40 completed, 9 unknown, 7 terminated, 6 recruiting. 22 Phase 4, 17 Phase 1, 14 Not applicable, 11 Phase 2, 10 Phase 3.
Follow Cephalexin: new trials by email Literature Review of Cephalexin trials Research Report on Cephalexin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Naproxen Versus Placebo as Adjunct Treatment of Cellulitis enteric-coated naproxen, Cephalexin Tablets, Placebo - Cellulitis, Skin Disease, Infectious | Phase 3 | Not yet recruiting | Ottawa Hospital Research Institute | 884 | 2026-11-01 | 2026-10-20 |
| Prophylactic Antibiotics for Outpatient Urethral Bulking Bactrim (800/160 mg), Keflex (500 mg), Cipro (250 mg), or Macrobid (100mg) - Urinary Tract Infections, Stress Urinary Incontinence | Phase 4 | Recruiting | University of Miami | 150 | 2026-08-01 | 2026-08-20 |
| The Effect of Losartan on Cephalexin losartan, cephalexin - Possible Interaction Between Losartan and Cephalexin, Healthy | Phase 1 | Completed | Aleksi Tornio | 13 | 2026-03-04 | 2026-10-01 |
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-09-04 |
| Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery Povidone-Iodine Swabs, Staphylococcus nasal swab, Antibiotic - Skin Cancer, Skin Cancer Face | Not applicable | Withdrawn | Mayo Clinic | 2024-09-01 | 2024-11-25 | |
| Patient-Directed Antimicrobial Duration in Acute Uncomplicated Pyelonephritis Cephalexin, Cephalexin or placebo - Pyelonephritis Acute | Phase 4 | Completed | Brett A Faine | 39 | 2024-06-04 | 2026-08-03 |
| Antibiotic Prophylaxis in Pediatric Open Fractures Cefazolin, Cephalexin - Fractures, Open, Infections | Phase 4 | Enrolling by invitation | St. Louis University | 800 | 2023-09-11 | 2025-10-20 |
| High-dose Cephalexin for Cellulitis (HI-DOCC) Cephalexin - Cellulitis | Phase 4 | Completed | Ottawa Hospital Research Institute | 454 | 2023-08-30 | 2026-08-03 |
| Comparing Oral Versus Parenteral Antimicrobial Therapy Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid, Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem - Endovascular Infection, Bone and Joint Infection | Phase 4 | Terminated | West Virginia University | 94 | 2023-08-04 | 2025-08-26 |
| The BLAST- 1 Trial - Cephalexin+Amoxicillin-clavulanate for Tuberculosis Cephalexin, Amoxicillin-Clavulanate 500 Mg-125 Mg Oral Tablet, Standard of care treatment of tuberculosis - Tuberculosis, Pulmonary | Phase 2 | Unknown | Western Sydney Local Health District | 30 | 2023-03-15 | 2023-06-26 |
| Role of Prophylactic Postoperative Antibiotics in HoLEP Nitrofurantoin, Cephalexin, Sulfamethoxazole Trimethoprim Combination - Benign Prostatic Hyperplasia, Urinary Tract Infections | Phase 4 | Withdrawn | Baylor Research Institute | 2023-03-01 | 2026-02-12 | |
| Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA Nitrofurantoin - Antibiotic Prophylaxis | Phase 4 | Recruiting | Atlantic Health System | 140 | 2022-08-16 | 2024-03-27 |
| Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL) Amoxycillin, Cefalexin, Dicloxacillin, Linezolid, Levofloxacin, Rifampicin, Ampicillin, Oxacillin, Vancomycin, Daptomycin, Ceftriaxone, Cefepime, Ceftaroline - Endocarditis | Phase 4 | Terminated | West Virginia University | 5 | 2022-03-16 | 2026-05-05 |
| Microbiome and Association With Implant Infections Cephalexin - Breast Cancer, Breast Cancer Female | Phase 2 | Recruiting | University of California, San Francisco | 200 | 2021-09-28 | 2026-03-18 |
