42 completed, 29 recruiting, 27 unknown, 11 not yet recruiting. 54 Not applicable, 10 Phase 3, 7 Phase 2, 4 Phase 4, 1 Early Phase 1.
Follow Foramen Ovale, Patent: new trials by email Literature Review of Foramen Ovale, Patent trials Research Report on Foramen Ovale, Patent
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale | Not applicable | Not yet recruiting | Luciano A. Sposato | 2400 | 2027-03-01 | 2026-09-18 |
| Dapagliflozin and Right Heart Recovery After ASD Device Closure trans catheter device closure - ASD2(Secundum Atrial Septal Defect) | Not applicable | Not yet recruiting | Assiut University | 70 | 2026-11-01 | 2026-09-17 |
| Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale | Phase 3 | Recruiting | Columbia University | 32 | 2026-10-15 | 2026-10-08 |
| The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-09-15 | 2026-08-03 | |
| Hummingbird ICE Study ICE Image Guidance - ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Atrial Fibrillation (AF) | Not yet recruiting | Philips Clinical & Medical Affairs Global | 1000 | 2026-09-01 | 2026-08-19 | |
| Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIA PFO Closure procedure - Patent Foramen Ovale, Stroke | Not applicable | Recruiting | Giuseppe Tarantini | 1260 | 2026-07-24 | 2026-10-05 |
| Safety and Efficacy of the Patent Foramen Ovale Suture System for the Closure of Patent Foramen Ovale Patent Foramen Ovale Suture System, Amplatzer PFO Occluder - Patent Foramen Ovale (PFO) | Not applicable | Not yet recruiting | Shenzhen Bihe Medical Co., Ltd | 244 | 2026-06-30 | 2026-07-27 |
| Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS Study Recross P3 Occluder (P3O) System - PFO, PFO - Patent Foramen Ovale | Not applicable | Recruiting | Recross Cardio, Inc. | 15 | 2026-06-17 | 2026-07-13 |
| Long-term Outcomes After Percutaneous Patent Foramen Ovale Closure (Severance PFO Registry) Patent Foramen Ovale, Cryptogenic Stroke | Recruiting | Yonsei University | 400 | 2026-06-05 | 2026-07-23 | |
| Pulmonary Embolism and Right-to-Left Shunts Pulmonary Embolism (PE), Right-to-Left Shunt | Recruiting | Tufts Medical Center | 256 | 2026-01-30 | 2026-04-09 | |
| Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine Percutaneous Patent Foramen Ovale Closure, No Intervention - Migraine Disorders, Patent Foramen Ovale | Not applicable | Recruiting | First Affiliated Hospital Xi'an Jiaotong University | 150 | 2026-01-14 | 2026-01-16 |
| Non-Invasive Detection of Right-to-Left Cardiac Shunts Point-of-care ultrasound - Patent Foramen Ovale (PFO) | Recruiting | Scripps Health | 75 | 2026-01-07 | 2026-02-19 | |
| Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device Transcranial Ultrasound Device - Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale | Not applicable | Recruiting | St. Antonius Hospital | 40 | 2026-01-07 | 2026-02-17 |
| Study on the Safety and Effectiveness of a Biodegradable Patent Foramen Ovale Occluder System Active Comparator, Experimental - Cardiovascular Diseases, Cardiovascular Abnormality | Not applicable | Not yet recruiting | Shanghai Lingsi Medical Technology Co., Ltd. | 258 | 2025-12-30 | 2025-12-23 |
| SENIOR: Stroke Prevention in the Elderly by Patent Foramen Ovale closuRe vs Anticoagulation PFO closure, Medication - Ischemic Stroke, Embolic Stroke of Undetermined Source | Recruiting | Taichung Veterans General Hospital | 400 | 2025-12-16 | 2026-03-23 | |
| Neurogenetic And Hemodynamic Of Migraine Aura And Pfo Intervention - Migraine With Aura | Recruiting | Azienda Usl di Bologna | 240 | 2025-11-24 | 2026-02-11 | |
| Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study Recross P3 Occluder (P3O) System - PFO, PFO - Patent Foramen Ovale | Not applicable | Recruiting | Recross Cardio, Inc. | 30 | 2025-10-09 | 2026-07-27 |
| Pioneering Advancements in Cardiocerebrovascular Interactions in the Asia pacFIC - Patent Foramen Ovale Study PFO closure using approved PFO closure devices, Surgical PFO closure, Medical management - Ischemic Stroke, Patent Foramen Ovale | Not yet recruiting | National University Hospital, Singapore | 1000 | 2025-07-01 | 2025-05-21 | |
| Percutaneous Repair for Drug - Resistant Epilepsy by Intervention of Closing the Patent Foramen Ovale（PREDICT-PFO Trial） patent foramen ovale closure - Epilepsy (treatment Refractory) | Not applicable | Recruiting | Sichuan University | 180 | 2025-02-28 | 2025-03-11 |
| Close Obstructive Sleep Apnea (OSA) Trial PFO closure - Obstructive Sleep Apnea, Patent Foramen Ovale | Not applicable | Withdrawn | University of Miami | 2025-02-01 | 2025-03-20 |
Showing 20 of 135. Sign in to see all of them.
