76 recruiting, 53 not yet recruiting, 28 completed, 13 active not recruiting. 117 Not applicable, 13 Phase 2, 11 Phase 1, 8 Phase 4, 1 Early Phase 1.
Follow Depression - Major Depressive Disorder: new trials by email Literature Review of Depression - Major Depressive Disorder trials Research Report on Depression - Major Depressive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma Cognitive Processing Therapy - Post-Traumatic Stress Disorder, Chronic, Depressed Mood | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 25 | 2027-01-01 | 2026-10-15 |
| Group PACBT for Depression Psilocybin (drug), Group Cognitive Behavioral Therapy - Depression - Major Depressive Disorder, Psilocybin | Phase 2 | Not yet recruiting | University of California, Los Angeles | 30 | 2027-01-01 | 2026-05-04 |
| Comparative Effects of Acceptance and Commitment Therapy, Cognitive Behavioral Therapy, and Treatment-as-Usual on Depression Among People With Marital Crisis Acceptance and Commitment Therapy, Cognitive Behavioral Therapy - Depression - Major Depressive Disorder, Anxiety | Not applicable | Not yet recruiting | Universiti Sains Malaysia | 120 | 2027-01-01 | 2026-09-08 |
| Effect of Neurofeedback and TMS Repetitive Transcranial Magnetic Stimulation, Alpha-down EEG Neurofeedback - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Massachusetts General Hospital | 20 | 2027-01-01 | 2026-10-23 |
| Sham-Controlled Rapid-Acting Neuromodulation for Depression intermittent theta burst stimulation, Sham (No Treatment) - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | University of California, Davis | 264 | 2026-12-01 | 2026-06-16 |
| Optimizing Stimulation Parameters for Electroconvulsive Therapy Electroconvulsive Therapy - Depression - Major Depressive Disorder, Catatonia | Not applicable | Not yet recruiting | University of Pennsylvania | 64 | 2026-12-01 | 2026-09-04 |
| Transcendental Meditation Intervention to Reduce Burnout and Enhance Resilience Among NewYork-Presbyterian Hospital and Weill Cornell Medicine Employees and Residents Transcendental Meditation - Anxiety, Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 15 | 2026-11-15 | 2026-10-09 |
| Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI) Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description - Dementia (Diagnosis), Alzheimer Dementia (AD) | Not yet recruiting | Zealand University Hospital | 440 | 2026-11-01 | 2026-09-02 | |
| Mobile Cognitive Behavioral Therapy in Early Stroke Recovery Mobile Cognitive Behavioral Therapy App - Anxiety, Stroke | Not applicable | Recruiting | Weill Medical College of Cornell University | 10 | 2026-11-01 | 2026-09-23 |
| Slow-Paced Breathing and Electrical Vagus Nerve Stimulation as Add-on Treatments for Depression Slow-Paced Breathing, Transcutaneous Auricular Vagus Nerve Stimulation (tVNS), Sham Auricular Electrical Stimulation - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Elisabeth Balint | 160 | 2026-11-01 | 2026-10-02 |
| Enhancing Operational Readiness With Digital Self-Managed Cognitive Behavioral Therapy for Insomnia (CBTI) Cognitive Behavioral Therapy for Insomnia - Insomnia, Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Madigan Army Medical Center | 144 | 2026-11-01 | 2026-10-22 |
| Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms Non-deceptive placebo (NDP) - Depression - Major Depressive Disorder, Psychological Distress | Not applicable | Not yet recruiting | Miami University | 330 | 2026-10-25 | 2026-10-22 |
| tDCS for Late-Life Depression High-intensity (6 mA) transcranial direct current stimulation (tDCS) - Late Life Depression (LLD), Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Recruiting | Andre Russowsky Brunoni | 20 | 2026-10-01 | 2026-09-25 |
| Teen Vulnerability to Irritability: Brain and Estrogen Changes Kurvelo, Placebo COC - Depression - Major Depressive Disorder, Irritability | Phase 4 | Not yet recruiting | University of North Carolina, Chapel Hill | 50 | 2026-10-01 | 2026-08-24 |
| PROMOTE: Effects of 5-HT4 Agonism on Cognition and Sleep in Peopl With Low Mood Prucalopride, Placebo Comparator - Low Mood, Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | University of Oxford | 60 | 2026-10-01 | 2026-10-06 |
| The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression. Aripiprazole Augmentation, Bupropion Augmentation - Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder | Phase 2 | Not yet recruiting | Washington University School of Medicine | 300 | 2026-10-01 | 2026-10-16 |
