35 completed, 5 recruiting, 5 unknown, 4 terminated. 16 Not applicable, 5 Phase 2, 4 Phase 1, 3 Phase 3, 2 Phase 4.
Follow Heart Septal Defects, Ventricular: new trials by email Literature Review of Heart Septal Defects, Ventricular trials Research Report on Heart Septal Defects, Ventricular
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IABP for MI-VSD Patients in SCAI SHOCK Stage B Insertion of IABP in SCAI SHOCK stage B - Acute Myocardial Infarction (AMI), Ventricular Septal Defects (VSD) | Not applicable | Not yet recruiting | Qilu Hospital of Shandong University | 100 | 2026-02-28 | 2026-03-19 |
| Bypass Clear Priming VSD Cardiopulmonary Bypass Circuit Reduce Bypass Associated Inflammation? Clear priming of the bypass pump - Ventricular Septal Defect | Not applicable | Not yet recruiting | Seattle Children's Hospital | 60 | 2026-02-25 | 2026-02-06 |
| A Multimodal AI Prediction Model for Complications After Transcatheter Closure of Perimembranous VSD in Children Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD) | Recruiting | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 5249 | 2026-02-01 | 2026-08-05 | |
| Investigation of Tetralogy of Fallot in Neonates corrective surgery within 28 days of birth, corrective surgery between 3-6 months of age - Tetralogy of Fallot (TOF), Pulmonary Stenosis | Not applicable | Recruiting | Beijing Anzhen Hospital | 160 | 2025-03-01 | 2026-10-13 |
| An International Multicenter Study on Transcatheter Device Closure of Perimembranous Ventricular Septal Defects Transcatheter device closure of perimembranous ventricular septal defects (PmVSDs) - Perimembranous Ventricular Septal Defect | Recruiting | Fondation Hôpital Saint-Joseph | 2000 | 2025-01-01 | 2026-09-08 | |
| Mechanical Complications of Acute Myocardial Infarction: a Multicenter Prospective Study Surgical treatment, Percutaneous treatment - Ventricular Septal Defect, Papillary Muscle Rupture | Recruiting | Maastricht University Medical Center | 800 | 2025-01-01 | 2025-05-11 | |
| Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart Surgery Pressure Controlled Ventilation, Volume Controlled Ventilation - Atrial Septal Defect, Ventricular Septal Defects | Not applicable | Completed | Nilratan Sircar Medical College | 72 | 2024-07-13 | 2026-08-10 |
| Clinical Evaluation Of Ventricular Septal Defect (VSD) In Children at Sohag Univesity Hospital ECHO - Ventricular Septal Defect | Unknown | Sohag University | 100 | 2024-06-24 | 2024-07-09 | |
| The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease Thiamine - Congenital Heart Disease, Thiamine Deficiency | Early Phase 1 | Completed | Universitas Sumatera Utara | 86 | 2024-05-01 | 2026-03-24 |
| Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children Ventricular Septal Defect | Completed | The Children's Hospital of Zhejiang University School of Medicine | 3 | 2024-01-01 | 2025-03-11 | |
| Cera™ VSD Occluder Post Market Clinical Follow-up Cera™ VSD occluder implantation - Ventricular Septal Defect | Completed | Cardiac Children's Foundation Taiwan | 152 | 2023-10-13 | 2025-06-12 | |
| Regional Anesthesia Following Pediatric Cardiac Surgery Regional Anesthesia, Wound infiltration, Ropivacaine 0.2% Injectable Solution - Atrial Septal Defect, Ventricular Septal Defect | Phase 4 | Completed | Duke University | 52 | 2023-03-29 | 2025-08-28 |
| Beta-blocker Administration for Cardiomyocyte Division N-thymidine, Urine Collection, Echocardiogram - Tetralogy of Fallot, Double Outlet Right Ventricle | Phase 1 | Recruiting | Weill Medical College of Cornell University | 40 | 2022-12-16 | 2025-11-18 |
| A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects L-citrulline, Plasmalyte A - Ventricular Septal Defect, Atrioventricular Septal Defect | Phase 3 | Terminated | Asklepion Pharmaceuticals, LLC | 64 | 2022-06-29 | 2024-09-19 |
| Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period Normoxia (with controlled re-oxygenation), Standard of care ventilation - Hypoplastic Left Heart Syndrome, Total Anomalous Pulmonary Venous Return | Not applicable | Completed | University of Michigan | 29 | 2021-01-18 | 2024-06-18 |
| Prediction Model of Spontaneous Closure of Congenital Perimembranous Ventricular Septal Defects Ventricular Septal Defects | Withdrawn | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | 2020-10-01 | 2026-08-03 | ||
