1072 completed, 234 unknown, 142 recruiting, 91 not yet recruiting. 587 Not applicable, 303 Phase 2, 238 Phase 4, 200 Phase 3, 122 Phase 1.
Follow Lacrimal Apparatus Diseases: new trials by email Literature Review of Lacrimal Apparatus Diseases trials Research Report on Lacrimal Apparatus Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of RCI001 Ophthalmic Solution in Participants With Dry Eye Disease RCI001 Ophthalmic Solution, Placebo Ophthalmic Solution - Dry Eye | Phase 2 | Not yet recruiting | Rudacure | 200 | 2027-09-01 | 2026-06-04 |
| Performance Evaluation of the OCUTOP Hand-held Corneal Topographer OCUTOP hand-held corneal topographer with OCUGRAPH software, Reference instrument measurement (corneal topography and tear-film assessment) - Corneal Topography, Dry Eye Syndromes | Not applicable | Not yet recruiting | University of Plymouth | 150 | 2027-01-01 | 2026-10-26 |
| Study of Platelet Rich Plasma Drops to Moderate Clinically Significant Dry Eye Platelet Poor Plasma Tear Drops, Platelet Rich Plasma Tear Drops - Dry Eye Syndromes | Not applicable | Withdrawn | University of Rochester | 2027-01-01 | 2026-07-16 | |
| Outcomes of Stentless Dacryocystorhinostomy in Primary Acquired Nasolacrimal Duct Obstruction. Stentless Endoscopic Dacryocystorhinostomy - Nasolacrimal Duct Obstruction, Epiphora | Not applicable | Not yet recruiting | Assiut University | 40 | 2027-01-01 | 2026-09-30 |
| Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome | Not yet recruiting | University of Pennsylvania | 220 | 2027-01-01 | 2026-03-02 | |
| Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artificial Tear on Dry Eye Disease: a Randomised Controlled Trial Baduanjin, Laughter exercise, Artificial tears - Dry Eye Disease (DED) | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 540 | 2027-01-01 | 2026-04-13 |
| Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 3 | Not yet recruiting | Bristol-Myers Squibb | 2300 | 2026-12-31 | 2026-09-03 |
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| A Phase 1 Study of QLS2416 Injection in Participants With Autoimmune Diseases QLS2416 Injection - Systemic Lupus Erythematosus, Rheumatoid Arthritis (RA) | Phase 1 | Not yet recruiting | Shanghai Qilu Pharmaceutical Research and Development Center LTD | 76 | 2026-12-01 | 2026-10-30 |
| Pain Phenotyping of Rheumatic Diseases - An Observational Study Bedside quantitative sensory testing - Rheumatic Diseases, Lupus Erythematosus, Systemic | Not yet recruiting | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | 225 | 2026-11-04 | 2026-10-30 | |
| Cooling Eyedrops for Dry Eye TRYPTYR Eye Drops, Purilens Plus Non-Preserved Saline Eye Drops - Dry Eye | Phase 4 | Not yet recruiting | University of California, Berkeley | 50 | 2026-11-01 | 2026-10-26 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| TearCare in Young Adults TearCare® - Meibomian Gland Dysfunction (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 45 | 2026-11-01 | 2026-10-29 |
| A Clinical Study to Evaluate the Safety and Effectiveness of MSCohi-O Lens in the Treatment of Immune-related Ocular Surface Diseases. MSCohi-O lens - Keratitis, Autoimmunity | Phase 1 | Not yet recruiting | Guangdong ProCapZoom Biosciences Co., Ltd. | 20 | 2026-11-01 | 2026-10-29 |
| A Study of BMS-986553 in Participants With Refractory Autoimmune Diseases BMS-986553 - Systemic Lupus Erythematosus, Sjögren's Disease | Phase 1 | Not yet recruiting | Bristol-Myers Squibb | 60 | 2026-10-30 | 2026-10-14 |
| Effectiveness of an Oral Exercise Program for Xerostomia in Patients With Sjögren Disease Oral exercise - Sjogren Syndrome | Not applicable | Not yet recruiting | Nazli Elif Nacar | 56 | 2026-10-26 | 2026-10-08 |
