29 completed, 7 terminated, 7 unknown, 3 not yet recruiting. 17 Phase 4, 11 Phase 2, 10 Not applicable, 8 Phase 3, 4 Phase 1.
Follow Nortriptyline: new trials by email Literature Review of Nortriptyline trials Research Report on Nortriptyline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH Nortriptyline, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Sultan Qaboos University | 90 | 2027-05-01 | 2026-10-02 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM) Galcanezumab, Erenumab 70 mg, Eptinezumab - Migraine Associated Vertigo, Tinnitus | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-07-01 | 2026-06-17 |
| Management of Acute Tinnitus With Migraine Medications Nortriptyline, Topiramate, Paroxetine - Tinnitus | Phase 4 | Active not recruiting | University of California, Irvine | 100 | 2025-06-01 | 2025-10-10 |
| Treatment of Meniere's Disease With Migraine Medications nortriptyline + topiramate - Ménière | Phase 4 | Recruiting | University of California, Irvine | 40 | 2022-08-01 | 2026-06-22 |
| Antidepressants Trial in Parkinson's Disease Nortriptyline, Escitalopram, Placebo - Depression, Parkinson Disease | Phase 3 | Completed | University College, London | 52 | 2021-03-05 | 2023-05-06 |
| Pediatric Concussion Outcomes Nortriptyline, Placebo - Concussion Post Syndrome, Headaches Posttraumatic | Phase 4 | Terminated | Lancaster General Hospital | 8 | 2020-02-15 | 2025-09-10 |
| Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline, Placebo cream - Vestibulodynia, Temporomandibular Disorder | Phase 2 | Completed | Duke University | 209 | 2019-11-04 | 2026-03-19 |
| Treatment of Tinnitus With Migraine Medications Nortriptyline + Topiramate, Verapamil + Paroxetine, Placebo - Tinnitus, Subjective, Tinnitus | Phase 4 | Completed | University of California, Irvine | 78 | 2019-09-26 | 2026-04-16 |
| RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Depression, Dementia | Phase 4 | Completed | Centre for Addiction and Mental Health | 87 | 2019-08-01 | 2024-11-25 |
| Nortriptyline for the Treatment of Functional Dyspepsia Nortriptyline, Placebo - Functional Dyspepsia | Phase 3 | Terminated | Maastricht University Medical Center | 96 | 2018-09-01 | 2025-07-03 |
| Optimizing Outcomes of Treatment-Resistant Depression in Older Adults Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Washington University School of Medicine | 742 | 2017-02-24 | 2024-10-03 |
| Paclitaxel and Nortriptyline Hydrochloride in Treating Patients With Relapsed Small Cell Carcinoma Nortriptyline Hydrochloride, Paclitaxel - Small Cell Carcinoma | Phase 1 | Completed | University of Washington | 2 | 2016-11-03 | 2019-12-17 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| Patient Assisted Intervention for Neuropathy: Comparison of Treatment in Real Life Situations Nortriptyline, Duloxetine, Pregabalin - Cryptogenic Sensory Polyneuropathy | Phase 4 | Completed | University of Kansas Medical Center | 402 | 2014-10-01 | 2018-07-06 |
| Trial of Nortriptyline and Topiramate in the Initial Treatment of Vestibular Migraine nortriptyline, Topiramate, Diet Modification - Migraine Disorders | Not applicable | Terminated | St. Louis University | 35 | 2014-08-22 | 2021-04-23 |
| Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis) NSAIDs; adjunctive analgesics; adjunctive anti-depressants, Lumbar epidural injection, Joint Mobilizations (spine, sacroiliac, hip) - Lumbar Spinal Stenosis | Not applicable | Completed | Michael Schneider, DC, PhD | 259 | 2013-11-20 | 2018-04-02 |
| Interpersonal Psychotherapy for Treatment Resistant Depression IPT+ antidepressant drugs, fluoxetine, sertraline - Treatment Resistant Depression | Not applicable | Unknown | Hospital de Clinicas de Porto Alegre | 74 | 2013-04-01 | 2013-07-11 |
| Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 Gene Paroxetine, Sertraline, Citalopram - Major Depression | Phase 4 | Unknown | HolsboerMaschmeyer NeuroChemie GmbH | 80 | 2011-09-01 | 2014-09-12 |
| Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode Lithium Carbonate, Sertraline, Nortriptyline - Bipolar Disorder | Phase 4 | Completed | Federal University of Rio Grande do Sul | 78 | 2010-05-01 | 2020-11-20 |
Showing 20 of 49. Sign in to see all of them.
