83 completed, 27 unknown, 13 terminated, 12 recruiting. 55 Phase 4, 41 Not applicable, 27 Phase 3, 17 Phase 2, 10 Phase 1.
Follow Cefazolin: new trials by email Literature Review of Cefazolin trials Research Report on Cefazolin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin Cefazolin 2 g Infusion, Placebo infusion of .9 normal saline - Breast Cancer, Breast Surgery | Phase 3 | Not yet recruiting | University Hospital, Clermont-Ferrand | 1600 | 2026-11-01 | 2026-10-27 |
| Azithromycin for Cerclage Prophylaxis Azithromycin Prophylaxis, Azithromycin Placebo, Cefazolin - Cervical Insufficiency | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 80 | 2026-10-15 | 2026-10-27 |
| Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients. Cefazolin 2 g Infusion, Cefazolin 2 GM Injection - Surgical Site Infection (SSI) | Phase 4 | Not yet recruiting | Helwan University | 100 | 2026-07-01 | 2026-06-24 |
| Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients. Cefazolin 2 g Infusion, Cefazolin 2 GM Injection - Surgical Site Infection (SSI) | Phase 4 | Not yet recruiting | Helwan University | 100 | 2026-07-01 | 2026-06-24 |
| Duration of Perioperative Antibiotics in Pancreatoduodenectomy single dose preoperative antibiotic, Prolonged perioperative antibiotics - Pancreatoduodenectomy, PPPD | Not applicable | Enrolling by invitation | Asan Medical Center | 558 | 2026-05-11 | 2026-05-28 |
| Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial Cefazolin, Vancomycin - Infection, Surgical Site | Phase 4 | Not yet recruiting | Hamilton Health Sciences Corporation | 38000 | 2026-03-01 | 2026-03-12 |
| Efficacy and Safety of Intraosseous Antibiotic Prophylaxis in Total Hip Replacement CeFAZolin 1000 MG, Saline (0.9%, sterile, for infusion) - Antibiotic Prophylaxis Surgery | Phase 4 | Enrolling by invitation | Rutgers, The State University of New Jersey | 25 | 2025-10-20 | 2026-04-29 |
| Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes? Early Dual IV Antibiotic Therapy - MRSA, Early Dual IV Antibiotic Therapy - MSSA, Single Agent IV Antibiotic Therapy - MRSA - Staphylococcus Aureus Bacteremia | Phase 4 | Enrolling by invitation | West Virginia University | 300 | 2025-09-15 | 2026-09-17 |
| Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic Cefazolin plus Gentamicin, Cefazolin - Surgical Site Infection (SSI) | Not applicable | Completed | Lahore General Hospital | 284 | 2025-07-01 | 2026-03-18 |
| Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing, Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge, Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge - Drug Allergy, Cephalosporin Allergy | Phase 2 | Recruiting | Massachusetts General Hospital | 300 | 2025-05-05 | 2026-09-04 |
| PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network Ertapenem, Cefazolin and Metronidazole. - Surgical Site Infection | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 300 | 2025-05-01 | 2025-04-11 |
| Antibiotic Prophylaxis to Prevent Obesity-Related Induction Complications in Nulliparae at Term 2.0 Azithromycin, Placebo - Obesity in Pregnancy, Labor Complication | Phase 2 | Recruiting | University of Oklahoma | 787 | 2025-04-29 | 2026-03-12 |
| Using Antibiotics to Prevent Infections in Hemodialysis Patients During Catheter Placement • Cefamezine (2 grams) and gentamicin (80 mg) administered intravenously. • Patients with penicillin allergies, a history of methicillin-resistant Staphylococcus aureus (MRSA) infection, or known MRSA - Infection Catheter-Related | Phase 4 | Recruiting | Western Galilee Hospital-Nahariya | 200 | 2024-10-28 | 2025-02-07 |
| Antibiotic Prophylaxis in Metabolic Bariatric Surgery 2000 mg of Cefazolin, 500 mg of Metronidazole IV, NACL 0.9% 100 ml - Antibiotic Reaction, Wound Infection Superficial | Not applicable | Unknown | General Committee of Teaching Hospitals and Institutes, Egypt | 3352 | 2024-10-01 | 2024-07-31 |
