13 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 18 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 18 | Completed 13, Recruiting 2, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 2 | 5 | Completed 4, Recruiting 1 |
Follow Major Depression: new trials by email Literature Review of Major Depression trials Research Report on Major Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Shortened LSD Intervention for Major Depressive Disorder LSD, Risperidone - Major Depression Moderate, Major Depression Severe | Phase 1 | Not yet recruiting | Johns Hopkins University | 10 | 2026-12-01 | 2026-11-03 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 100 | 2026-10-01 | 2026-10-30 |
| Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults SM-001 - Major Depression, Post Traumatic Stress Disorder | Phase 1 | Unknown | Advanced Integrative Medical Science Institute | 12 | 2023-10-01 | 2023-07-07 |
| Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression Arm 1, 2, 3 device interventions, Arm 2 Interventions, Arm 1, 2, 3 drug Interventions - Depression, Major Depressive Disorder | Phase 1 | Recruiting | National Institute of Mental Health (NIMH) | 70 | 2020-01-21 | 2026-11-12 |
| Technology Enhanced Family Treatment Family-Focused Treatment with MCC App - Mood Disorders, Bipolar Disorder | Phase 1 / Phase 2 | Completed | University of California, Los Angeles | 65 | 2018-11-15 | 2024-05-28 |
| Pilot BA Study of New LY03005 vs Pristiq LY03005, Pristiq - Major Depression | Phase 1 | Completed | Luye Pharma Group Ltd. | 20 | 2016-12-07 | 2017-03-20 |
| Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression Ayahuasca, placebo - Major Depression | Phase 1 / Phase 2 | Completed | Universidade Federal do Rio Grande do Norte | 35 | 2014-02-01 | 2025-04-06 |
| Effects of Deep Brain Stimulation in Treatment Resistant Major Depression DBS, No Stimulation (Sham) - Major Depression | Phase 1 | Completed | University Hospital, Bonn | 7 | 2011-04-01 | 2018-08-06 |
| Safety and Pharmacology Study of BMS-866949 Placebo, BMS-866949 - Major Depression | Phase 1 | Terminated | Bristol-Myers Squibb | 47 | 2010-05-01 | 2012-03-27 |
| Individually Based Psychosocial Rehabilitation for Older People With Serious Mental Illness (SMI) HOPES-I - Schizophrenia, Schizoaffective Disorder | Phase 1 | Completed | Dartmouth-Hitchcock Medical Center | 38 | 2009-11-01 | 2014-05-07 |
| Photobiomodulation to Alter Cerebral Blood Flow and to Affect the Emotional Status of Patients With Major Depression Photobiomodulation with a super-luminous light emitting diode - Major Depression, Anxiety Disorder | Phase 1 | Completed | Massachusetts General Hospital | 10 | 2009-01-01 | 2009-08-19 |
| Interpersonal Psychotherapy for Depressed Adolescents and Parents Interpersonal Therapy for Depressed Adolescents & Parents - Major Depression, Dysthymic Disorder | Phase 1 | Completed | New York State Psychiatric Institute | 10 | 2007-11-01 | 2012-03-09 |
| Antidepressant Effects of NR2B in Major Depression MK-0657, Placebo - Major Depression | Phase 1 | Completed | National Institute of Mental Health (NIMH) | 5 | 2007-05-01 | 2012-08-03 |
| Evaluation of the Deep TMS H-Coil in the Treatment of Major Depression- Augmentation of Antidepressant Medication Transcranial Magnetic Stimulation (TMS) - Major Depression | Phase 1 / Phase 2 | Completed | Hadassah Medical Organization | 57 | 2007-04-01 | 2015-03-20 |
