1039 completed, 223 unknown, 143 recruiting, 88 not yet recruiting. 568 Not applicable, 297 Phase 2, 232 Phase 4, 196 Phase 3, 121 Phase 1.
Follow Dry Eye Syndromes: new trials by email Literature Review of Dry Eye Syndromes trials Research Report on Dry Eye Syndromes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of RCI001 Ophthalmic Solution in Participants With Dry Eye Disease RCI001 Ophthalmic Solution, Placebo Ophthalmic Solution - Dry Eye | Phase 2 | Not yet recruiting | Rudacure | 200 | 2027-09-01 | 2026-06-04 |
| Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive® PRO-240, Optive® - Dry Eye Disease, Dry Eye Sensation | Phase 1 | Not yet recruiting | Laboratorios Sophia S.A de C.V. | 32 | 2027-07-30 | 2026-11-10 |
| Performance Evaluation of the OCUTOP Hand-held Corneal Topographer OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment) - Corneal Topography, Dry Eye Syndromes | Not applicable | Not yet recruiting | University of Plymouth | 150 | 2027-01-01 | 2026-10-26 |
| Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye Platelet Poor Plasma Tear Drops, Platelet Rich Plasma Tear Drops - Dry Eye Syndromes | Not applicable | Withdrawn | University of Rochester | 2027-01-01 | 2026-07-16 | |
| Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome | Not yet recruiting | University of Pennsylvania | 220 | 2027-01-01 | 2026-03-02 | |
| Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artificial Tear on Dry Eye Disease: a Randomised Controlled Trial Baduanjin, Laughter exercise, Artificial tears - Dry Eye Disease (DED) | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 540 | 2027-01-01 | 2026-04-13 |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Decentralized Dry Eye Study, Planning & Feasibility Evaporative Loss Dry Eye Disease | Not yet recruiting | University of California, San Francisco | 50 | 2026-12-10 | 2026-11-12 | |
| LacriFill Canalicular Occlusion for Dry Eye After LASIK LacriFill Canalicular Filler - Dry Eye Syndrome | Not applicable | Not yet recruiting | Mann Eye Institute | 75 | 2026-12-09 | 2026-11-03 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Evaluation of Allogenic Mesenchymal Stem Cell (MSC) Injection Therapy for Refractory Graft-versus-Host Disease (GVHD) Unresponsive to Conventional Treatments Subconjuntival injection of expanded allogenic adult adipose tissue-derived mesenchymal stem cells (ASC - Dry Eye Disease (DED), Graft-Versus-Host Disease(GVHD) | Phase 2 | Not yet recruiting | Instituto de Investigación Biomédica de Salamanca | 30 | 2026-12-01 | 2026-11-04 |
| MYTP01 for Immune-Mediated Diseases MYTP01, MYTP01 Placebo - IgA Nephropathy, Kidney Transplant Recipients | Not applicable | Not yet recruiting | Zhejiang Provincial People's Hospital | 160 | 2026-12-01 | 2026-11-04 |
| A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases QLS2416 Injection - Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA) | Phase 1 | Not yet recruiting | Shanghai Qilu Pharmaceutical Research and Development Center LTD | 76 | 2026-12-01 | 2026-10-30 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-11-09 | 2026-11-12 | |
| Cooling Eyedrops for Dry Eye TRYPTYR Eye Drops, Purilens Plus Non-Preserved Saline Eye Drops - Dry Eye | Phase 4 | Not yet recruiting | University of California, Berkeley | 50 | 2026-11-01 | 2026-10-26 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| R-2487 in Patients With Sjogren's Syndrome (SjD) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-11-06 |
