23 completed, 19 unknown, 9 terminated, 6 active not recruiting. 21 Not applicable, 13 Phase 2, 7 Phase 1, 4 Phase 3, 2 Phase 4.
Follow Fractures, Ununited: new trials by email Literature Review of Fractures, Ununited trials Research Report on Fractures, Ununited
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Allograft vs. Autograft Nonunion Autograft, Allograft - Nonunion Fracture | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 156 | 2027-01-01 | 2026-10-26 |
| Descriptive Single-center Retrospective Study of a Series of Cases of Clavicle Pseudarthrosis: Epidemiology, Surgical Management, and Functional Outcomes Pseudarthrosis, Clavicle Fracture | Active not recruiting | University Hospital, Brest | 30 | 2026-01-01 | 2026-02-17 | |
| A Study to Assess How Effective and Safe NVD003 is for Treating Patients With Congenital Pseudarthrosis of the Tibia. NVD003, Iliac Crest Bone Graft - Congenital Pseudarthrosis of Tibia | Phase 3 | Recruiting | Novadip Biosciences | 12 | 2025-09-02 | 2026-04-01 |
| Hierarchy of Effects of Laboratory Markers and Their Interaction With Comorbidity Concerning Outcome and Personalized Treatment of Trauma Patients in Emergency Care and Rehabilitation Postoperative Complications, Surgical Site Infection | Not yet recruiting | Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu | 2300 | 2025-02-01 | 2025-01-03 | |
| Impact of Time Interval Between Trauma and Operation on Clinical Outcome in Patients With Delayed Rib Fixation (Nonunion) Rib Fractures, Nonunion of Fracture | Active not recruiting | University Hospital, Basel, Switzerland | 41 | 2025-01-13 | 2025-08-07 | |
| Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System Fitbone Transport and Lengthening System - Fractures, Bone, Fractures, Closed | Terminated | Orthofix Inc. | 1 | 2024-11-19 | 2026-04-02 | |
| Using the Boneflo System During Orthopedic and Trauma Surgery: A Prospective Multicenter Study Intraoperative bioactivation of bone substitute materials using the Boneflo® Tissue Collector System. - Nonunion Fracture, Delayed Bone Healing | Not applicable | Completed | Universität Duisburg-Essen | 100 | 2024-07-01 | 2026-05-01 |
| PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics - Infections, Infected Wound | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 250 | 2023-05-30 | 2026-09-11 |
| G7 Freedom Constrained Vivacit-E Liners Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners - Osteoarthritis, Hip, Rheumatoid Arthritis | Not applicable | Enrolling by invitation | Zimmer Biomet | 202 | 2023-05-08 | 2025-10-20 |
| Exactech Proximal Humerus Fracture Plate System Post Market Clinical Follow-up Proximal Humeral Fracture, Fracture Dislocation | Recruiting | Exactech | 151 | 2023-04-19 | 2026-09-16 | |
| Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments - Osteoarthritis, Knee, Fractures, Ununited | Not applicable | Active not recruiting | Zaporizhzhiya State Medical University | 100 | 2023-01-13 | 2026-06-04 |
| NVD-003 in the Treatment of Congenital Pseudarthrosis of the Tibia NVD-003, an autologous 3D scaffold free osteogenic graft - Congenital Pseudarthrosis of Tibia | Phase 1 | Unknown | Novadip Biosciences | 4 | 2022-11-24 | 2024-01-26 |
| Lumbar Fusion With Porous Versus Non-Porous Cages CONDUIT Porous Titanium Spinal Cage, PROTI 360 Titanium-Coated PEEK Spinal Cage - Spinal Fusion, Lumbar Fusion | Not applicable | Active not recruiting | Francis Farhadi | 108 | 2022-11-01 | 2026-07-06 |
| Prospective Post-market Clinical Follow-up Study of the HBS 2 Resorb Mg in Patients With Intra- and Extraarticular Fractures, Pseudarthroses and Arthrodesis of Small Bones and Bone Fragments. Treatment with HBS 2 Resorb Mg - Intraarticular Fracture, Extraarticular Fracture | Phase 4 | Unknown | KLS Martin | 60 | 2022-11-01 | 2023-03-08 |
| Distal Targeter vs Free-hand Distal targeting jig, Free-hand/perfect circles technique - Femur Fracture, Tibial Fractures | Not applicable | Completed | Cedars-Sinai Medical Center | 89 | 2022-10-31 | 2025-04-10 |
