85 completed, 22 unknown, 17 terminated, 14 recruiting. 151 Phase 3, 28 Phase 2.
Follow Fractures, Bone: new trials by email Literature Review of Fractures, Bone trials Research Report on Fractures, Bone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB - Rib Fractures, Acute Pain | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-18 |
| Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures Vancomycin (VAN) treatment, Standard Open Fracture Care - Open Fracture | Phase 3 | Not yet recruiting | Atlantic Health System | 100 | 2026-06-10 | 2026-06-22 |
| Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO] - Postoperative Cognitive Dysfunction, Orthopedic Procedures | Phase 3 | Recruiting | Romanian Society for Enteral and Parenteral Nutrition | 120 | 2025-10-01 | 2025-10-01 |
| A Study to Assess How Effective and Safe NVD003 is for Treating Patients With Congenital Pseudarthrosis of the Tibia. NVD003, Iliac Crest Bone Graft - Congenital Pseudarthrosis of Tibia | Phase 3 | Recruiting | Novadip Biosciences | 12 | 2025-09-02 | 2026-11-09 |
| Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures Incisional Negative Pressure Wound Therapy (NPWT) - Fracture of Tibia, Wound Heal | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 352 | 2025-01-01 | 2026-05-12 |
| Dexmedetomidine in Attenuation of Haemodynamic Response to Laryngoscopy in Controlled Hypertensive Patients Dexmedetomidine, Normal Saline - Hypertension, Hemodynamic Response | Phase 3 | Completed | Sindh Institute of Urology and Transplantation | 70 | 2025-01-01 | 2026-04-29 |
| VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma Cholecalciferol D3, Olive oil - Asthma, Respiratory Tract Infections | Phase 3 | Recruiting | Professor Klaus Bønnelykke | 2000 | 2024-12-20 | 2025-09-30 |
| Fish Oil in pREgnancY for Personalized Prevention of Early Childhood Asthma n-3 fatty acid, Rape seed oil - Asthma, Respiratory Tract Infections | Phase 3 | Recruiting | Professor Klaus Bønnelykke | 2000 | 2024-12-20 | 2025-09-30 |
| The MANTRA Trial (MANdibular TRauma and Antibiotic Use) Different post-operative antibiotic regimens following surgical treatment of mandible fractures - Mandible Fracture, Post-operative Antibiotics | Phase 3 | Recruiting | East Lancashire Hospitals NHS Trust | 2841 | 2024-12-06 | 2026-01-22 |
| Bone in CKD Alkali Response (BICARb Pilot Trial) Potassium Citrate Extended Release Oral Tablet, Placebo, Potassium Citrate and Citric Acid Oral Solution - Chronic Kidney Diseases, Bone Loss | Phase 2 / Phase 3 | Terminated | Albert Einstein College of Medicine | 6 | 2024-08-15 | 2026-07-28 |
| Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery USG GUIDED SUPRA-INGUINAL FASCIA ILIACA BLOCK, PERICAPSULAR NERVE BLOCK - Post Operative Pain, Bradycardia | Phase 2 / Phase 3 | Recruiting | Sahiwal medical college sahiwal | 70 | 2024-07-10 | 2025-10-23 |
| Effectiveness of 3D-printed Patient-specific Resorbable Scaffolds for Maxillary Bone Regeneration PCL Scaffold, PTFE + Bio-Oss® - Bone Loss, Jaw, Edentulous | Phase 3 | Enrolling by invitation | Universidad Austral de Chile | 10 | 2024-07-01 | 2025-01-15 |
| Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures Ropivacaine 0.2% Injectable Solution, Lidocaine epinephrine, Ropivacaine 0.5% Injectable Solution - Distal Radius Fractures, Lidocaine | Phase 3 | Completed | Nordsjaellands Hospital | 67 | 2024-04-23 | 2025-06-26 |
