62 completed, 27 unknown, 14 recruiting, 12 terminated. 76 Not applicable, 14 Phase 2, 12 Phase 4, 4 Phase 1, 4 Phase 3.
Follow Lacerations: new trials by email Literature Review of Lacerations trials Research Report on Lacerations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bone-Patellar Tendon-Bone Versus Quadriceps Tendon Autograft for Anterior Cruciate Ligament Reconstruction: A Non-Inferiority Trial Regarding Anterior Knee Pain Bone-Patellar Tendon-Bone Autograft ACL Reconstruction, Quadriceps Tendon Autograft ACL Reconstruction - Anterior Cruciate Ligament (ACL) Tear | Not applicable | Not yet recruiting | Hospital del Mar | 150 | 2026-10-05 | 2026-10-07 |
| Tear Biomarkers for Migraine Patients with migraine - Migraine | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 400 | 2026-09-30 | 2026-07-10 | |
| The Effect of Osteopathic Manipulative Techniques on Human Tear Composition Osteopathic Manipulative Treatment, Sham - No Disease or Condition is Being Directly Studied, The Focus of the Study in Healthy Volunteers | Not applicable | Enrolling by invitation | Lake Erie College of Osteopathic Medicine | 30 | 2026-09-01 | 2026-08-25 |
| Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction | Recruiting | Gazi University | 45 | 2026-08-04 | 2026-08-25 | |
| Measuring Knee Laxity and Pivot Shift in ACL-Deficient Patients Anterior Cruciate Ligament (ACL) Tear | Not yet recruiting | Arthroresearch LLC | 25 | 2026-07-07 | 2026-07-07 | |
| Prospective Cohort Study of Villarreal CF Youth Players Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament (ACL) | Not yet recruiting | Cardenal Herrera University | 200 | 2026-07-01 | 2026-06-17 | |
| Adductor Canal Block With IPACK Versus 4-in-1 Block for Postoperative Analgesia in Knee Surgery Adductor canal block with IPACK, 4 in 1 block - Knee Surgeries, Total Ankle Arthroplasty | Not applicable | Completed | Zagazig University | 24 | 2026-06-22 | 2026-07-17 |
| Augmented Reality in Surgery Primary arthroscopic anterior cruciate ligament reconstruction - Anterior Cruciate Ligament (ACL) Tear | Recruiting | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 100 | 2026-05-26 | 2026-06-09 | |
| Active Noise-Cancelling Headphones With Closed-Loop Communication During Arthroscopic ACL Reconstruction Active Noise-Cancelling Headphones With Closed-Loop Communication, Standard Operating Room Communication - Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear | Not applicable | Active not recruiting | Fatih Sultan Mehmet Training and Research Hospital | 54 | 2026-04-25 | 2026-09-10 |
| Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment Varenicline 0.03Mg/Spray Nasal Soln - Dry Eye, Meibomian Gland Dysfunction | Phase 4 | Recruiting | University of California, Berkeley | 65 | 2026-03-06 | 2026-05-27 |
| Effects of a Preoperative Cognitive-Behavioral Intervention on Kinesiophobia and Function in Anterior Cruciate Ligament Reconstruction Cognitive-Behavioral Intervention, Control group - Anterior Cruciate Ligament (ACL) Tear | Not applicable | Recruiting | Peking University Third Hospital | 44 | 2026-02-14 | 2026-04-13 |
| OJO-miR: microRNA Expression in Allergic Conjunctivitis. Conjunctivitis, Allergic | Active not recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 40 | 2026-01-05 | 2026-02-04 | |
| Physiotherapeutic Protocol Compared to Usual Care in the Treatment of Primiparas After Perineal Trauma Physiotherapeutic protocol, Usual maternity care - Episiotomy, Lacerations Perineal | Not applicable | Recruiting | University of Sao Paulo | 82 | 2025-11-11 | 2025-11-26 |
| Study on Fewer Tears (SOFT) - The Effect of Local Anesthesia on the Incidence of Perineal Tears in the First Vaginal Birth Perineal protection techniques - Perineal Laceration, Tear, or Rupture During Delivery | Enrolling by invitation | Karolinska Institutet | 1350 | 2025-10-20 | 2026-04-13 | |
| Evaluation of Pain Management After Surgery When Using Nerve Blocks in the Pediatric Population Ropivacaine 0.2% Injectable Solution - Anterior Cruciate Ligament (ACL) Tear, Sports Injuries in Children | Phase 2 | Not yet recruiting | Texas Scottish Rite Hospital for Children | 160 | 2025-09-01 | 2025-09-16 |
| Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation Joint Manipulation - Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction Rehabilitation | Not applicable | Withdrawn | University of North Carolina, Chapel Hill | 2025-08-01 | 2026-05-05 | |