| TearCare in Young Adults TearCare® - Meibomian Gland Dysfunction (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 45 | 2026-11-01 | 2026-10-29 |
| A Clinical Study to Evaluate the Safety and Effectiveness of MSCohi-O Lens in the Treatment of Immune-related Ocular Surface Diseases. MSCohi-O lens - Keratitis, Autoimmunity | Phase 1 | Not yet recruiting | Guangdong ProCapZoom Biosciences Co., Ltd. | 20 | 2026-11-01 | 2026-10-29 |
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Sjogren's Syndrome (322) · Meibomian Gland Dysfunction (97) · Keratoconjunctivitis Sicca (85) · Lupus Erythematosus, Systemic (72) · Arthritis, Rheumatoid (49) · Xerostomia (47) · Scleroderma, Systemic (45) · Autoimmune Diseases (44) · Myositis (32) · Cataract (31) · Xerophthalmia (29) · Corneal Diseases (28) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (20) · Scleroderma, Diffuse (20)
Lacrimal Apparatus Diseases (1644) · Eye Diseases (1634) · Immune System Diseases (356) · Skin and Connective Tissue Diseases (344) · Mouth Diseases (331) · Stomatognathic Diseases (331) · Musculoskeletal Diseases (328) · Connective Tissue Diseases (325) · Joint Diseases (325) · Rheumatic Diseases (320) · Salivary Gland Diseases (320) · Arthritis (317) · Autoimmune Diseases (291) · Xerostomia (279)
Ophthalmic Solutions (50) · Lubricant Eye Drops (45) · Cyclosporins (43) · Cyclosporine (33) · lifitegrast (31) · Hyaluronic Acid (26) · Carboxymethylcellulose Sodium (17) · Loteprednol Etabonate (15) · Sodium Chloride (14) · Calcium Dobesilate (12) · Nasal Sprays (12) · Propylene Glycol (12) · rebamipide (12) · Intense Pulsed Light Therapy (11) · diquafosol (10)
Alcon Research (87) · Allergan (43) · Medical University of Vienna (24) · Bausch & Lomb Incorporated (23) · Singapore National Eye Centre (21) · Novartis Pharmaceuticals (18) · He Eye Hospital (17) · National Institute of Dental and Craniofacial Research (NIDCR) (17) · Peking University Third Hospital (17) · University of Alabama at Birmingham (15) · University of Waterloo (15) · Innovative Medical (14) · Aldeyra Therapeutics, Inc. (13) · Laboratoires Thea (13) · Laboratorios Sophia S.A de C.V. (13)
United States (636) · China (153) · France (100) · South Korea (72) · Italy (67) · Taiwan (63) · Canada (62) · Spain (61) · United Kingdom (55) · Austria (44) · Germany (41) · Mexico (38) · Australia (35) · Brazil (35) · Turkey (Türkiye) (35)
Gail Torkildsen, MD (17) · Louis Tong, PhD (13) · Pedram Hamrah, MD (8) · Ching-Mao Chang, M.D., Ph.D. (6) · John Hovanesian, MD (6) · Emmanuel Eric Pazo (5) · Lyndon Jones, PhD, FCOptom (5) · Sandeep Jain, MD (5) · Sonja Kroesser, PhD (5)
PMID 12649304, PMID 12823990, PMID 25179431, PMID 32280196, PMID 36729473, PMID 9778415, PMID 27929721, PMID 28736340, PMID 39839752, PMID 11237914, PMID 11879137, PMID 14508260, PMID 15161834, PMID 15286669, PMID 15832184, PMID 18848318, PMID 20973888, PMID 23445780, PMID 23665202, PMID 27119078, PMID 27294831, PMID 27893109, PMID 28190580, PMID 28280298, PMID 28319106, PMID 28475124, PMID 28736335, PMID 29075094, PMID 29671255, PMID 29731019, PMID 31518657, PMID 31800960, PMID 31834617, PMID 34707360, PMID 37096956, PMID 42470519, PMID 10815152, PMID 15090417, PMID 15502479, PMID 17102664, PMID 17216085, PMID 17508121, PMID 20631232, PMID 20735287, PMID 21280008, PMID 21750611, PMID 22670856, PMID 26365210, PMID 27055211, PMID 27445067
2018 (6), 2015 (4), 2016 (4), 2023 (4), 2025 (4), 2019 (3), R01EY022038 (1), R01EY022663 (1), R01EY024966 (1), R01EY038655 (1), R33NS113341 (1), R34EY017626 (1), R34EY037743 (1), R37AI049660 (1), U01NS106845 (1)