168 completed, 21 terminated, 18 unknown, 16 recruiting. 81 Phase 2, 45 Phase 3, 45 Phase 4, 38 Phase 1, 28 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose Ranging Study to Examine TDS-Testosterone 5% Testosterone, Pump Sprayer - Hypogonadotropism | Phase 2 | Not yet recruiting | Transdermal Delivery Solutions Corp | 48 | 2027-06-01 | 2026-09-30 |
| The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans GnRH antagonist, Estradiol (E2), Testosterone - Cerebral Blood Flow, Cerebral Blood Flow Regulation | Not applicable | Not yet recruiting | University of British Columbia | 50 | 2026-04-01 | 2026-02-10 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| Testosterone Supplementation in Patients in Best Supportive Care: Impact on Quality of Life Sustanon 250 - Hypotestosteronism, Palliative Care | Early Phase 1 | Recruiting | Jules Bordet Institute | 20 | 2026-02-11 | 2026-02-13 |
| Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial Estradiol 0.01% Vag Cream, testosterone 0.1% and estradiol 0.01% vaginal cream - Vulvodynia, Dyspareunia | Phase 2 / Phase 3 | Not yet recruiting | TriHealth Inc. | 44 | 2025-12-01 | 2025-12-03 |
| COMPASS - COpenhagen MenoPAuSe Study Triptorelin 11.25 mg, Sodium Chloride 0.9%, Estradiol (E2) - Menopausal Osteoporosis, Bone Markers | Phase 2 | Recruiting | Martin Blomberg Jensen | 192 | 2025-10-02 | 2026-03-02 |
| Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance Biopsy of Prostate, Biospecimen Collection, Magnetic Resonance Imaging - Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8 | Phase 4 | Recruiting | Roswell Park Cancer Institute | 600 | 2025-01-15 | 2026-05-14 |
| Puberty, Testosterone, and Brain Development Testosterone - Gender Identity, Gender Dysphoria in Adolescents and Adults | Recruiting | University of Colorado, Denver | 100 | 2024-12-31 | 2026-09-21 | |
| Comparing Direct and Indirect Detection Methods of Multiple Routes of Testosterone Administration Testosterone injection, Testosterone gel, Testosterone Oral - Healthy | Early Phase 1 | Completed | Sports Medicine Research and Testing Laboratory | 14 | 2024-11-27 | 2024-12-03 |
| Klinefelter Syndrome and Testosterone Treatment in Puberty Testosterone gel, Placebo - Klinefelter Syndrome | Phase 4 | Recruiting | Lise Aksglæde | 32 | 2024-08-15 | 2025-02-19 |
| Adaptions and Resiliency to Multi-Stressor OpeRations Goserelin 3.6 MG, Multi-Stressor Training, Testosterone gel (AndroGel 5g) - Musculoskeletal Injury, Hypogonadism | Phase 4 | Recruiting | Bradley Nindl | 120 | 2024-07-15 | 2026-08-18 |
| Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering From Gender Dysphoria hormonal treatment with cross sex hormones (testosterone or oestrogenes) started at 14 years old +/- 6 months, Cross sex hormones ( œstrogenes or testosterone) started at 15.5 years old +/- 6 months - Gender Dysphoria | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 60 | 2024-06-25 | 2026-08-10 |
| DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment Tamoxifen, Exemestane, Letrozole - Ductal Carcinoma in Situ | Phase 2 | Recruiting | QuantumLeap Healthcare Collaborative | 400 | 2024-02-17 | 2026-10-26 |
| The Developmental Origins of Endometriosis Blood samples for testosterone and SHBG measurements, Saliva samples for oxytocin measurements - Endometriosis | Completed | University Hospital, Montpellier | 40 | 2024-01-08 | 2026-06-18 | |
| LH/FSH, Testosterone, Prolactin, and Ferritin in PCOS Patients in Jordan Serum levels of LH, FSH, testosterone, prolactin, and ferritin - PCOS (Polycystic Ovary Syndrome) | Completed | Future University in Egypt | 140 | 2024-01-02 | 2025-08-08 | |
| Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc stereotactic ablative radiotherapy, Pluvicto, topical testosterone - Prostate Cancer | Phase 2 | Recruiting | VA Office of Research and Development | 60 | 2023-12-14 | 2025-12-31 |
| Effects of Early Testosterone Gel Administration on Physical Performance in the Critically Ill Androgel Topical Product, Placebo, Physical performance - Critical Illness | Phase 2 | Recruiting | University Hospital, Clermont-Ferrand | 600 | 2023-07-21 | 2023-10-02 |
| Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men Testosterone, GnRH - Hypogonadism, Male, Testosterone Deficiency | Unknown | Royal College of Surgeons, Ireland | 60 | 2023-03-12 | 2023-03-17 | |
| Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomy Testosterone gel, Placebo - Prostatic Neoplasms, Hypogonadism | Phase 3 | Recruiting | Canisius-Wilhelmina Hospital | 140 | 2022-12-12 | 2025-05-02 |
| Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial) Testosterone Cypionate, Placebo - Pain, Opioid Use | Phase 2 | Completed | Brigham and Women's Hospital | 36 | 2022-11-15 | 2026-04-15 |
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Hypogonadism (90) · Insulin Resistance (15) · Obesity (14) · Prostatic Neoplasms (14) · Diabetes Mellitus (11) · Eunuchism (11) · Metabolic Syndrome (9) · Diabetes Mellitus, Type 2 (8) · Neoplasms (8) · Motor Activity (7) · Sarcopenia (7) · Frailty (6) · Breast Neoplasms (5) · Depression (5) · Erectile Dysfunction (5)
University of Washington (14) · Gulhane School of Medicine (9) · Massachusetts General Hospital (9) · VA Office of Research and Development (7) · The University of Texas Medical Branch, Galveston (6) · Acerus Pharmaceuticals Corporation (5) · Repros Therapeutics Inc. (5) · Antares Pharma Inc. (4) · National Institute on Aging (NIA) (4) · Warner Chilcott (4) · Barnsley Hospital (3) · Brigham and Women's Hospital (3) · Mayo Clinic (3) · Memorial Sloan Kettering Cancer Center (3) · Merck Sharp & Dohme LLC (3)
United States (147) · Denmark (10) · United Kingdom (10) · Turkey (Türkiye) (9) · France (7) · Canada (6) · Australia (5) · Brazil (5) · Netherlands (5) · Spain (5) · Germany (4) · Israel (3) · Italy (3) · Puerto Rico (3) · Austria (2)
William J Bremner, MD, PhD (5) · Christina Wang, MD (4) · Shalender Bhasin, MD (4) · Frances J Hayes, MD (3) · Karen K Miller, MD (3) · Samuel Denmeade, MD (3) · Sandeep Dhindsa, MD (3) · Shehzad Basaria, MD (3) · Stephanie T Page, MD, PhD (3) · Abraham Morgentaler, MD (2) · Aydogan Aydogdu, MD (2) · Elena Volpi, MD, PhD (2) · Gary Bedel, MD (2)
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2025 (2), K23HD045386 (2), U54HD012629 (2), U54HD042454 (2), 1UL1RR025758 (1), 2004 (1), 2009 (1), 2014 (1), 2015 (1), 2017 (1), 2019 (1), 2023 (1), I01CX001665 (1), I01CX002775 (1), K23DK002858 (1)