61 completed, 15 unknown, 8 not yet recruiting, 6 recruiting. 30 Not applicable, 22 Phase 4, 5 Phase 2, 2 Phase 1, 1 Phase 3.
Follow Delayed Emergence from Anesthesia: new trials by email Literature Review of Delayed Emergence from Anesthesia trials Research Report on Delayed Emergence from Anesthesia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Sugammadex Timing and Recovery Profile in Pediatric Adenotonsillectomy Neuromuscular Blockade, Delayed Emergence From Anesthesia | Not yet recruiting | Namik Kemal University | 140 | 2026-12-01 | 2026-10-28 | |
| Diaphragm Ultrasound and Neuromuscular Monitoring for Predicting Early Respiratory Events After Extubation Diaphragm ultrasonography4 - Residual Neuromuscular Blockade, Diaphragm Dysfunction | Not yet recruiting | Mustafa Duran | 100 | 2026-11-01 | 2026-11-03 | |
| Postoperative Residual Neuromuscular Block and Passive Smoke Exposure in Pediatric Dental Patients Passive Smoke Exposure - Postoperative Residual Curarization, Neuromuscular Block Prolonged | Not yet recruiting | Istanbul University - Cerrahpasa | 55 | 2026-09-01 | 2026-09-21 | |
| Comparison of NMTCuff and Standard TOF in Gynecologic Oncology Surgery (NMTCUFF-TOF) Dual Neuromuscular Transmission Monitoring - Gynecologic Cancer, Neuromuscular Blockade | Recruiting | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | 45 | 2026-09-01 | 2026-11-10 | |
| Acceleromyography Versus Electromyography for Neuromuscular Recovery Assessment at the End of Surgery Simultaneous Acceleromyography and Electromyography Monitoring - Neuromuscular Blockade, Cholecystectomy | Not yet recruiting | Clínica Dávila | 70 | 2026-08-01 | 2026-07-31 | |
| A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old Sugammadex - Curarization, Postoperative Residual | Phase 4 | Not yet recruiting | University Hospital, Caen | 99 | 2026-03-30 | 2026-03-17 |
| Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function Sugammadex, Neostigmine - Residual Neuromuscular Block | Not applicable | Recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 240 | 2025-12-30 | 2026-06-22 |
| Methylprednisolone vs Dexamethasone: Effects on Sugammadex Reversal, Pain, and Nausea in Adults Methylprednisolone (MP), Dexamethasone - Neuromuscular Block, Residual, Pain | Not applicable | Not yet recruiting | Konya City Hospital | 130 | 2025-10-01 | 2025-09-22 |
| Quantitative Versus qUAlitative NeuromoniToring of neUroMuscular Block for Non-cardiothoracic Surgery Quantitative monitoring, Qualitative monitoring - Neuromuscular Block, Residual | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 1032 | 2025-09-22 | 2025-10-10 |
| Methylprednisolone vs Dexamethasone Interaction With Sugammadex in Pediatric Patients Methyl Prednisolone (MP), Dexamethasone (0.2 mg/kg), Saline (0.9% NaCl) - Neuromuscular Block, Residual, Pain Management | Not applicable | Completed | Konya City Hospital | 60 | 2025-09-16 | 2025-12-29 |
| International Focus Group Discussion on Neuromuscular Monitoring. Focus-Group discussion - Anesthesia, Neuromuscular Blockade | Suspended | Universitair Ziekenhuis Brussel | 16 | 2025-07-01 | 2026-05-04 | |
| Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia pipecuronium bromide, Rocuronium bromide - Neuromuscular Blocking Agents, Residual Neuromuscular Block | Phase 4 | Not yet recruiting | Tamas Vegh, MD | 80 | 2025-06-26 | 2025-06-29 |
| Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Propofol Anesthesia pipecuronium bromide, Rocuronium bromide - Neuromuscular Blocking Agents, Residual Neuromuscular Block | Phase 4 | Active not recruiting | Tamas Vegh, MD | 80 | 2025-06-26 | 2025-08-07 |
| To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU. Placebo drug ( normal saline ), neostigmine (reversal agent) - Tachycardia, Hypertension | Phase 1 / Phase 2 | Completed | Ziauddin University | 100 | 2025-03-12 | 2025-07-31 |
| Diagnostic Feasibility of 100 Hz Tetanic Stimulation Polyneuropathies | Recruiting | University of Debrecen | 40 | 2025-01-06 | 2025-03-27 | |
| Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery L-thyroxine, Placebo Oral Tablet - Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia | Phase 3 | Completed | Ain Shams University | 70 | 2024-11-30 | 2025-08-17 |
| Comparison of Adductor Pollicis and Abductor Digiti Minimi Muscles (Thumb Vs. Fifth Digit) As Sites for Neuromuscular Monitoring with Electromyography Postoperative Residual Curarization, Neuromuscular Blockade | Recruiting | Tamas Vegh, MD | 46 | 2024-10-18 | 2024-11-15 | |
| Measuring of the Duration of Action of Different Doses of Rocuronium-induced Neuromuscular Block in Infants During Surgical Treatment of Craniosynostosis Sevofluorane, Propofol - Neuromuscular Blocking Agents, Residual Neuromuscular Block | Phase 4 | Enrolling by invitation | Tamas Vegh, MD | 20 | 2024-07-06 | 2025-08-05 |
| Efficacy and Safety of Sugammadex in Thoracoscopy Thymectomy for Chinese Adults With Myasthenia Gravis Sugammadex, Neostigmine - Reversal of Neuromuscular Blockade | Not applicable | Completed | Beijing Tongren Hospital | 62 | 2024-06-01 | 2025-04-02 |
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Postoperative Complications (8) · Emergence Delirium (4) · Pain, Postoperative (4) · Postoperative Nausea and Vomiting (4) · Delirium (3) · Cognitive Dysfunction (2) · Agnosia (1) · Brain Diseases (1) · Brain Injuries, Traumatic (1) · Cardiovascular Diseases (1) · Cerebral Hemorrhage (1) · Confusion (1) · Disease (1) · Euthyroid Sick Syndromes (1)
Pathologic Processes (98) · Pathological Conditions, Signs and Symptoms (98) · Postoperative Complications (90) · Signs and Symptoms (13) · Nervous System Diseases (11) · Neurologic Manifestations (10) · Mental Disorders (6) · Neurobehavioral Manifestations (6) · Neurocognitive Disorders (5) · Confusion (4) · Nausea (4) · Signs and Symptoms, Digestive (4) · Vomiting (4) · Cognition Disorders (3) · Pain (3)
Sugammadex (21) · Neostigmine (18) · Rocuronium (6) · Propofol (4) · cisatracurium (4) · Sodium Chloride (3) · Desflurane (2) · Dexamethasone (2) · Ketamine (2) · Neuromuscular Monitoring (2) · Pipecuronium (2) · Remifentanil (2) · Vecuronium Bromide (2) · Accelerometry (1) · Aging (1)
Tamas Vegh, MD (6) · Mayo Clinic (5) · Endeavor Health (4) · Seoul National University Hospital (4) · Beth Israel Deaconess Medical Center (3) · Onze Lieve Vrouw Hospital (3) · Poitiers University Hospital (3) · Technical University of Munich (3) · Ankara City Hospital Bilkent (2) · Campus Bio-Medico University (2) · Federal University of Minas Gerais (2) · Konya City Hospital (2) · Pontificia Universidade Catolica de Sao Paulo (2) · University Hospital Ulm (2) · University of Regensburg (2)
United States (25) · Hungary (9) · Turkey (Türkiye) (9) · Germany (8) · Italy (7) · Belgium (5) · France (5) · South Korea (5) · China (4) · Brazil (3) · Czechia (2) · Denmark (2) · Egypt (2) · Portugal (2) · Chile (1)
J.Ross Renew, MD (4) · Eduardo T Moro, MD (2) · Glenn S. Murphy, MD (2) · Matias Vested, MD, PhD (2) · Matthias Eikermann, MD, PhD (2) · AhYoung Oh, M.D Ph. D (1) · Alain D'Hollander, Prof (1) · Alessandra Piersanti, MD (1) · Ana Fernandez-Bustamante, M.D., Ph.D. (1) · Asma Abdus Salam, Consultant anaesthesiology (1) · Aysun Postaci (1) · Bertrand Debaene, MD phD (1)
PMID 10492412, PMID 10793602, PMID 11339776, PMID 12717123, PMID 1356374, PMID 17264722, PMID 17893459, PMID 18946293, PMID 20375901, PMID 20576632, PMID 20683334, PMID 20876699, PMID 20885293, PMID 22091288, PMID 23372884, PMID 23599531, PMID 25192270, PMID 26086278, PMID 26508869, PMID 26634077, PMID 26787792, PMID 27324403, PMID 27463265, PMID 28044330, PMID 28399799, PMID 28778151, PMID 28891911, PMID 29229252, PMID 29261883, PMID 29744239, PMID 29756064, PMID 29904285, PMID 30032875, PMID 30140502, PMID 30219643, PMID 30400850, PMID 30573962, PMID 30584640, PMID 30875518, PMID 31094777, PMID 31124838, PMID 31421671, PMID 31744470, PMID 31882015, PMID 31915045, PMID 31977627, PMID 32213163, PMID 32532654, PMID 32536445, PMID 32800503
2019 (1), 2023 (1), 2025 (1), R01AG046634 (1), R21AG050850 (1)