| Supraclavicular Bupivacaine Vs. Supraclavicular Liposomal Bupivacaine for Orthopedic Wrist Surgery Liposomal bupivacaine, Bupivacaine Hydrochloride - Distal Radius Fractures, Wrist Fractures | Phase 3 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2024-04-10 | 2025-10-24 |
| Intramedullary Calcium Sulfate Antibiotic Depot Vancomycin Hydrochloride, Gentamicin, Standard Intramedullary Nail - Open tíbia Fracture, Osteomyelitis Tibia | Phase 3 | Recruiting | Wake Forest University Health Sciences | 242 | 2024-04-08 | 2026-10-14 |
| Kinesiotaping Method for Rib Fractures Kinesiotaping, Painkillers - Rib Fractures, Pain, Chest | Phase 2 / Phase 3 | Completed | Kastamonu University | 34 | 2024-01-24 | 2024-10-09 |
| Effect of Adding Magnesium Sulphate in Pericapsular Nerve Group Block Pericapsular nerve group block using bupivicaine and magnesium sulphate - Hip Fractures | Phase 2 / Phase 3 | Unknown | Assiut University | 62 | 2024-01-01 | 2023-12-22 |
| PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics - Infections, Infected Wound | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 250 | 2023-05-30 | 2026-09-11 |
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Hip Fractures (36) · Osteoporosis (23) · Bone Diseases, Metabolic (13) · Fractures, Stress (10) · Femoral Neck Fractures (8) · Pain (8) · Tibial Fractures (7) · Osteoporosis, Postmenopausal (6) · Spinal Fractures (6) · Wrist Fractures (6) · Ankle Fractures (5) · Fractures, Open (5) · Osteoporotic Fractures (5) · Wounds and Injuries (5)
Wounds and Injuries (146) · Leg Injuries (59) · Hip Injuries (44) · Femoral Fractures (43) · Pathological Conditions, Signs and Symptoms (40) · Musculoskeletal Diseases (34) · Bone Diseases (27) · Metabolic Diseases (26) · Nutritional and Metabolic Diseases (26) · Signs and Symptoms (24) · Pathologic Processes (23) · Neurologic Manifestations (21) · Nervous System Diseases (17) · Bone Diseases, Metabolic (12)
Dexmedetomidine (8) · Teriparatide (8) · Alendronate (7) · Bupivacaine (7) · Denosumab (6) · Ketamine (6) · Tranexamic Acid (6) · Zoledronic Acid (6) · Saline Solution (5) · abaloparatide (4) · Cholecalciferol (3) · Dexamethasone (3) · Enoxaparin (3) · Ibuprofen (3) · Midazolam (3)
Assiut University (6) · Amgen (5) · Assistance Publique - Hôpitaux de Paris (5) · Radius Health, Inc. (5) · Chinese University of Hong Kong (4) · Major Extremity Trauma Research Consortium (4) · Columbia University (3) · Eli Lilly and Company (3) · Instituto Mexicano del Seguro Social (3) · Prince of Songkla University (3) · GTx (2) · Lancaster General Hospital (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Medical University of Graz (2) · Novartis Pharmaceuticals (2)
United States (51) · Canada (22) · France (18) · Denmark (12) · Germany (11) · Spain (11) · Poland (10) · United Kingdom (10) · Sweden (9) · China (8) · Italy (8) · Australia (7) · Czechia (7) · Romania (7) · Argentina (6)
Naveen Poonai, MD (3) · Bo Chawes, PhD (2) · Boonsin Tangtrakulwanich, MD.,Ph.D (2) · Elizabeth Shane, MD (2) · Kwok Sui Leung, MD (2) · Kwok-Sui Leung, MD (2) · Renan Castillo, PhD (2) · Adeel Riaz, MD (1) · Adi Cohen, MD (1) · Alaa M Attia, Professor (1) · Alejandro Gonzalez Ojeda, M.D., Ph.D. (1) · Alejandro Gonzalez-Ojeda, PhD (1)
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