26 completed, 10 unknown, 4 not yet recruiting, 2 recruiting. 15 Not applicable, 13 Phase 3, 4 Phase 4, 3 Phase 2, 1 Early Phase 1.
Follow Non-Erosive Reflux Disease: new trials by email Literature Review of Non-Erosive Reflux Disease trials Research Report on Non-Erosive Reflux Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux Disease Inspiratory Muscle Training (IMT), Sham IMT - Non-erosive Reflux Disease (NERD) | Not applicable | Not yet recruiting | Izmir University of Economics | 60 | 2026-07-22 | 2026-06-24 |
| New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial) Esophageal barrier medical device, Placebo oral formulation - GERD (Gastroesophageal Reflux Disease), NERD | Not applicable | Recruiting | Cellmedis | 50 | 2026-05-28 | 2026-07-10 |
| Clinical Efficacy Evaluation of Chaizhi Hewei Decoction in the Treatment of Non-Erosive Reflux Disease With Liver-Stomach Disharmony Syndrome Chaizhi Hewei Decoction, Placebo - Non-erosive Reflux Disease (NERD) | Not applicable | Not yet recruiting | Xiyuan Hospital of China Academy of Chinese Medical Sciences | 66 | 2026-05-15 | 2026-04-08 |
| Transcutaneous Electrical Acustimulation (TEA) for the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD) Transcutaneous Electrical Acustimulation - Non-erosive Reflux Disease (NERD) | Not applicable | Not yet recruiting | Ningbo Medical Center Lihuili Hospital | 204 | 2026-05-01 | 2026-05-15 |
| Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 in Patients With Non-erosive Gastroesophageal Reflux Disease JP-1366 + placebo, Placebo + Placebo - Non-erosive Gastroesophageal Reflux Disease | Phase 3 | Not yet recruiting | Onconic Therapeutics Inc. | 321 | 2025-09-02 | 2025-09-08 |
| Evaluation of the Efficacy and Safety of Eolo in Patients With NERD EOLO, PPI (proton pump inhibitor), Group C: Eolo - Non-erosive Reflux Disease, Reflux Disease, Gastro-Esophageal | Not applicable | Completed | University of Bologna | 60 | 2025-05-30 | 2025-06-27 |
| Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Non-Erosive Gastroesophageal Reflux Disease (NERD) DWP14012 20mg, DWP14012 40mg, Placebo - Non-erosive Reflux Disease, Non-Erosive Gastro-Esophageal Reflux Disease | Phase 3 | Unknown | Daewoong Pharmaceutical Co. LTD. | 324 | 2023-08-31 | 2023-11-08 |
| A Study to Evaluate the Long-Term Safety of BLI5100 in Patients With Gastroesophageal Reflux Disease BLI5100 - Non-erosive Reflux Disease, Erosive Esophagitis | Phase 3 | Completed | Braintree Laboratories | 400 | 2023-04-05 | 2025-09-26 |
| A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Non-Erosive Reflux Disease BLI5100, Placebo - Non-erosive Reflux Disease | Phase 3 | Completed | Braintree Laboratories | 788 | 2022-09-06 | 2026-10-13 |
| Efficacy and Safety of WPQW Granule for Overlap of NERD and IBS-D WPQW granule, WPQW granule simulant - Non-erosive Reflux Disease, Diarrhea-Predominant Irritable Bowel Syndrome | Early Phase 1 | Unknown | Xiyuan Hospital of China Academy of Chinese Medical Sciences | 216 | 2021-12-01 | 2022-05-11 |
| Comorbid Esophageal Disorders in IBS Patients Upper endoscopy, esophageal manometry, 24-hour pH monitoring - GERD, Non-erosive Reflux Disease | Not applicable | Unknown | Assiut University | 50 | 2021-02-25 | 2021-02-18 |
| Study on the Rule and Mechanism of Treating Functional Gastrointestinal Diseases From the Perspective of Liver and Spleen tong-jiang granules, Chang 'an II Recipe, The placebo of tong-jiang granules - Non-erosive Reflux Disease/Diarrheal Irritable Bowel Syndrome | Phase 4 | Unknown | Xiyuan Hospital of China Academy of Chinese Medical Sciences | 100 | 2020-06-25 | 2020-07-02 |
| Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence diet adherence, No diet adherence, Change in physical activity - Gastroesophageal Reflux Disease, GERD | Not applicable | Recruiting | Federal State Budgetary Scientific Institution | 150 | 2020-01-31 | 2025-08-03 |
| Study of Dietary Patterns and Food Diversity in Russian GERD Patients Dietary assessment - Gastroesophageal; Reflux With Esophagitis, Gastroesophageal Reflux | Not applicable | Unknown | Russian Academy of Medical Sciences | 150 | 2020-01-30 | 2022-02-03 |
