23 completed, 6 recruiting, 2 unknown, 1 active not recruiting. 11 Not applicable, 10 Phase 3, 2 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 10, Recruiting 1 |
| Phase 3 | 10 | Completed 5, Recruiting 4, Unknown 1 |
| Phase 2 | 2 | Active not recruiting 1, Recruiting 1 |
| Phase 4 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures Incisional Negative Pressure Wound Therapy (NPWT) - Fracture of Tibia, Wound Heal | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 352 | 2025-01-01 | 2026-05-12 |
| Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS) Tissue Ultrafiltration Catheters - Acute Compartment Syndrome, Fracture, Bone | Not applicable | Recruiting | Major Extremity Trauma Research Consortium | 60 | 2024-01-01 | 2025-08-28 |
| Evaluating the Safety and Efficacy of Polyethylene Glycol (PEG) Mediated Fusion (PEG Fusion) NTX-001 - Peripheral Nerve Injuries | Phase 2 | Active not recruiting | Major Extremity Trauma Research Consortium | 40 | 2023-06-01 | 2026-09-10 |
| PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics - Infections, Infected Wound | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 250 | 2023-05-30 | 2026-09-11 |
| Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees. Autologous Volar Fibroblast Injection into the Terminal Limb of Amputees - Amputation | Phase 2 | Recruiting | Major Extremity Trauma Research Consortium | 20 | 2022-09-26 | 2025-10-14 |
| Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures Ibuprofen - Tibia Fracture | Phase 3 | Unknown | Major Extremity Trauma Research Consortium | 1000 | 2021-09-14 | 2021-10-06 |
| Serum-Protein-Based Indices for the Progression of Fracture Healing and Nonunion Humerus Fractures | Completed | Major Extremity Trauma Research Consortium | 45 | 2021-06-26 | 2026-02-27 | |
| Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: TOBRA Treatment group, Control group - Post Operative Surgical Site Infection | Phase 3 | Completed | Major Extremity Trauma Research Consortium | 1660 | 2021-06-18 | 2026-07-22 |
| Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial 600 mg Ibuprofen - Tibial Fractures, Pain | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 1000 | 2021-05-26 | 2025-06-05 |
| Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2 Standard of care, Vancomycin and Tobramycin - Post Operative Surgical Site Infection | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 600 | 2021-05-07 | 2026-07-22 |
| Effects of Early Weight Bearing on Rehabilitation Outcomes in Patients With Traumatic Ankle and Tibial Plateau Fractures Early Weight Bearing - Rehabilitation | Not applicable | Completed | Major Extremity Trauma Research Consortium | 435 | 2020-01-01 | 2026-05-26 |
| A Prospective Study of Early Mechanical Stabilization and Bleeding in Disruption of the Pelvic Ring Application of circumferential pelvic compression (CPC) device - Pelvic Fracture | Unknown | Major Extremity Trauma Research Consortium | 600 | 2019-05-17 | 2022-08-30 | |
| Patient-Specific Precision Injury Signatures in Multiply Injured Orthopaedic Patients Pelvic, Acetabular, Femur, or Diaphyseal Tibial Operative Orthopaedic Injuries | Completed | Major Extremity Trauma Research Consortium | 320 | 2019-03-20 | 2023-10-18 | |
| Early Advanced Weight Bearing for Peri-articular Knee and Pilon Injuries AlterG anti-gravity treadmill - Distal Femur Fracture, Tibial Plateau Fracture | Not applicable | Completed | Major Extremity Trauma Research Consortium | 81 | 2019-02-25 | 2023-12-22 |
| The Mobility Toolkit: Electronically Augmented Assessment of Functional Recovery Following Lower-extremity Trauma None- Observational Study - Gait | Completed | Major Extremity Trauma Research Consortium | 244 | 2019-01-01 | 2025-10-06 | |
| Improving Recovery After Orthopaedic Trauma: Cognitive-Behavioral Based Physical Therapy (CBPT) CBPT, Education Treatment - Lower Extremity Injury | Not applicable | Completed | Major Extremity Trauma Research Consortium | 633 | 2018-07-18 | 2025-09-26 |
| PREVENTion of Clot in Orthopaedic Trauma Acetylsalicylic acid, Low Molecular Weight Heparin (LMWH) - Blood Clot, Trauma | Phase 3 | Completed | Major Extremity Trauma Research Consortium | 12424 | 2017-04-24 | 2024-05-14 |
| Rehabilitation Enhanced by Partial Arterial Inflow Restrictions Blood Flow Restriction, Delfi PTSII Tourniquet System - Closed Femur Fracture | Not applicable | Completed | Major Extremity Trauma Research Consortium | 219 | 2016-04-01 | 2026-05-26 |
| Study of Nerve Repair and Reconstruction Associated With Major Extremity Trauma Peripheral Nerve Injury(Ies) | Completed | Major Extremity Trauma Research Consortium | 242 | 2016-03-01 | 2025-01-23 | |
| Prosthetic Fit Assessment in Transtibial Amputees Secondary to Trauma Traumatic Amputation of Lower Extremity | Completed | Major Extremity Trauma Research Consortium | 33 | 2015-01-01 | 2021-03-24 |
Showing 20 of 33. Sign in to see all of them.
Tibial Fractures (5) · Wound Infection (3) · Wounds and Injuries (3) · Agnosia (2) · Fractures, Bone (2) · Infections (2) · Leg Injuries (2) · Acute Pain (1) · Ankle Injuries (1) · Chronic Pain (1) · Dystocia (1) · Femoral Fractures, Distal (1) · Foot Injuries (1) · Fractures, Open (1) · Fractures, Ununited (1)
Ibuprofen (2) · Therapeutics (2) · Anti-Bacterial Agents (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Aspirin (1) · Blood Flow Restriction Therapy (1) · Bone Plates (1) · Control Groups (1) · Enoxaparin (1) · Heparin, Low-Molecular-Weight (1) · Ketorolac (1) · Ketorolac Tromethamine (1) · Meloxicam (1) · Pregabalin (1) · Spectroscopy, Near-Infrared (1)
United States (33) · Canada (2)
Renan Castillo, PhD (7) · Lisa Reider, PhD (5) · Lisa Reider, MHS, PhD (3) · Renan C Castillo, PhD (3) · Robert O'Toole, MD (3) · Anthony Carlini, MS (2) · Anthony R Carlini, MS (2) · Michael J Bosse, MD (2) · Tara Taylor, MPH (2) · Ala Elhelali, PhD (1) · Andrew Schmidt, MD (1) · Daniel J Stinner, MD (1) · Daniel Stinner, MD (1) · Ellen J MacKenzie, PhD (1) · I. Leah Gitajn, MD (1)
PMID 31604788, PMID 33760010, PMID 34425087, PMID 34924512, PMID 36652352, PMID 37052578, PMID 39841468, PMID 40667718, PMID 41984450