538 completed, 272 unknown, 240 recruiting, 115 terminated. 395 Not applicable, 380 Phase 2, 142 Phase 3, 92 Phase 1, 35 Phase 4.
Follow Surgical Procedures, Operative: new trials by email Literature Review of Surgical Procedures, Operative trials Research Report on Surgical Procedures, Operative
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Oral Gallium Maltolate for Recurrent Glioblastoma Gallium Maltolate, Surgical Intervention - Glioblastoma | Early Phase 1 | Not yet recruiting | Medical College of Wisconsin | 8 | 2027-03-01 | 2026-09-23 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration - Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone | Not applicable | Not yet recruiting | City of Hope Medical Center | 50 | 2027-01-10 | 2026-07-16 |
| Testing Short-Course Radiation Versus Standard-Course Radiation for Soft Tissue Sarcomas That Need Surgery and Radiation 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection, Computed Tomography - Recurrent Soft Tissue Sarcoma of the Trunk and Extremities, Resectable Soft Tissue Sarcoma of the Trunk and Extremities | Phase 3 | Recruiting | SWOG Cancer Research Network | 296 | 2026-12-02 | 2026-10-13 |
| PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma Chemical Exchange Saturation Transfer Magnetic Resonance Imaging, Contrast-enhanced Magnetic Resonance Imaging, Magnetic Resonance Imaging - Glioblastoma | Phase 3 | Not yet recruiting | Jonsson Comprehensive Cancer Center | 60 | 2026-12-01 | 2026-07-07 |
| Pembrolizumab and Radiation Therapy With or Without Neoadjuvant Doxorubicin and Ifosfamide for the Treatment of High-Risk Resectable Undifferentiated Pleomorphic Sarcoma or Liposarcoma of the Extremity or Trunk Wall Biospecimen Collection, Computed Tomography, Doxorubicin - Resectable Liposarcoma, Resectable Soft Tissue Sarcoma | Phase 3 | Not yet recruiting | Ohio State University Comprehensive Cancer Center | 228 | 2026-12-01 | 2026-09-16 |
| Neoadjuvant Pembrolizumab in Patients With High Risk, Stage IIB/IIC Cutaneous Melanoma: a Single Arm Proof of Concept Phase IIA Study. Pembrolizumab neoadjuvant treatment, surgery, Adjuvant treatment - Stage IIB Melanoma, Stage IIC Melanoma | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Besancon | 19 | 2026-11-01 | 2026-10-20 |
| Comparison of an Initial Active Follow-up and Therapeutic Care on Functional Outcome and Quality of Life in Patients With Head and Neck Paragangliomas Active follow-up, Surgery, Radiation - Paragangliomas | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 122 | 2026-10-10 | 2026-08-25 |
| Decode the Environment Variation of Targeted Aldosterone Inducer and siLencer Aldosterone circulation, Medication, Operation - Hypertension, Aldosteronemia | Not applicable | Not yet recruiting | DejthidaNathaphong | 100 | 2026-10-10 | 2026-10-01 |
| Immunotherapy and Nodal-Sparing Irradiation for T-Cell Induction and Unmasking of Tumor Antigenicity in the Microenvironment for Head and Neck Cancer Pembrolizumab, Radiotherapy, ENI - Head and Neck Cancer Squamous Cell Carcinoma | Phase 2 | Recruiting | Medical College of Wisconsin | 20 | 2026-10-08 | 2026-10-19 |
| Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection) Surgery, Radiochimiotherapy - Colorectal Neoplasms | Not yet recruiting | University Hospital, Bordeaux | 1200 | 2026-10-01 | 2026-10-16 | |
| SAMe in Prevention of Oxaliplatin-associated Liver Injury Standard of care oxaliplatin-based chemotherapy, S-adenosylmethionine (SAMe) supplement, Surgery - Colorectal Cancer, Liver Metastases | Phase 2 | Not yet recruiting | Cedars-Sinai Medical Center | 30 | 2026-10-01 | 2026-09-30 |
| Surgery After Verifying Existing Disease in Locally Advanced Operable Lung Cancer: A Pilot Study Observation without surgery, Standard-of-care surgery - Non-Small Cell Lung Cancer, Immunotherapy | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 14 | 2026-10-01 | 2026-08-14 |
