18 completed, 4 unknown, 4 withdrawn, 3 recruiting. 34 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 34 | Completed 18, Unknown 4, Withdrawn 4, Recruiting 3, Terminated 3, Not yet recruiting 2 |
Follow Knee Injuries: new trials by email Literature Review of Knee Injuries trials Research Report on Knee Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction Losartan, Placebo - ACL Injury, ACL Reconstruction | Phase 4 | Not yet recruiting | Rush University Medical Center | 144 | 2026-08-01 | 2025-12-15 |
| Extended Oral Tranexamic Acid After Anterior Cruciate Ligament Reconstruction Tranexamic Acid (TXA), Placebo - ACL Injury, ACL Tears | Phase 4 | Withdrawn | Campbell Clinic | 2026-04-01 | 2026-03-03 | |
| Nalbuphine With Remimazolam Versus Nalbuphine With Propofol for Knee Arthroscopy Nalbuphine, Remimazolam, Propofol - Knee Injuries | Phase 4 | Completed | Wuhan Fourth Hospital | 100 | 2025-04-10 | 2026-09-24 |
| Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction Intraosseous Morphine - Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Injuries | Phase 4 | Recruiting | The Methodist Hospital Research Institute | 84 | 2024-08-19 | 2026-04-09 |
| Local Anesthetic for Plateau Fractures Bupivacaine injection, Saline - Tibial Plateau Fractures | Phase 4 | Not yet recruiting | University of Washington | 100 | 2024-08-01 | 2024-06-26 |
| Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction Concentrated Bone Marrow Aspirate Injection, Sham Incision, Revision Anterior Cruciate Ligament Reconstruction - Anterior Cruciate Ligament Injuries, Post-Traumatic Osteoarthritis of Knee | Phase 4 | Recruiting | Hospital for Special Surgery, New York | 40 | 2024-01-22 | 2025-11-20 |
| IPACK on Early Pain Scores After ACL Reconstruction IPACK, PLACEBO - Pain, Postoperative, Anterior Cruciate Ligament Injuries | Phase 4 | Unknown | Loyola University | 78 | 2023-08-03 | 2023-08-14 |
| Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery Genicular Nerve Block with bupivacaine and preservative free dexamethasone - ACL, Anterior Cruciate Ligament Injuries | Phase 4 | Completed | Hospital for Special Surgery, New York | 192 | 2023-01-12 | 2026-01-26 |
| Duloxetine Tibial Plateau Duloxetine, Placebo, Standard of care (SOC) for tibial plateau surgery - Tibial Plateau Fracture, Pain, Postoperative | Phase 4 | Withdrawn | Boston Medical Center | 2022-10-01 | 2022-11-21 | |
| iPACK for Post-op Pain Following ACL Reconstruction Adductor Canal Block (ACB) Only, Adductor Canal Block (ACB) + iPACK Block - ACL Injury, Post Operative Pain | Phase 4 | Completed | Medical University of South Carolina | 82 | 2022-08-25 | 2024-10-16 |
| Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following ACL Reconstruction With Bone Patellar Tendon Bone Autograft: IPACK block - Anterior Cruciate Ligament Rupture | Phase 4 | Completed | NYU Langone Health | 102 | 2022-07-11 | 2024-04-26 |
| Knee Nerve Cryoneurolysis and Impact on Pain After Prosthetic Surgery standard pain relievers - Knee Injuries | Phase 4 | Terminated | GCS Ramsay Santé pour l'Enseignement et la Recherche | 52 | 2022-01-12 | 2025-05-16 |
| Oral Administration of Tranexamic Acid in Anterior Cruciate Ligament Surgery Reduce Postoperative Haemarthrosis Oral tablet, Placebo - Hemorrhage Postoperative, Anterior Cruciate Ligament Rupture | Phase 4 | Unknown | University of Liege | 104 | 2021-07-06 | 2021-07-28 |
| Are Opioids Needed After ACL Reconstruction Oxycodone, Placebo oral tablet - Anterior Cruciate Ligament Rupture | Phase 4 | Completed | Emory University | 98 | 2020-09-16 | 2023-10-11 |
| Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery Norco 5Mg-325Mg Tablet, Ibuprofen 600 mg, Acetaminophen 325Mg Tab - Knee Injuries, Pain, Postoperative | Phase 4 | Recruiting | Sanford Health | 148 | 2018-10-29 | 2026-02-10 |
