16 completed, 2 unknown, 1 recruiting. 4 Not applicable, 4 Phase 2, 3 Phase 3, 2 Phase 1, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 3, Unknown 1 |
| Phase 2 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 3 |
| Phase 1 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
Follow Euthyroid Sick Syndromes: new trials by email Literature Review of Euthyroid Sick Syndromes trials Research Report on Euthyroid Sick Syndromes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Factors Influencing Outcomes in ECMO and Impella Patients: Metabolic and Thyroid Hormone Dynamics Cardiogenic Shock, Euthyroid Sick Syndrome | Recruiting | Gottsegen National Cardiovascular Institute | 160 | 2026-08-17 | 2026-10-21 | |
| Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery L-thyroxine, Placebo Oral Tablet - Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia | Phase 3 | Completed | Ain Shams University | 70 | 2024-11-30 | 2025-08-17 |
| Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral Hemorrhage Euthyrox - Intracerebral Hemorrhage, Low T3 Syndrome | Not applicable | Unknown | Peking Union Medical College Hospital | 100 | 2023-10-11 | 2024-04-09 |
| Thyroid Hormone Supplementation in Patients With Septic Shock triiodothyronine - Euthyroid Sick Syndromes, Septic Shock | Phase 2 | Completed | Cantonal Hospital Zenica | 108 | 2022-05-01 | 2023-09-28 |
| Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome Euthyroid Sick Syndrome, Obesity Hypoventilation Syndrome (OHS) | Completed | Mansoura University | 49 | 2021-09-01 | 2025-05-21 | |
| The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course. COVID-19, Low Triiodothyronine Syndrome | Completed | Medical University of Gdansk | 180 | 2021-01-26 | 2022-02-24 | |
| Developing Oral LT3 Therapy for Heart Failure - HFpEF liothyronine, Placebo - Heart Failure With Preserved Ejection Fraction, Low Triiodothyronine Syndrome | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 28 | 2020-03-08 | 2025-01-08 |
| Developing Oral LT3 Therapy for Heart Failure - HFrEF Liothyronine, Placebo - Heart Failure With Reduced Ejection Fraction (HFrEF), Low T3 Syndrome | Phase 1 / Phase 2 | Completed | University of Pennsylvania | 28 | 2020-02-11 | 2024-12-24 |
| Feeding the Critically Ill During Phases of Altered Redox Status Jevity 1.5 - Acute Respiratory Distress Syndrome, Oxidative Stress | Not applicable | Completed | University of Illinois at Chicago | 35 | 2017-03-15 | 2019-04-16 |
| Hormone Deficiency in Heart Failure With Preserved Ejection Fraction Heart Failure, Hormone Deficiencies | Completed | Federico II University | 35 | 2015-01-01 | 2016-11-29 | |
| An Analysis of the Relative Risk for Low Triiodothyronine Syndrome in Patients With Chronic Radiation Enteritis Thyroid function tests - The Clinical Incidence of Low Triiodothyronine Syndrome | Completed | Shengxian Fan | 48 | 2014-01-01 | 2015-05-22 | |
| Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia Oral triiodothyronine, Placebo - Postoperative; Dysfunction Following Cardiac Surgery | Phase 3 | Completed | National Cardiovascular Center Harapan Kita Hospital Indonesia | 177 | 2013-07-01 | 2016-02-17 |
| Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia Tetronine, Placebo - Postoperative; Dysfunction Following Cardiac Surgery | Phase 3 | Completed | National Cardiovascular Center Harapan Kita Hospital Indonesia | 224 | 2013-06-01 | 2016-02-17 |
| Levothyroxine for Children With Euthyroid Sick Syndrome Levothyroxine, Calcium magnesia - Euthyroid Sick Syndrome | Phase 4 | Completed | Sinaloa Pediatric Hospital | 80 | 2012-01-01 | 2014-03-05 |
| Effects of N-acetylcysteine on Low T3 Syndrome N-acetylcysteine - Acute Myocardial Infarction, Euthyroid Sick Syndrome | Phase 4 | Completed | Federal University of Rio Grande do Sul | 83 | 2011-11-01 | 2015-03-31 |
| Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) Liothyronine - Heart Failure, Low T3 Syndrome | Not applicable | Completed | Jens Faber | 21 | 2011-07-01 | 2019-07-16 |
| Peri-operative Oral Triiodothyronine Replacement Therapy to Decrease the Risk of Transient Atrial Fibrillation After Off-pump Coronary Artery Bypass Surgery liothyronine sodium, placebo - Non-thyroidal Illness Syndrome | Not applicable | Completed | Yonsei University | 100 | 2010-06-01 | 2012-07-24 |
| Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? Oral T3 Low dose, Placebo, Oral T3 high dose - Low T3 Syndrome | Phase 2 | Completed | National Cardiovascular Center Harapan Kita Hospital Indonesia | 45 | 2010-04-01 | 2013-03-08 |
| Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome | Unknown | Ruhr University of Bochum | 590 | 2007-05-01 | 2020-11-19 |
Heart Failure (4) · Critical Illness (2) · Heart Defects, Congenital (2) · Adrenal Insufficiency (1) · COVID-19 (1) · Cerebral Hemorrhage (1) · Delayed Emergence from Anesthesia (1) · Dwarfism, Pituitary (1) · Hyperthyroidism (1) · Hypothyroidism (1) · Myocardial Ischemia (1) · Obesity Hypoventilation Syndrome (1) · Pituitary Diseases (1) · Respiratory Distress Syndrome (1)
Endocrine System Diseases (19) · Thyroid Diseases (18) · Cardiovascular Diseases (9) · Heart Diseases (8) · Pathologic Processes (6) · Pathological Conditions, Signs and Symptoms (6) · Nervous System Diseases (4) · Brain Diseases (3) · Central Nervous System Diseases (3) · Respiratory Tract Diseases (3) · Shock (3) · Vascular Diseases (3) · Cardiovascular Abnormalities (2) · Congenital Abnormalities (2) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2)
Triiodothyronine (8) · Thyroxine (3) · Acetylcysteine (1)
National Cardiovascular Center Harapan Kita Hospital Indonesia (3) · University of Pennsylvania (2) · Ain Shams University (1) · Cantonal Hospital Zenica (1) · Federal University of Rio Grande do Sul (1) · Federico II University (1) · Gottsegen National Cardiovascular Institute (1) · Jens Faber (1) · Mansoura University (1) · Medical University of Gdansk (1) · Peking Union Medical College Hospital (1) · Ruhr University of Bochum (1) · Shengxian Fan (1) · Sinaloa Pediatric Hospital (1) · University of Illinois at Chicago (1)
Indonesia (3) · United States (3) · Egypt (2) · Bosnia and Herzegovina (1) · Brazil (1) · China (1) · Denmark (1) · Germany (1) · Hungary (1) · Italy (1) · Mexico (1) · Poland (1) · South Korea (1)
Anne R Cappola, MD,ScM (2) · Eva M Marwali, MD (2) · Alan Diamond, PhD (1) · Antonio Bianco, MD, PhD (1) · Antonio Cittadini, Professor (1) · Carol A Braunschweig, PhD (1) · Eva M Marwali, MD, PhD (1) · H H Klein, M.D. (1) · Jens Faber, MDSci (1) · Jesus J Martinez, MD (1) · Johannes W Dietrich, M.D. (1) · Josi Vidart (1) · Liam B McKeever, MS, PhD(c) (1)
PMID 20837917, PMID 25148231, PMID 31581295, PMID 31995239, PMID 33179374, PMID 34851445, PMID 38061681
R61HL146390 (2)