24 completed, 2 terminated, 1 recruiting, 1 unknown. 12 Phase 1, 6 Phase 3, 4 Phase 4, 3 Not applicable, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Completed 11, Unknown 1 |
| Phase 3 | 6 | Completed 5, Terminated 1 |
| Phase 4 | 4 | Completed 3, Terminated 1 |
| Not applicable | 3 | Completed 2, Withdrawn 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow zopiclone: new trials by email Literature Review of zopiclone trials Research Report on zopiclone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Learn if Elinzanetant Affects the Ability to Drive and Brain Function in Healthy Women Elinzanetant (BAY3427080), Placebo to elinzanetant, Zopiclone - Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and Men, Hot Flashes | Phase 1 | Completed | Bayer | 64 | 2024-01-08 | 2024-05-08 |
| A Study to Investigate the Next-day Residual Effects of TS-142 in Healthy Elderly Subjects TS-142, Zopiclone, Placebo - Healthy Subjects | Phase 1 | Completed | Taisho Pharmaceutical Co., Ltd. | 43 | 2023-05-15 | 2025-02-28 |
| Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain Patients Lemborexant - Chronic Insomnia, Chronic Pain | Recruiting | Salem Anaesthesia Pain Clinic | 250 | 2023-01-02 | 2026-11-02 | |
| Clonidine is Better Than Zopiclone for Insomnia Treatment in Chronic Pain Patients Clonidine 0.1mg pill, Clonidine 0.2mg pill, Zopiclone 3.75mg pill - Insomnia Chronic, Pain, Chronic | Completed | Salem Anaesthesia Pain Clinic | 150 | 2022-03-01 | 2022-11-18 | |
| A Study to Evaluate Next Day Effects of TS-142 on Driving Performance in Healthy Subjects TS-142, Zopiclone, Placebo - Healthy Subjects | Phase 1 | Completed | Taisho Pharmaceutical Co., Ltd. | 61 | 2021-01-16 | 2025-02-28 |
| A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder Seltorexant Dose 1, Seltorexant Dose 2, Placebo - Depressive Disorder, Major | Phase 1 | Completed | Janssen Research & Development, LLC | 63 | 2020-07-16 | 2025-04-27 |
| A Clinical Study to Assess Next-day Driving Performance Following Administration of ACT-541468 in Middle-aged and Elderly Subjects ACT-541468, Zopiclone 7.5 mg, Placebo - Healthy | Phase 1 | Completed | Idorsia Pharmaceuticals Ltd. | 56 | 2019-03-25 | 2019-10-31 |
| Hangover and Residual Zopiclone Effect on Spatial Perception Zopiclone, hangover, Placebo oral capsule - Healthy, Alcohol Drinking | Phase 1 | Unknown | Petri Vainio | 16 | 2018-09-01 | 2018-08-15 |
| Efficacy of Multimodal Analgesia Following Hip Arthroscopy Zopiclone, Gabapentin, Celebrex - Hip Pain Chronic | Not applicable | Completed | Western University, Canada | 100 | 2018-04-06 | 2021-10-15 |
| SleepSure: A Trial to Assess the Effects of Eye Masks and Earplugs on Hospital Inpatient Sleep Ear plugs, Eye Mask, Zopiclone - Sleep | Phase 3 | Completed | Oxford University Hospitals NHS Trust | 206 | 2016-11-25 | 2019-10-01 |
| Pharmacological Treatment of Insomnia in Palliative Care Zopiclone, Placebo - Sleep, Insomnia | Phase 4 | Completed | St. Olavs Hospital | 43 | 2016-11-15 | 2021-07-16 |
| Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Zopiclone, Placebo - Sleep Apnea, Central, Ventricular Dysfunction | Phase 4 | Terminated | University Hospital, Grenoble | 2 | 2016-05-01 | 2021-05-26 |
