21 completed, 7 terminated, 5 withdrawn, 3 recruiting. 14 Not applicable, 9 Phase 2, 5 Early Phase 1, 5 Phase 3, 4 Phase 1.
Follow Fluorescein: new trials by email Literature Review of Fluorescein trials Research Report on Fluorescein
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy CONVIVO system, Fluorescein injection, USP 10% - Endonasal Surgery, Endoscopic Sinus Surgery | Early Phase 1 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 36 | 2026-11-03 | 2026-10-20 |
| Study to Confirm the AuthenTicity of Point of Care Urine samplEs Using Oral fluoreScein Sodium in adulTs With substancE Use Disorder (ATTESTED) Fluorescein, placebo - Substance Use Disorder (SUD) | Phase 3 | Not yet recruiting | UpTru Inc. | 114 | 2026-01-15 | 2026-01-23 |
| Feasibility and Safety of MB-102 in Ocular Angiography as Compared to Fluorescein Sodium Fluorescein sodium and Zeiss FF450 fundus camera, MB-102 and Zeiss FF450 fundus camera, Fluorescein sodium and commercially available optical angiography imaging system - Retinopathy, Retinal Vein Occlusion | Early Phase 1 | Recruiting | MediBeacon | 10 | 2025-11-06 | 2026-02-04 |
| A Study of Fluorescein Sodium in People Undergoing Vulvectomy for Extramammary Paget's Disease (EMPD) Fluorescein Sodium - Extramammary Paget's Disease | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 27 | 2025-03-07 | 2026-01-12 |
| Identification of Nerves Using Fluorescein Sodium Fluorescein Sodium - Pleomorphic Adenoma of the Parotid, Warthin Tumor | Phase 2 | Completed | Stanford University | 8 | 2024-11-07 | 2026-05-20 |
| A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion) Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_higher dose, Aflibercept, VEGF Trap-Eye(Eylea, BAY86-5321)_2 mg, Sham - Macular Edema Secondary to Retinal Vein Occlusion | Phase 3 | Completed | Bayer | 892 | 2023-05-15 | 2026-06-17 |
| Needle-Based Confocal Laser Endomicroscopy for Diagnosis of Lung Cancer in Patients With Peripheral Pulmonary Nodules Fluorescein, Image-Guided Needle Confocal Laser Endomicroscopy, Ultrasound-Guided Transbronchial Needle Aspiration - Lung Carcinoma | Not applicable | Terminated | Mayo Clinic | 3 | 2023-05-12 | 2025-09-17 |
| Dose Optimization for Safe and Efficient Fluorescein Angiography (DOSE Study) Fluorescein Sodium - Retinal Disease | Phase 4 | Completed | Seoul National University Bundang Hospital | 144 | 2023-02-01 | 2024-04-17 |
| Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560 Fluorescein Sodium, YELLOW560 filter - Vestibular Schwannoma | Phase 2 | Completed | Mayo Clinic | 12 | 2021-10-06 | 2023-08-01 |
| Sodium Fluorescein-Guided Resection of Pediatric Neurosurgical Tumors Sodium Fluorescein, Microscopic Resection - Pediatric Neurosurgical Tumors | Not applicable | Terminated | University of Colorado, Denver | 2 | 2021-08-11 | 2025-03-06 |
| Comparison of Fluorescein-INtra-VItal Microscopy Versus Conventional Frozen Section Diagnosis for intraOperative Histopathological Evaluation Alcon - Intracranial Tumor | Phase 2 | Completed | Technical University of Munich | 210 | 2020-12-30 | 2022-11-10 |
| Aerosol and Droplet Dispersion During Gastrointestinal Motility Investigations Fluorescein, Particle measurement - Aerosol Generation and Droplet Dispersion and Deposition During Naso-gastric Intubation for Gastrointestinal Motility Investigations | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 15 | 2020-07-23 | 2020-12-29 |
| Optical Tissue Identification for Myocardial Architecture Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes - Ventricular Septal Defect, Complete Atrioventricular Canal | Phase 2 | Active not recruiting | Aditya Kaza | 70 | 2019-12-20 | 2023-06-15 |