| A Novel Analgesia Technique for ACL Reconstruction Bupivacaine, Ultrasound, Dexamethasone - Anterior Cruciate Ligament Injury | Phase 4 | Completed | Hospital for Special Surgery, New York | 78 | 2017-10-04 | 2024-09-19 |
| Intra-articular Administration of 3.0g Tranexamic Acid Has no Effect on Reducing Intra-articular Hemarthrosis and Postoperative Pain After Primary Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial intraarticular administration of tranexamic acid - Anterior Cruciate Ligament Rupture | Phase 4 | Unknown | Korea University Guro Hospital | 47 | 2017-07-01 | 2019-08-02 |
| Effect of PRP Injection After Arthroscopic Meniscal Repair in the Healing Process platelet rich plasma - Knee Pain, Knee Injuries | Phase 4 | Completed | Alexandria University | 30 | 2017-03-03 | 2019-04-11 |
| Motor-Sparing Femoral Nerve Block Dose Same Bupivacaine Concentration, Lower Bupivacaine Concentration - Osteoarthritis, Knee, Knee Injuries | Phase 4 | Terminated | University of Chile | 31 | 2016-09-01 | 2020-05-14 |
| Effects of Intraarticular IL1-Ra on Pain and Inflammatory Mediators After Knee Arhroscopy Anakinra 100 mg in 2 ml saline IA - Knee Injuries | Phase 4 | Withdrawn | Oslo University Hospital | 2016-03-01 | 2021-06-11 |
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Anterior Cruciate Ligament Injuries (23) · Pain, Postoperative (4) · Pain (2) · Tibial Plateau Fractures (2) · Acute Pain (1) · Agnosia (1) · Exsanguination (1) · Inflammation (1) · Osteoarthritis, Knee (1) · Postoperative Hemorrhage (1)
Leg Injuries (34) · Wounds and Injuries (34) · Pathological Conditions, Signs and Symptoms (8) · Neurologic Manifestations (7) · Signs and Symptoms (7) · Pathologic Processes (6) · Pain (5) · Postoperative Complications (5) · Fractures, Bone (2) · Knee Fractures (2) · Tibial Fractures (2) · Arthritis (1) · Hemorrhage (1) · Joint Diseases (1)
Bupivacaine (5) · Sodium Chloride (5) · Ropivacaine (3) · Dexamethasone (2) · Acetaminophen (1) · Calcium Dobesilate (1) · Clonidine (1) · Dexmedetomidine (1) · Duloxetine Hydrochloride (1) · Etoricoxib (1) · Ibuprofen (1) · Interleukin 1 Receptor Antagonist Protein (1) · Ketorolac (1) · Losartan (1) · Midazolam (1)
Hospital for Special Surgery, New York (3) · Emory University (2) · Northwestern University (2) · Oslo University Hospital (2) · Alexandria University (1) · Asker & Baerum Hospital (1) · Assaf-Harofeh Medical Center (1) · Boston Medical Center (1) · Campbell Clinic (1) · Centre Hospitalier Universitaire Vaudois (1) · GCS Ramsay Santé pour l'Enseignement et la Recherche (1) · Konkuk University Medical Center (1) · Korea University Guro Hospital (1) · Loyola University (1) · Medical University of South Carolina (1)
United States (19) · Norway (3) · South Korea (3) · Belgium (1) · Chile (1) · China (1) · Denmark (1) · Egypt (1) · France (1) · Switzerland (1)
John Xerogeanes, MD (2) · Andrew Bi, MD (1) · Antoun Nader, MD (1) · Brian A. Williams, MD, MBA (1) · Bruce Piatt, MD (1) · Carey Breabaker, MD (1) · David H Kim, MD (1) · Eric Albrecht, PD Dr (1) · Eric J Strauss, MD (1) · Jashvant Poeran, MD/PhD (1) · Jihoon Bae (1) · Jonah Hebert-Davies (1) · Jonathan Beathe, MD (1) · Jorge Chahla, MD, PhD (1)
PMID 11429362, PMID 11890313, PMID 15029544, PMID 16436852, PMID 17377133, PMID 17456710, PMID 17543812, PMID 17543813, PMID 17720111, PMID 17999004, PMID 18042869, PMID 18042893, PMID 18073577, PMID 20838248, PMID 21270721, PMID 23338666, PMID 23440367, PMID 26237001, PMID 27159290, PMID 30733025, PMID 31130273, PMID 31348866, PMID 32743011, PMID 34477016, PMID 36860772, PMID 37152546, PMID 40308075, PMID 42459597
2004 (1), K23AR047631 (1)