20 completed. 20 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 20 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
Follow Emergencies: new trials by email Literature Review of Emergencies trials Research Report on Emergencies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Short-Term Prednisone Therapy on C-Reactive Protein Change in Emergency Department Patients With Acute Heart Failure and Elevated Inflammatory Markers ( CORTAHF ) Prednisone arm, Usual care - Acute Heart Failure | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 3 | 2023-02-16 | 2026-01-21 |
| Erector Spinae Plane Block for Uncomplicated Renal Colic Erector Spinae Plane Block (ESPB), Ropivacaine - Renal Colic, Kidney Stone | Phase 2 | Completed | University of Michigan | 5 | 2023-02-08 | 2025-10-30 |
| Restrictive Fluid Administration vs. Standard of Care in Emergency Department Sepsis Patients Isotonic crystalloids - Sepsis | Phase 2 | Completed | Marie Kristine Jessen, MD | 124 | 2021-11-03 | 2022-03-25 |
| Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries Ibuprofen, Acetaminophen, Hydromorphone - Musculoskeletal Injury | Phase 2 | Completed | University of Alberta | 710 | 2019-04-20 | 2024-09-19 |
| Rapid Agitation Control With Ketamine in the Emergency Department Ketalar, Midazolam injection, Haloperidol - Violent Aggressive Behavior, Ketamine | Phase 2 | Completed | David Barbic | 81 | 2018-05-29 | 2020-11-30 |
| Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) VRT Care - Vertigo, Dizziness | Phase 2 | Completed | Johns Hopkins University | 130 | 2017-12-04 | 2025-12-26 |
| Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED) oxycodone/APAP, hydrocodone/APAP, codeine/APAP - Musculoskeletal Pain | Phase 2 | Completed | Albert Einstein College of Medicine | 600 | 2017-11-28 | 2022-02-01 |
| PREMIX vs PREMED Intranasal Lidocaine and Midazolam Lidocaine, Lidocaine and midazolam (PREMIX), Midazolam - Pain | Phase 2 | Completed | Columbia University | 55 | 2017-04-03 | 2019-09-11 |
| Intranasal Hydromorphone for the Treatment of Acute Pain in Children: A Pilot Study. Hydromorphone - Pain | Phase 2 | Completed | Columbia University | 35 | 2015-05-01 | 2019-05-28 |
| Nitrous Oxide Analgesia Vaso-occlusive Crisis Nitrous oxide 50% - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 2 | Completed | Columbia University | 5 | 2013-11-12 | 2026-01-28 |
| Association Between Body Size and Response to Hydromorphone in ED Hydromorphone - Pain | Phase 2 | Completed | Albert Einstein College of Medicine | 174 | 2011-10-01 | 2020-10-08 |
| Intravenous Fluid for Pediatric Migraine in the Emergency Department Normal saline - Migraine, Headache | Phase 1 / Phase 2 | Completed | University of Alberta | 46 | 2010-07-01 | 2026-02-06 |
| Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis IV cefazolin plus oral probenecid and placebo cephalexin, Oral cephalexin and saline IV plus probenecid placebo - Cellulitis | Phase 2 | Completed | Kelowna General Hospital | 206 | 2010-05-01 | 2018-08-13 |
| Fentanyl Administered Intraorally for Rapid Treatment of Orthopedic Pain Fentanyl, Lansoprazole, Oxycodone - Pain, Fracture, Sprain | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 60 | 2008-08-01 | 2017-02-09 |
| N-Acetylcysteine to Prevent Radiocontrast Nephropathy in Emergency Department Patients N-Acetylcysteine (NAC), 0.9% Sodium-chloride - Radiocontrast Nephropathy | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 399 | 2007-10-16 | 2024-10-29 |
| Lidocaine Patches Prior to Intravenous Insertion Lidocaine tetracaine, Placebo - Need for Intravenous Catheter | Phase 2 | Completed | Stony Brook University | 45 | 2007-08-01 | 2012-10-22 |
| Safety of Hydromorphone in Adult Patients Presenting to the Emergency Department With Acute Severe Pain 2 mg IV hydromorphone - Acute Pain | Phase 2 | Completed | Montefiore Medical Center | 298 | 2006-01-01 | 2018-08-20 |
| Emergency Department Initiated Tobacco Treatment (EDITT) Behavior change counseling - Tobacco Use | Phase 1 / Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 75 | 2005-12-01 | 2017-01-11 |
| Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain Morphine, Hydromorphone - Acute Pain | Phase 2 / Phase 3 | Completed | Montefiore Medical Center | 194 | 2005-07-01 | 2018-08-20 |
| Safety and Efficacy Study of Hydromorphone and Morphine Morphine, Hydromorphone - Pain | Phase 2 | Completed | Montefiore Medical Center | 198 | 2004-10-01 | 2018-08-15 |
Pain (8) · Acute Pain (4) · Aggression (1) · Agnosia (1) · Anemia, Sickle Cell (1) · Benign Paroxysmal Positional Vertigo (1) · Cellulitis (1) · Dizziness (1) · Fractures, Bone (1) · Headache (1) · Hypotension (1) · Kidney Calculi (1) · Lymphoma, Follicular (1) · Migraine Disorders (1)
Disease Attributes (20) · Pathologic Processes (20) · Pathological Conditions, Signs and Symptoms (20) · Neurologic Manifestations (13) · Signs and Symptoms (13) · Nervous System Diseases (3) · Pain (3) · Behavior (2) · Brain Diseases (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Hemic and Lymphatic Diseases (2) · Infections (2) · Inflammation (2) · Vascular Diseases (2)
Hydromorphone (6) · Acetaminophen (2) · Ibuprofen (2) · Midazolam (2) · Morphine (2) · Saline Solution (2) · Sodium Chloride (2) · oxycodone-acetaminophen (2) · Acetylcysteine (1) · Behavior Therapy (1) · Cefazolin (1) · Cephalexin (1) · Fentanyl (1) · Haloperidol (1) · Ketamine (1)
Columbia University (3) · Montefiore Medical Center (3) · Albert Einstein College of Medicine (2) · University of Alberta (2) · Assistance Publique - Hôpitaux de Paris (1) · Beth Israel Deaconess Medical Center (1) · David Barbic (1) · Johns Hopkins University (1) · Kelowna General Hospital (1) · Marie Kristine Jessen, MD (1) · Massachusetts General Hospital (1) · National Institute on Drug Abuse (NIDA) (1) · Stony Brook University (1) · University of Michigan (1)
United States (14) · Canada (4) · Denmark (1) · France (1)
Andrew K Chang, MD (3) · Daniel S Tsze, MD, MPH (2) · Adam J Singer, MD (1) · Adrienne Birnbaum, MD (1) · Benjamin Friedman, MD (1) · Chris Fung (1) · Daniel Tsze, MD, MPH (1) · David Barbic, MD MSc FRCPC, (1) · David Newman-Toker, MD, PhD (1) · Dawn Dalen, PharmD (1) · Edwin D Boudreaux, PhD (1) · Lawrence P Richer, MD, MSc (1) · Marie K Jessen, MD (1) · Peter Zed, PharmD (1) · Samina Ali, MD (1)
PMID 19050988, PMID 23570477, PMID 23769807, PMID 25168404, PMID 26286816, PMID 29914924, PMID 30477544, PMID 30902361, PMID 32565458, PMID 32883371, PMID 33358232, PMID 33675203, PMID 35351214, PMID 35652491, PMID 37023945, PMID 37166022, PMID 41315052, PMID 41505155
U01DC013778 (1)