46 completed. 46 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 46 | Completed 46 |
Follow Insomnia: new trials by email Literature Review of Insomnia trials Research Report on Insomnia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe Insomnia Chloral Hydrate - Insomnia, Insomnia Chronic | Phase 4 | Completed | Pharmanovia | 100 | 2023-09-01 | 2024-11-07 |
| Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA Eszopiclone 3 mg, Placebo - Obstructive Sleep Apnea, Insomnia | Phase 4 | Completed | University of Sao Paulo General Hospital | 60 | 2023-08-24 | 2026-05-29 |
| Solriamfetol and CBT-I in Patients With Insomnia Disorder Solriamfetol 75 MG, Cognitive Behavioral Therapy for Insomnia (CBT-I), Monitoring - Insomnia | Phase 4 | Completed | University of Pennsylvania | 115 | 2023-07-31 | 2026-05-12 |
| Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia Suvorexant, Placebo - Insomnia, Metabolic Health | Phase 4 | Completed | Brigham and Women's Hospital | 31 | 2023-01-06 | 2026-04-16 |
| Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia Suvorexant, Placebo - Restless Legs Syndrome, Insomnia | Phase 4 | Completed | Massachusetts General Hospital | 46 | 2021-08-12 | 2024-01-16 |
| An Open-label, Multicenter Study to Evaluate the Efficacy and Safety of Transitioning to Lemborexant in Japanese Subjects With Insomnia Lemborexant (LEM) 5 mg (Z-Drug-mono cohort), Lemborexant (LEM) 5 mg (SUV-mono cohort), Lemborexant (LEM) 5 mg (SUV-combination cohort) - Insomnia | Phase 4 | Completed | Kurume University | 97 | 2021-03-24 | 2023-03-15 |
| Suvorexant and Sleep/Delirium in ICU Patients Suvorexant 20 mg, Placebo oral tablet - Insomnia, Sleep Fragmentation | Phase 4 | Completed | Beth Israel Deaconess Medical Center | 100 | 2020-02-28 | 2025-10-27 |
| Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder Pimavanserin - Post-traumatic Stress Disorder, Insomnia | Phase 4 | Completed | Baylor College of Medicine | 6 | 2020-01-06 | 2022-08-31 |
| Treatment of Disturbed Sleep in Progressive Supranuclear Palsy (PSP) Suvorexant, Zolpidem, Placebo oral capsule - Progressive Supranuclear Palsy(PSP), Insomnia | Phase 4 | Completed | University of California, San Francisco | 40 | 2019-06-02 | 2026-09-01 |
| Partial Reinforcement II: Three Approaches to Maintenance Therapy for Chronic Insomnia Zolpidem tartrate - Insomnia, Insomnia Chronic | Phase 4 | Completed | University of Pennsylvania | 197 | 2019-04-15 | 2025-05-09 |
| Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes Suvorexant, Placebo - Type 2 Diabetes Mellitus, Insomnia | Phase 4 | Completed | Massachusetts General Hospital | 108 | 2019-03-15 | 2024-08-20 |
| Study to Compare the Awakening Threshold Effects of Belsomra 10 mg and 20 mg to Placebo in Non-elderly Insomniacs Suvorexant 10 mg, Suvorexant 20 mg, Placebo oral capsule - Insomnia | Phase 4 | Completed | Henry Ford Health System | 12 | 2018-04-15 | 2019-11-01 |
| Efficacy of Suvorexant in the Treatment of Hot Flash-associated Insomnia suvorexant, placebo - Insomnia | Phase 4 | Completed | Brigham and Women's Hospital | 60 | 2017-05-25 | 2022-03-14 |
| The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy Ramelteon - Insomnia, Major Depressive Disorder | Phase 4 | Completed | Takeda | 26 | 2017-05-09 | 2019-07-22 |
| A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia Suvorexant, Placebo - Multiple Sclerosis, Fatigue | Phase 4 | Completed | Theodore R. Brown, MD MPH | 36 | 2017-03-28 | 2025-02-03 |
