187 completed, 35 unknown, 27 recruiting, 22 terminated. 134 Not applicable, 50 Phase 4, 36 Phase 2, 21 Phase 3, 18 Phase 1.
Follow Major Depression: new trials by email Literature Review of Major Depression trials Research Report on Major Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin for Depression in Veterans Psilocybin, modafinil, zolpidem - Major Depression | Phase 2 | Not yet recruiting | VA Office of Research and Development | 150 | 2027-01-01 | 2026-10-26 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-12-31 | 2026-10-30 |
| Shortened LSD Intervention for Major Depressive Disorder LSD, Risperidone - Major Depression Moderate, Major Depression Severe | Phase 1 | Not yet recruiting | Johns Hopkins University | 10 | 2026-12-01 | 2026-11-03 |
| EEG-Guided Transcranial Magnetic Stimulation for Adults With Depression MagVenture TMS Therapy System with Localite Navigation System and actiCHamp EEG - Major Depressive Disorder (MDD), Treatment Resistant Depression | Not applicable | Recruiting | Mayo Clinic | 60 | 2026-11-02 | 2026-11-03 |
| Individual Narratives of Stimulation (ECT and TMS) There is no intervention in this observation study (qualitative interviews about past treatment experiences) - Major Depression | Not yet recruiting | University of Nottingham | 12 | 2026-11-01 | 2026-09-30 | |
| Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 TMS, NRX-101 - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 30 | 2026-10-01 | 2026-10-30 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 100 | 2026-10-01 | 2026-10-30 |
| Evaluation of an 8-week Behavior Skills-based Virtual Reality Program for Adolescents With Depression. (MDD) Virtual reality - Major Depression | Not applicable | Not yet recruiting | Edward Via Virginia College of Osteopathic Medicine | 10 | 2026-09-01 | 2026-09-08 |
| Relationship of Peripheral Inflammatory and Neuroprotective Biomarkers With Response to Intermittent Theta Burst Stimulation in Treatment-Resistant Depression Intermittent Theta Burst Stimulation (iTBS) - Treatment-resistant Depression (TRD), Major Depression | Not applicable | Recruiting | Gulhane Training and Research Hospital | 100 | 2026-09-01 | 2026-09-14 |
| Non-Coding RNAs Gene Expression in Psychiatric Disorders Reverse Transcription Quantitative Polymerase Chain Reaction - Schizophrenia Disorders, Major Depression | Not yet recruiting | Carmen Concerto | 384 | 2026-09-01 | 2026-06-23 | |
| Neural Mechanisms of Real-world Emotions and Internalizing Academic Performance Feedback - Major Depression, Generalized Anxiety | Not applicable | Recruiting | University of Miami | 144 | 2026-08-24 | 2026-10-23 |
| Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression Psilocybin - Major Depression | Phase 3 | Recruiting | VA Office of Research and Development | 240 | 2026-08-03 | 2026-10-23 |
| Inhaled DMT for Major Depressive Disorder N,N-Dimethyltryptamine (15 mg + 60 mg), N,N-Dimethyltryptamine (1 mg + 4 mg) - MDD, Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Universidade Federal do Rio Grande do Norte | 140 | 2026-08-01 | 2026-07-13 |
| Study of Psilocybin Under Anesthesia Controlled by EEG Psilocybin (Usona Institute), Propofol, Placebo - Major Depression | Phase 2 | Not yet recruiting | Stanford University | 10 | 2026-07-01 | 2026-05-06 |
| iTBS Versus Standard 10 Hz rTMS for Treatment-Resistant Depression (TRD) iTBS, rTMS - Major Depression | Not applicable | Active not recruiting | Kafrelsheikh University | 182 | 2026-06-30 | 2026-10-01 |
| Study on iTBS Regulating the Reward Circuit Function to Improve Anhedonia in Depression Left DLPFC + OFC iTBS, Left DLPFC iTBS - Major Depression, Anhedonia | Not applicable | Recruiting | Guo Wenbin | 60 | 2026-05-19 | 2026-09-10 |
| Modular Intervention for Depression Study Modular Intervention for Depression Therapy (MIND Therapy), Psychotherapy as Usual (TAU) - Major Depression | Not applicable | Recruiting | Pontificia Universidad Catolica de Chile | 150 | 2026-05-01 | 2026-05-12 |
| Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 80 | 2026-03-11 | 2026-05-13 |