| High-dose vs. Standard-dose Cephalexin for Cellulitis Cephalexin, Cephalexin + placebo - Cellulitis | Phase 4 | Completed | Ottawa Hospital Research Institute | 69 | 2021-08-16 | 2025-01-17 |
| Oral Amoxicillin and Cephalexin PK/PD in Neonates Amoxicillin, Cephalexin - Neonatal Infection | Phase 1 | Completed | University of Colorado, Denver | 72 | 2021-07-14 | 2026-05-19 |
| Postoperative Antibiotics Following Primary and Secondary Breast Augmentation Cefazolin, Cephalexin, Placebo - Surgical Site Infection, Capsular Contracture Associated With Breast Implant | Phase 4 | Withdrawn | University of California, Los Angeles | 2021-04-01 | 2022-09-14 | |
| The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions Cephalexin, Placebo oral capsule - Skin Lesion | Not applicable | Withdrawn | Rambam Health Care Campus | 2021-03-01 | 2022-05-04 | |
| SSI Rates in Patients Undergoing Mastectomy Without Reconstruction- A Multicenter, Double-blinded RCT. Cephalexin 500 MG, Placebo - Surgical Site Infection | Phase 3 | Unknown | Aga Khan University | 384 | 2020-11-01 | 2020-10-08 |
| Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery Cephalexin, Placebo capsules - Surgical Site Infection | Phase 4 | Active not recruiting | Carilion Clinic | 574 | 2020-10-01 | 2026-03-25 |
Showing 20 of 72. Sign in to see all of them.
Infections (8) · Surgical Wound Infection (8) · Cellulitis (7) · Urinary Tract Infections (4) · Arrhythmias, Cardiac (3) · Respiratory Tract Infections (3) · Soft Tissue Infections (3) · Abscess (2) · Lacerations (2) · Obesity (2) · Skin Diseases, Infectious (2) · Staphylococcal Infections (2) · Wound Infection (2) · Adrenal Insufficiency (1) · Anaphylaxis (1)
Eli Lilly and Company (5) · Bayer (3) · GlaxoSmithKline (3) · Ottawa Hospital Research Institute (3) · Population Health Research Institute (3) · Mayo Clinic (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · University of British Columbia (2) · University of California, San Francisco (2) · University of Colorado, Denver (2) · West Virginia University (2) · Aaron Chen (1) · Abbott (1) · Aga Khan University (1) · Ain Shams University (1)
United States (34) · Canada (11) · Mexico (8) · Argentina (1) · Australia (1) · Austria (1) · Brazil (1) · Chile (1) · Finland (1) · Georgia (1) · Germany (1) · Israel (1) · Italy (1) · Latvia (1) · Lithuania (1)
Andrew Haynes, MD (2) · Krishan Yadav, MD, MSc (2) · Aaron E Chen, MD (1) · Abida K. Sattar, MD, FACS (1) · Aleksi Tornio, M.D., Ph.D. (1) · Andrew Krahn, MD (1) · Antonio F Saad, MD (1) · Arif R. Sarwari, MD, MSc, MBA (1) · Ben Chew, MD (1) · Caroline Altergott, MD (1) · Carolyn Botros, DO (1)
PMID 11486303, PMID 16225607, PMID 16792648, PMID 17355677, PMID 17574960, PMID 19124814, PMID 19788787, PMID 19808441, PMID 22184305, PMID 2292525, PMID 23457080, PMID 24799810, PMID 24842503, PMID 24973422, PMID 25079934, PMID 25605319, PMID 25992781, PMID 26904404, PMID 26962903, PMID 27025829, PMID 27122728, PMID 27531595, PMID 27899130, PMID 28444977, PMID 28535235, PMID 28535819, PMID 28645776, PMID 28975304, PMID 28987525, PMID 29299899, PMID 29869364, PMID 29914924, PMID 30545448, PMID 30575054, PMID 30926187, PMID 31378847, PMID 31806127, PMID 32304015, PMID 33395210, PMID 34244280, PMID 34859113, PMID 36592299, PMID 36960716, PMID 37358858, PMID 39836173, PMID 40403315, PMID 41419216, PMID 438352
2014 (1), 2025 (1), U01AI184071 (1), U10CA032102 (1)