35 completed, 14 unknown, 5 not yet recruiting, 3 recruiting. 26 Not applicable, 22 Phase 4, 9 Phase 2, 7 Phase 3, 3 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Berberine on Cardiometabolic Outcomes Berberine, Placebo - Cardiometabolic Syndrome | Not applicable | Not yet recruiting | University of Central Lancashire | 40 | 2026-07-01 | 2026-04-21 |
| Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort Berberine, Bifidobacterium longum, Bifidobacterium longum and Berberine - Intestinal Discomfort, Abdominal Pain/ Discomfort | Not applicable | Recruiting | Université Catholique de Louvain | 140 | 2026-03-16 | 2026-05-06 |
| Berberine Supplementation, Sprint Interval Training, and Immune Function Study Berberine, Placebo, Sprint Interval Training - Berberine, Sprint Training | Not applicable | Completed | University of Northern Colorado | 40 | 2026-01-01 | 2026-06-05 |
| Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes Metformin, Berberine - Diabetes Mellitis | Not applicable | Not yet recruiting | S.LAB (SOLOWAYS) | 60 | 2025-07-01 | 2025-04-20 |
| Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota. Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine - HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome | Phase 4 | Recruiting | Nanjing First Hospital, Nanjing Medical University | 120 | 2025-04-17 | 2026-04-13 |
| A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects. Akkermansia muciniphila, Berberine, Placebo - Prediabetes | Not applicable | Completed | Yu Chen | 110 | 2025-03-12 | 2025-12-22 |
| Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication Berberine, Vonoprazan, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 558 | 2024-09-20 | 2025-07-03 |
| Effect of Gamma-cyclodextrin on the Bioavailability of Berberine Berberine incorporated in gamma cyclodextrin, Berberine - Drug Absorption | Phase 1 | Not yet recruiting | EuroPharma, Inc. | 16 | 2024-09-01 | 2023-09-14 |
| Study on the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine Berberine, Placebo - Hyperlipidemia | Phase 2 / Phase 3 | Enrolling by invitation | The University of Hong Kong | 100 | 2024-08-01 | 2025-01-20 |
| A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 Polymorphisms Berberine - Diabetes Mellitus | Not applicable | Completed | S.LAB (SOLOWAYS) | 40 | 2024-05-03 | 2025-03-07 |
| Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori. esomeprazole, Bismuth, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Unknown | Xijing Hospital of Digestive Diseases | 548 | 2023-11-20 | 2024-09-19 |
| Effects of Berberine on Preventing Cardiovascular Disease and Diabetes Mellitus Berberine plus lifestyle intervention, Placebo plus lifestyle intervention - PreDiabetes, Abdominal Obesity | Phase 4 | Active not recruiting | China National Center for Cardiovascular Diseases | 2024 | 2023-10-31 | 2025-12-31 |
| Berberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms Berberine - Schizophrenia, Negative Symptoms of Schizophrenia | Not applicable | Enrolling by invitation | Tianjin Anding Hospital | 120 | 2023-09-26 | 2026-09-21 |
| Berberine Improving Cognitive Impairments in Schizophrenia Berberine - Schizophrenia Therapeutics | Not applicable | Completed | Tianjin Anding Hospital | 124 | 2023-07-21 | 2026-06-30 |
| Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals with Obesity and NAFLD Berberine plus lifestyle intervention, Placebo plus lifestyle intervention - Obesity, Obesity, Abdominal | Phase 4 | Completed | China National Center for Cardiovascular Diseases | 337 | 2023-07-06 | 2025-01-29 |
| Sex Differences in Berberine Pharmacokinetics Berberine - Pharmacokinetic Study in Healthy Volunteers | Not applicable | Completed | University Medicine Greifswald | 30 | 2023-05-05 | 2024-12-20 |
| Treatment Benefits of Berberine Supplementation for Women With PCOS Berberine - Polycystic Ovary Syndrome | Not applicable | Completed | Ayub Teaching Hospital | 120 | 2022-11-01 | 2023-05-18 |
| Effect of Probiotics or Berberine in Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL. Probiotic, Berberine, Placebo - Non Alcoholic Fatty Liver, Obesity | Not applicable | Unknown | Poznan University of Medical Sciences | 140 | 2022-08-02 | 2022-08-31 |
| Impact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy Volunteers Berberine - Pharmacokinetic Study in Healthy Volunteers | Not applicable | Completed | University Medicine Greifswald | 42 | 2022-07-19 | 2024-12-24 |
| Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA Berberine, Inulin, Berberine placebo tablets - Type 1 Diabetes Mellitus, Autoimmune Diabetes | Phase 4 | Not yet recruiting | Second Xiangya Hospital of Central South University | 240 | 2022-05-01 | 2022-02-25 |
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Metabolic Syndrome (12) · Schizophrenia (7) · Dyslipidemias (5) · Non-alcoholic Fatty Liver Disease (5) · Obesity (5) · Diabetes Mellitus (4) · Polycystic Ovary Syndrome (4) · Diabetes Mellitus, Type 2 (3) · Dyspepsia (3) · Gastritis (3) · Prediabetic State (3) · Coronary Artery Disease (2) · Glucose Intolerance (2) · Hyperglycemia (2) · Obesity, Abdominal (2)
Xijing Hospital of Digestive Diseases (8) · Tianjin Anding Hospital (6) · The University of Hong Kong (3) · China National Center for Cardiovascular Diseases (2) · Heilongjiang University of Chinese Medicine (2) · Nanjing First Hospital, Nanjing Medical University (2) · Peking Union Medical College Hospital (2) · S.LAB (SOLOWAYS) (2) · Shanghai Jiao Tong University School of Medicine (2) · University Medicine Greifswald (2) · University of Guadalajara (2) · Ayub Teaching Hospital (1) · Azienda di Servizi alla Persona di Pavia (1) · Carmel Biosciences (1) · Chinese Medical Association (1)
China (32) · United States (5) · Italy (4) · Hong Kong (3) · Germany (2) · Mexico (2) · Russia (2) · Armenia (1) · Belgium (1) · Canada (1) · Iran (1) · Pakistan (1) · Poland (1) · Sweden (1)
Haibo Zhang, MD (2) · Jing Li, PhD (2) · Lihui Hou, MD. (2) · Stefan Engeli, Prof. (2) · Xiaoke Wu, MD.PhD. (2) · Yongquan Shi, Ph. D (2) · Aghavni Ginosyan, PhD, MD (1) · Alexander G Panossian, PhD (1) · Areg Hovhannisyan, PhD (1) · Bruno Trimarco, MD (1) · Chad Kerksick, PhD (1) · Cheng Huang, MD. (1) · Gary P Wang, MD PhD, FIDSA (1) · James Backes, PharmD (1)
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