69 completed, 16 recruiting, 10 unknown, 9 active not recruiting. 129 Phase 1, 34 Phase 2.
Follow Marijuana Abuse: new trials by email Literature Review of Marijuana Abuse trials Research Report on Marijuana Abuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC) 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie - Cannabis Intoxication | Phase 1 | Not yet recruiting | Johns Hopkins University | 70 | 2027-02-01 | 2026-10-15 |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
| Cannabis and Opioid Use Disorder, Study 2 Inhaled Cannabis, Intranasal Opioid - Opioid Use Disorders, Cannabis Use | Phase 1 | Not yet recruiting | University of Kentucky | 100 | 2026-11-30 | 2026-10-09 |
| Cannabis Effects on Opioid Self-Administration Cannabis, Placebo Cannabis, Intranasal Opioid Agonist - Opioid Use Disorder, Cannabis Use | Phase 1 | Not yet recruiting | Shanna Babalonis, PhD | 30 | 2026-11-30 | 2026-10-14 |
| Lemborexant for Cannabis Use Disorder Lemborexant 10mg, Placebo, Brief Behavioural Intervention - Cannabis Use Disorder | Phase 1 / Phase 2 | Not yet recruiting | University of Calgary | 28 | 2026-11-01 | 2026-09-22 |
| Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes Cannabis, 0 mg THC (placebo) - Cannabis Intoxication | Phase 1 | Recruiting | Johns Hopkins University | 70 | 2026-09-15 | 2026-09-18 |
| Acute Effects of Cannabis on Cognition and Affect THC 20mg, Placebo - Cannabis Use | Phase 1 | Recruiting | Washington State University | 92 | 2026-09-11 | 2026-10-29 |
| A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users Cannabis, placebo - Cannabis | Phase 1 / Phase 2 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 80 | 2026-09-01 | 2025-12-22 |
| Evaluation of BRC-002 Safety, Tolerability, Pharmacokinetics, and Food Effects in Healthy Participants BRC-002, Placebo - Healthy Adult Participants | Phase 1 | Enrolling by invitation | Biopharmaceutical Research Company | 50 | 2026-06-15 | 2026-07-13 |
| Impact of Cannabis Consumption on Psychotic Symptoms and Reality Monitoring in Patients With Schizophrenia: a Real-life Study Ecological Momentary Assessment (EMA) and Reality Monitoring tasks - Schizophrenia | Phase 1 / Phase 2 | Not yet recruiting | Centre Hospitalier Charles Perrens, Bordeaux | 120 | 2026-06-01 | 2026-03-16 |
| The Pharmacokinetics of a Hemp-Based Topical Product CBD, THC - Cannabis | Phase 1 | Recruiting | Johns Hopkins University | 20 | 2026-05-26 | 2026-09-03 |
| A Study Testing the Effects of Different THC Doses on Psychological and Biological Function AVCN319301b (6mg), AVCN319301b (9mg), AVCN319301b (15mg) - Evaluate PK Profile, Evaluate PD Profile | Phase 1 | Not yet recruiting | University of Calgary | 24 | 2026-02-01 | 2026-01-16 |
| Clinical Study to Evaluate the Effects of Oral Delta-9-tetrahydrocannabinol (Δ9-THC) With and Without Alcohol on Perception and Driving Performance in Healthy Adults 5 mg Dronabinol (Marinol®) + Placebo Beverage, 10 mg Dronabinol (Marinol®) + Placebo Beverage, 5 mg Dronabinol (Marinol®) + Alcohol Beverage - Cannabis, Drug Effects, Driving Performance | Phase 1 | Completed | Food and Drug Administration (FDA) | 48 | 2025-12-29 | 2026-09-30 |
| Drug-Drug Interaction Between THC and AEF0117 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one, Placebo - Cannabis Abuse | Phase 1 | Withdrawn | Aelis Farma | 2025-12-01 | 2026-02-27 | |
| THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy Placebo, THC, CBD 20 mg - Abuse, Drug, Pain | Phase 1 | Recruiting | University of California, Los Angeles | 30 | 2025-11-05 | 2025-12-17 |
| Warrior CARE: Cannabis Behavioral Health Tetrahydrocannabinol, Cannabidiol, Placebo - Post Traumatic Stress Disorder, Cannabis Use | Phase 1 / Phase 2 | Recruiting | Wayne State University | 500 | 2025-09-22 | 2026-08-07 |
| CANnabinoids in Pediatric ONCology MPL-001, MPL-005, MPL-009 - Childhood Cancer, Cancer | Phase 1 / Phase 2 | Recruiting | University of Manitoba | 60 | 2025-07-18 | 2026-06-11 |
| High Potency Cannabis: Acute and Protracted Effects Placebo Comparator: Placebo, Low dose THC, High dose THC - Abuse Cannabis, Pain | Phase 1 | Recruiting | University of California, Los Angeles | 30 | 2025-07-03 | 2026-09-04 |
| Age-dependent Effects of Smoked and Oral Delta-9-THC Cannabis, Dronabinol, Smoked Placebo - Pain, Abuse, Drug | Phase 1 | Recruiting | University of California, Los Angeles | 103 | 2025-04-30 | 2026-01-07 |
| The Effects of Cannabis on Male Reproductive Functions Cannabis plant (THC 20mg), Cannabis (0%/ THC / 0% CBD), Cannabis plant (THC 40mg) - Male Reproductive Problem | Phase 1 | Withdrawn | Kanako Hayashi | 2025-04-01 | 2026-08-19 |
Showing 20 of 129. Sign in to see all of them.
