39 completed, 9 recruiting, 7 terminated, 3 active not recruiting. 16 Not applicable, 16 Phase 1, 11 Phase 2, 3 Phase 3.
Follow Hypoplastic Left Heart Syndrome: new trials by email Literature Review of Hypoplastic Left Heart Syndrome trials Research Report on Hypoplastic Left Heart Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome Fetal Aortic Valvuloplasty Procedure, Emerge Monorail and Over-The-Wire PTCA Dilatation Catheter, Trek RX and Mini Trek RX Coronary Dilatation Catheter - Hypoplastic Left Heart Syndrome | Not applicable | Enrolling by invitation | Mauro H. Schenone | 80 | 2027-01-01 | 2026-05-01 |
| Long-term Safety Study Following to JRM-001 Treatment in Pediatric Patients With Congenital Heart Disease Single Ventricle, Hypoplastic Left Heart Syndrome (HLHS) | Recruiting | Metcela Inc. | 40 | 2026-09-01 | 2026-10-20 | |
| 3D Modalities for Medical Student Education of Congenital Heart Disease 3D-printed heart models and augmented reality - Tetralogy of Fallot (TOF), Hypoplastic Left Heart Syndrome (HLHS) | Not applicable | Completed | Case Western Reserve University | 26 | 2025-11-20 | 2025-12-26 |
| Seeking for Perfected Aortic Arch Reconstruction Using a Graphically Designed Patient-specific Surgical Patch Personalized patch template - Hypoplastic Left Heart Syndrome (HLHS), Aortic Arch Hypoplasia | Not applicable | Not yet recruiting | The Hospital for Sick Children | 30 | 2025-09-01 | 2025-08-01 |
| Study of Intramyocardial Injection of Ventrix Bio Extracellular Matrix (VentriGel) to Assess the Safety and Feasibility in Pediatric Patients with Hypoplastic Left Heart Syndrome (HLHS) Ventrix Bio Extracellular Matrix - Hypoplastic Left Heart Syndrome | Phase 1 | Not yet recruiting | Emory University | 12 | 2025-08-01 | 2025-03-10 |
| Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease Congenital Heart Disease, Cyanotic Congenital Heart Disease | Recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 174 | 2025-06-27 | 2026-07-30 | |
| The Co-Op @ HeartWorks Congenital Heart Disease | Recruiting | HeartWorks, Inc. | 500 | 2024-01-24 | 2025-10-07 | |
| Hypoplastic Left Heart Syndrome: Subendocardial Viability After Norwood Palliation Hypoplastic Left Heart Syndrome | Terminated | IRCCS Policlinico S. Donato | 6 | 2022-07-28 | 2024-10-21 | |
| An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart Disease Congenital Heart Disease, Coarctation of Aorta | Recruiting | Beijing Anzhen Hospital | 10000 | 2022-01-01 | 2025-01-10 | |
| Evaluation of Lomecel-B™ Injection in Patients With Hypoplastic Left Heart Syndrome (HLHS): A Phase IIb Clinical Trial. Lomecel-B medicinal signaling cells - Hypoplastic Left Heart Syndrome | Phase 2 | Active not recruiting | Longeveron Inc. | 40 | 2021-06-25 | 2025-06-25 |
| Intramyocardial Injection of Autologous UCB-MNC During Fontan Surgery for SRV Dependent CHD Autologous mononuclear cells - Congenital Heart Disease, SRV Dependent | Phase 1 | Active not recruiting | Timothy J Nelson, MD, PhD | 30 | 2021-06-01 | 2025-06-27 |
| Training in Exercise Activities and Motion for Growth (TEAM 4 Growth) RCT passive range of motion exercise therapy - Congenital Heart Disease | Phase 3 | Unknown | Carelon Research | 144 | 2021-02-23 | 2024-07-03 |
| Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period Normoxia (with controlled re-oxygenation), Standard of care ventilation - Hypoplastic Left Heart Syndrome, Total Anomalous Pulmonary Venous Return | Not applicable | Completed | University of Michigan | 29 | 2021-01-18 | 2024-06-18 |
| Effect of Fetal Aortic Valvuloplasty on Outcomes Fetal aortic balloon dilatation - Congenital Heart Disease, Aortic Valve Stenosis | Recruiting | Queen Silvia Children's Hospital, Gothenburg, Sweden | 200 | 2021-01-01 | 2025-03-21 | |
| Impact of NAVA Ventilation on Brain Oxygenation and Perfusion in Children With Congenital Heart Disease Two ventilation periods with two different modes: conventional ventilation followed by NAVA. - Tetralogy of Fallot, Hypoplastic Left Heart Syndrome | Not applicable | Completed | St. Justine's Hospital | 30 | 2020-10-05 | 2026-09-21 |
| Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts Tissue Engineered Vascular Grafts - HLH - Hypoplastic Left Heart Syndrome, DORV | Phase 2 | Recruiting | Nationwide Children's Hospital | 24 | 2020-07-15 | 2025-06-27 |
| Cold Heart Study: A Randomized Pilot Trial of Surfactant Therapy Curosurf, Sham - Congenital Heart Disease, Hypoplastic Left Heart Syndrome | Phase 1 | Terminated | University of Michigan | 2 | 2020-02-25 | 2023-09-13 |
| Use of Oxandrolone to Promote Growth in Infants With HLHS Oxandrolone - Hypoplastic Left Heart, Congenital Heart Disease | Phase 1 / Phase 2 | Terminated | Carelon Research | 34 | 2019-12-20 | 2024-05-23 |
| The CHILD Trial: Hypoplastic Left Heart Syndrome Study. c-kit+ cells - Hypoplastic Left Heart Syndrome | Phase 1 | Completed | Joshua M Hare | 25 | 2019-10-16 | 2026-01-23 |
| NIRS in Congenital Heart Defects - Correlation With Echocardiography NIRS evaluation - Congenital Heart Defect, Single-ventricle | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2019-10-11 | 2025-06-17 |
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Heart Defects, Congenital (34) · Univentricular Heart (16) · Tetralogy of Fallot (8) · Tricuspid Atresia (8) · Transposition of Great Vessels (6) · Aortic Coarctation (4) · Heart Diseases (4) · Aortic Valve Stenosis (3) · Endocardial Cushion Defects (3) · Heart Failure (2) · Pulmonary Atresia (2) · Pulmonary Valve Stenosis (2) · Scimitar Syndrome (2) · Stress, Psychological (2)
Congenital Abnormalities (67) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (67) · Cardiovascular Abnormalities (66) · Cardiovascular Diseases (66) · Heart Diseases (63) · Heart Defects, Congenital (33) · Heart Valve Diseases (12) · Heart Septal Defects (5) · Ventricular Outflow Obstruction (4) · Aortic Valve Disease (3) · Behavior (3) · Respiratory Tract Diseases (3) · Vascular Malformations (3) · Aortopulmonary Septal Defect (2) · Behavioral Symptoms (2)
Dexmedetomidine (2) · Sildenafil Citrate (2) · Ascorbic Acid (1) · Blood Vessel Prosthesis (1) · Bosentan (1) · Cardiac Surgical Procedures (1) · Cardiopulmonary Bypass (1) · Circulatory Arrest, Deep Hypothermia Induced (1) · Epoetin Alfa (1) · Erythropoietin (1) · Magnetic Resonance Spectroscopy (1) · Oxandrolone (1) · Oxygen (1) · Peritoneal Dialysis (1) · Positive-Pressure Respiration (1)
Emory University (5) · University of Michigan (5) · Timothy J Nelson, MD, PhD (4) · Children's Hospital of Philadelphia (3) · Medical College of Wisconsin (3) · The Hospital for Sick Children (3) · University of Alberta (3) · University of California, San Francisco (3) · Athena Zuppa (2) · Baylor College of Medicine (2) · Beijing Anzhen Hospital (2) · Boston Children's Hospital (2) · Carelon Research (2) · Longeveron Inc. (2) · Metcela Inc. (2)
United States (44) · Canada (13) · Japan (4) · Australia (2) · China (2) · Sweden (2) · Austria (1) · Denmark (1) · Finland (1) · France (1) · Germany (1) · Italy (1) · Netherlands (1) · Norway (1) · Poland (1)
William Mahle, MD (3) · Hidemasa Oh, M.D., Ph.D. (2) · James Jaggers, M.D. (2) · James Tweddell, M.D. (2) · Kathleen A Mussatto, PhD, RN (2) · Muhammad Y Qureshi, MBBS (2) · Ram Kumar Subramanyan, M.D., Ph.D. (2) · Alexander Lowenthal, MD (1) · Alison Meadows, MD, PhD (1) · Anders H Hebert, MD (1) · Anita Moon-Grady, MD (1) · Anthony Oliva, MD (1) · Arpit Agarwal, MD (1) · Athena Zuppa, MD, MSCE (1) · Benjamin Peeler, M.D. (1)
PMID 29367212, PMID 37844519, PMID 39526355, PMID 1904091, PMID 19127223, PMID 19840577, PMID 20837917, PMID 21081737, PMID 21382896, PMID 21600541, PMID 22152530, PMID 22176653, PMID 22196786, PMID 22503201, PMID 22572758, PMID 22939929, PMID 23102686, PMID 23390999, PMID 23663658, PMID 23823195, PMID 24141323, PMID 24201857, PMID 25218539, PMID 25403163, PMID 25446057, PMID 26048877, PMID 26232942, PMID 27806964, PMID 28031423, PMID 28052915, PMID 30371784, PMID 3108622, PMID 34217109, PMID 34253175, PMID 35394149, PMID 37527726, PMID 38629477, PMID 40312733, PMID 41258851, PMID 41436266, PMID 41491678
R01HL090615 (2), 5UH3HL148693 (1), 5UL1TR002240-05 (1), 7UG3HL148318-02 (1), R01HL088488 (1), R21HD055501 (1), U01HL068270 (1), U24HL148316 (1)