18 completed, 6 unknown, 5 not yet recruiting, 4 recruiting. 14 Not applicable, 10 Phase 4, 5 Phase 2, 5 Phase 3, 1 Phase 1.
Follow Fentanyl: new trials by email Literature Review of Fentanyl trials Research Report on Fentanyl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstructive Sleep Apnea Group A: Fentanyl-Based Analgesia, Group B: Opioid-Free Multimodal Analgesia - Adenotonsillectomy, Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | Ain Shams University | 64 | 2026-11-30 | 2026-02-27 |
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation Injectable buprenorphine, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets) - Opioid Use Disorder, Fentanyl | Phase 4 | Not yet recruiting | University of California, San Francisco | 50 | 2026-06-01 | 2026-03-13 |
| Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Fentanyl (IV), lidocaine - Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction | Not applicable | Completed | Cairo University | 48 | 2025-12-01 | 2026-08-07 |
| Dexmedetomidine and Propofol for Sedation in Cataract Surgery. Dexmedetomidine (DEX), Propofol (PRO), Fentanyl (FEN) - Sedation, Cataract | Not applicable | Recruiting | Saint-Joseph University | 1000 | 2025-11-09 | 2026-04-29 |
| Intrathecal Dexmedetomidine-Fentanyl Combination Versus Fentanyl Alone as Adjuvant to Bupivacaine in Spinal Anesthesia for Above Knee Amputation in Sarcomas of Lower Extremity Fentanyl + Dexmedetomidine, Fentanyl - Intrathecal, Dexmedetomidine | Not applicable | Recruiting | National Cancer Institute, Egypt | 58 | 2025-10-20 | 2025-12-11 |
| D-FAB-POUR Trial: Dexmedetomidine vs Fentanyl as Adjuvants to Bupivacaine on Postoperative Urinary Retention Intervention 1: Intrathecal Dexmedetomidine with Bupivacaine, Intervention 2: Intrathecal Fentanyl with Bupivacaine - Spinal Anesthesia, Postoperative Complications | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 190 | 2025-09-15 | 2025-08-12 |
| Comparison of Caudal Block Combined With General Anesthesia and Penile Block and Intravenous Fentanyl in Pediatric Surgeries Group 1 ( Caudal block group ), Group 2 (Penile block and IV Fentanyl group) - Caudal Block, Pediatric Urologic Surgeries | Completed | Miray Gözde Özdemir | 120 | 2025-04-01 | 2026-05-27 | |
| Premixed, Sequential and Manually Mixed Administration of Intrathecal Fentanyl and Bupivacaine in Cesarean Section Fentanyl and Bupivacaine - Premixed, Sequential | Not applicable | Completed | Tanta University | 90 | 2025-02-12 | 2025-07-25 |
| Comparative Study Between Intrathecal Magnesium Sulfate, Neostigmine and Fentanyl as Adjuvant for Bubivacaine in Postoperative Analgesia in Lower Abdominal Surgeries Magnesium Sulfate and Bupivacaine 0.125%, bupivacaine and Neostigmine, fentanyl and bupivacaine - Magnesium Sulfate, Neostigmine | Phase 4 | Not yet recruiting | Assiut University | 66 | 2024-12-01 | 2024-11-12 |
| Fentanyl Versus Ketorolac as an Adjuvant to Peribulbar Block for Anterior Segment Surgeries Lidocaine + Bupivacaine + Hyaluronidase, Fentanyl + Lidocaine + Bupivacaine + Hyaluronidase, Ketorolac + Lidocaine + Bupivacaine + Hyaluronidase - Fentanyl, Ketorolac | Not applicable | Recruiting | Cairo University | 168 | 2024-08-25 | 2025-08-26 |
| Fentanyl and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided Superficial Cervical Plexus Block in Thyroid Surgeries Superficial cervical plexus block, Superficial cervical plexus block + Fentanyl, Superficial cervical plexus block + Dexmedetomidine - Fentanyl, Dexmedetomidine | Not applicable | Completed | Kafrelsheikh University | 60 | 2024-06-30 | 2025-07-10 |
| Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy Aurora 1:1 Drops (Indica), Placebo - Opioid Use Disorder, Methadone | Phase 2 | Recruiting | BC Centre on Substance Use | 24 | 2024-05-23 | 2025-02-17 |
| Opioid-based Versus Opioid-free Endotracheal Intubation ketamine-lidocaine-dexmedetomidine, fentanyl - Anesthesia, Anesthesia Intubation | Not applicable | Completed | Aretaieion University Hospital | 70 | 2024-03-20 | 2025-07-22 |
| Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring Propofol-Fentanyl, Propofol-Fentanyl-Dexmedetomidine, Propofol-Fentanyl-Sevoflurane - Propofol, Fentanyl | Not applicable | Completed | Ain Shams University | 78 | 2024-01-20 | 2025-12-22 |
| Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial Fentanyl Citrate, Esketamine - Acute Pain Due to Trauma, Analgesia | Phase 3 | Terminated | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 235 | 2024-01-11 | 2026-09-15 |
| Fentanyl Vs Dexmedetomidine as Adjuvants to Bupivacaine in Erector Spinae Plane Block for Postoperative Analgesia in Patients Undergoing Arthroscopic Shoulder Surgeries Bupivacaine 0.25%, Bupivacaine 0.25% + Fentanyl 1µg/kg, Bupivacaine 0.25% + dexmedetomidine 1µg/kg - Fentanyl, Dexmedetomidine | Not applicable | Completed | Tanta University | 90 | 2024-01-01 | 2026-09-23 |
| Hemodynamic Effects of Bolus of Ketamine Versus Fentanyl in Patients With Septic Shock Ketamine, Fentanyl - Ketamine, Fentanyl | Not applicable | Completed | Cairo University | 86 | 2023-08-01 | 2023-12-22 |
| Fentanyl Versus Dexmedetomidine as an Adjuvant to Bupivacaine in Spinal Anesthesia ; Peritoneal Symptomatic Effects Dexmedetomidine Injection [Precedex], Fentanyl HCl - Dexmedetomidine, Fentanyl | Phase 3 | Unknown | Aswan University | 148 | 2023-07-01 | 2025-02-21 |
| Lidocaine Versus Fentanyl for Hemodynamic Stability Lidocaine IV, Fentanyl - Hypertension, Fentanyl | Phase 4 | Completed | Theodor Bilharz Research Institute | 40 | 2023-04-01 | 2024-08-23 |
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Agnosia (5) · Opioid-Related Disorders (3) · Acute Pain (2) · Chronic Pain (2) · Behavior, Addictive (1) · Bradycardia (1) · Breast Feeding (1) · Cataract (1) · Coronary Artery Disease (1) · Drug-Related Side Effects and Adverse Reactions (1) · Emergencies (1) · Harm Reduction (1) · Hypertension (1) · Marijuana Abuse (1) · Nausea (1)
Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (9) · Neurologic Manifestations (7) · Nervous System Diseases (6) · Neurobehavioral Manifestations (5) · Pathologic Processes (5) · Perceptual Disorders (5) · Chemically-Induced Disorders (4) · Pain (4) · Cardiovascular Diseases (3) · Mental Disorders (3) · Narcotic-Related Disorders (3) · Substance-Related Disorders (3) · Behavior (2) · Eye Diseases (2)
Fentanyl (22) · Dexmedetomidine (8) · Bupivacaine (6) · Levobupivacaine (3) · Esketamine (2) · Ketamine (2) · Lidocaine (2) · Midazolam (2) · Morphine (2) · Remifentanil (2) · Sodium Chloride (2) · Anesthesia, General (1) · Anesthesia, Spinal (1) · Buprenorphine (1) · Buprenorphine, Naloxone Drug Combination (1)
Tanta University (4) · Assiut University (3) · Cairo University (3) · Ain Shams University (2) · Aretaieion University Hospital (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Aswan University (1) · BC Centre on Substance Use (1) · Corewell Health South (1) · Daniel Gioielli de Castilho (1) · Guangzhou Institute of Respiratory Disease (1) · Helwan University (1) · IRCCS Burlo Garofolo (1) · Kafrelsheikh University (1) · M. Eugenia Socias (1)
Egypt (16) · Canada (4) · United States (4) · China (3) · Greece (2) · Netherlands (2) · Turkey (Türkiye) (2) · Brazil (1) · Italy (1) · Lebanon (1) · Nepal (1)
Ahmed A Mahmoud, MD (1) · Ashley L Szabo, M.D. (1) · Ayman M Eldemrdash, MD (1) · Laura Travan, MD (1) · Le May Sylvie, PhD (1) · Leslie W Suen, MD (1) · M Eugenia Socias, MD, MSc. (1) · M. Eugenia Socias, MD, MSc (1) · Markus W Hollmann, Prof. dr. dr. (1) · Naji Abou Jalad, MD (1) · Shiyue Li, Professor (1) · Xudong Yang, MD (1)
PMID 23160979, PMID 23355160, PMID 23389068, PMID 25429720, PMID 27746548, PMID 28741894, PMID 29284839, PMID 30211725, PMID 30622224, PMID 30982564, PMID 31362883, PMID 32024465, PMID 35016456, PMID 35803751, PMID 37601044, PMID 37811840, PMID 38429736, PMID 39154316, PMID 40420189, PMID 40642177, PMID 42458331
K23DA060329 (1)