| Identification of Diagnosis Biomarkers in the Tears of Alzheimer's Disease Patients: The COG-EYE Pilot Study Basal tear collection for the analysis of metabo-lipidomic profiles and concentrations of protein biomarkers (Tau, phosphorylated Tau, Aβ 1-40, and Aβ 1-42), Collection of a blood sample (5 mL) for blood biomarkers analysis - Alzheimer Disease | Not applicable | Recruiting | University Hospital, Tours | 90 | 2025-07-09 | 2025-10-07 |
| ACB vs no Block for Pediatric ACL Reconstruction Ropivacaine 2-2.5mg/kg + dexmedetomidine 1 mcg/kg delivered via a single-shot adductor canal block under ultrasound guidance - Anterior Cruciate Ligament, Anterior Cruciate Ligament (ACL) Tear | Phase 3 | Recruiting | Isabella Jaramillo | 38 | 2025-07-01 | 2025-09-26 |
| The Effect of Birth Ball and Perineal Massage on Perineal Pain, Perineal Trauma and Birth Satisfaction Birth Ball, Perineal Massage, Control Group - Perineal Pain, Birth Satisfaction | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 144 | 2025-05-01 | 2025-04-24 |
| Wear and Tear on Military Personnel Post Caledonian Crisis No intervention - Chronic Stress Disorder | Recruiting | Direction Centrale du Service de Santé des Armées | 200 | 2025-04-03 | 2025-04-09 |
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Wounds and Injuries (19) · Dry Eye Syndromes (8) · Pain (7) · Anxiety Disorders (5) · Rotator Cuff Injuries (5) · Surgical Wound (5) · Agnosia (4) · Anterior Cruciate Ligament Injuries (4) · Conjunctivitis, Allergic (4) · COVID-19 (3) · Emergencies (3) · Inflammation (3) · Knee Injuries (3) · Rupture (3)
Wounds and Injuries (120) · Pathological Conditions, Signs and Symptoms (33) · Eye Diseases (21) · Signs and Symptoms (21) · Neurologic Manifestations (17) · Pathologic Processes (16) · Nervous System Diseases (14) · Immune System Diseases (9) · Infections (8) · Lacrimal Apparatus Diseases (8) · Mental Disorders (7) · Leg Injuries (6) · Respiratory Tract Diseases (6) · Central Nervous System Diseases (5) · Conjunctival Diseases (5)
Botulinum Toxins, Type A (4) · Control Groups (3) · Midazolam (3) · Cephalexin (2) · Dexamethasone (2) · Dexmedetomidine (2) · Epinephrine (2) · Gels (2) · Lidocaine (2) · Low-Level Light Therapy (2) · Nitrous Oxide (2) · Ropivacaine (2) · Sutures (2) · Tissue Adhesives (2) · octyl 2-cyanoacrylate (2)
Hacettepe University (3) · Aesculap AG (2) · Baylor College of Medicine (2) · Children's Hospitals and Clinics of Minnesota (2) · Federal University of Rio Grande do Sul (2) · Instituto Nacional de Rehabilitacion (2) · Lille Catholic University (2) · Sun Yat-sen University (2) · Temple University (2) · The University of Texas Health Science Center, Houston (2) · University Hospital, Tours (2) · University of Michigan (2) · Zhongshan Ophthalmic Center, Sun Yat-sen University (2) · Ain Shams University (1) · Alcon Research (1)
United States (42) · France (11) · Turkey (Türkiye) (8) · Canada (7) · China (7) · Germany (7) · Italy (6) · Spain (6) · Brazil (4) · Israel (4) · United Kingdom (4) · Denmark (3) · Mexico (3) · South Korea (3) · Austria (2)
Bruno Brochet, MD, PhD (2) · Christian Confavreux, MD (2) · Clemente Ibarra, M.D. (2) · Enrique Villalobos, M.D. (2) · Gilles Defer, MD (2) · Jean Pelletier, MD, PhD (2) · Marc Debouverie, MD, PhD (2) · Olivier Heinzlef, MD (2) · Patrick Hautecoeur, MD (2) · Patrick Vermersch, MD, PhD (2) · Pierre Clavelou, MD (2) · Abdalla Mohamed Goda, MD (1) · Ahmad A Aref, MD (1) · Albert Verier, MD (1) · Aldo F Izaguirre, M.D. (1)
PMID 10892855, PMID 12620368, PMID 15572968, PMID 15620501, PMID 16877412, PMID 18304416, PMID 19094458, PMID 19132976, PMID 19922917, PMID 19936413, PMID 20814774, PMID 21194248, PMID 22389568, PMID 22694845, PMID 23187987, PMID 23280527, PMID 24244272, PMID 25039547, PMID 25047001, PMID 26152492, PMID 26152493, PMID 26861702, PMID 26885381, PMID 27263447, PMID 27279368, PMID 27748042, PMID 28007090, PMID 28109296, PMID 28146402, PMID 28400877, PMID 28562455, PMID 28846123, PMID 28984729, PMID 29923977, PMID 30033738, PMID 30900196, PMID 30951598, PMID 31579987, PMID 31811355, PMID 32336042, PMID 32573448, PMID 32661917, PMID 32833188, PMID 32977649, PMID 33643965, PMID 33675971, PMID 33735595, PMID 34048286, PMID 34928491, PMID 35100752
2016 (1), 2025 (1), R01AR071398 (1), R01EY012526 (1), UL1TR000005 (1)