 |
| Platelet-Rich Plasma With or Without Tadalafil for Erectile Dysfunction Tadalafil, Intracavernosal Platelet-Rich Plasma Injection - Erectile Dysfunction | Phase 4 | Completed | Benha University | 160 | 2025-04-15 | 2026-05-22 |
| A Bundled Intervention a bundled intervention, including peer support specialist, buprenorphine, physician care, and telehealth - Opioid Use Disorder, Opioid Overdose | Phase 4 | Completed | University of Alabama at Birmingham | 30 | 2025-02-13 | 2026-10-28 |
| The Use of Cyproheptadine in Pediatric Feeding Disorders Cyproheptadine, Nutritional Counseling, Behavioral Counseling - Pediatric Feeding Disorder, Chronic, Avoidant Restrictive Food Intake Disorder | Phase 4 | Completed | University of Miami | 18 | 2024-12-30 | 2026-06-04 |
| Effects of Ciprofol on Postoperative Delirium and Outcomes in Elderly Patients Undergoing Major Thoracic Surgery Ciprofol, Propofol - Postoperative Delirium (POD) | Phase 4 | Completed | Wang Tianlong | 225 | 2024-12-23 | 2026-06-30 |
| C-Raven, a Virtual Tobacco Cessation Intervention in the Community C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker - Tobacco Dependence | Phase 4 | Completed | Johns Hopkins University | 10 | 2024-10-30 | 2026-02-02 |
| Satisfaction With Orodispersible vs Conventional Memantine in Moderate to Severe Alzheimer's Disease Memantine, Memantine Oral Tablet - Alzheimer Disease | Phase 4 | Completed | Carnot Laboratories | 105 | 2024-10-04 | 2026-02-18 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium Dexmedetomidine, Esketamine, Normal saline - Older Patients, Nasal Administration | Phase 4 | Completed | Peking University First Hospital | 340 | 2024-09-02 | 2025-07-31 |
| Effectiveness of Ultrasonography-guided Pericapsular Nerve Group Block in Patients With Adhesive Capsulitis ultrasonography-guided PENG block, Mobilization - Pericapsular Nerve Group Block (PENG Block), Kinesiophobia | Phase 4 | Completed | Ondokuz Mayıs University | 61 | 2024-06-01 | 2024-11-21 |
| Comparative Evaluation of Safety and Efficacy of Dapoxetine, Silodosin, and Citalopram in the Management of Premature Ejaculation Oral intake of medication - Premature (Early) Ejaculation | Phase 4 | Completed | Beni-Suef University | 450 | 2024-06-01 | 2025-08-08 |
| Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment Patient-Oriented Dosing (POD), Pain Self-Management (PSM), Usual Care - Opioid Use Disorder, Chronic Pain | Phase 4 | Completed | Erin Winstanley | 273 | 2024-05-28 | 2026-11-05 |
| Intranasal Dexmedetomidine Versus Oral Midazolam Premedication for Postoperative Negative Behavior Changes in Children Dexmedetomidine Hydrochloride, Midazolam, normal Saline - Behavior Problem | Phase 4 | Completed | Fujian Provincial Hospital | 324 | 2024-05-22 | 2026-07-30 |
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Schizophrenia (331) · Depressive Disorder, Major (222) · Depression (190) · Bipolar Disorder (164) · Attention Deficit Disorder with Hyperactivity (154) · Psychotic Disorders (153) · Anxiety Disorders (114) · Alcoholism (95) · Alzheimer Disease (86) · Sleep Initiation and Maintenance Disorders (82) · Erectile Dysfunction (80) · Tobacco Use Disorder (69) · Cognitive Dysfunction (67) · Stress Disorders, Post-Traumatic (67) · Substance-Related Disorders (62)
Nervous System Diseases (463) · Mood Disorders (416) · Behavior (350) · Schizophrenia Spectrum and Other Psychotic Disorders (350) · Pathological Conditions, Signs and Symptoms (343) · Chemically-Induced Disorders (303) · Signs and Symptoms (291) · Neurocognitive Disorders (263) · Substance-Related Disorders (241) · Neurologic Manifestations (238) · Depressive Disorder (237) · Behavioral Symptoms (231) · Neurodevelopmental Disorders (194) · Central Nervous System Diseases (184)
Risperidone (98) · Olanzapine (80) · Escitalopram (79) · Aripiprazole (76) · Quetiapine Fumarate (71) · Methylphenidate (69) · Dexmedetomidine (47) · Atomoxetine Hydrochloride (46) · Naltrexone (44) · Bupropion (43) · Sugars (42) · Sertraline (40) · ziprasidone (37) · Duloxetine Hydrochloride (36) · Memantine (36)
Massachusetts General Hospital (78) · Eli Lilly and Company (72) · New York State Psychiatric Institute (45) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (30) · University of Pennsylvania (30) · University of California, Los Angeles (27) · University of Pittsburgh (23) · NYU Langone Health (22) · National Institute of Mental Health (NIMH) (20) · Emory University (19) · University of Texas Southwestern Medical Center (18) · Bayer (17) · University of Wisconsin, Madison (17) · Sanofi (16) · Yale University (15)
United States (1054) · Canada (102) · China (86) · Germany (76) · South Korea (65) · Spain (53) · France (49) · United Kingdom (46) · Italy (44) · Brazil (40) · Taiwan (33) · Denmark (32) · Netherlands (31) · Russia (30) · Australia (28)
Joseph Biederman, MD (11) · Dong-Xin Wang, MD, PhD (10) · Amit Anand, MD (7) · Janet Wozniak, MD (6)
PMID 25019647, PMID 37230961, PMID 37142273, PMID 37335995, PMID 37811711, PMID 28892218, PMID 33189083, PMID 28832750, PMID 33884617, PMID 34231914, PMID 35141873, PMID 36063082, PMID 38767196, PMID 38958149, PMID 39868569, PMID 19578654, PMID 19617584, PMID 20840778, PMID 21095016, PMID 21256799, PMID 21569378, PMID 21586165, PMID 21975110, PMID 25441015, PMID 25758058, PMID 25980552, PMID 26107752, PMID 26709542, PMID 26803397, PMID 28980198, PMID 29608461, PMID 29856773, PMID 30097769, PMID 31415936, PMID 34183490, PMID 34582562, PMID 34611902, PMID 35592490, PMID 35833913, PMID 36999619, PMID 37936553, PMID 39428602, PMID 40342086, PMID 40728007, PMID 40779812, PMID 42030496, PMID 42214294, PMID 10070549, PMID 10372604, PMID 10492856
2009 (9), 2015 (7), 2014 (6), 2005 (5), 2008 (4), N01MH090001 (4), 2004 (3), 2019 (3), N01MH90001 (3), P50CA143188 (3), P50DA019706 (3), 2017 (2), 2018 (2), P50AA003510 (2), P50MH066286 (2)