| Effect of Psychobiotics With Standard Antiddepressants in Treatment of Major Depressive Disorder Lactobacillus Helveticus and bifidobacterium Longum, Placebo Capsule(s) - Major Depression | Not applicable | Recruiting | Dr Sadia yasir | 86 | 2026-01-31 | 2026-09-30 |
| EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT Electroconvulsive Therapy - Major Depression Moderate, Major Depression Severe | Recruiting | Istanbul University - Cerrahpasa | 62 | 2026-01-01 | 2026-08-05 |
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Depressive Disorder, Major (296) · Depression (88) · Bipolar Disorder (39) · Schizophrenia (27) · Anxiety Disorders (26) · Depressive Disorder (18) · Psychotic Disorders (16) · Mental Disorders (14) · Mood Disorders (14) · Dysthymic Disorder (13) · Stress Disorders, Post-Traumatic (13) · Depressive Disorder, Treatment-Resistant (8) · Generalized Anxiety Disorder (8) · Sleep Initiation and Maintenance Disorders (5) · Alcoholism (4)
Mental Disorders (282) · Mood Disorders (282) · Depressive Disorder (278) · Behavior (95) · Behavioral Symptoms (91) · Bipolar and Related Disorders (39) · Schizophrenia Spectrum and Other Psychotic Disorders (31) · Nervous System Diseases (25) · Pathological Conditions, Signs and Symptoms (20) · Trauma and Stressor Related Disorders (18) · Stress Disorders, Traumatic (13) · Signs and Symptoms (12) · Neurologic Manifestations (11) · Central Nervous System Diseases (9) · Nutritional and Metabolic Diseases (9)
Escitalopram (23) · Transcranial Magnetic Stimulation (16) · Sertraline (11) · Cognitive Behavioral Therapy (10) · Transcranial Direct Current Stimulation (9) · Fluoxetine (8) · Ketamine (7) · Bupropion (6) · Duloxetine Hydrochloride (6) · Interpersonal Psychotherapy (6) · Venlafaxine Hydrochloride (6) · Citalopram (5) · Paroxetine (5) · Therapeutics (5) · Cycloserine (4)
National Institute of Mental Health (NIMH) (10) · New York State Psychiatric Institute (8) · The University of New South Wales (8) · Massachusetts General Hospital (7) · Centre for Addiction and Mental Health (5) · Charite University, Berlin, Germany (5) · University of Pittsburgh (5) · VA Office of Research and Development (5) · Weill Medical College of Cornell University (5) · Emory University (4) · Hillerod Hospital, Denmark (4) · Karolinska Institutet (4) · Mclean Hospital (4) · US Department of Veterans Affairs (4) · University of California, Los Angeles (4)
United States (130) · Canada (21) · Germany (21) · France (14) · Australia (10) · Denmark (10) · Israel (10) · China (8) · Sweden (8) · Brazil (6) · Norway (6) · Taiwan (5) · Turkey (Türkiye) (5) · Spain (4) · Chile (3)
Carlos A Zarate, M.D. (4) · Amit Anand, MD (3) · Jonathan W. Stewart, MD. (3) · Thomas E. Schlaepfer, MD (3) · Benjamin Van Voorhees, MD, MPH (2) · Christian Otte, MD (2) · Colleen Loo, MBBS, FRANZCP, MD (2) · Dominique Malauzat, MD (2) · Dunja Hinze-Selch, MD (2) · Gordon B Parker, Dsc MD PhD (2) · John D Matthews, MD (2) · Joshua C Brown, MD, PhD (2) · Lisa V. Rubenstein, MD MSPH (2) · Volker Coenen, MD (2) · Aaron S Heller, PhD (1)
PMID 34817851, PMID 17503104, PMID 18279507, PMID 19101777, PMID 30253883, PMID 42171126, PMID 11939866, PMID 12472325, PMID 15067160, PMID 15213794, PMID 15365580, PMID 15876903, PMID 16174141, PMID 16677714, PMID 16836631, PMID 16862248, PMID 16946178, PMID 17264696, PMID 17299509, PMID 17365393, PMID 17548749, PMID 17623814, PMID 17702053, PMID 18061147, PMID 18678695, PMID 19061681, PMID 19117524, PMID 19146566, PMID 19193344, PMID 19194795, PMID 19211468, PMID 19264942, PMID 19288975, PMID 19414708, PMID 19545857, PMID 19785754, PMID 19820552, PMID 19892408, PMID 19995444, PMID 20144692, PMID 20157139, PMID 20187924, PMID 20331933, PMID 20367694, PMID 20695669, PMID 21672502, PMID 21731830, PMID 21764215, PMID 21975821, PMID 22032247
2009 (2), R01MH077210 (2), 2005 (1), 2014 (1), I01RD001520 (1), K23MH069784 (1), K99MH141192 (1), M01RR000071 (1), P30MH082760 (1), P30MH090333 (1), R00AA024142 (1), R01CA105269 (1), R01DK103769 (1), R01HL071992 (1), R01MH056946 (1)