79 completed. 79 Phase 2, 15 Phase 1, 12 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 79 | Completed 79 |
| Phase 1 | 15 | Completed 15 |
| Phase 3 | 12 | Completed 12 |
Follow Low Back Pain: new trials by email Literature Review of Low Back Pain trials Research Report on Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PRP Spinoplasty for Chronic Low Back Pain With Multiple Pathologies: A Quasi-Experimental Study Spinoplasty with Platelet Rich Plasma - Lower Back Pain Chronic, Lumbar Disc Disease | Phase 2 | Completed | Allmed Medical Center | 35 | 2024-09-15 | 2025-12-08 |
| Dose-Response Characterization of VER-01 in the Treatment of Patients With Chronic Non-specific Low Back Pain VER-01, Placebo - Chronic Non-specific Low Back Pain | Phase 2 | Completed | Vertanical GmbH | 652 | 2024-06-28 | 2025-08-11 |
| Open-label Placebo in Manual Therapy Open-label placebo, Osteopathic manipulative treatment - Low Back Pain, Recurrent | Phase 2 | Completed | Studio Osteopatico Busto Arsizio | 31 | 2024-02-26 | 2025-08-11 |
| Efficacy and Safety of S (+) - Ibuprofen in the Treatment of Mechanical Low Back Pain S (+) - Ibuprofen, Ibuflex® - Low Back Pain, Mechanical, Low Back Pain | Phase 2 | Completed | Apsen Farmaceutica S.A. | 177 | 2022-06-03 | 2026-09-08 |
| Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain SP-103, Placebo - Moderate to Severe Acute Lower Back Pain | Phase 2 | Completed | Scilex Pharmaceuticals, Inc. | 76 | 2022-04-29 | 2026-07-06 |
| Breathing and Attention Training for Chronic Low Back Pain Breathing and Attention Training - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | University of Florida | 29 | 2021-07-18 | 2024-06-10 |
| Alberta Back Care Pathway (ABCp) ABCp, Usual Care - Low Back Pain | Phase 2 | Completed | University of Alberta | 713 | 2021-03-31 | 2026-10-26 |
| Treating Negative Affect in Low Back Pain Patients Antidepressant, Enhanced Fear Avoidance Rehabilitation - Chronic Low Back Pain, Negative Affectivity | Phase 2 | Completed | Ajay Wasan, MD, Msc | 308 | 2021-03-31 | 2026-08-28 |
| Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain PP353, Placebo - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | Persica Pharmaceuticals Ltd | 43 | 2020-01-20 | 2026-03-27 |
| Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD Autologous BM-MSC, Sham Procedure - Intervertebral Disc Degeneration, Chronic Low-back Pain | Phase 2 | Completed | Fondazione Policlinico Universitario Campus Bio-Medico | 48 | 2019-11-03 | 2025-05-25 |
| Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study GTX 2/3, Placebo - Back Pain, Acute Pain | Phase 1 / Phase 2 | Completed | Algenis SpA | 30 | 2019-10-11 | 2021-03-16 |
| Effects of Sleep Disruption on Drug Response Within-Subject test of blinded study medication - Low Back Pain, Recurrent, Healthy | Phase 2 | Completed | Johns Hopkins University | 109 | 2019-10-07 | 2026-10-21 |
| Tolperisone in Acute Muscle Spasm of the Back Tolperisone, Placebo - Back Pain, Acute Pain | Phase 2 | Completed | Neurana Pharmaceuticals, Inc. | 415 | 2019-02-01 | 2022-02-01 |
| BOL-DP-o-04 in Patients With Low Back Pain and Sciatica BOL-DP-o-04 + SCO, Placebo + SCO - Low Back Pain, Sciatica | Phase 1 / Phase 2 | Completed | Breath of Life International Pharma Ltd | 26 | 2018-11-27 | 2022-12-08 |
| Effectiveness of Chiropractic Application for Acute Low Back Pain diclophenac sodium (75 mg, IM) and thiocolchicoside (4 mg, IM), Chiropractic Treatment - Low Back Pain, Mechanical | Phase 2 | Completed | Medipol University | 98 | 2018-10-01 | 2021-04-22 |
