1783 completed, 605 recruiting, 563 terminated, 553 unknown. 1525 Phase 2, 1321 Phase 1, 544 Not applicable, 373 Phase 3, 62 Phase 4.
Follow Neoplasm Metastasis: new trials by email Literature Review of Neoplasm Metastasis trials Research Report on Neoplasm Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma 9-ING-41, Carboplatin - Salivary Gland Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Withdrawn | Actuate Therapeutics Inc. | 2030-12-18 | 2022-02-22 | |
| A Phase 1/2 Study of Personalized PSMA Radiopharmaceutical Therapy 177Lu-PSMA-I&T - escalating renal absorbed dose, 177Lu-PSMA-I&T - recommended phase 2 regime - Cancer, Prostate Cancer | Phase 1 / Phase 2 | Not yet recruiting | CHU de Quebec-Universite Laval | 500 | 2028-03-01 | 2025-03-30 |
| Study of Trastuzumab Deruxtecan in Combination With Stereotactic Radiosurgery in Patients With HER2-Positive Metastatic Breast Cancer and First Diagnosis of Brain Metastases (HERBRAIN) SRS/fSRT+T-Dxd - Breast Cancer (Advanced/Metastatic) | Phase 2 | Not yet recruiting | Azienda Ospedaliero-Universitaria Careggi | 60 | 2027-05-15 | 2026-10-29 |
| Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options Liver transplantation - Colorectal Neoplasms, Liver Neoplasms | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 260 | 2027-04-01 | 2026-09-10 |
| High Dose Radiotherapy for Palliation (Hi-D) Palliative Radiotherapy - Metastases, Palliative Radiotherapy | Not applicable | Not yet recruiting | British Columbia Cancer Agency | 21 | 2027-03-01 | 2026-08-12 |
| Improving Processes of Cancer Care Delivery at a Comprehensive Cancer Center Discussion, Electronic Health Record Review, Questionnaire Administration - Metastatic Malignant Solid Neoplasm | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2027-01-30 | 2026-09-11 | |
| Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Not yet recruiting | Baptist Health South Florida | 20 | 2027-01-01 | 2026-10-01 |
| Study of ACC-1898 in Adult Participants With Advanced Solid Tumors ACC-1898 - Hepatocellular Carcinoma, Renal Cell Carcinoma | Phase 1 | Not yet recruiting | AccSalus Biosciences, Inc. | 40 | 2027-01-01 | 2026-10-28 |
| Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor) | Phase 2 | Not yet recruiting | Girish Dhall, MD | 25 | 2027-01-01 | 2026-10-28 |
| Predicting Severe Cardiac Arrhythmias in the Perioperative Period Using AI-ECG digital single-channel ECG recording - Atrial Fibrillation, Atrioventricular Block, Second and Third Degree | Not yet recruiting | I.M. Sechenov First Moscow State Medical University | 300 | 2026-12-31 | 2026-02-10 | |
| Aspirin and PAClitaxel in Head & Neck Squamous Cell Carcinoma Aspirin, Paclitaxel - Head and Neck (HNSCC), Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 40 | 2026-12-31 | 2026-10-28 |
| Study of ISM5939 in Patients With Advanced and/or Metastatic Solid Tumors ISM5939, Cisplatin, Docetaxel - Advanced Solid Tumor, Metastatic Solid Tumor | Phase 1 | Not yet recruiting | InSilico Medicine Hong Kong Limited | 159 | 2026-12-30 | 2026-07-23 |
| Adoption of Audio Recording in the Outpatient Supportive Care Center Communication Intervention, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2026-12-30 | 2026-07-16 | |
| An Investigational Study of BON-106 in Adults With Advanced or Metastatic Solid Tumors BON-106 - Solid Tumor, Advanced Solid Tumor | Phase 1 | Not yet recruiting | BeOne Medicines | 96 | 2026-12-01 | 2026-10-26 |
| Labyrinthin Vaccination in Veterans With Lung Adenocarcinoma LabVax 3(22)-23 and GM-CSF (adjuvant) in combination with pembrolizumab - Type and Grade of Toxicities, Demographic and Background Characteristics, Advanced, Metastatic, Recurrent Adenocarcinoma and Malignant Solid Neoplasm | Phase 2 | Not yet recruiting | VA Office of Research and Development | 30 | 2026-12-01 | 2026-10-06 |
| Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Breast Cancer Epigenetic Assay - Breast Cancer (Locally Advanced or Metastatic), Healthy Volunteers (HV) | Not yet recruiting | University of Maryland, Baltimore | 450 | 2026-12-01 | 2026-09-10 | |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Magnetic Resonance-Guided Stereotactic Body Radiation Therapy for the Treatment of Metastatic Solid Tumors, ONE SHOT Trial Computed Tomography, Magnetic Resonance Imaging, MRI-guided Stereotactic Body Radiation Therapy - Metastatic Malignant Solid Neoplasm | Not applicable | Not yet recruiting | Jonsson Comprehensive Cancer Center | 25 | 2026-12-01 | 2026-08-24 |
| Plant-Based Nutrition for Breast or Endometrial Cancer Control, Whole Food, Plant-Based Diet with Behavioral Education and Support - Breast Cancer Metastatic, Endometrial Cancer Stage IV | Not applicable | Not yet recruiting | University of Rochester | 60 | 2026-12-01 | 2026-04-08 |
| Real-world Trial of Individualized Precision Oncology Molecularly matched therapy, Standard of care - Metastatic Cancer, Unresectable Carcinoma | Phase 2 | Not yet recruiting | University of California, San Diego | 280 | 2026-12-01 | 2026-09-03 |
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Neoplasms (674) · Breast Neoplasms (638) · Colorectal Neoplasms (475) · Carcinoma, Non-Small-Cell Lung (382) · Melanoma (295) · Prostatic Neoplasms (294) · Lung Neoplasms (280) · Recurrence (264) · Pancreatic Neoplasms (259) · Neoplastic Cells, Circulating (226) · Lymphatic Metastasis (213) · Stomach Neoplasms (192) · Carcinoma, Renal Cell (186) · Colonic Neoplasms (174)
Pathological Conditions, Signs and Symptoms (4111) · Pathologic Processes (4101) · Neoplastic Processes (4099) · Neoplasms (3438) · Neoplasms by Site (2825) · Neoplasms by Histologic Type (1156) · Digestive System Diseases (1077) · Digestive System Neoplasms (1049) · Skin and Connective Tissue Diseases (927) · Skin Diseases (921) · Neoplasms, Glandular and Epithelial (793) · Gastrointestinal Diseases (781) · Urogenital Diseases (757) · Gastrointestinal Neoplasms (720) · Urogenital Neoplasms (720)
pembrolizumab (169) · Gemcitabine (160) · Paclitaxel (136) · Capecitabine (134) · Fluorouracil (124) · Oxaliplatin (117) · Bevacizumab (116) · Carboplatin (106) · Cisplatin (105) · Docetaxel (105) · Leucovorin (103) · Nivolumab (103) · Irinotecan (96) · Radiosurgery (93) · Cetuximab (78)
M.D. Anderson Cancer Center (136) · National Cancer Institute (NCI) (127) · Eli Lilly and Company (72) · Memorial Sloan Kettering Cancer Center (54) · AstraZeneca (53) · Novartis Pharmaceuticals (42) · Pfizer (42) · Fudan University (38) · H. Lee Moffitt Cancer Center and Research Institute (33) · University Health Network, Toronto (33) · Amgen (29) · UNICANCER (26) · Dana-Farber Cancer Institute (24) · Centre Leon Berard (22) · Duke University (22)
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