| To Compare the Effectiveness of Suvorexant vs Placebo on Sleep Pressure in Hypertensives With Insomnia suvorexant, Placebo - Hypertension, Insomnia | Phase 4 | Completed | Jichi Medical University | 82 | 2017-01-17 | 2019-08-05 |
| Pharmacological Treatment of Insomnia in Palliative Care Zopiclone, Placebo - Sleep, Insomnia | Phase 4 | Completed | St. Olavs Hospital | 43 | 2016-11-15 | 2021-07-16 |
| Suvorexant and Trauma Related Insomnia suvorexant, placebo - Insomnia, Posttraumatic Stress Disorder | Phase 4 | Completed | Howard University | 41 | 2016-05-01 | 2023-02-15 |
| A Pilot Study of Suvorexant for Insomnia in Parkinson Disease Suvorexant, Placebo - Insomnia | Phase 4 | Completed | Burdick, Daniel, M.D. | 21 | 2016-04-01 | 2024-08-20 |
| Efficacy of Suvorexant to Treat Insomnia Related to Bipolar Disorder Suvorexant, Placebo - Insomnia, Bipolar Disorder | Phase 4 | Completed | Stanford University | 61 | 2015-09-01 | 2022-10-06 |
Showing 20 of 46. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (46) · Sleep Wake Disorders (5) · Depressive Disorder, Major (3) · Anxiety Disorders (2) · Depression (2) · Fatigue (2) · Hot Flashes (2) · Stress Disorders, Post-Traumatic (2) · Attention Deficit Disorder with Hyperactivity (1) · Bipolar Disorder (1) · Bronchiolitis Obliterans Syndrome (1) · Delirium (1) · Diabetes Mellitus, Type 2 (1) · Emergence Delirium (1) · Fibromyalgia (1)
Dyssomnias (46) · Mental Disorders (46) · Nervous System Diseases (46) · Sleep Disorders, Intrinsic (46) · Sleep Wake Disorders (41) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Neurologic Manifestations (7) · Mood Disorders (4) · Central Nervous System Diseases (3) · Depressive Disorder (3) · Immune System Diseases (3) · Behavior (2) · Behavioral Symptoms (2) · Brain Diseases (2)
suvorexant (12) · Zolpidem (11) · Eszopiclone (9) · ramelteon (4) · Sugars (3) · Cognitive Behavioral Therapy (2) · Temazepam (2) · zopiclone (2) · Atomoxetine Hydrochloride (1) · Chloral Hydrate (1) · Doxepin (1) · Escitalopram (1) · Ethanol (1) · Gabapentin (1) · Rabeprazole (1)
Sanofi (4) · Duke University (3) · Astellas Pharma Inc (2) · Brigham and Women's Hospital (2) · Massachusetts General Hospital (2) · Sumitomo Pharma America, Inc. (2) · Takeda (2) · University of Pennsylvania (2) · Augusta University (1) · Baylor College of Medicine (1) · Beth Israel Deaconess Medical Center (1) · Burdick, Daniel, M.D. (1) · Butler Hospital (1) · Henry Ford Health System (1) · Howard University (1)
United States (31) · Japan (5) · Norway (2) · Brazil (1) · Canada (1) · United Kingdom (1)
Phyllis Diener (3) · Andrew Krystal, MD (2) · Andrew D Krystal, MD (1) · Balachundhar Subramaniam (1) · Bruno Jolain (1) · Chris L Drake, PhD (1) · Claudio N Soares, MD, PhD (1) · Daniel Burdick, MD (1) · Egilius LH Spierings, M.D., Ph.D. (1) · Hadine Joffe, MD MSc (1) · Inger H Nordhus, PhD (1) · Jamie M. Zeitzer, PhD (1) · John W Winkelman, MD, PhD (1) · John W Winkelman, MD/PhD (1)
PMID 16804151, PMID 17068990, PMID 18417099, PMID 18458207, PMID 18627623, PMID 19317379, PMID 20175406, PMID 20814317, PMID 21208574, PMID 21208597, PMID 22131611, PMID 23143411, PMID 24090266, PMID 25323219, PMID 31238203, PMID 31537089, PMID 31538599, PMID 32329435, PMID 32690536, PMID 32918323, PMID 33884617, PMID 35022783, PMID 36534165, PMID 38460107, PMID 39119911, PMID 39260076, PMID 41103818, PMID 42199304, PMID 42337809
2015 (1), R01AG054521 (1), R01MH095776 (1)