| Study to Evaluate the Effect of Lemborexant Versus Placebo on Driving Performance in Healthy Adult and Elderly Subjects Placebo tablet matching lemborexant, Placebo tablet matching zopiclone, Zopiclone 7.5 mg - Healthy Participants | Phase 1 | Completed | Eisai Inc. | 48 | 2015-11-01 | 2018-09-06 |
| Effectiveness of BBT-I and Zopiclone for Chronic Insomnia Brief behavioral therapy, Zopiclone - Insomnia Chronic | Phase 2 | Completed | I.M. Sechenov First Moscow State Medical University | 42 | 2015-04-07 | 2019-09-16 |
| Pharmacovigilance in Gerontopsychiatric Patients Phenobarbital, Phenytoin, Carbamazepine - Dementia, Depression | Phase 3 | Terminated | Hannover Medical School | 407 | 2015-01-01 | 2018-02-28 |
| MELA Study - Hedonic Study on the Taste of Drugs Crushed in Food: Observational Study Involving 16 Healthy Volunteers Jelly with:Paracetamol, Jelly with Furosemide, Jelly with Levothyroxine sodium salt - Healthy | Phase 1 | Completed | Centre Hospitalier Universitaire de Nice | 16 | 2014-06-01 | 2015-10-07 |
| Driving Simulator Performance After Intake of Zopiclone Sleeping Pills Zopiclone, Ethanol, Placebo pill - Automobile Driving | Not applicable | Withdrawn | St. Olavs Hospital | 2012-08-01 | 2013-12-13 | |
| Reassessment of Premedication in Surgery Zopiclone, Alprazolam, placebo - Anxiety | Phase 4 | Completed | University Hospital, Angers | 455 | 2012-03-01 | 2013-09-25 |
| Effect of Zopiclone on Compliance With Continuous Positive Airway Pressure in Obstructive Sleep Apnea Placebo, Zopiclone - Obstructive Sleep Apnea | Phase 3 | Completed | OSR Medical Inc. | 264 | 2011-05-01 | 2015-07-17 |
| A Study to Evaluate Next Day Effects of MK-4305 on Driving Performance (MK-4305-035 AM1) MK-4305 40 mg, MK-4305 20 mg, Zopiclone - Insomnia | Phase 1 | Completed | Merck Sharp & Dohme LLC | 28 | 2011-04-01 | 2016-02-22 |
Showing 20 of 29. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (13) · Anxiety Disorders (2) · Chronic Pain (2) · Hot Flashes (2) · Alcohol Drinking (1) · Arrhythmias, Cardiac (1) · Dementia (1) · Depression (1) · Depressive Disorder, Major (1) · Hypercapnia (1) · Hypoxia (1) · Lung Diseases (1) · Mental Disorders (1) · Mood Disorders (1) · Multiple Endocrine Neoplasia Type 1 (1)
Merck Sharp & Dohme LLC (2) · Salem Anaesthesia Pain Clinic (2) · St. Olavs Hospital (2) · Taisho Pharmaceutical Co., Ltd. (2) · Bayer (1) · Centre Hospitalier Universitaire de Nice (1) · Eisai Inc. (1) · Eurofarma Laboratorios S.A. (1) · GlaxoSmithKline (1) · Hannover Medical School (1) · I.M. Sechenov First Moscow State Medical University (1) · Idorsia Pharmaceuticals Ltd. (1) · Janssen Research & Development, LLC (1) · LHL Helse (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1)
Canada (6) · Netherlands (5) · France (3) · Norway (3) · Germany (2) · Japan (2) · United Kingdom (2) · Belgium (1) · Brazil (1) · Finland (1)
Annemiek Vermeeren, PhD (1) · Barbara Capozzolo, MSc (1) · Derick T Wade, MD (1) · Germaine Tanzimat, RN (1) · Helge Frieling, Prof., MD (1) · Inger H Nordhus, PhD (1) · Joris Verster, PhD (1) · Kateri Champagne, MD DABSM (1) · Laurent Beydon, MD (1) · Marcel Baltzan, MDCM DABSM (1)
PMID 16804151, PMID 17068990, PMID 18417099, PMID 21966064, PMID 24587571, PMID 26004882, PMID 26872077, PMID 28777364, PMID 30597112, PMID 35112665, PMID 36534165, PMID 39120786, PMID 40569207, PMID 42174196
2004 (1), 2015 (1), 2019 (1)