21 completed, 6 unknown, 2 recruiting, 2 terminated. 34 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 34 | Completed 21, Unknown 6, Recruiting 2, Terminated 2, Enrolling by invitation 1, Not yet recruiting 1, Withdrawn 1 |
Follow Heartburn: new trials by email Literature Review of Heartburn trials Research Report on Heartburn
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antireflux Surgery Without Preoperative Esophageal Manometry Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry - GERD, Hiatal Hernia | Not applicable | Not yet recruiting | McMaster University | 96 | 2026-10-01 | 2026-08-10 |
| New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial) Esophageal barrier medical device, Placebo oral formulation - GERD (Gastroesophageal Reflux Disease), NERD | Not applicable | Recruiting | Cellmedis | 50 | 2026-05-28 | 2026-07-10 |
| Potassium Competitive Acid Blocker (PCAB) Test-Guided vs Physiologic Test-Guided Treatment in Patients With Typical Reflux Symptoms PCAB-test guided - GERD, Acid Reflux, Treatment | Not applicable | Enrolling by invitation | Mahidol University | 120 | 2026-03-18 | 2026-07-16 |
| A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep Outcomes PepZinGI, Placebo - Heartburn | Not applicable | Completed | NutriScience Innovations, LLC | 50 | 2026-01-15 | 2026-06-17 |
| The Anti-gastroesophageal Reflux Effect of Anvitra Gastric Suspension on Outpatients With Gastroesophageal Reflux Disease Anvitra Gastric Suspension - GERD (Heartburn, Regurgitation, and Dyspepsia) Frequency, GERD (Heartburn, Regurgitation, and Dyspepsia) Severity | Not applicable | Completed | Haiphong University of Medicine and Pharmacy | 27 | 2024-08-06 | 2025-09-15 |
| A Pre-market, Two-stages Interventional Clinical Investigation to Evaluate the Safety and the Performance of Fibroin Syrup in Reducing the Gastroesophageal Reflux Disease (GERD) Symptomatology in Nonerosive Reflux Disease (NERD) Patients Syrup made by hyaluronic acid - GERD (Heartburn, Regurgitation, and Dyspepsia), Gastroesophageal Reflux (GERD) | Not applicable | Completed | Rose Pharma SA | 47 | 2024-07-24 | 2026-05-04 |
| Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy Volunteers Antareit - Heartburn, Acid-dependent Diseases of the Gastrointestinal Tract | Not applicable | Unknown | Valenta Pharm JSC | 50 | 2024-04-25 | 2024-07-22 |
| A Study of Breath Testing for Small Intestinal Bacterial Overgrowth Breath Testing - Gastroesophageal Reflux, Regurgitation | Not applicable | Recruiting | Mayo Clinic | 50 | 2023-11-17 | 2026-02-12 |
| Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms Butyrate Formulation, Butyrate + Polyphenol Formulation, Placebo - Gut Health | Not applicable | Completed | Supplement Formulators, Inc. | 143 | 2023-10-31 | 2026-01-13 |
| The Effect of the LEFT Smartwatch App as Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux Symptoms. LEFT smartwatch app - Gastroesophageal Reflux, Heartburn | Not applicable | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 18 | 2023-10-01 | 2025-05-31 |
| Smartphone App-assisted PPI App-based treatment support - Heartburn, Dyspepsia | Not applicable | Completed | University Hospital, Basel, Switzerland | 60 | 2023-09-05 | 2025-02-13 |
| Study to Evaluate the Efficacy of Poppi Apple Cider Vinegar Prebiotic Soda to Improve Gut Health In Participants Drink Poppi Soda - IBS - Irritable Bowel Syndrome | Not applicable | Completed | Drink Poppi | 38 | 2022-04-01 | 2022-06-15 |
| Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml), Placebo 1.4 ml - Heartburn | Not applicable | Completed | Microbiome Health Sciences | 211 | 2022-02-10 | 2023-07-18 |
| Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg Chewable Tablets and Riopan 800 mg Chewable Tablets in Healthy Volunteers Magaldrate - Heartburn, Acid-dependent Diseases of the Gastrointestinal Tract | Not applicable | Completed | Valenta Pharm JSC | 40 | 2021-07-07 | 2024-08-14 |
| Implementation of a Minor Ailment Service in Community Pharmacy Practice Minor ailment service - Acne, Bites | Not applicable | Completed | Universidad de Granada | 20987 | 2020-10-01 | 2023-12-07 |
| Remote Guided Caffeine Reduction Caffeine Reduction Manual - Caffeine Dependence, Anxiety | Not applicable | Completed | Johns Hopkins University | 109 | 2020-09-10 | 2025-01-14 |
| Efficacy of Vitamin C Supplement vs Spinal Manipulation to Treatment in Lateral Epicondylitis Vitamin C, spinal manipulation, Transcutaneous electrical nerve stimulation (TENS) - Lateral Epicondylitis, Tennis Elbow | Not applicable | Unknown | Universidad Rey Juan Carlos | 130 | 2020-05-21 | 2020-06-26 |
| Study of Dietary Patterns and Food Diversity in Russian GERD Patients Dietary assessment - Gastroesophageal; Reflux With Esophagitis, Gastroesophageal Reflux | Not applicable | Unknown | Russian Academy of Medical Sciences | 150 | 2020-01-30 | 2022-02-03 |
| Upset Stomach Relief for Mild and Moderate Indigestion and Heartburn HLNatural, Inc. Upset Stomach Relief - Indigestion, Heartburn | Not applicable | Completed | Hawthorne Effect Inc. | 161 | 2019-10-16 | 2021-11-15 |
| Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients Diaphragm Training - GERD | Not applicable | Completed | Mayo Clinic | 192 | 2019-09-24 | 2023-01-19 |
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Gastroesophageal Reflux (22) · Dyspepsia (8) · Diarrhea (3) · Abdominal Pain (2) · Constipation (2) · Cough (2) · Duodenal Ulcer (2) · Esophagitis (2) · Esophagitis, Peptic (2) · Non-Erosive Reflux Disease (2) · Sleep Wake Disorders (2) · Acne Vulgaris (1) · Anxiety Disorders (1) · Barrett Esophagus (1)
Pathological Conditions, Signs and Symptoms (34) · Signs and Symptoms (34) · Signs and Symptoms, Digestive (34) · Digestive System Diseases (26) · Gastrointestinal Diseases (26) · Deglutition Disorders (22) · Esophageal Diseases (22) · Esophageal Motility Disorders (22) · Intestinal Diseases (6) · Neurologic Manifestations (6) · Duodenal Diseases (4) · Pain (4) · Peptic Ulcer (4) · Stomach Diseases (4) · Gastroenteritis (3)
Ascorbic Acid (1) · Biofeedback, Psychology (1) · Butyrates (1) · Dexlansoprazole (1) · Diet, Fat-Restricted (1) · Dietary Supplements (1) · Lansoprazole (1) · Manipulation, Spinal (1) · Musculoskeletal Manipulations (1) · Nutrition Assessment (1) · Transcutaneous Electric Nerve Stimulation (1) · magaldrate (1)
Mayo Clinic (3) · EndoGastric Solutions (2) · Valenta Pharm JSC (2) · Aboca Spa Societa' Agricola (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assaf-Harofeh Medical Center (1) · Azienda Ospedaliera Universitaria Policlinico "G. Martino" (1) · Beth Israel Deaconess Medical Center (1) · Cellmedis (1) · Changhai Hospital (1) · Cook Group Incorporated (1) · Dallas VA Medical Center (1) · Drink Poppi (1) · Haiphong University of Medicine and Pharmacy (1) · Hawthorne Effect Inc. (1)
United States (18) · Russia (3) · Spain (3) · Italy (2) · Canada (1) · China (1) · Netherlands (1) · Poland (1) · Switzerland (1) · Thailand (1) · Vietnam (1)
Andree Koop, MD (1) · Andrew Swick, Ph.D (1) · Christopher J Yelvington, DPT (1) · David I. Rosenthal, MD, MA, BA (1) · Dustin Lee, PhD (1) · Gioacchino Calapai, MD (1) · Glen A. Lehman, MD (1) · Isabelle Arnet, Dr. PD (1) · Karim Trad, MD, FACS (1) · Michael Shapiro, MD (1) · Michelle Dossett, MD, PhD, MPH (1)
PMID 15365964, PMID 19028251, PMID 22923162, PMID 24378321, PMID 25246239, PMID 25284142, PMID 26149189, PMID 26422466, PMID 27187303, PMID 27694141, PMID 28861199, PMID 30081223
R01DA003890 (1), R01DK063621 (1)