15 completed, 2 not yet recruiting, 2 unknown, 1 recruiting. 22 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 22 | Completed 15, Not yet recruiting 2, Unknown 2, Recruiting 1, Terminated 1, Withdrawn 1 |
Follow Marijuana Abuse: new trials by email Literature Review of Marijuana Abuse trials Research Report on Marijuana Abuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis Metformin - Psychosis, Cannabis Use | Phase 4 | Not yet recruiting | Nova Scotia Health Authority | 24 | 2027-02-01 | 2026-11-10 |
| Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder Delayed-release, extended-release methylphenidate, Placebo - ADHD, Cannabis Use Disorder | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 66 | 2026-11-01 | 2026-09-28 |
| E-cigarette Cessation in Adults Who Co-use Cannabis Varenicline Pill, Contingency management, Counseling - Nicotine Dependence, Tobacco Use Disorder | Phase 4 | Recruiting | Medical University of South Carolina | 105 | 2025-02-19 | 2026-06-12 |
| N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use N-Acetyl cysteine, Placebo comparator, Cognitive behavioral therapy (CBT) - Cannabis Use, Tobacco Use Disorder | Phase 4 | Completed | Ellen Herbst | 41 | 2021-08-25 | 2026-08-11 |
| Effects of THC and Alcohol on Driving Performance THC 0, THC 5, THC 10 - Cannabis, Alcohol Drinking | Phase 4 | Withdrawn | Lakehead University | 2021-07-01 | 2022-04-25 | |
| EMERALD TRIAL Open Label Extension Study MediCabilis CBD oil - Amyotrophic Lateral Sclerosis, Cannabis | Phase 4 | Unknown | Gold Coast Hospital and Health Service | 7 | 2021-05-17 | 2023-04-03 |
| Capsaicin for the Treatment of Cannabinoid Hyperemesis Syndrome Capsaicin, Placebo - Cannabinoid Hyperemesis Syndrome | Phase 4 | Completed | University of Virginia | 20 | 2020-12-01 | 2024-10-18 |
| Reducing Cannabis Overuse With Prazosin Prazosin Hydrochloride - Cannabis Dependence, Posttraumatic Stress Disorder | Phase 4 | Completed | VA Puget Sound Health Care System | 11 | 2020-11-09 | 2025-06-15 |
| Effects of Pregnancy-associated Hormones on THC Metabolism in Women Dronabinol - Pregnancy Related, Cannabis Use | Phase 4 | Completed | University of Washington | 14 | 2020-10-19 | 2026-05-06 |
| Treatment Strategies in CHS Haloperidol - Cannabis Hyperemesis Syndrome | Phase 4 | Completed | University of Calgary | 4 | 2020-10-13 | 2022-08-10 |
| Cannabinoids for Pain Control During Medical Abortion Dronabinol 5mg Cap, Placebo - Medical Abortion, Pain | Phase 4 | Completed | Oregon Health and Science University | 72 | 2018-11-01 | 2020-04-07 |
| Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC) Ondansetron 8mg, Haloperidol 0.05mg/kg, Haloperidol 0.1mg/kg - Cannabis Use Disorder | Phase 4 | Completed | Dr. Marco L.A. Sivilotti | 33 | 2017-05-21 | 2024-04-03 |
| N-acetylcysteine for the Treatment of Cannabis Dependence: Working Mechanisms N-acetylcysteine, Placebo Oral Tablet, Magnetic Resonance Imaging - Cannabis Use Disorder, Cannabis Dependence | Phase 4 | Unknown | Universitair Ziekenhuis Brussel | 75 | 2016-05-15 | 2020-12-08 |
| Varenicline for Co-occurring Cannabis and Tobacco Use Standard clinical care first, followed by standard clinical care and varenicline, Standard clinical care and varenicline first, followed by standard clinical care - Cannabis Dependence, Tobacco Dependence | Phase 4 | Completed | Albert Einstein College of Medicine | 7 | 2015-01-01 | 2024-09-24 |
| Clozapine for Cannabis Use in Schizophrenia Clozapine, Risperidone - Schizophrenia, Cannabis Abuse | Phase 4 | Completed | Dartmouth-Hitchcock Medical Center | 49 | 2013-05-01 | 2020-05-05 |
| Nicotine Patch for Marijuana Withdrawal Nicotine, Placebo Patch - Marijuana Dependence | Phase 4 | Completed | Southern Illinois University Carbondale | 127 | 2011-04-01 | 2015-04-30 |
| Improving Substance Use and Clinical Outcomes in Heavy Cannabis Users With Quetiapine Behavioral Intervention - Cannabis Dependence | Phase 4 | Completed | Northwell Health | 124 | 2010-10-22 | 2018-04-17 |
| Buspirone Treatment for Marijuana Dependence Buspirone, Placebo - Marijuana Dependence | Phase 4 | Completed | Medical University of South Carolina | 175 | 2009-09-01 | 2016-08-10 |
| Pilot Evaluation of Atomoxetine on Attention Deficit Hyperactivity Disorder (ADHD) Symptoms in Adolescents With Cannabis abusE Atomoxetine - Attention Deficit Hyperactivity Disorder, Cannabis Abuse | Phase 4 | Terminated | Eli Lilly and Company | 7 | 2008-09-01 | 2010-08-24 |
| Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania Quetiapine and placebo, Quetiapine and Topiramate - Bipolar Disorder, Cannabis-Related Disorder | Phase 4 | Completed | University of Cincinnati | 75 | 2006-11-01 | 2017-09-26 |
Showing 20 of 22. Sign in to see all of them.