| Randomized Trial of Psychotherapy for Persistently Depressed Primary Care Patients behavior therapy, Medication prescribed by PCP - Major Depression | Phase 1 | Completed | Butler Hospital | 40 | 2007-04-01 | 2011-07-08 |
| Evaluation of Deep Transcranial Magnetic Stimulation (TMS) H-Coil in the Treatment of Major Depression H1 and H2 deep TMS coils - Major Depression | Phase 1 | Completed | Shalvata Mental Health Center | 2006-05-01 | 2009-02-05 | |
| Evaluation of Three Continuation Therapies After ECT Concerning Efficacy and Cognition in Severly Depressed Patients TCAs, SSRIs, NARIs, SNRIs, Lithium, Electroconvulsive therapy, Cognitive behavioral group therapy - Depression, Major Depression | Phase 1 | Completed | Charite University, Berlin, Germany | 90 | 2005-03-01 | 2011-11-10 |
| Dichotic Listening as a Predictor of Medication Response in Depression Fluoxetine, Imipramine - Major Depression, Dysthymia | Phase 1 / Phase 2 | Completed | New York State Psychiatric Institute | 25 | 1994-04-01 | 2019-05-30 |
Depressive Disorder, Major (18) · Depression (6) · Bipolar Disorder (2) · Dysthymic Disorder (2) · Stress Disorders, Post-Traumatic (2) · Adjustment Disorders (1) · Anxiety Disorders (1) · Depressive Disorder (1) · Depressive Disorder, Treatment-Resistant (1) · Mood Disorders (1) · Psychotic Disorders (1) · Schizophrenia (1) · Substance-Related Disorders (1)
Mental Disorders (18) · Depressive Disorder (17) · Mood Disorders (17) · Behavior (6) · Behavioral Symptoms (6) · Trauma and Stressor Related Disorders (3) · Bipolar and Related Disorders (2) · Stress Disorders, Traumatic (2) · Chemically-Induced Disorders (1) · Schizophrenia Spectrum and Other Psychotic Disorders (1)
Transcranial Magnetic Stimulation (2) · 4-methylbenzyl 3-fluoro-4-((pyrimidin-2-ylamino)methyl)piperidine-1-carboxylate (1) · Behavior Therapy (1) · Cycloserine (1) · Desvenlafaxine Succinate (1) · Electroconvulsive Therapy (1) · Fluoxetine (1) · Imipramine (1) · Lithium (1) · Low-Level Light Therapy (1) · Lysergic Acid Diethylamide (1) · Risperidone (1) · Selective Serotonin Reuptake Inhibitors (1) · Serotonin and Noradrenaline Reuptake Inhibitors (1) · Therapeutics (1)
National Institute of Mental Health (NIMH) (2) · New York State Psychiatric Institute (2) · Advanced Integrative Medical Science Institute (1) · Bristol-Myers Squibb (1) · Butler Hospital (1) · Charite University, Berlin, Germany (1) · Dartmouth-Hitchcock Medical Center (1) · Hadassah Medical Organization (1) · Johns Hopkins University (1) · Luye Pharma Group Ltd. (1) · Massachusetts General Hospital (1) · Mclean Hospital (1) · Shalvata Mental Health Center (1) · Universidade Federal do Rio Grande do Norte (1) · University Hospital, Bonn (1)
United States (11) · Germany (2) · Israel (2) · Brazil (1) · Sweden (1)
Andrea Johnston, BA (1) · Armen Arevian, MD (1) · Carlos A Zarate, M.D. (1) · Carlos A Zarate, MD (1) · David J Miklowitz, PhD (1) · Draulio B de Araujo, Ph.D (1) · Eva-Lotta Brakemeier, MA (1) · Hilik Levkovits (1) · Jonathan W. Stewart, MD. (1) · Joshua C Brown, MD, PhD (1) · Leanna J Standish, ND PhD (1) · Lisa Uebelacker, PhD (1) · Malek Bajbouj, PhD (1)
PMID 18061147, PMID 19995444, PMID 21731830, PMID 22722512, PMID 23562618, PMID 23916389, PMID 24462229, PMID 29903051, PMID 30253883, PMID 31231276, PMID 31798447, PMID 33360365, PMID 38094620, PMID 40109484, PMID 40494497
R34MH117200 (1)