| iPath for CP Pilot depression app for care partners of persons with dementia - Depression - Major Depressive Disorder | Not applicable | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 15 | 2026-10-01 | 2026-10-02 |
| Individualized fMRI-guided TMS for Depression Active Repetitive Transcranial Magnetic Stimulation (rTMS), Sham Transcranial Magnetic Stimulation (TMS) - Depression, Major Depressive Disorder (MDD) | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 60 | 2026-09-15 | 2026-09-09 |
| Fasting, Exercise, and Diet to Activate Autophagy in Depression Performance test - Depression - Major Depressive Disorder, Overweight (BMI > 25) | Not applicable | Not yet recruiting | University of Zurich | 120 | 2026-09-11 | 2026-06-24 |
| An Evaluation of the Impact of Pharmacist Comprehensive Medication Management With Pharmacogenomic Results to Improve Depression Outcomes in Community Pharmacies. Comprehensive medication management with PGx testing results, Usual Care - Pharmacogenetics, Depression - Major Depressive Disorder | Not applicable | Recruiting | University of Pittsburgh | 220 | 2026-09-09 | 2026-09-14 |
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Depression (93) · Anxiety Disorders (48) · Depressive Disorder, Major (28) · Psychological Well-Being (15) · Bipolar Disorder (12) · Stress Disorders, Post-Traumatic (12) · Depressive Disorder, Treatment-Resistant (11) · Cognitive Dysfunction (7) · Generalized Anxiety Disorder (7) · Mood Disorders (7) · Sleep Initiation and Maintenance Disorders (7) · Attention Deficit Disorder with Hyperactivity (5) · Dementia (5) · Depressive Disorder (5) · Inflammation (5)
Mental Disorders (109) · Behavior (108) · Behavioral Symptoms (98) · Mood Disorders (43) · Depressive Disorder (35) · Nervous System Diseases (25) · Pathological Conditions, Signs and Symptoms (23) · Personal Satisfaction (15) · Trauma and Stressor Related Disorders (15) · Signs and Symptoms (14) · Stress Disorders, Traumatic (14) · Bipolar and Related Disorders (12) · Neurocognitive Disorders (12) · Central Nervous System Diseases (11) · Neurologic Manifestations (10)
Transcranial Magnetic Stimulation (10) · Cognitive Behavioral Therapy (6) · Psilocybin (6) · Therapeutics (4) · Escitalopram (3) · Ketamine (3) · Transcranial Direct Current Stimulation (3) · Acceptance and Commitment Therapy (2) · Electroconvulsive Therapy (2) · Fluoxetine (2) · Antidepressive Agents (1) · Aripiprazole (1) · Behavior Therapy (1) · Blood Specimen Collection (1) · Bupropion (1)
First Affiliated Hospital of Chongqing Medical University (5) · Peking University (4) · Accexible (3) · Massachusetts General Hospital (3) · Medical University of South Carolina (3) · University of Oxford (3) · University of Pennsylvania (3) · Weill Medical College of Cornell University (3) · Centre for Addiction and Mental Health (2) · Karolinska Institutet (2) · Ludwig-Maximilians - University of Munich (2) · Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital (2) · Natalia Dewi Wardani, MD (2) · National Science and Technology Council, Taiwan (2) · Pulvinar Neuro, LLC (2)
United States (48) · China (16) · Canada (14) · United Kingdom (10) · Denmark (8) · France (7) · Germany (7) · Spain (6) · Sweden (6) · Turkey (Türkiye) (5) · Mexico (4) · Norway (4) · Belgium (3) · Hong Kong (3) · Poland (3)
Rita Bakhru, MD (2) · Ruth Benca, MD, PhD (2) · Abhishek Jaywant, PhD (1) · Adrianna Giuffre, PhD. (1) · Andre Russowsky Brunoni, MD PhD (1) · Andreas Reif, Prof. Dr. med. (1) · Anne Hilger, PhD (1) · Atta-ul Raheem R Chaudhry, B.Sc. (Hons.), M.B.B.S. (1) · Aws Al-Rubaye Lecturer, Internal Medicine (1)
PMID 23497551, PMID 24005242, PMID 25692174, PMID 31282938, PMID 26782765, PMID 30979801, PMID 33211157, PMID 34969856, PMID 35940423, PMID 37339227, PMID 37682331, PMID 38476648, PMID 38880208, PMID 10401442, PMID 10719131, PMID 12775843, PMID 12893099, PMID 15538992, PMID 18450663, PMID 18458203, PMID 19399585, PMID 20528216, PMID 20716567, PMID 22381456, PMID 24399027, PMID 25963497, PMID 26037806, PMID 26313057, PMID 27289172, PMID 27829093, PMID 27836112, PMID 27923088, PMID 28575777, PMID 29631563, PMID 30967483, PMID 31317130, PMID 31551908, PMID 32520341, PMID 33685410, PMID 33773085, PMID 33851004, PMID 33963435, PMID 33976395, PMID 34029378, PMID 34095192, PMID 34303492, PMID 35002238, PMID 35130906, PMID 35653896, PMID 35700600
2023 (3), 2025 (2), 1UG3MH137353-01 (1), K01MH130226 (1), K23DA062034 (1), K23MH137406 (1), P30DA029926 (1), P50MH119467 (1), R01HD113299 (1), R01MH132667 (1), R01TW012893 (1), R03AG088962 (1), R33MH135428 (1), R44MH119872 (1), R61MH132809 (1)