66 completed. 66 Phase 3, 10 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 66 | Completed 66 |
| Phase 2 | 10 | Completed 10 |
Follow Leg Injuries: new trials by email Literature Review of Leg Injuries trials Research Report on Leg Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Counterpain PXM Versus Diclofenac Versus Piroxicam Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel) - Ankle Sprain, Back Pain | Phase 3 | Completed | Taisho Pharmaceutical Indonesia | 180 | 2025-11-04 | 2026-03-16 |
| Phase III Trial to Evaluate the Efficacy and Safety in Patients With Ankle Sprains. Esflurbiprofen Topical System (EFTS), Placebo Patch - Ankle Sprains | Phase 3 | Completed | Teikoku Seiyaku Co., Ltd. | 69 | 2025-03-31 | 2025-11-26 |
| Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery Continuous compression cryotherapy, Conventional ice treatment - Postoperative Pain, Acute, Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | University Medical Center Ho Chi Minh City (UMC) | 72 | 2023-06-01 | 2024-10-08 |
| Feasibility of a RCT That Compares Immediate Versus Optional Delayed Surgical Repair After ACL Injury Immediate anterior cruciate ligament reconstruction, Rehabilitation, Optional delayed anterior cruciate ligament reconstruction - Anterior Cruciate Ligament Injuries | Phase 3 | Completed | Universitaire Ziekenhuizen KU Leuven | 29 | 2020-09-15 | 2023-11-15 |
| Evaluation of TXA Prior to Surgery in the Geriatric Hip Fracture Population Tranexamic Acid Injectable Solution, Placebo - Hip Fractures | Phase 3 | Completed | Lancaster General Hospital | 283 | 2020-02-01 | 2024-10-10 |
| Voltaren Emulgel 2% Acute Ankle Sprain Non Inferiority Study Diclofenac diethylamine 2.32% gel, Diclofenac diethylamine 1.16% gel, Placebo - Pain | Phase 3 | Completed | GlaxoSmithKline | 313 | 2019-10-24 | 2022-04-12 |
| Traumatologic Acute Pain Management With Fentanyl Transdermal Therapeutic System (TTS) Fentanyl Transdermal System, Placebo - Hip Fractures (ICD-10 72.01-72.2) | Phase 3 | Completed | Medical University of Graz | 145 | 2019-06-30 | 2020-07-22 |
| Can Continuous Non-invasive Monitoring Improve Stability of Intraoperative Blood Pressure - A Feasibility Study. Continuous non-invasive blood pressure monitoring - Hip Fractures, Hypotension on Induction | Phase 3 | Completed | University Hospital Birmingham NHS Foundation Trust | 30 | 2019-06-13 | 2022-05-18 |
| Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic ACL Surgery Ketorolac, Oxycodone-Acetaminophen - ACL Injury, Postoperative Pain | Phase 3 | Completed | University Hospitals Cleveland Medical Center | 49 | 2019-05-21 | 2021-12-21 |
| Ketorolac as an Adjuvant Agent for Postoperative Pain Control Following Arthroscopic Meniscus Surgery Ketorolac, Oxycodone-Acetaminophen - Meniscus Tear, Tibial, Pain, Postoperative | Phase 3 | Completed | University Hospitals Cleveland Medical Center | 48 | 2019-04-23 | 2022-03-03 |
| Starting a Testosterone and Exercise Program After Hip Injury Testosterone, Placebo gel, Supervised exercise training - Hip Fracture, Frailty | Phase 3 | Completed | Washington University School of Medicine | 129 | 2019-03-05 | 2025-02-04 |
| Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction Celecoxib, Hydrocodone-Acetaminophen, Ketorolac - Anterior Cruciate Ligament Injury | Phase 2 / Phase 3 | Completed | Henry Ford Health System | 90 | 2019-01-22 | 2026-03-19 |
| Objective Results of Anterior Cruciate Ligament Reconstruction With and Without Internal Suture Augmentation Technique all- inside anterior cruciate ligament reconstruction - Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | Ain Shams University | 38 | 2018-09-01 | 2021-06-02 |
| Treatment of Muscle Injury Following Arthroplasty for Hip Fracture (HF) PLX-PAD, Placebo - Hip Fracture | Phase 3 | Completed | Pluristem Ltd. | 240 | 2018-07-26 | 2023-09-28 |