| Impact of Preoperative Bowel Preparation on Healing Outcomes in FiLaC Bowel preparation before fistula laser closure (FiLaC) surgery - Anal Fistula, Fistula in Ano | Not yet recruiting | Acibadem Kent Hospital | 100 | 2026-10-01 | 2026-09-02 | |
| Comparing Surgical and Nonsurgical Outcomes of Tennis Elbow Conservative Arm, Surgical - Lateral Epicondylitis | Not applicable | Not yet recruiting | University of Pittsburgh | 200 | 2026-10-01 | 2026-10-21 |
| Use of Reconstructive Microsurgery for the Treatment of Lymphedema Surgery with and without the aid of Indocyanine Green (ICG) - Lymphedema | Recruiting | Istituto Ortopedico Rizzoli | 15 | 2026-09-29 | 2026-10-22 | |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| Proton Spatially Fractionated Radiotherapy or Photon Stereotactic Body Radiotherapy in Combination With Pembrolizumab Before Surgery for the Treatment of Locally Advanced and Radiation-Naive Locoregionally Recurrent Oral Cavity Cancer, OSPRI Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Locally Advanced Oral Cavity Squamous Cell Carcinoma, Locally Recurrent Oral Cavity Squamous Cell Carcinoma | Phase 2 | Not yet recruiting | Mayo Clinic | 30 | 2026-09-07 | 2026-08-25 |
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Carcinoma, Non-Small-Cell Lung (74) · Breast Neoplasms (70) · Rectal Neoplasms (53) · Glioblastoma (47) · Stomach Neoplasms (45) · Esophageal Neoplasms (42) · Colorectal Neoplasms (39) · Squamous Cell Carcinoma of Head and Neck (36) · Brain Neoplasms (35) · Lung Neoplasms (35) · Pancreatic Neoplasms (31) · Glioma (27) · Neoplasms (26) · Sarcoma (24) · Head and Neck Neoplasms (23)
National Cancer Institute (NCI) (25) · Sun Yat-sen University (23) · Fudan University (18) · Alliance for Clinical Trials in Oncology (17) · M.D. Anderson Cancer Center (15) · SWOG Cancer Research Network (12) · Washington University School of Medicine (11) · H. Lee Moffitt Cancer Center and Research Institute (10) · Assistance Publique - Hôpitaux de Paris (9) · Shanghai Pulmonary Hospital, Shanghai, China (9) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (9) · Karolinska Institutet (8) · NYU Langone Health (8) · Northwestern University (8) · Seoul National University Hospital (8)
United States (409) · China (255) · France (102) · Canada (80) · Italy (76) · Germany (68) · Spain (63) · Netherlands (52) · United Kingdom (50) · Sweden (49) · South Korea (40) · Switzerland (40) · Denmark (36) · Australia (33) · Taiwan (33)
Jiayi Huang, M.D. (3) · Ming Kuang, MD (3) · Peng Zhang, PhD (3) · Bernard Nordlinger, Pr. (2) · Ching-Hsia Hung, PhD (2) · Daniel C. Betticher, MD (2) · Darell D. Bigner, MD, PhD (2) · Douglas Adkins, M.D. (2) · Erwei Song, M.D., Ph.D. (2) · Farshad Frozanpor (2) · George H. Yoo, MD (2) · Henry S. Friedman, MD (2)
PMID 36648215, PMID 32827353, PMID 26808342, PMID 27864853, PMID 32861308, PMID 33668061, PMID 34008425, PMID 38913933, PMID 10071296, PMID 10210538, PMID 10575079, PMID 10581077, PMID 10722813, PMID 10782451, PMID 10874807, PMID 10974628, PMID 11060529, PMID 11241082, PMID 11448365, PMID 11556297, PMID 11767723, PMID 11845345, PMID 12007937, PMID 12084585, PMID 12117328, PMID 12167786, PMID 12377921, PMID 12389279, PMID 12394893, PMID 12471405, PMID 12502975, PMID 12610186, PMID 12697884, PMID 12721251, PMID 12838028, PMID 12956475, PMID 13129557, PMID 13287061, PMID 14520092, PMID 14645636, PMID 14673047, PMID 14801776, PMID 14961842, PMID 15001263, PMID 15158627, PMID 15222781, PMID 15296892, PMID 15328187, PMID 15542799, PMID 15547181
2023 (9), U10CA032102 (9), 2017 (6), 2018 (6), U10CA031946 (6), P30CA060553 (4), U10CA180886 (4), 2014 (3), 2016 (3), 2019 (3), P30CA022453 (3), P30CA138292 (3), U10CA098543 (3), U10CA180820 (3), U10CA180821 (3)