Heart Septal Defects: Clinical Trials

103 completed, 46 recruiting, 44 unknown, 19 not yet recruiting. 102 Not applicable, 18 Phase 3, 13 Phase 2, 12 Phase 4, 6 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	102	Completed 40, Recruiting 21, Unknown 18, Not yet recruiting 9, Active not recruiting 4, Terminated 4, Withdrawn 4, Enrolling by invitation 1, Suspended 1
Phase 3	18	Completed 5, Terminated 5, Active not recruiting 2, Recruiting 2, Unknown 2, Not yet recruiting 1, Withdrawn 1
Phase 2	13	Completed 6, Unknown 4, Active not recruiting 1, Terminated 1, Withdrawn 1
Phase 4	12	Completed 5, Unknown 3, Not yet recruiting 2, Recruiting 1, Suspended 1
Phase 1	6	Completed 3, Recruiting 1, Unknown 1, Withdrawn 1
Early Phase 1	2	Completed 2

Follow Heart Septal Defects: new trials by email Literature Review of Heart Septal Defects trials Research Report on Heart Septal Defects

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale	Not applicable	Not yet recruiting	Luciano A. Sposato	2400	2027-03-01	2026-09-18
Dapagliflozin and Right Heart Recovery After ASD Device Closure trans catheter device closure - ASD2(Secundum Atrial Septal Defect)	Not applicable	Not yet recruiting	Assiut University	70	2026-11-01	2026-09-17
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale - Migraine Disease, Patent Foramen Ovale	Phase 3	Recruiting	Columbia University	32	2026-10-15	2026-10-08
The Cardiovascular Effects of Patent Foramen Ovale in Hypoxia Patent Foramen Ovale (PFO), High Altitude Pulmonary Edema		Not yet recruiting	University of Texas Southwestern Medical Center	50	2026-09-15	2026-08-03
Hummingbird ICE Study ICE Image Guidance - ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Atrial Fibrillation (AF)		Not yet recruiting	Philips Clinical & Medical Affairs Global	1000	2026-09-01	2026-08-19
Comparing Two PFO Closure Devices in Adults With Previous Stroke or TIA PFO Closure procedure - Patent Foramen Ovale, Stroke	Not applicable	Recruiting	Giuseppe Tarantini	1260	2026-07-24	2026-10-05
Safety and Efficacy of the Patent Foramen Ovale Suture System for the Closure of Patent Foramen Ovale Patent Foramen Ovale Suture System, Amplatzer PFO Occluder - Patent Foramen Ovale (PFO)	Not applicable	Not yet recruiting	Shenzhen Bihe Medical Co., Ltd	244	2026-06-30	2026-07-27
Evaluating Percutaneous Repair Of The Atrial Septum With A Novel PFO Occluder: The PROTEA-PFO OUS Study Recross P3 Occluder (P3O) System - PFO, PFO - Patent Foramen Ovale	Not applicable	Recruiting	Recross Cardio, Inc.	15	2026-06-17	2026-07-13
Long-term Outcomes After Percutaneous Patent Foramen Ovale Closure (Severance PFO Registry) Patent Foramen Ovale, Cryptogenic Stroke		Recruiting	Yonsei University	400	2026-06-05	2026-07-23
Safety and Effectiveness of GENOSS PCB in Patients With Long Femoropopliteal Lesion PTA (Percutaneous Transluminal Angioplasty), Femoropopliteal Artery Disease		Recruiting	Genoss Co., Ltd.	300	2026-04-13	2026-09-11
Safety and Efficacy of the AbsnowTM II Absorbable Atrial Septal Defect Closure System for Atrial Septal Defect Closure Therapy Absnow II Absorbable Atrial Septal Defect Occluder System, Cera Atrial Septal Defect Occluder - Atrial Septal Defect	Not applicable	Not yet recruiting	Lifetech Scientific (Shenzhen) Co., Ltd.	236	2026-04-01	2026-04-14
A Novel Echocardiography-Guided Strategy for Percutateous Closure of Atrial Septal Defect Assisted by PannaWire Ultrasound-guided intervention with assistance of specialized instruments, fluoroscopy-guided intervention - Atrial Septal Defect (ASD)	Phase 4	Not yet recruiting	Chinese Academy of Medical Sciences, Fuwai Hospital	666	2026-03-14	2026-03-17
IABP for MI-VSD Patients in SCAI SHOCK Stage B Insertion of IABP in SCAI SHOCK stage B - Acute Myocardial Infarction (AMI), Ventricular Septal Defects (VSD)	Not applicable	Not yet recruiting	Qilu Hospital of Shandong University	100	2026-02-28	2026-03-19
Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation? Clear priming of the bypass pump - Ventricular Septal Defect	Not applicable	Not yet recruiting	Seattle Children's Hospital	60	2026-02-25	2026-02-06
Utility of the Perclose ProGlide™ Suture-Mediated Closure Device After Cardiologic Procedures Via the Femoral Vein Approach (Eight-Clover) Perclose ProStyle™ Suture-Mediated Closure System, Conventional Hemostasis (Manual Compression or Figure-of-Eight Suture) - Atrial Fibrillation, Atrial Septal Defect	Not applicable	Enrolling by invitation	Ewha Womans University Mokdong Hospital	200	2026-02-02	2026-09-18
A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD)		Recruiting	Xinhua Hospital, Shanghai Jiao Tong University School of Medicine	5249	2026-02-01	2026-08-05
Pulmonary Embolism and Right-to-Left Shunts Pulmonary Embolism (PE), Right-to-Left Shunt		Recruiting	Tufts Medical Center	256	2026-01-30	2026-04-09
Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine Percutaneous Patent Foramen Ovale Closure, No Intervention - Migraine Disorders, Patent Foramen Ovale	Not applicable	Recruiting	First Affiliated Hospital Xi'an Jiaotong University	150	2026-01-14	2026-01-16
Non-Invasive Detection of Right-to-Left Cardiac Shunts Point-of-care ultrasound - Patent Foramen Ovale (PFO)		Recruiting	Scripps Health	75	2026-01-07	2026-02-19
Non-Invasive Detection of Pulmonary Right-to-Left Shunts Using the SONAS Ultrasound Device Transcranial Ultrasound Device - Hereditary Haemorrhagic Telangiectasia, PFO - Patent Foramen Ovale	Not applicable	Recruiting	St. Antonius Hospital	40	2026-01-07	2026-02-17