Stroke (40) · Ischemic Stroke (31) · Migraine Disorders (25) · Heart Septal Defects, Atrial (23) · Atrial Fibrillation (13) · Ischemic Attack, Transient (11) · Epilepsy (5) · Migraine with Aura (5) · Pulmonary Embolism (5) · Heart Valve Diseases (4) · Embolism, Paradoxical (3) · Heart Septal Defects (3) · Sleep Apnea, Obstructive (3) · Decompression Sickness (2)
Congenital Abnormalities (135) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (135) · Cardiovascular Abnormalities (134) · Cardiovascular Diseases (134) · Heart Defects, Congenital (133) · Heart Diseases (133) · Heart Septal Defects (132) · Heart Septal Defects, Atrial (112) · Nervous System Diseases (84) · Brain Diseases (81) · Central Nervous System Diseases (81) · Vascular Diseases (64) · Cerebrovascular Disorders (60) · Headache Disorders (26) · Headache Disorders, Primary (26)
Aspirin (8) · Clopidogrel (6) · Septal Occluder Device (4) · Aspirin, Dipyridamole Drug Combination (2) · Dipyridamole (2) · Drug Delivery Systems (2) · Echocardiography (2) · Prasugrel Hydrochloride (2) · Rivaroxaban (2) · apixaban (2) · Anticoagulants (1) · Blood Specimen Collection (1) · Cilostazol (1) · Conservative Treatment (1) · Dabigatran (1)
Abbott Medical Devices (11) · Lifetech Scientific (Shenzhen) Co., Ltd. (6) · Chinese Academy of Medical Sciences, Fuwai Hospital (4) · W.L.Gore & Associates (4) · Assistance Publique - Hôpitaux de Paris (3) · China National Center for Cardiovascular Diseases (3) · Cierra (3) · University of Oregon (3) · Assiut University (2) · Carag AG (2) · Cardiox Corporation (2) · Centro Cardiologico Monzino (2) · Columbia University (2) · First Affiliated Hospital Xi'an Jiaotong University (2) · Josep Rodes-Cabau (2)
United States (35) · Germany (21) · China (19) · France (15) · Canada (14) · Italy (11) · South Korea (8) · Switzerland (8) · United Kingdom (7) · Denmark (4) · Netherlands (4) · Spain (4) · Belgium (3) · Czechia (3) · Ireland (3)
Andrew Lovering, PhD (2) · Daniela Trabattoni, MD (2) · David Dodick, MD (2) · Eric Horlick, MD (2) · Horst Sievert, MD (2) · Horst Sievert, Prof. Dr. (2) · Lusine Abrahamyan, MD, PhD (2) · Mark Reisman, MD (2) · Robert Sommer, MD (2) · Xiangbin Pan, Doctor (2) · Akiva Tamir, M.D (1) · Alan M. Haltiner, Ph.D. (1) · Alec Vahanian, MD (1) · Aleksandra Pikula, MD (1) · Anastasios Apostolos, MD (1)
PMID 32381162, PMID 34032839, PMID 36891906, PMID 12045168, PMID 13678932, PMID 15232117, PMID 19380621, PMID 21051670, PMID 21356042, PMID 22417252, PMID 22958084, PMID 23514285, PMID 24630875, PMID 24762035, PMID 25147037, PMID 25313847, PMID 25967578, PMID 26470854, PMID 26908949, PMID 27056964, PMID 27649347, PMID 27966652, PMID 28902580, PMID 28902593, PMID 29090661, PMID 29191325, PMID 29368313, PMID 29544871, PMID 29910193, PMID 31060047, PMID 31140194, PMID 31211145, PMID 31612072, PMID 32208831, PMID 32797064, PMID 33303305, PMID 33789756, PMID 34006504, PMID 34455822, PMID 34753444, PMID 35818509, PMID 37086083, PMID 37699623, PMID 37795589, PMID 38109984, PMID 38216511, PMID 38541922, PMID 38580946, PMID 38939654, PMID 39222035
2019 (1), R01NS032525 (1), R01NS067139 (1)