11 completed, 4 unknown, 1 not yet recruiting, 1 recruiting. 10 Phase 4, 2 Not applicable, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 10 | Completed 6, Unknown 4 |
| Not applicable | 2 | Completed 1, Recruiting 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 3 | 2 | Completed 2 |
Follow Vecuronium Bromide: new trials by email Literature Review of Vecuronium Bromide trials Research Report on Vecuronium Bromide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg) - Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery | Phase 2 | Not yet recruiting | Amckaus PTY LTD. | 64 | 2026-08-01 | 2026-05-19 |
| Effect of Opioid-Free vs Opioid-Based Anesthesia on Postoperative Pain and Emergence Agitation in Children Undergoing Cleft Surgery Ketamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg - Cleft Lip Palate, Orofacial Cleft | Not applicable | Recruiting | Iva Smiljanić | 90 | 2024-05-16 | 2026-04-29 |
| Platform Adaptive Embedded Trial for Acute Respiratory Distress Syndrome protective ventilation, prone position ventilation, glucocorticoid therapy - Acute Respiratory Distress Syndrome | Phase 4 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 1000 | 2022-10-01 | 2022-12-21 |
| Efficacy and Safety of Sugammadex Dosed According to Actual Body Weight (ABW) or Ideal Body Weight (IBW) in Reversal of Neuromuscular Blockade (NMB) in Morbidly Obese Participants (MK-8616-146) Sugammadex 2 mg/kg ABW, Sugammadex 2 mg/kg IBW, Sugammadex 4 mg/kg ABW - Neuromuscular Blockade | Phase 4 | Completed | Merck Sharp & Dohme LLC | 207 | 2018-01-01 | 2021-01-28 |
| Safety of Sugammadex for the Reversal of Neuromuscular Blockade in American Society of Anesthesiologists (ASA) Class 3 or 4 Participants (MK-8616-145) Sugammadex 2 mg/kg, Sugammadex 4 mg/kg, Sugammadex 16 mg/kg - Reversal of Neuromuscular Blockade | Phase 4 | Completed | Merck Sharp & Dohme LLC | 344 | 2017-12-20 | 2020-10-08 |
| Evaluation of Atracurium-vecuronium Combination in Laparosocpic Surgery Vecuronium, Atracurium, Vecuronium + Atracurium - Patients Undergoing Laparoscopic Surgery | Phase 4 | Unknown | Sir Ganga Ram Hospital | 48 | 2017-12-20 | 2017-12-14 |
| Does Deep Neuromuscular Blockade Improve Operating Conditions During Total Hip Replacements? Vecuronium 0.1 mg/kg, Vecuronium 0.2mg/kg - Arthropathy of Hip | Phase 4 | Completed | Craig Curry | 116 | 2017-05-01 | 2019-09-18 |
| Opioid-Free Shoulder Arthroplasty Gabapentin, Celecoxib, toradol - Opioid Use, Shoulder Osteoarthritis | Phase 4 | Completed | OrthoCarolina Research Institute, Inc. | 86 | 2016-09-01 | 2020-10-14 |
| Intraoperative Lidocaine Infusion vs. Esmolol Infusion for Postoperative Analgesia in Laparoscopic Cholecystectomy Lidocaine, Esmolol, Paracetamol - Gall Stone Disease | Phase 4 | Completed | B.P. Koirala Institute of Health Sciences | 90 | 2015-01-01 | 2018-11-30 |
| Mask Ventilation Before and After Neuromuscular Blockade Rocuronium, Vecuronium Bromide, Succinylcholine - Anesthesia | Phase 4 | Completed | University of Washington | 210 | 2014-08-01 | 2015-04-09 |
| Effects of Dexmedetomidine on Postoperative Cognitive Dysfunction During One-lung Ventilation in Elder Patients Induction of anesthesia,midazolam ,sufentanil,etomidate and rocuronium, Dexmedetomidine, Normal saline - Postoperative Confusion | Phase 4 | Unknown | Tang-Du Hospital | 120 | 2014-07-01 | 2014-07-11 |