Depression (17) · Depressive Disorder, Major (7) · Migraine Disorders (6) · Depressive Disorder, Treatment-Resistant (4) · Pain (4) · Depressive Disorder (3) · Tinnitus (3) · Bipolar Disorder (2) · Dementia (2) · Drug-Related Side Effects and Adverse Reactions (2) · Gastroesophageal Reflux (2) · Heartburn (2) · Irritable Bowel Syndrome (2) · Mood Disorders (2) · Parkinson Disease (2)
Samsung Medical Center (5) · Zalicus (4) · New York State Psychiatric Institute (3) · University of California, Irvine (3) · Duke University (2) · Federal University of Rio Grande do Sul (2) · US Department of Veterans Affairs (2) · Centre for Addiction and Mental Health (1) · Hannover Medical School (1) · Hillerod Hospital, Denmark (1) · HolsboerMaschmeyer NeuroChemie GmbH (1) · Hospital Universitari de Bellvitge (1) · Hospital de Clinicas de Porto Alegre (1) · Johns Hopkins University (1) · Lancaster General Hospital (1)
United States (24) · Germany (6) · South Korea (5) · Canada (3) · Brazil (2) · Denmark (1) · Iran (1) · Netherlands (1) · Oman (1) · Spain (1) · United Kingdom (1)
Doh Kwan Kim, M.D., Ph.D. (3) · Johannes Gassmueller, M.D. (2) · Marcelo Fleck, PhD (2) · A. John Rush, MD (1) · Allan V. Prochazka, MD MSc (1) · Andrea Nackley, PhD (1) · Andrew Bishara, MD (1) · Anette Schrag (1) · Anthony A Mikulec, MD (1) · Aristotle Voineskos, MD (1) · Carlos Blanco, MD, PhD (1) · Charles Reynolds, MD (1) · Doh Kwan Kim, M.D.,Ph.D. (1) · Doh Kwan Kim, MD PhD (1)
PMID 28832750, PMID 10450257, PMID 15534159, PMID 16390886, PMID 16426099, PMID 16457894, PMID 16551710, PMID 16554525, PMID 16554526, PMID 16566612, PMID 16566901, PMID 16636629, PMID 16642436, PMID 16690084, PMID 16754414, PMID 16816220, PMID 16824617, PMID 16946176, PMID 16946177, PMID 17074942, PMID 17091129, PMID 17195602, PMID 17302619, PMID 18162025, PMID 18678792, PMID 18681756, PMID 19026268, PMID 19092112, PMID 19192454, PMID 19339358, PMID 19341509, PMID 19460188, PMID 19493369, PMID 19945804, PMID 20010317, PMID 20194481, PMID 20463113, PMID 20808132, PMID 21114950, PMID 21216475, PMID 21518864, PMID 21929846, PMID 21964277, PMID 22008447, PMID 22057975, PMID 22884879, PMID 22933451, PMID 23158458, PMID 23158959, PMID 23303512
2017 (1), P30CA015704 (1), R01DE013906 (1), R01HD096331 (1), R01MH043832 (1), R01MH055716 (1), R01MH061609 (1), R01MH076051 (1), R01MH114966 (1), R01MH114970 (1), R01MH114980 (1), R01MH114981 (1), R34MH073677 (1), U01DK073974 (1), U01DK073975 (1)