| Optimizing Chronic Low Back Pain Exercise Therapies With Cerebral Electrical Stimulation Real transcranial direct current stimulation + therapeutic exercises for back pain, Sham transcranial direct current stimulation + therapeutic exercises for back pain - Low Back Pain, Recurrent, Chronic Low Back Pain | Phase 2 / Phase 3 | Completed | Universidade Federal do Piauí | 60 | 2018-04-10 | 2021-01-19 |
| Evaluating the Role of Neuroinflammation in Low Back Pain Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging, Placebo Capsule - Low Back Pain, Back Pain With Radiation | Phase 2 | Completed | Marco Loggia | 60 | 2017-10-10 | 2026-02-11 |
| Optimization of Spinal Manipulative Therapy Protocols SMT, Mobilizing Exercises, Activation Exercises - Low Back Pain | Phase 2 | Completed | University of Utah | 273 | 2017-02-22 | 2023-05-17 |
| Trial of Dronabinol and Vaporized Cannabis in Chronic Low Back Pain Placebos, dronabinol, Vaporized Cannabis 3.7% THC/5.6% CBD - Cannabis, Low Back Pain | Phase 2 | Completed | University of California, San Diego | 131 | 2016-12-01 | 2023-09-28 |
| Transverse Abdominis Plane Block for Anterior Approach Spine Surgery TAP block ropivacaine, TAP block placebo, General anesthesia - Spine Surgery, Low Back Pain | Phase 2 | Completed | Rennes University Hospital | 43 | 2016-11-07 | 2023-05-24 |
Showing 20 of 79. Sign in to see all of them.
Back Pain (12) · Pain (9) · Chronic Pain (8) · Motor Activity (8) · Sciatica (6) · Radiculopathy (5) · Intervertebral Disc Degeneration (4) · Neuralgia (4) · Acute Pain (3) · Agnosia (2) · Bronchiolitis Obliterans Syndrome (2) · Health Education (2) · Intervertebral disc disease (2) · Musculoskeletal Diseases (2)
Neurologic Manifestations (79) · Pathological Conditions, Signs and Symptoms (79) · Signs and Symptoms (79) · Pain (70) · Back Pain (67) · Nervous System Diseases (15) · Neuromuscular Diseases (12) · Behavior (11) · Peripheral Nervous System Diseases (11) · Musculoskeletal Diseases (9) · Mononeuropathies (6) · Sciatic Neuropathy (6) · Bone Diseases (5) · Neuralgia (5) · Spinal Diseases (5)
Exercise (3) · Manipulation, Osteopathic (3) · Manipulation, Spinal (3) · Naproxen (3) · Cognitive Behavioral Therapy (2) · Ibuprofen (2) · Manipulation, Chiropractic (2) · Massage (2) · Mindfulness (2) · Sodium Chloride (2) · Tapentadol (2) · tanezumab (2) · Acupuncture Therapy (1) · Acupuncture, Ear (1) · Anesthesia, General (1)
Johns Hopkins University (3) · National Institute of Dental and Craniofacial Research (NIDCR) (3) · Northwestern Health Sciences University (3) · Janssen Pharmaceutical K.K. (2) · Kovacs Foundation (2) · Pfizer (2) · University of Florida (2) · Ajay Wasan, MD, Msc (1) · Algenis SpA (1) · Allmed Medical Center (1) · Alza Corporation, DE, USA (1) · Annette C. Toledano MD (1) · Apsen Farmaceutica S.A. (1) · Ataturk Training and Research Hospital (1) · Boston Medical Center (1)
United States (41) · Spain (7) · United Kingdom (5) · Canada (4) · Germany (4) · Australia (3) · Brazil (3) · Denmark (3) · Italy (3) · Austria (2) · Finland (2) · Hungary (2) · Israel (2) · Poland (2) · Turkey (Türkiye) (2)
Gert Bronfort, DC, PhD (2) · Aage Indahl, Ph.d (1) · Adrian Jury, MD (1) · Ajay Wasan, MD, MSc (1) · Aleksandra Zgierska, MD PhD (1) · Alex F Manini, MD, MS, FACMT (1) · Ana Sanchez, MD, PhD (1) · Annette C Toledano, MD (1) · Anthony Rosner, PhD (1) · Antonio Ruiz, MD (1) · Anupama Kizhakkeveettil, MAOM (1) · Avril Drummond, PhD (1)
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