33 completed, 9 unknown, 8 terminated. 50 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 50 | Completed 33, Unknown 9, Terminated 8 |
Follow Major Depression: new trials by email Literature Review of Major Depression trials Research Report on Major Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bupropion Versus Escitalopram on Reward Circuitry and Motivational Deficits Bupropion XL, Escitalopram - Major Depression | Phase 4 | Completed | Emory University | 18 | 2020-09-23 | 2023-12-29 |
| Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of Vortioxetine Vortioxetine - Depressive Disorder, Major Depression | Phase 4 | Terminated | Massachusetts General Hospital | 2 | 2017-08-24 | 2019-10-14 |
| The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. Ketamine Hydrochloride - Major Depression, Bipolar I Disorder | Phase 4 | Completed | Mayo Clinic | 75 | 2017-06-01 | 2022-03-15 |
| Escitalopram Plus PS128 vs. Escitalopram Lactobacillus plantarum PS128 - Major Depression | Phase 4 | Terminated | Kaohsiung Kai-Suan Psychiatric Hospital | 41 | 2016-11-18 | 2019-09-18 |
| Bupropion for Depression in ESRD Patients on Hemodialysis Fluoxetine, Bupropion - Major Depression, End Stage Renal Disease | Phase 4 | Terminated | University of Arkansas | 1 | 2016-03-31 | 2018-07-17 |
| Measurement-based Care for Depression in Resource-Poor Settings Fluoxetine, Enhanced Usual Care - Major Depression | Phase 4 | Completed | Florida International University | 140 | 2014-02-01 | 2016-12-01 |
| Effectiveness of Repetitive Transcranial Magnetic Stimulation in Depressed Patients Transcranial Magnetic Stimulation, Sham Transcranial Magnetic Stimulation - Major Depression | Phase 4 | Unknown | Universidad Nacional Autonoma de Mexico | 80 | 2013-09-01 | 2014-08-11 |
| Comparison of Venlafaxine and Fluoxetine in the Treatment of Postmenopausal Women With Major Depression venlafaxine, fluoxetine - Major Depression | Phase 4 | Completed | Capital Medical University | 189 | 2013-03-07 | 2017-09-14 |
| Effectiveness Study of Mirtazapine Combined With Paroxetine in Major Depressive Patients Without Early Improvement mirtazapine, paroxetine 20mg QD - Major Depression | Phase 4 | Completed | Capital Medical University | 525 | 2012-11-14 | 2017-08-31 |
| Effects of Sevoflurane and Ketamine on QT in Electroconvulsive Therapy Sevoflurane, Ketamine - Major Depression, Electroconvulsive Therapy | Phase 4 | Completed | Inonu University | 24 | 2012-02-01 | 2013-06-06 |
| Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI Selective Serotonin Reuptake Inhibitor (SSRI) - Bipolar Disorder, Major Depression | Phase 4 | Completed | The Cleveland Clinic | 192 | 2011-11-01 | 2019-12-02 |
| Effect of Antidepressants on White Matter Structure Desvenlafaxine - Major Depression | Phase 4 | Unknown | Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal | 40 | 2011-11-01 | 2011-12-15 |
| Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Paroxetine, Sertraline, Citalopram - Major Depression | Phase 4 | Unknown | HolsboerMaschmeyer NeuroChemie GmbH | 80 | 2011-09-01 | 2014-09-12 |
| Inflammatory Markers and Cognitive Function in Major Depression Duloxetine - Major Depression | Phase 4 | Unknown | Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal | 20 | 2011-07-01 | 2012-07-19 |
| Efficacy Study of Botox for Depression Botox, Saline Solution - Major Depression | Phase 4 | Unknown | Capital Clinical Research Associates, LLC | 60 | 2011-02-01 | 2012-03-19 |
| Efficacy and Safety Curcumin in Depression curcumin - Major Depression | Phase 4 | Completed | Vladimir Lerner | 40 | 2010-08-01 | 2013-02-07 |
| Interpersonal Therapy for Depression in Breast Cancer Interpersonal Psychotherapy, Problem-Solving Therapy, Brief Supportive Psychotherapy - Major Depression | Phase 4 | Completed | New York State Psychiatric Institute | 134 | 2009-10-01 | 2017-07-18 |
| Relapse Prevention With Escitalopram or Nortriptyline Following Electro-Convulsive Treatment (DUAG-7) escitalopram, nortriptyline - Major Depression | Phase 4 | Terminated | Hillerod Hospital, Denmark | 47 | 2009-08-01 | 2014-12-09 |
| Electroconvulsive Therapy (ECT) for Elderly Patients With Major Depression ECT - Major Depression | Phase 4 | Completed | Diakonhjemmet Hospital | 92 | 2009-08-01 | 2015-07-09 |
| Changes of Functional Connectivity After rTMS in Depression repetitive transcranial magnetic stimulation(rTMS), Sham repetitive transcranial magnetic stimulation(rTMS) - Major Depression | Phase 4 | Completed | Yonsei University | 44 | 2009-05-01 | 2012-02-02 |
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PMID 16946178, PMID 19193344, PMID 19288975, PMID 19545857, PMID 19820552, PMID 20144692, PMID 20187924, PMID 21672502, PMID 22964160, PMID 24345483, PMID 24504819, PMID 24972362, PMID 25271445, PMID 25590761, PMID 26529118, PMID 27379563, PMID 29940870, PMID 30579045, PMID 34011310, PMID 34718252, PMID 34838606, PMID 38142892, PMID 38479192, PMID 42702010
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