| The Effect of TEAS on the Quality of Early Recovery TEAS, Con, propofol, remifentanil, vecuronium - C.Delivery; Surgery (Previous), Gynecological, Inappropriate Device Stimulation of Tissue | Not applicable | Completed | Guizhou Provincial People's Hospital | 60 | 2013-11-01 | 2015-12-02 |
| A Study of Residual Curarization Incidence in China Vecuronium Bromide, Rocuronium, Cisatracurium - Perioperative/Postoperative Complications, PORC (Postoperative Residual Curarization) | Phase 4 | Unknown | Peking University First Hospital | 6090 | 2012-10-01 | 2013-05-24 |
| Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care: - Adenovirus, Anesthesia | Completed | Daniel Benjamin | 3520 | 2011-11-01 | 2023-09-06 | |
| Comparison of Sugammadex (MK-8616/Org 25969) With Neostigmine Administered at 1-2 Post-tetanic Counts (PTCs) After Administration of Rocuronium or Vecuronium (19.4.302/P05945/MK-8616-025) sugammadex, neostigmine, vecuronium - Anesthesia, General | Phase 3 | Completed | Merck Sharp & Dohme LLC | 182 | 2005-11-28 | 2019-03-19 |
| A Bridging Trial Comparing Sugammadex (Org 25969) at Reappearance of T2 in Japanese and Caucasian Participants. Part B: Caucasian Participants (P05971) Sugammadex, Placebo, Rocuronium - Anesthesia, General | Phase 2 | Completed | Merck Sharp & Dohme LLC | 100 | 2005-09-20 | 2019-11-25 |
| Comparative Study of Rocuronium With Vecuronium (Study 71101)(COMPLETED) Rocuronium 0.6 mg/kg intubating dose, Rocuronium 0.9 mg/kg intubating dose, Rocuronium 0.1 mg/kg maintenance dose - Anesthesia | Phase 3 | Completed | Merck Sharp & Dohme LLC | 90 | 2003-02-01 | 2015-04-17 |
Arrhythmias, Cardiac (2) · Bradycardia (2) · Delayed Emergence from Anesthesia (2) · Adenoviridae Infections (1) · Agnosia (1) · Anxiety Disorders (1) · Arthritis (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Central Nervous System Infections (1) · Cytomegalovirus Retinitis (1) · Emergence Delirium (1) · Endocarditis (1) · Epilepsy (1) · Headache (1)
Merck Sharp & Dohme LLC (5) · Amckaus PTY LTD. (1) · B.P. Koirala Institute of Health Sciences (1) · Craig Curry (1) · Daniel Benjamin (1) · Guizhou Provincial People's Hospital (1) · Iva Smiljanić (1) · OrthoCarolina Research Institute, Inc. (1) · Peking University First Hospital (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Sir Ganga Ram Hospital (1) · Tang-Du Hospital (1) · University of Washington (1)
United States (6) · Austria (2) · China (2) · Denmark (2) · Germany (2) · Belgium (1) · Canada (1) · Croatia (1) · India (1) · Israel (1) · Nepal (1) · Singapore (1) · United Kingdom (1)
Aaron M Joffe, DO (1) · Amitabh Dutta, MD,PGDHR (1) · Asish Subedi, MD (1) · Chi Hornik, PharmD (1) · Craig Curry, MD (1) · Iva Smiljanic, MD, MSc (1) · Savitar Malhotra, MD (1) · Subhash Gupta, MD (1) · Xinmin Wu, Doctor (1) · Zhaocai Zhang, Doctor (1)
PMID 18946293, PMID 20809967, PMID 20876699, PMID 24614374, PMID 24949994, PMID 26039810, PMID 26444853, PMID 26926644, PMID 27522443, PMID 28137820, PMID 28290120, PMID 28779462, PMID 29084742, PMID 29271816, PMID 29435949, PMID 29677389, PMID 30790601, PMID 31317556, PMID 31548185, PMID 31684867, PMID 31814149, PMID 31915045, PMID 32324313, PMID 32497307, PMID 33029806, PMID 33639839, PMID 33903114, PMID 34302290, PMID 34711192, PMID 35370711, PMID 35491971, PMID 41247430
2017 (2), 2005 (1)