| Clinical Trial to Assess the Efficacy and Safety of YYD601 in NERD Patients YYD601 20mg, Nexium 20mg, Placebos - Non-erosive Reflux Disease | Phase 3 | Completed | Yooyoung Pharmaceutical Co., Ltd. | 170 | 2019-04-10 | 2021-05-11 |
| Clinical Trial to Evaluate the Efficacy and Safety of EsoDuo Tab. 20/800mg EsoDuo Tab. 20/800mg - Non-erosive Reflux Disease(NERD) | Phase 4 | Completed | Chong Kun Dang Pharmaceutical | 379 | 2019-01-29 | 2019-12-24 |
| Phase III Study to Evaluate Safety and Efficacy of Ilaprazole in Patients With NERD Ilaprazole - Non-erosive Reflux Disease | Phase 3 | Completed | Il-Yang Pharm. Co., Ltd. | 277 | 2018-10-31 | 2021-01-05 |
| A Multi-center, Randomized, Double-blind, Parallel-group, Placebo Controlled Phase III Study to Evaluate the Efficacy and Safety of LXI-15028 in Non-erosive Reflux Disease in Chinese Patients for 4 Weeks LXI-15028, Placebo - Non-erosive Reflux Disease | Phase 3 | Completed | Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. | 291 | 2018-10-29 | 2020-04-08 |
| Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERD Gastroesophageal Reflux Disease, Minimal Change Disease | Unknown | Affiliated Hospital to Academy of Military Medical Sciences | 90 | 2017-01-15 | 2017-09-19 | |
| Efficacy of Traditional Chinese Medicine Combined With Omeprazole in Patients With Non-erosive Reflux Disease Treatment group, Control group - Non-erosive Reflux Disease | Phase 1 / Phase 2 | Unknown | Xiyuan Hospital of China Academy of Chinese Medical Sciences | 204 | 2017-01-01 | 2019-08-26 |
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Gastroesophageal Reflux (19) · Heartburn (5) · Esophagitis, Peptic (3) · Irritable Bowel Syndrome (2) · Sleep Wake Disorders (2) · Barrett Esophagus (1) · Duodenal Ulcer (1) · Dyspepsia (1) · Esophagitis (1) · Gastrointestinal Diseases (1) · Laryngopharyngeal Reflux (1) · Nephrosis, Lipoid (1) · Stomach Ulcer (1) · Zollinger-Ellison Syndrome (1)
Deglutition Disorders (46) · Digestive System Diseases (46) · Esophageal Diseases (46) · Esophageal Motility Disorders (46) · Gastrointestinal Diseases (45) · Gastroesophageal Reflux (27) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Signs and Symptoms, Digestive (6) · Intestinal Diseases (5) · Duodenal Diseases (3) · Gastroenteritis (3) · Peptic Ulcer (3) · Stomach Diseases (3) · Colonic Diseases (2)
Esomeprazole (6) · Omeprazole (5) · Pantoprazole (5) · Proton Pump Inhibitors (4) · Rabeprazole (2) · Sucralfate (2) · Acupuncture Therapy (1) · Control Groups (1) · Endoscopy, Digestive System (1) · Exercise (1) · Fluoxetine (1) · Gastroscopy (1) · Lansoprazole (1) · Nutrition Assessment (1) · Therapeutics (1)
AstraZeneca (4) · Xiyuan Hospital of China Academy of Chinese Medical Sciences (4) · Nycomed (3) · Seoul National University Bundang Hospital (3) · Braintree Laboratories (2) · Midwest Biomedical Research (2) · Affiliated Hospital to Academy of Military Medical Sciences (1) · Ahn-Gook Pharmaceuticals Co.,Ltd (1) · Assiut University (1) · Cellmedis (1) · Chong Kun Dang Pharmaceutical (1) · Daewoong Pharmaceutical Co. LTD. (1) · Federal State Budgetary Scientific Institution (1) · HK inno.N Corporation (1) · Hospital Authority, Hong Kong (1)
China (9) · South Korea (9) · United States (8) · Germany (3) · Japan (3) · Russia (2) · Ecuador (1) · Iran (1) · Italy (1) · Netherlands (1) · Poland (1) · Switzerland (1) · Taiwan (1) · Thailand (1) · Turkey (Türkiye) (1)
Dr. Thomas D. Bethke, MD, MBA (2) · Sergey Morozov, MD, PhD (2) · Akbar Fotouhi, MD, PhD (1) · Arash Etemadi, MD, PhD (1) · Behtash Saeidi, MD (1) · Carlo Calabrese, Prof of Gastroenterology, PI (1) · Carlos A Robles-Medranda, MD (1) · DongHo Lee, MD.PhD (1) · George B Smallfield, MD, MSPH (1) · Kaveh Hajifathalian, MD (1) · Leah Hollins (1) · Loren Laine, MD (1)
PMID 15233698, PMID 17681166, PMID 21952699, PMID 22156539, PMID 24533896, PMID 25628366, PMID 30302374, PMID 34119741, PMID 34227708, PMID 35487299, PMID 35730245