Substance-Related Disorders (5) · Tobacco Use Disorder (3) · Attention Deficit Disorder with Hyperactivity (2) · Cannabinoid Hyperemesis Syndrome (2) · Psychotic Disorders (2) · Schizophrenia (2) · Alcohol Drinking (1) · Alcohol-Related Disorders (1) · Alcoholism (1) · Amyotrophic Lateral Sclerosis (1) · Bipolar Disorder (1) · Familial cyclic vomiting syndrome (1) · Hyperemesis Gravidarum (1) · Motor Neuron Disease (1)
Chemically-Induced Disorders (22) · Mental Disorders (22) · Substance-Related Disorders (17) · Schizophrenia Spectrum and Other Psychotic Disorders (3) · Attention Deficit and Disruptive Behavior Disorders (2) · Behavior (2) · Neurodevelopmental Disorders (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Bipolar and Related Disorders (1) · Central Nervous System Diseases (1) · Drinking Behavior (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Metabolic Diseases (1)
Dronabinol (3) · Acetylcysteine (2) · Clozapine (2) · Haloperidol (2) · Varenicline (2) · Atomoxetine Hydrochloride (1) · Behavior Therapy (1) · Buspirone (1) · Capsaicin (1) · Capsules (1) · Cognitive Behavioral Therapy (1) · Counseling (1) · Fluoxetine (1) · Magnetic Resonance Spectroscopy (1) · Metformin (1)
Dartmouth-Hitchcock Medical Center (2) · Medical University of South Carolina (2) · Albert Einstein College of Medicine (1) · Dr. Marco L.A. Sivilotti (1) · Eli Lilly and Company (1) · Ellen Herbst (1) · Gold Coast Hospital and Health Service (1) · Lakehead University (1) · Massachusetts General Hospital (1) · National Institute on Drug Abuse (NIDA) (1) · Northwell Health (1) · Nova Scotia Health Authority (1) · Oregon Health and Science University (1) · Southern Illinois University Carbondale (1) · Universitair Ziekenhuis Brussel (1)
United States (14) · Canada (3) · Australia (1) · Belgium (1) · Netherlands (1)
Aimee McRae-Clark, Pharm.D. (1) · Alan Green, MD (1) · Alan I Green, MD (1) · Angela Holian, PharmD (1) · David G Gilbert, PhD (1) · Ellen Herbst, MD (1) · Erin A McClure, PhD (1) · Garth E Terry, MD, PhD (1) · Madeline Martinez Rivas, PhD (1) · Marco LA Sivilotti, MD, MSc (1) · Melissa P DelBello, MD (1) · Nina Isoherranen, PhD (1) · Paula Riggs, M.D. (1)
PMID 32034447, PMID 32459420, PMID 33160719, PMID 37271412, PMID 39697396
K12DA000357 (1), K23DA025736 (1), P01DA032507 (1), R01DA013196 (1), R01DA022221 (1), R01DA026782 (1), R01DA031006 (1), R01DA032533 (1), R25DA023021 (1), R25GM104547 (1), R37CA237245 (1)