87 completed, 29 unknown, 17 terminated, 12 recruiting. 163 Phase 2, 30 Phase 1, 28 Phase 3.
Follow Fractures, Bone: new trials by email Literature Review of Fractures, Bone trials Research Report on Fractures, Bone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Local Iloprost Therapy to Promote Bone Healing in High Risk Fractures Ilomedin, Normal saline placebo - Nonunion Bone Fracture, Fractures Ununited | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 60 | 2027-01-01 | 2026-11-09 |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB - Rib Fractures, Acute Pain | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-18 |
| Multiregion BHA in Open Tibia Fractures BHA - Tibial Fractures | Phase 2 | Withdrawn | Carmell Therapeutics Corporation | 2026-07-01 | 2024-02-08 | |
| CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium Citicoline - Cognitive Decline, Delirium | Phase 2 | Recruiting | University of Milano Bicocca | 122 | 2026-06-03 | 2026-09-09 |
| Subjective Experience Following Psilocybin Psilocybin high-dose, Psilocybin low-dose, Risperidone 1 MG - Investigating the Importance of the Subjective Psychedelic Experience | Phase 2 | Recruiting | University of Calgary | 128 | 2026-05-15 | 2026-09-02 |
| Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV - Fracture | Phase 1 / Phase 2 | Recruiting | The Cooper Health System | 48 | 2026-05-07 | 2026-06-29 |
| Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children. Intranasal Sufentanil, Intranasal Ketamine (IN) - Traumatology, Wounds and Injury | Phase 2 | Not yet recruiting | Fondation Lenval | 116 | 2026-02-05 | 2026-01-28 |
| Comparison of Submucosal Dexamethasone and Methylprednisolone in Postoperative Sequelae of Parasymphsis Fractures Dexamethasone, Methylprednisolone (Corticosteroid) - Mandible Fracture, Edema Face | Phase 2 | Recruiting | Nishtar Medical University | 72 | 2026-01-03 | 2026-04-06 |
| Cannabidiol After Multi-Trauma for Pain and Opioid Therapy Cannabidiol, Placebo - Fracture | Phase 2 | Recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 225 | 2025-06-01 | 2025-07-30 |
| Ultrasound Guided Emergency Physician Performed Erector Spinae Nerve Block for Rib Fracture Analgesia ESP block with bupivacaine, Saline control/sham injection - Rib Fractures | Phase 1 / Phase 2 | Withdrawn | Yale University | 2025-05-01 | 2025-07-01 | |
| Comparison of Continuous Intravenous Lidocaine Infusion Versus ESP Block for Rib Fracture Analgesia Lidocaine IV Infusion, 2% Lidocaine via ESPB - Rib Fractures | Phase 2 | Withdrawn | Stanford University | 2025-05-01 | 2026-05-05 | |
| Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hip or Thigh Bone Fractures Isomyosamine 250mg, Placebo 250 mg - Sarcopenia in Elderly, Frailty | Phase 2 | Not yet recruiting | TNF Pharmaceuticals, Inc. | 60 | 2025-05-01 | 2025-04-24 |
| A Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD) Satralizumab - Duchenne Muscular Dystrophy | Phase 2 | Active not recruiting | Hoffmann-La Roche | 30 | 2025-04-04 | 2026-09-04 |
| Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease ACT for SCD - Race-related Stress, Depression, Anxiety | Phase 1 / Phase 2 | Recruiting | Children's Hospital Los Angeles | 66 | 2025-04-01 | 2026-05-06 |
| BDSF Vs DHS With Anterotational Screw in Vertical FNF Dynamic Hip Screw with Anterotation Screw Fixation, Biplane Double-Supported Screw Fixation - Evaluation of BDSF in FNF | Phase 2 | Active not recruiting | Ain Shams University | 30 | 2024-09-01 | 2026-10-26 |
| Long-term Safety Trial with NVDX3 NVDX3 - Distal Radius Fractures, Degenerative Lumbar Spondylolisthesis | Phase 1 / Phase 2 | Recruiting | Novadip Biosciences | 15 | 2024-08-22 | 2024-09-05 |