| Validity of the Non-union Scoring System in Management of Long Bone Fracture Non-union Improving the stability and re-fixation with different modalities, Re-fixation with biological stimulation, complex care with non-union resection and bone reconstruction - Fracture Non Union | Not applicable | Completed | Ain Shams University | 60 | 2022-02-10 | 2025-10-06 |
| Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care Vivigen Cellular Bone Matrix - Fractures, Bone, Nonunion of Fracture | Recruiting | LifeNet Health | 250 | 2021-06-01 | 2026-09-15 | |
| Ankle Arthrodesis Nail for 2-level Pathologic Tibial Fracture osteosynthesis - Bone Metastases, Fracture Nonunion | Not applicable | Unknown | Orthopaedie Zentrum Zuerich | 1 | 2021-04-08 | 2021-08-17 |
| Results of the Staged Surgical Approach for Management of Infected Un-united Femoral Shaft Fractures in Adults Staged approach using antibiotic-cement impregnated PMMA spacer - Fracture Non Union | Unknown | Assiut University | 40 | 2021-03-01 | 2020-12-23 | |
| Comparative Study of Gene-activated Bone Substitute and Autobone in Treatment of Long Bone Nonunions "Histograft", a bone substitute based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA gene - Non Union Fracture, Non-Union of Ankle Joint Without Infection | Unknown | Histograft Co., Ltd. | 20 | 2020-08-01 | 2021-01-13 |
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Pseudarthrosis (32) · Fractures, Bone (7) · Spondylolisthesis (6) · Femoral Fractures (4) · Osteonecrosis (4) · Tibial Fractures (4) · Arthritis, Rheumatoid (3) · Femoral Neck Fractures (3) · Fractures, Open (3) · Hip Fractures (3) · Infections (3) · Intervertebral Disc Degeneration (3) · Osteoarthritis (3) · Wounds and Injuries (3)
Wounds and Injuries (66) · Fractures, Bone (62) · Musculoskeletal Diseases (18) · Bone Diseases (14) · Leg Injuries (9) · Pathological Conditions, Signs and Symptoms (9) · Joint Diseases (8) · Pathologic Processes (8) · Spinal Diseases (7) · Spondylolysis (6) · Spondylosis (6) · Arthritis (5) · Rheumatic Diseases (5) · Femoral Fractures (4)
Surgical Procedures, Operative (2) · Therapeutics (2) · Administration, Cutaneous (1) · Amputation, Surgical (1) · Anti-Bacterial Agents (1) · Arthroplasty, Replacement, Hip (1) · Clinical Protocols (1) · Control Groups (1) · Cost-Benefit Analysis (1) · Culture Media (1) · Debridement (1) · Dopamine beta-Hydroxylase (1) · Fracture Fixation, Internal (1) · Surveys and Questionnaires (1) · Transplantation, Autologous (1)
Zimmer Biomet (7) · Istituto Ortopedico Rizzoli (3) · Department of Trauma and Reconstructive Surgery at Eberhard Karls University Tuebingen, BG Klinik Tu (2) · Emdadi Kamyab Hospital (2) · Hospices Civils de Lyon (2) · Novadip Biosciences (2) · Academisch Ziekenhuis Maastricht (1) · Ain Shams University (1) · Assiut University (1) · Banc de Sang i Teixits (1) · Baxano Surgical, Inc. (1) · Bone Therapeutics S.A (1) · CHU de Reims (1) · Cedars-Sinai Medical Center (1) · Central Hospital, Nancy, France (1)
United States (24) · France (8) · Germany (8) · Belgium (5) · Spain (5) · Italy (4) · Canada (3) · Iran (3) · Switzerland (3) · Egypt (2) · China (1) · Finland (1) · India (1) · Indonesia (1) · Mexico (1)
Marie K Reumann, MD (2) · Aaron Nauth, MD FRCS(C) (1) · Abhishek Ganta, MD (1) · Brandon Lawrence, MD (1) · Carlos Acosta-Olivo, MD, PhD (1) · Chris Arts, PhD (1) · Craig van Horne, MD, PhD (1) · Dante Dallari, MD (1) · Donatella Granchi, MD (1) · Edgar Araiza, MD (1) · Eeric Truumees, MD (1) · Emil Schemitsch, MD FRCS(C) (1) · Enrique Gomez-Barrena, Prof (1) · Enrique Jimenez, MD (1)
PMID 10102814, PMID 14563800, PMID 14960673, PMID 15998219, PMID 16129630, PMID 16410387, PMID 16557516, PMID 16619257, PMID 16870478, PMID 17318898, PMID 17383488, PMID 17522996, PMID 17975221, PMID 18065397, PMID 18379826, PMID 20046678, PMID 20157290, PMID 20919913, PMID 21287233, PMID 21321995, PMID 22576926, PMID 23082252, PMID 23359411, PMID 23507085, PMID 23695220, PMID 23732992, PMID 23829460, PMID 23874472, PMID 23936800, PMID 24005862, PMID 24156444, PMID 24192520, PMID 24351605, PMID 27388241, PMID 27538760, PMID 38789992, PMID 40892974, PMID 42632350, PMID 9186204, PMID 9698003
2015 (1), 2025 (1)