| Evaporative Dry Eye acoltremon 0.003%. - Dry Eye, Evaporative Dry Eye | Phase 4 | Not yet recruiting | Southern College of Optometry | 41 | 2026-10-26 | 2026-10-28 |
| Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease BUFY01 eye drops in single-dose containers, SVS20 eye drops in single-dose containers - Dry Eye Disease | Not applicable | Recruiting | TRB Chemedica International SA | 80 | 2026-10-26 | 2026-10-29 |
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Dry Eye Syndromes (1352) · Sjogren's Syndrome (320) · Meibomian Gland Dysfunction (96) · Keratoconjunctivitis Sicca (85) · Lupus Erythematosus, Systemic (72) · Arthritis, Rheumatoid (49) · Xerostomia (47) · Scleroderma, Systemic (45) · Autoimmune Diseases (44) · Myositis (32) · Cataract (31) · Corneal Diseases (30) · Lacrimal Duct Obstruction (29) · Xerophthalmia (29)
Eye Diseases (1685) · Immune System Diseases (357) · Skin and Connective Tissue Diseases (343) · Mouth Diseases (329) · Stomatognathic Diseases (329) · Musculoskeletal Diseases (326) · Connective Tissue Diseases (323) · Joint Diseases (323) · Rheumatic Diseases (318) · Salivary Gland Diseases (318) · Arthritis (315) · Dry Eye Syndromes (290) · Autoimmune Diseases (289) · Xerostomia (277)
Ophthalmic Solutions (49) · Lubricant Eye Drops (46) · Cyclosporins (45) · Cyclosporine (33) · lifitegrast (31) · Hyaluronic Acid (27) · Carboxymethylcellulose Sodium (16) · Loteprednol Etabonate (15) · Sodium Chloride (13) · Calcium Dobesilate (12) · Nasal Sprays (12) · Propylene Glycol (12) · rebamipide (12) · Intense Pulsed Light Therapy (11) · Dexamethasone (10)
Alcon Research (87) · Allergan (43) · Medical University of Vienna (25) · Bausch & Lomb Incorporated (23) · Singapore National Eye Centre (22) · Novartis Pharmaceuticals (18) · He Eye Hospital (17) · National Institute of Dental and Craniofacial Research (NIDCR) (17) · Peking University Third Hospital (17) · University of Alabama at Birmingham (15) · University of Waterloo (15) · Innovative Medical (14) · Aldeyra Therapeutics, Inc. (13) · Laboratoires Thea (13) · Laboratorios Sophia S.A de C.V. (13)
United States (645) · China (159) · France (101) · South Korea (72) · Italy (67) · Canada (63) · Taiwan (63) · Spain (60) · United Kingdom (55) · Austria (44) · Mexico (41) · Germany (40) · Turkey (Türkiye) (36) · Australia (35) · Brazil (35)
Gail Torkildsen, MD (17) · Louis Tong, PhD (13) · Pedram Hamrah, MD (8) · Ching-Mao Chang, M.D., Ph.D. (6) · John Hovanesian, MD (6) · Emmanuel Eric Pazo (5) · Lyndon Jones, PhD, FCOptom (5) · Sandeep Jain, MD (5) · Sonja Kroesser, PhD (5)
PMID 12649304, PMID 12823990, PMID 25179431, PMID 32280196, PMID 36729473, PMID 9778415, PMID 27929721, PMID 28736340, PMID 39839752, PMID 11237914, PMID 11879137, PMID 14508260, PMID 15161834, PMID 15286669, PMID 15832184, PMID 18848318, PMID 20973888, PMID 23445780, PMID 23665202, PMID 27119078, PMID 27294831, PMID 27893109, PMID 28190580, PMID 28280298, PMID 28319106, PMID 28475124, PMID 28736335, PMID 29075094, PMID 29671255, PMID 29731019, PMID 31518657, PMID 31800960, PMID 31834617, PMID 34707360, PMID 37096956, PMID 42470519, PMID 10815152, PMID 15090417, PMID 15502479, PMID 17102664, PMID 17216085, PMID 17508121, PMID 18806663, PMID 20631232, PMID 20735287, PMID 21280008, PMID 21386741, PMID 21750611, PMID 22241928, PMID 22670856
2018 (6), 2015 (4), 2016 (4), 2023 (4), 2025 (4), 2019 (3), U10EY011751 (3), R01EY022038 (1), R01EY022663 (1), R01EY024966 (1), R01EY038655 (1), R33NS113341 (1), R34EY017626 (1), R37AI049660 (1), U01NS106845 (1)