| The Role of Antibiotic Prophylaxis in Lowering Wound Infection Rates Post-Open Repair of Primary Elective Groin Hernias in High-Risk Patients Cefazolin 1000 MG - Antibiotic Prophylaxis, Wound Infection | Phase 3 | Unknown | University of Aleppo | 200 | 2024-08-01 | 2024-08-28 |
| Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Trial Cefazolin with Daptomycin, Cefazolin with vancomycin - Periprosthetic Joint Infection | Not applicable | Unknown | Chang Gung Memorial Hospital | 184 | 2024-08-01 | 2024-01-05 |
| Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid, IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline - Staphylococcus Aureus Bacteremia | Phase 3 | Unknown | Clinical Research Centre, Malaysia | 290 | 2024-06-28 | 2024-07-05 |
| Antibiotic Tumescent For Chronic Wounds CeFAZolin Injectable Solution - Non-healing Wound | Phase 2 | Recruiting | University of California, Los Angeles | 60 | 2024-05-17 | 2026-04-23 |
| Antibiotics for Prevention of Infection Following Orthognathic Surgery Cefazolin 2 GM Injection, Cefazolin Injection - Orthognathic Surgical Site Infection | Phase 4 | Recruiting | Abdul El-Rabbany | 400 | 2024-01-09 | 2026-03-19 |
| Randomized Assessment of Antibiotic Prophylaxis Prior to Port Placement Cefazolin, saline - Vascular Access Ports | Not applicable | Withdrawn | Dartmouth-Hitchcock Medical Center | 2024-01-01 | 2024-04-26 |
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Surgical Wound Infection (28) · Infections (18) · Wound Infection (11) · Staphylococcal Infections (7) · Bacteremia (6) · Breast Neoplasms (5) · Obesity (5) · Communicable Diseases (4) · Osteomyelitis (4) · Arthritis, Infectious (3) · Cellulitis (3) · Hernia, Inguinal (3) · Sepsis (3) · Uterine Cervical Incompetence (3) · Appendicitis (2)
Population Health Research Institute (4) · Duke University (3) · West Virginia University (3) · Assistance Publique - Hôpitaux de Paris (2) · B. Braun Medical Inc. (2) · Chinese University of Hong Kong (2) · HaEmek Medical Center, Israel (2) · Hamilton Health Sciences Corporation (2) · Helwan University (2) · Hospital for Special Surgery, New York (2) · Isfahan University of Medical Sciences (2) · McMaster University (2) · Radboud University Medical Center (2) · Rush University Medical Center (2) · Samsung Medical Center (2)
United States (66) · Canada (19) · Brazil (8) · Israel (8) · Netherlands (8) · Australia (6) · France (6) · Egypt (4) · Iran (4) · New Zealand (4) · Singapore (4) · South Korea (4) · Spain (4) · Malaysia (3) · South Africa (3)
Daniela F Veiga, MD, PhD (2) · Dominik Mertz, MD, MSc (2) · Michael L Stitely, MD (2) · Stephanie Pierce, MD (2) · William H Holls, MD (2) · Achim J Kaasch, MD (1) · Adriano Germano, PhD (1) · Ahmed M. Ibrahim Taha, Dr (1) · Alan G Smulian, M.B.B.Ch. (1) · Alena Jamdourek, MD (1) · Alexandra Zhernakova, MD/PhD (1) · Allison R Lauver, PharmD (1) · Allison Rao, MD (1) · Amanda Gwee, PhD (1) · Anca Amza (1)
PMID 10219875, PMID 10998650, PMID 12841893, PMID 18839083, PMID 19376733, PMID 20934625, PMID 21126927, PMID 21412147, PMID 21601826, PMID 22083832, PMID 23052809, PMID 23325435, PMID 23461695, PMID 24807330, PMID 25376070, PMID 25532706, PMID 25932849, PMID 26452342, PMID 27029920, PMID 27106640, PMID 27412673, PMID 27682068, PMID 28505360, PMID 29146633, PMID 29279933, PMID 29793587, PMID 29914924, PMID 30027615, PMID 30173161, PMID 30234517, PMID 30264119, PMID 30545448, PMID 30558680, PMID 30995208, PMID 31236724, PMID 31331757, PMID 31737738, PMID 31806127, PMID 31993070, PMID 32044943, PMID 32051007, PMID 32557558, PMID 33239101, PMID 33395210, PMID 33416442, PMID 33618788, PMID 33743753, PMID 33752752, PMID 34499720, PMID 34825283
2014 (1), 2025 (1), 5UM1AI104681-12 (1), K23HD060040 (1), U01AI184071 (1)