Showing 20 of 259. Sign in to see all of them.

Narrower conditions

Foramen Ovale, Patent (135)  ·  Heart Septal Defects, Atrial (81)  ·  Heart Septal Defects, Ventricular (52)  ·  Stroke (40)  ·  Heart Defects, Congenital (33)  ·  Ischemic Stroke (31)  ·  Migraine Disorders (26)  ·  Atrial Fibrillation (16)  ·  Tetralogy of Fallot (14)  ·  Truncus Arteriosus, Persistent (14)  ·  Transposition of Great Vessels (12)  ·  Ischemic Attack, Transient (11)  ·  Endocardial Cushion Defects (8)  ·  Cardiovascular Diseases (7)

Broader conditions

Congenital Abnormalities (258)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (258)  ·  Cardiovascular Abnormalities (256)  ·  Cardiovascular Diseases (252)  ·  Heart Diseases (252)  ·  Heart Defects, Congenital (226)  ·  Heart Septal Defects, Atrial (112)  ·  Nervous System Diseases (89)  ·  Brain Diseases (83)  ·  Central Nervous System Diseases (83)  ·  Vascular Diseases (77)  ·  Cerebrovascular Disorders (60)  ·  Pathological Conditions, Signs and Symptoms (39)  ·  Pathologic Processes (31)