| Improving Care for Children With Congenital Heart Disease. Biomarker analysis at enrolment, Biomarker analyses throughout the study - Heart Disease Congenital, Ventricular Septal Defect | Not applicable | Completed | Lund University Hospital | 313 | 2020-02-17 | 2026-05-08 |
| Optical Tissue Identification for Myocardial Architecture Fluorescite, Cellvizio 100 Series System with Confocal Miniprobes - Ventricular Septal Defect, Complete Atrioventricular Canal | Phase 2 | Active not recruiting | Aditya Kaza | 70 | 2019-12-20 | 2023-06-15 |
| Lifetech KONAR MFO Post-Market Clinical Follow-Up Study KONAR-MF™ VSD Occluder - Ventricular Septal Defect | Completed | Lifetech Scientific (Shenzhen) Co., Ltd. | 40 | 2019-12-04 | 2024-04-15 | |
| A Trial to Evaluate the Safety and Efficacy of a Fully Degradable Ventricular Septal Defect (VSD) Closure Fully Absorbable VSD Occlusion System, VSD Occluder - Ventricular Septal Defect | Not applicable | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 108 | 2019-04-11 | 2019-05-08 |
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Heart Defects, Congenital (21) · Heart Septal Defects, Atrial (10) · Double Outlet Right Ventricle (7) · Tetralogy of Fallot (7) · Transposition of Great Vessels (6) · Atrioventricular Septal Defect (5) · Cardiovascular Diseases (5) · Endocardial Cushion Defects (5) · Heart Diseases (4) · Ductus Arteriosus, Patent (3) · Heart Septal Defects (3) · Pulmonary Valve Stenosis (3) · Truncus Arteriosus, Persistent (3) · Hypertension, Pulmonary (2)
Congenital Abnormalities (57) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (57) · Cardiovascular Abnormalities (56) · Heart Septal Defects (54) · Heart Diseases (53) · Cardiovascular Diseases (52) · Heart Defects, Congenital (36) · Pathological Conditions, Signs and Symptoms (10) · Pathologic Processes (7) · Vascular Diseases (6) · Transposition of Great Vessels (5) · Heart Valve Diseases (4) · Lung Diseases (4) · Respiratory Tract Diseases (4)
Dexmedetomidine (2) · Surgical Procedures, Operative (2) · Acetaminophen (1) · Aging (1) · Albuterol (1) · Anesthesia, Conduction (1) · Cardiac Surgical Procedures (1) · Cardiopulmonary Bypass (1) · Carnitine (1) · Citrulline (1) · Conversion to Open Surgery (1) · Enalapril (1) · Exercise Test (1) · Fentanyl (1) · Fluorescein (1)
National Heart, Lung, and Blood Institute (NHLBI) (4) · University of Aarhus (4) · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (3) · Abbott Medical Devices (2) · Asklepion Pharmaceuticals, LLC (2) · Children's Healthcare of Atlanta (2) · Kayseri City Hospital (2) · National Taiwan University Hospital (2) · Aditya Kaza (1) · Arkansas Children's Hospital Research Institute (1) · Beijing Anzhen Hospital (1) · Bentong Yu (1) · Boston Children's Hospital (1) · Cardiac Children's Foundation Taiwan (1) · Carelon Research (1)
United States (21) · China (8) · Denmark (5) · Germany (5) · Taiwan (3) · Turkey (Türkiye) (3) · Canada (2) · Egypt (2) · France (2) · Indonesia (2) · Italy (2) · Sweden (2) · Belarus (1) · Belgium (1) · Hong Kong (1)
Ronald Lauer (2) · Aditya K Kaza, MD (1) · Adnan T Bhutta, MD (1) · Allan Doctor, MD (1) · Andrew Redington, MD, DMSc, Prof. (1) · Aymen N Naguib, MD (1) · Bentong Yu, MD (1) · Bernhard Kuhn, MD (1) · Brian Kogon, MD (1) · Britta Butzbach, MD (1) · Catherine A. Leitch (1) · Catherine Krawczeski, MD (1) · Christopher Mastropietro, MD, FCCM (1) · Chun-An Chen, MD, PhD (1) · Daniel Levi, MD (1)
PMID 18442545, PMID 19064683, PMID 19808531, PMID 19856409, PMID 20495149, PMID 20513701, PMID 20801925, PMID 21163497, PMID 21315203, PMID 21875911, PMID 21908707, PMID 21926656, PMID 22157844, PMID 22730421, PMID 22920912, PMID 24132714, PMID 24509270, PMID 26715570, PMID 26796197, PMID 28886621, PMID 29643872, PMID 30233808, PMID 31623840, PMID 32291090, PMID 32519889, PMID 33032536, PMID 33157063, PMID 34265312, PMID 34551835, PMID 35115207, PMID 37548158, PMID 40014670, PMID 40939873, PMID 41032451, PMID 42083863
2019 (1), 5UL1TR002240-05 (1), P50HL042266 (1), P50HL062178 (1), R01HL039052 (1), R01HL041786 (1), R01HL155597 (1), R56HL128813 (1), U01HL068269 (1), U01HL068270 (1), U01HL068279 (1), U01HL068281 (1), U01HL068285 (1), U01HL068288 (1), U01HL068290 (1)