| Bone in CKD Alkali Response (BICARb Pilot Trial) Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution - Chronic Kidney Diseases, Bone Loss | Phase 2 / Phase 3 | Terminated | Albert Einstein College of Medicine | 6 | 2024-08-15 | 2026-07-28 |
| Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing Active Treatment Arm, Control Treatment Arm - Fractures, Bone | Phase 1 / Phase 2 | Unknown | Cairo University | 2 | 2024-07-16 | 2024-07-24 |
| Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery USG GUIDED SUPRA-INGUINAL FASCIA ILIACA BLOCK, PERICAPSULAR NERVE BLOCK - Post Operative Pain, Bradycardia | Phase 2 / Phase 3 | Recruiting | Sahiwal medical college sahiwal | 70 | 2024-07-10 | 2025-10-23 |
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Hip Fractures (34) · Osteoporosis (14) · Fractures, Stress (11) · Fractures, Ununited (11) · Tibial Fractures (8) · Wrist Fractures (8) · Bone Diseases, Metabolic (7) · Pain (7) · Pseudarthrosis (7) · Wounds and Injuries (6) · Ankle Fractures (5) · Inflammation (5) · Osteoporotic Fractures (5) · Rib Fractures (5)
Wounds and Injuries (157) · Leg Injuries (55) · Pathological Conditions, Signs and Symptoms (43) · Hip Injuries (38) · Femoral Fractures (37) · Musculoskeletal Diseases (34) · Signs and Symptoms (29) · Neurologic Manifestations (27) · Pathologic Processes (24) · Bone Diseases (20) · Nervous System Diseases (20) · Nutritional and Metabolic Diseases (19) · Metabolic Diseases (18) · Arm Injuries (11)
Teriparatide (6) · Cholecalciferol (5) · Surgical Procedures, Operative (5) · Dexmedetomidine (4) · Saline Solution (4) · Sodium Chloride (4) · Alendronate (3) · Bupivacaine (3) · Fentanyl (3) · Lidocaine (3) · Tranexamic Acid (3) · Acetaminophen (2) · Administration, Cutaneous (2) · Dexamethasone (2) · Fracture Fixation, Internal (2)
Assiut University (4) · Bone Therapeutics S.A (4) · Chinese University of Hong Kong (3) · Hadassah Medical Organization (3) · Hospital for Special Surgery, New York (3) · Isfahan University of Medical Sciences (3) · University of Calgary (3) · Washington University School of Medicine (3) · Wyeth is now a wholly owned subsidiary of Pfizer (3) · Banc de Sang i Teixits (2) · Cairo University (2) · Changhua Christian Hospital (2) · Charite University, Berlin, Germany (2) · Columbia University (2) · Emdadi Kamyab Hospital (2)
United States (62) · Canada (16) · Germany (13) · Spain (13) · Australia (10) · Belgium (10) · Sweden (10) · France (9) · Israel (8) · Denmark (7) · Finland (7) · Iran (7) · United Kingdom (7) · Hungary (6) · Norway (6)
Hamid Gourabi, PhD (2) · Jeri W Nieves, PhD (2) · Kwok Sui Leung, MD (2) · Nasser Aghdami, MD,PhD (2) · Torsten Gerich, MD (2) · Abdulhadi Al'Saflan, MD (1) · Adeel Riaz, MD (1) · Adi Cohen, MD (1) · Afshin Farhadi, MD (1) · Ahmed Resk Mohammed, Assistant Professor (1) · Alaa M Attia, Professor (1) · Alaa M. Khidr, MD (1)
PMID 35727196, PMID 12795371, PMID 16557516, PMID 16619257, PMID 17322494, PMID 17904460, PMID 18088349, PMID 19594305, PMID 20163739, PMID 21067829, PMID 21742071, PMID 21963127, PMID 22091574, PMID 22631877, PMID 22863663, PMID 23016882, PMID 24330470, PMID 24676848, PMID 25878305, PMID 27388241, PMID 27538760, PMID 27609854, PMID 28265448, PMID 28279428, PMID 28842733, PMID 29211866, PMID 29397119, PMID 29398998, PMID 31768262, PMID 31870451, PMID 31915160, PMID 32639394, PMID 33238043, PMID 33407719, PMID 33795297, PMID 34016037, PMID 34174963, PMID 34383100, PMID 34460897, PMID 34766330, PMID 34789700, PMID 36070134, PMID 36098133, PMID 37718930, PMID 38789992, PMID 38874505, PMID 39665575, PMID 39691747, PMID 39979051, PMID 40053806
2017 (2), 2023 (2), 2025 (2), N01CM00039 (1), P30AR072572 (1), P30CA016672 (1), R01AR045655 (1), R01AR052293 (1), R01AR060261 (1), R01DK131811 (1), R03HD041944 (1), R21AG027549 (1), U01CA062461 (1), U54MD010706 (1), UL1TR000457-06 (1)