| Clinical Application of Mg Based Biodegradable Material for Fracture Fixation in the Adult Skeleton BRI.MAG 2 - Fracture of Medial Malleolus | Phase 2 / Phase 3 | Completed | Medical University of Graz | 20 | 2018-07-09 | 2023-01-31 |
| TRAUMED - a Clinical Trial in Acute Ankle Sprain Traumeel®, Diclofenac sodium gel 1%, Placebo - Ankle Sprain | Phase 3 | Completed | Biologische Heilmittel Heel GmbH | 809 | 2018-02-26 | 2024-01-31 |
| Intra-articular Dexmedetomidine Versus Neostigmine After Knee Arthroscopy (a Comparative Study) dexamedetomidine, neostigmine - Knee Injuries | Phase 2 / Phase 3 | Completed | Assiut University | 100 | 2017-08-01 | 2018-01-11 |
| Topical Tranexamic Acid (TXA) in Hip Fractures Tranexamic Acid, Saline Wash - Hip Fracture, Anemia | Phase 3 | Completed | Sault Area Hospital | 65 | 2016-11-01 | 2019-08-19 |
| Clinical Outcomes of ACL Reconstruction Augmented by an Injectable Osteoconductive/Osteoinductive Compound OOC - ACL Injury | Phase 3 | Completed | University of Miami | 26 | 2016-10-24 | 2021-09-05 |
| Post Approval Study to Evaluate the Effectiveness and Safety of Cartiva Implant in the Treatment of OA of the Great Toe Cartiva - Osteoarthritis of First Metatarsalphalangeal Joint | Phase 3 | Completed | Cartiva, Inc. | 135 | 2016-10-01 | 2019-03-22 |
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Hip Fractures (26) · Ankle Injuries (17) · Anterior Cruciate Ligament Injuries (7) · Pain (6) · Knee Injuries (5) · Soft Tissue Injuries (5) · Osteoporosis (4) · Pain, Postoperative (4) · Ankle Fractures (3) · Osteoarthritis (3) · Anemia (2) · Bone Diseases, Metabolic (2) · Femoral Neck Fractures (2) · Fractures, Bone (2) · Hallux Limitus (2)
Wounds and Injuries (64) · Fractures, Bone (31) · Hip Injuries (28) · Femoral Fractures (27) · Pathological Conditions, Signs and Symptoms (17) · Neurologic Manifestations (12) · Signs and Symptoms (12) · Pathologic Processes (11) · Knee Injuries (8) · Musculoskeletal Diseases (8) · Bone Diseases (4) · Joint Diseases (4) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4)
Tranexamic Acid (4) · Diclofenac (3) · Ketorolac (3) · oxycodone-acetaminophen (3) · Acetaminophen (2) · Alendronate (2) · Bupivacaine (2) · Celecoxib (2) · Dexmedetomidine (2) · Enoxaparin (2) · OMS 103HP (2) · Ropivacaine (2) · Sodium Chloride (2) · Teriparatide (2) · Testosterone (2)
Novartis (3) · Biologische Heilmittel Heel GmbH (2) · Cartiva, Inc. (2) · Chinese University of Hong Kong (2) · Eli Lilly and Company (2) · Hisamitsu Pharmaceutical Co., Inc. (2) · Medical University of Graz (2) · Omeros Corporation (2) · Prince of Songkla University (2) · Sanofi (2) · University Hospitals Cleveland Medical Center (2) · Washington University School of Medicine (2) · Abbott Nutrition (1) · Actavis Inc. (1) · Ain Shams University (1)
United States (28) · Canada (9) · Germany (7) · Spain (5) · China (4) · France (4) · India (4) · United Kingdom (4) · Austria (3) · Israel (3) · Sweden (3) · Turkey (Türkiye) (3) · Australia (2) · Belgium (2) · Bulgaria (2)
Boonsin Tangtrakulwanich, MD.,Ph.D (2) · Michael Karns, MD (2) · Scott Houston (2) · Ahmed A Khater, MD (1) · Alexander G. Turpie (1) · Anis Aribogan, Prof., MD (1) · Anne C Voss, PhD (1) · Carlos Gonzalez de Vega, MD (1) · Cathleen S. Colon-Emeric, MD, MHSc (1) · David Flanigan, MD (1) · Donald W Morrish, MD, PhD (1) · Ellen F Binder, MD (1) · Ellen F. Binder, MD (1)
PMID 15329580, PMID 16835255, PMID 17113683, PMID 17878149, PMID 17904460, PMID 18567675, PMID 18767928, PMID 19926634, PMID 20973952, PMID 21037195, PMID 21249332, PMID 22152181, PMID 22353604, PMID 22429800, PMID 22631877, PMID 23812596, PMID 23889885, PMID 24330470, PMID 24839241, PMID 25043629, PMID 26323728, PMID 26631990, PMID 27195774, PMID 27779431, PMID 29377866, PMID 33238043, PMID 34388107, PMID 34766330, PMID 35277406, PMID 36045358, PMID 36070134, PMID 36476466, PMID 36566202, PMID 38085188, PMID 40340976, PMID 40372752, PMID 40468690, PMID 40540943, PMID 41624165, PMID 41837612
2008 (1), 2009 (1), 2016 (1)