Interventions

Aspirin (8)  ·  Clopidogrel (7)  ·  Dexmedetomidine (5)  ·  Septal Occluder Device (5)  ·  Echocardiography (3)  ·  Sodium Chloride (3)  ·  Aspirin, Dipyridamole Drug Combination (2)  ·  Cardiac Surgical Procedures (2)  ·  Cardiopulmonary Bypass (2)  ·  Dipyridamole (2)  ·  Drug Delivery Systems (2)  ·  Exercise Test (2)  ·  Fluorescein (2)  ·  Prasugrel Hydrochloride (2)  ·  Rivaroxaban (2)

Sponsors

Abbott Medical Devices (14)  ·  Lifetech Scientific (Shenzhen) Co., Ltd. (12)  ·  Chinese Academy of Medical Sciences, Fuwai Hospital (7)  ·  W.L.Gore & Associates (7)  ·  University of Aarhus (5)  ·  China National Center for Cardiovascular Diseases (4)  ·  National Heart, Lung, and Blood Institute (NHLBI) (4)  ·  Assistance Publique - Hôpitaux de Paris (3)  ·  Carag AG (3)  ·  Children's Healthcare of Atlanta (3)  ·  Cierra (3)  ·  Genoss Co., Ltd. (3)  ·  University Health Network, Toronto (3)  ·  University of Oregon (3)  ·  Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (3)

Countries

United States (74)  ·  China (35)  ·  Germany (30)  ·  France (21)  ·  Canada (20)  ·  South Korea (15)  ·  Italy (14)  ·  Denmark (10)  ·  Switzerland (10)  ·  Egypt (8)  ·  United Kingdom (8)  ·  Netherlands (7)  ·  Poland (6)  ·  Turkey (Türkiye) (6)  ·  Belgium (5)

Top investigators

Eric Horlick, MD (3)  ·  Lusine Abrahamyan, MD, PhD (3)  ·  Robert Sommer, MD (3)  ·  Andrew Lovering, PhD (2)  ·  D. Scott Lim, MD (2)  ·  Daniela Trabattoni, MD (2)  ·  David Dodick, MD (2)  ·  Horst Sievert, MD (2)  ·  Horst Sievert, Prof. Dr. (2)  ·  Mark Reisman, MD (2)  ·  Ronald Lauer (2)  ·  Werner Budts, MD, PhD (2)  ·  Xiangbin Pan, Doctor (2)  ·  Aditya K Kaza (1)  ·  Aditya K Kaza, MD (1)

Results publications

PMID 32381162, PMID 34032839, PMID 36891906, PMID 12045168, PMID 13678932, PMID 15232117, PMID 18442545, PMID 19064683, PMID 19380621, PMID 19808512, PMID 19808531, PMID 19856409, PMID 20484101, PMID 20495149, PMID 20513701, PMID 20801925, PMID 20837917, PMID 21051670, PMID 21163497, PMID 21315203, PMID 21356042, PMID 21875911, PMID 21908707, PMID 21926656, PMID 22157844, PMID 22313193, PMID 22417252, PMID 22730421, PMID 22920912, PMID 22958084, PMID 23514285, PMID 24132714, PMID 24509270, PMID 24630875, PMID 24762035, PMID 25147037, PMID 25313847, PMID 25967578, PMID 26470854, PMID 26551304, PMID 26715570, PMID 26796197, PMID 26908949, PMID 27056964, PMID 27649347, PMID 27966652, PMID 28633478, PMID 28801537, PMID 28874164, PMID 28886621

NIH funding

2019 (2), R56HL128813 (2), 5UL1TR002240-05 (1), P50HL042266 (1), P50HL062178 (1), R01HL039052 (1), R01HL041786 (1), R01HL155597 (1), R01NS032525 (1), R01NS067139 (1), U01HL068269 (1), U01HL068270 (1), U01HL068279 (1), U01HL068281 (1), U01HL068285 (1)