| The Study of Oral Fluorescite to Confirm the Authenticity of Point of Care Urine Samples fluorescein sodium, Placebo - Urine Sample Authenticity | Phase 1 | Completed | UpTru Inc. | 40 | 2019-08-22 | 2020-01-06 |
| Intravital Microscopy in Human Solid Tumors Diagnostic Microscopy, Fluorescein Sodium Injection - Solid Tumor, Adult, Clinical Stage IV Gastric Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 85 | 2019-02-28 | 2026-06-02 |
| Utilization of Confocal Microscopy During Cardiac Surgery Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes - Atrial Septal Defect | Phase 1 | Completed | Aditya Kaza | 6 | 2018-04-02 | 2020-07-07 |
| Intravital Microscopy in Evaluating Patients With Primary Peritoneal, Fallopian Tube, or Stage IA-IV Ovarian Cancer Diagnostic Microscopy, Fluorescein Sodium Injection, Laboratory Biomarker Analysis - Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma | Early Phase 1 | Completed | Roswell Park Cancer Institute | 19 | 2017-11-06 | 2021-10-06 |
| Interest of Fluorescein in Fluorescence-guided Resection of Gliomas (FLEGME) Fluorescéine Sodique Faure, White-light surgery - Glioblastoma, Adult | Phase 3 | Completed | Rennes University Hospital | 51 | 2017-10-05 | 2022-11-09 |
| Intestinal Permeability in Patients With Liver Cirrhosis Using Confocal Endoscopy Fluorescein - Cirrhosis, Liver | Terminated | Johannes Gutenberg University Mainz | 15 | 2017-08-01 | 2022-04-06 | |
| Study of Performance of Confocal Endomicroscope With Fluorescein Imaging Agent in the Colon confocal endomicroscope, Fluorescein - Colonic Dysplasia, Adenomatous Polyps | Not applicable | Terminated | University of Michigan | 72 | 2017-07-28 | 2022-11-22 |
Showing 20 of 42. Sign in to see all of them.
Brain Neoplasms (6) · Glioma (3) · Melanoma (3) · Neoplasms (3) · Breast Neoplasms (2) · Glioblastoma (2) · Hyperemia (2) · Retinal Diseases (2) · Stomach Neoplasms (2) · Adenolymphoma (1) · Adenomatous Polyps (1) · Anosmia (1) · Astrocytoma (1) · Barrett Esophagus (1) · Carcinoma, Hepatocellular (1)
Mayo Clinic (3) · Roswell Park Cancer Institute (3) · Aditya Kaza (2) · Bausch & Lomb Incorporated (2) · Stanford University (2) · University of Colorado, Denver (2) · University of Utah (2) · UpTru Inc. (2) · AdventHealth (1) · Alcon Research (1) · Anandasabapathy, Sharmila, M.D. (1) · Bayer (1) · CHU de Quebec-Universite Laval (1) · Cecilia Calvo (1) · Columbia University (1)
United States (29) · Canada (3) · Germany (3) · China (2) · France (2) · South Korea (2) · Australia (1) · Austria (1) · Belgium (1) · Bulgaria (1) · Czechia (1) · Estonia (1) · Georgia (1) · Hungary (1) · Israel (1)
Heleen DeCory (2) · Joseph Skitzki (2) · Aaron A Cohen, MD, MSc (1) · Aditya K Kaza (1) · Aditya K Kaza, MD (1) · Alexander Burnett, MD (1) · Alexandriah Alas, MD (1) · Cara Grimes, MD (1) · Danielle Kim Turgeon, MD (1) · David R Ormond, MD (1) · David W Roberts, MD (1) · Emese Zsiros, MD (1) · Emmanuel M Gabriel, M.D., Ph.D. (1) · Eric A Hurtado, MD (1) · Guillermo Davila, MD (1)
PMID 12001988, PMID 17704903, PMID 19906081, PMID 19917863, PMID 20061178, PMID 20233873, PMID 20336386, PMID 20374484, PMID 20490982, PMID 20737573, PMID 21153378, PMID 21909917, PMID 21926464, PMID 22162570, PMID 23456602, PMID 24956510, PMID 25013744, PMID 26883450, PMID 27824741, PMID 2801858, PMID 29461408, PMID 32083653, PMID 33654117, PMID 36240730, PMID 37124504, PMID 3808620, PMID 39933138, PMID 40034788
R56HL128813 (2), P30CA016056 (1), R01NS052274 (1), R25DC020174 (1), U54CA136465 (1), UM1TR004772 (1)