Substance-Related Disorders (12) · Pain (10) · Psychotic Disorders (5) · Driving Under the Influence (4) · Multiple Sclerosis (4) · Muscle Spasticity (4) · Neuralgia (4) · Tobacco Use (4) · Behavior, Addictive (3) · Opioid-Related Disorders (3) · Schizophrenia (3) · Tobacco Use Disorder (3) · Alcoholism (2) · Coitus (2)
Chemically-Induced Disorders (128) · Mental Disorders (127) · Substance-Related Disorders (117) · Pathological Conditions, Signs and Symptoms (24) · Behavior (20) · Signs and Symptoms (20) · Neurologic Manifestations (19) · Nervous System Diseases (13) · Schizophrenia Spectrum and Other Psychotic Disorders (7) · Immune System Diseases (6) · Autoimmune Diseases (5) · Musculoskeletal Diseases (5) · Neuromuscular Diseases (5) · Autoimmune Diseases of the Nervous System (4) · Criminal Behavior (4)
nabiximols (46) · Dronabinol (38) · Cannabidiol (5) · Analgesics, Opioid (3) · Ethanol (3) · Acetylcysteine (2) · Oxycodone (2) · Alprazolam (1) · Capsules (1) · Cognitive Behavioral Therapy (1) · Contraceptives, Oral (1) · Ecological Momentary Assessment (1) · Eszopiclone (1) · Exercise (1) · Guanfacine (1)
Johns Hopkins University (17) · Yale University (13) · National Institute on Drug Abuse (NIDA) (8) · Center for Medicinal Cannabis Research (7) · University of California, Los Angeles (7) · New York State Psychiatric Institute (6) · Jazz Pharmaceuticals (5) · Shanna Babalonis, PhD (4) · Aelis Farma (3) · Boston Children's Hospital (3) · Centre hospitalier de l'Université de Montréal (CHUM) (3) · University of California, San Diego (3) · Wayne State University (3) · Battelle Memorial Institute (2) · CannaXan GmbH (2)
United States (91) · Canada (12) · Israel (4) · Germany (3) · Austria (2) · Denmark (2) · Netherlands (2) · United Kingdom (2) · Australia (1) · Jamaica (1) · Spain (1) · Thailand (1)
Ziva Cooper, PhD (6) · Ryan Vandrey, PhD (4) · Shanna Babalonis, PhD (4) · Margaret Haney, PhD (3) · Ryan Vandrey, Ph.D. (3) · Tory Spindle, PhD (3) · Carlos A Zamarripa, PhD (2) · Didier Jutras-Aswad, MD,MS (2) · Donald I Abrams, M.D. (2) · Dustin Lee, PhD (2) · Fred Konikoff, professor (2) · Godfrey Pearlson, M.D (2) · John R Knight, MD (2) · Leslie Lundahl, PhD (2) · Louis Cantilena, M.D. (2)
PMID 31527291, PMID 34173005, PMID 15094417, PMID 16223067, PMID 17063973, PMID 17355521, PMID 17429350, PMID 17916224, PMID 19099294, PMID 21049267, PMID 21296508, PMID 21359104, PMID 21671456, PMID 21869692, PMID 22921474, PMID 23052407, PMID 23179176, PMID 23648372, PMID 23750331, PMID 23831756, PMID 24821356, PMID 25220020, PMID 26011657, PMID 26144593, PMID 26257143, PMID 27089154, PMID 27121791, PMID 27899456, PMID 28138971, PMID 28188235, PMID 28349233, PMID 29689485, PMID 30615854, PMID 30646391, PMID 33571293, PMID 33605440, PMID 34185831, PMID 34264732, PMID 35080588, PMID 35787693, PMID 37531115, PMID 37731936, PMID 38832949, PMID 40040421, PMID 40069983, PMID 41514385, PMID 42009751, PMID 42454450, PMID 42514343
2014 (2), R01DA025044 (2), R01DA045700 (2), R01DA058624 (2), U01DA053832 (2), K12DA000357 (1), K24DA029647 (1), R01AT010762 (1), R01DA027131 (1), R01DA038807 (1), R01DA047296 (1), R01DA057252 (1), R01DA059584 (1), R01DA064583 (1), R21DA020831 (1)