25 completed, 16 unknown, 8 recruiting, 7 terminated. 63 Phase 1, 30 Phase 2.
Follow Fractures, Bone: new trials by email Literature Review of Fractures, Bone trials Research Report on Fractures, Bone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV - Fracture | Phase 1 / Phase 2 | Recruiting | The Cooper Health System | 48 | 2026-05-07 | 2026-06-29 |
| Phase I Clinical Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of LYN101 LYN101, Placebo - Osteoporotic Fracture | Phase 1 | Active not recruiting | Shanghai TTM-Bio Technology Co., Ltd | 64 | 2025-09-06 | 2026-09-02 |
| Intravenous Infusion of Human Mesenchymal Stem Cells (HMM910 ) in Postmenopausal Women With Osteoporosis at High Risk of Fracture Human Umbilical Cord-derived Mesenchymal stem cell - Osteoporosis in Post-menopausal Women, Osteoporosis | Phase 1 | Active not recruiting | HELP Therapeutics Co., Ltd. | 9 | 2025-06-20 | 2026-02-10 |
| Ultrasound Guided Emergency Physician Performed Erector Spinae Nerve Block for Rib Fracture Analgesia ESP block with bupivacaine, Saline control/sham injection - Rib Fractures | Phase 1 / Phase 2 | Withdrawn | Yale University | 2025-05-01 | 2025-07-01 | |
| Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease ACT for SCD - Race-related Stress, Depression, Anxiety | Phase 1 / Phase 2 | Recruiting | Children's Hospital Los Angeles | 66 | 2025-04-01 | 2026-05-06 |
| Impact of OnabotulinumtoxinA (BOTOX®) on Stress Intramuscular injection, OnabotulinumtoxinA (Botox®) Injections, Sodium Chloride - Stress (Psychology), Stress | Phase 1 | Completed | Center for Advanced Facial Plastic Surgery | 4 | 2025-03-19 | 2026-04-29 |
| Healing Assessment of External Inflammatory Root Resorption After Revascularization Technique of Avulsed Permanent Central Incisor (Case Study) Regeneration of traumatic tooth - Avulsion | Phase 1 | Active not recruiting | Badr University | 4 | 2024-11-27 | 2025-01-21 |
| Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau Bupivacain - Tibial Plateau Fractures | Phase 1 | Recruiting | University of Chicago | 38 | 2024-11-01 | 2026-02-05 |
| Long-term Safety Trial with NVDX3 NVDX3 - Distal Radius Fractures, Degenerative Lumbar Spondylolisthesis | Phase 1 / Phase 2 | Recruiting | Novadip Biosciences | 15 | 2024-08-22 | 2024-09-05 |
| Impact of Early ADL Education on Outcomes Post DRF ORIF ADL/Postoperative Instruction, Postoperative Instruction - Distal Radius Fractures | Phase 1 | Recruiting | George Washington University | 64 | 2024-08-01 | 2026-10-19 |
| Biomechanical Analysis of Distal Radius (Greenstick) Fracture Healing Active Treatment Arm, Control Treatment Arm - Fractures, Bone | Phase 1 / Phase 2 | Unknown | Cairo University | 2 | 2024-07-16 | 2024-07-24 |
| Comparison Between Bupivacaine-Dexmedetomidine Versus Bupivacaine-Dexamethasone in Pericapsular Nerve Group (PENG) Block Pericapsular Nerve Group (PENG) Block - Hip Fractures, Post Operative Pain | Phase 1 | Unknown | Ain Shams University | 60 | 2024-03-01 | 2024-03-05 |
| Management Of Patellar Fractures By Craniofacial Mesh Plate Osteosynthesis Augmented by Screws fixation of patella fractures by craniofacial mesh plate osteosynthesis augmented by screws - Patella Fracture | Phase 1 | Unknown | Sohag University | 30 | 2024-01-01 | 2024-01-16 |
| Proof-of-concept Study With NVDX3 for Treatment of Distal Radius Fractures. NVDX3 - Distal Radius Fractures | Phase 1 / Phase 2 | Completed | Novadip Biosciences | 11 | 2023-08-08 | 2026-01-28 |
| Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture Sustained Acoustic Device with 2.5% Diclofenac Patch, 2.5% Diclofenac Patches - Bone Fracture, Fresh Fracture | Phase 1 | Recruiting | ZetrOZ, Inc. | 90 | 2023-06-01 | 2025-02-28 |
| Assess Safety and Compare PK of New Oral hPTH(1-34) Tablet Formulations vs. EBP05 Tablets and Subcutaneous Forteo EBP05, Forteo 0.02 mg, EBP11 - Hypoparathyroidism, Osteoporosis | Phase 1 | Completed | Entera Bio Ltd. | 45 | 2023-05-11 | 2026-02-17 |
| Impact of Early ADL Participation on Outcomes Post DRF ADL/Cast Care instruction, Cast Care Instruction - Distal Radius Fracture | Phase 1 | Completed | George Washington University | 62 | 2023-04-18 | 2026-10-19 |
| AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip Autologous matrix-induced chondrogenesis (AMIC) - Hip Arthroscopy, Articular Cartilage Defect | Phase 1 | Recruiting | McMaster University | 40 | 2023-03-13 | 2026-10-07 |
| Biological and Behavioral Outcomes of Community Nature Walks Reclaiming Nature Intervention - Stress, Psychological, Telomere Shortening | Phase 1 | Unknown | Charlotte Tate | 200 | 2023-02-01 | 2023-09-28 |
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Fractures, Stress (9) · Wrist Fractures (7) · Fractures, Ununited (6) · Pseudarthrosis (5) · Hip Fractures (4) · Osteoporosis (4) · Femoral Fractures (3) · Ankle Fractures (2) · Anxiety Disorders (2) · Femoral Neck Fractures (2) · Pain (2) · Pain, Postoperative (2) · Rib Fractures (2) · Stress, Psychological (2)
Wounds and Injuries (62) · Leg Injuries (16) · Pathological Conditions, Signs and Symptoms (9) · Arm Injuries (8) · Musculoskeletal Diseases (8) · Femoral Fractures (7) · Wrist Injuries (7) · Bone Diseases (6) · Hip Injuries (6) · Neurologic Manifestations (6) · Pathologic Processes (6) · Signs and Symptoms (6) · Nutritional and Metabolic Diseases (5) · Behavior (4)
Bupivacaine (3) · Surgical Procedures, Operative (3) · Cholecalciferol (2) · Fracture Fixation, Internal (2) · Sodium Chloride (2) · Administration, Cutaneous (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Anesthetics, Local (1) · Arthroplasty, Replacement, Hip (1) · Botulinum Toxins, Type A (1) · Buprenorphine (1) · Celecoxib (1) · Clindamycin (1) · Control Groups (1) · Debridement (1)
Hadassah Medical Organization (3) · Novadip Biosciences (3) · University of British Columbia (3) · Banc de Sang i Teixits (2) · George Washington University (2) · Ain Shams University (1) · Amorphical Ltd. (1) · Arcadia University (1) · Badr University (1) · Bone Therapeutics S.A (1) · BonusBio Group Ltd (1) · Cairo University (1) · Center for Advanced Facial Plastic Surgery (1) · Changhua Christian Hospital (1) · Charite University, Berlin, Germany (1)
United States (19) · Israel (7) · Canada (6) · Egypt (4) · China (3) · Spain (3) · Belgium (2) · Denmark (2) · Luxembourg (2) · Finland (1) · France (1) · Germany (1) · India (1) · Netherlands (1) · Saudi Arabia (1)
Torsten Gerich, MD (2) · Ahmed Resk Mohammed, Assistant Professor (1) · Amal Khoury, M.D (1) · Amr Imam, Professor (1) · Andrew Skinner, MD (1) · Anthony Christiano, MD (1) · Babak Azizzadeh, MD, FACS (1) · Babar Shafi, MD, MSPT (1) · Bryant Tran, MD (1) · Ching Liang Hsieh, MD, PhD (1) · Christopher Reilly, MD (1) · Cristiana Baloescu, MD (1) · Dan Gazit, Prof. (1) · Dennis Clifton, PharmD (1) · Dina Abd Allah, Lecturer (1)
PMID 16557516, PMID 16619257, PMID 22136481, PMID 26136594, PMID 26774115, PMID 27388241, PMID 27538760, PMID 28265448, PMID 28396863, PMID 30341095, PMID 34174963, PMID 35704085, PMID 36905458, PMID 40405317, PMID 42727576
2017 (1), 2023 (1), R03HD041944 (1)