6 completed, 4 unknown, 1 active not recruiting, 1 terminated. 13 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 6, Unknown 4, Active not recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 1 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 2 | Unknown 2 |
Follow Heart Septal Defects: new trials by email Literature Review of Heart Septal Defects trials Research Report on Heart Septal Defects
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale Aspirin 300mg, Metoprolol 25mg, Clopidogrel 75mg - Patent Foramen Ovale, Migraine | Phase 2 | Completed | Chinese Academy of Medical Sciences, Fuwai Hospital | 1000 | 2022-10-15 | 2026-04-22 |
| Optical Tissue Identification for Myocardial Architecture Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes - Ventricular Septal Defect, Complete Atrioventricular Canal | Phase 2 | Active not recruiting | Aditya Kaza | 70 | 2019-12-20 | 2023-06-15 |
| Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle MPC; rexlemestrocel-L - Hypoplastic Left Heart Syndrome, Atrioventricular Canal | Phase 1 / Phase 2 | Unknown | Boston Children's Hospital | 19 | 2017-11-27 | 2023-04-21 |
| Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches the transcatheter closure of PFO - Patent Foramen Ovale | Phase 2 | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 100 | 2017-01-01 | 2017-07-19 |
| Patients With Patent Foramen Ovale and Endocardial Device Leads on Apixaban for Prevention of Paradoxical Emboli Apixaban, Placebo - Patent Foramen Ovale, Cardiac Implantable Electronic Device | Phase 2 | Withdrawn | Mayo Clinic | 2015-05-01 | 2018-11-16 | |
| Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol Intravenous L-Citrulline, Placebo of Intravenous L-Citrulline - Atrial Septal Defect, Ventricular Septal Defect | Phase 1 / Phase 2 | Completed | Asklepion Pharmaceuticals, LLC | 22 | 2010-09-01 | 2022-07-27 |
| Measures to Lower the Stress Response in Pediatric Cardiac Surgery Fentanyl (High Dose), Fentanyl (Low Dose), Fentanyl (Low Dose) + Dexmedetomidine - Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD) | Phase 2 | Completed | Nationwide Children's Hospital | 52 | 2008-11-01 | 2018-07-27 |
| Safety Study of Varisolve® Procedure for Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Polidocanol (1%) Microfoam (Varisolve), Endovenous Microfoam Occlusion - Varicose Veins | Phase 2 | Completed | Boston Scientific Corporation | 60 | 2007-03-01 | 2021-04-21 |
| PRIMA PFO Migraine Trial AMPLATZER® PFO Occluder Device - Migraine, Migraine With Aura | Phase 2 | Terminated | Abbott Medical Devices | 107 | 2006-05-01 | 2019-02-04 |
| MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant BioSTAR Septal Repair Implant System, Sham Procedure - Migraine, Aura | Phase 2 / Phase 3 | Unknown | NMT Medical | 610 | 2006-02-01 | 2008-01-25 |
| Use of Ketamine Prior to Cardiopulmonary Bypass in Children saline, ketamine - Ventricular Septal Defect | Phase 2 | Completed | Arkansas Children's Hospital Research Institute | 24 | 2004-07-01 | 2007-11-12 |
| Hypertonic Saline Dextran in Pediatric Cardiac Surgery 7.5% NaCl in 6% dextran 70 solution - Heart Defects, Congenital, Transposition of Great Vessels | Phase 2 | Completed | Oslo University Hospital | 14 | 2003-06-01 | 2011-07-01 |
| Evaluation of the STARFlex® Septal Closure System in Patients With a Stroke or TIA Due to the Possible Passage of a Clot of Unknown Origin Through a Patent Foramen Ovale (PFO) STARFlex septal closure system, Best medical therapy - Patent Foramen Ovale, Stroke | Phase 2 / Phase 3 | Unknown | NMT Medical | 900 | 2003-06-01 | 2008-12-30 |
Foramen Ovale, Patent (7) · Heart Septal Defects, Ventricular (5) · Migraine Disorders (4) · Endocardial Cushion Defects (3) · Heart Septal Defects, Atrial (3) · Atrioventricular Septal Defect (2) · Stroke (2) · Cognitive Dysfunction (1) · Complete atrioventricular septal defect (1) · Embolism, Paradoxical (1) · Epilepsy (1) · Fractures, Stress (1) · Headache (1) · Heart Defects, Congenital (1) · Hypoplastic Left Heart Syndrome (1)
Cardiovascular Abnormalities (13) · Cardiovascular Diseases (13) · Congenital Abnormalities (13) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (13) · Heart Diseases (13) · Heart Defects, Congenital (12) · Brain Diseases (6) · Central Nervous System Diseases (6) · Nervous System Diseases (6) · Heart Septal Defects, Atrial (5) · Headache Disorders (4) · Headache Disorders, Primary (4) · Vascular Diseases (3) · Cerebrovascular Disorders (2)
Aspirin (1) · Clopidogrel (1) · Dexmedetomidine (1) · Fentanyl (1) · Fluorescein (1) · Ketamine (1) · Metoprolol (1) · Polidocanol (1) · Rivaroxaban (1) · Sodium Chloride (1) · apixaban (1)
NMT Medical (2) · Abbott Medical Devices (1) · Aditya Kaza (1) · Arkansas Children's Hospital Research Institute (1) · Asklepion Pharmaceuticals, LLC (1) · Boston Children's Hospital (1) · Boston Scientific Corporation (1) · Chinese Academy of Medical Sciences, Fuwai Hospital (1) · First Affiliated Hospital Xi'an Jiaotong University (1) · Mayo Clinic (1) · Nationwide Children's Hospital (1) · Oslo University Hospital (1)
United States (9) · China (2) · Canada (1) · Germany (1) · Switzerland (1) · United Kingdom (1)
Mark Reisman, MD (2) · Aditya K Kaza, MD (1) · Adnan T Bhutta, MD (1) · Allan Doctor, MD (1) · Anthony Furlan, MD (1) · Aymen N Naguib, MD (1) · Catherine Krawczeski, MD (1) · Christopher DeSimone, MD (1) · Frederick E Barr, MD (1) · Gunnar Bentsen, MD (1) · Janet Rush, MD (1) · Paul Friedman, MD (1) · Samuel Asirvatham, MD (1) · Sitaram M Emani, MD (1)
PMID 21051670, PMID 21926656, PMID 22417252, PMID 25147037, PMID 26908949, PMID 31211145, PMID 38109984, PMID 42526943
R56HL128813 (1)