25 completed, 10 unknown, 2 not yet recruiting, 2 recruiting. 23 Phase 4, 12 Not applicable, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 23 | Completed 17, Unknown 4, Recruiting 2 |
| Not applicable | 12 | Completed 5, Unknown 4, Terminated 2, Not yet recruiting 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 3 | 1 | Completed 1 |
Follow Bismuth: new trials by email Literature Review of Bismuth trials Research Report on Bismuth
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy And Safety of Bismuth-Tetracycline-Rabeprazole Triple For First-Line Eradication of Helicobacter Pylori Infection Bismuth, Bismuth quadruple therapy - Helicobatcer Pylori, First-Line Eradication | Not applicable | Not yet recruiting | Chih-An Shih, MD | 300 | 2026-09-01 | 2026-08-26 |
| Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment Bismuth, Esomeprazole, Tetracycline - Gastritis, Dyspepsia | Phase 4 | Recruiting | Yongquan Shi | 1248 | 2025-10-28 | 2025-12-02 |
| Tegoprazan-Based Therapies for H. Pylori Eradication: A Randomized Controlled Trial Tegoprazan, Amoxicillin, Tetracycline - Helicobacter Pylori Eradication, Adverse Reaction | Not applicable | Completed | Zhongshan Hospital (Xiamen), Fudan University | 640 | 2025-06-10 | 2026-05-19 |
| Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial Vonoprazan, Tetracycline 500mg tid, Minocycline - Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer | Phase 4 | Recruiting | Yongquan Shi | 400 | 2025-04-01 | 2025-08-14 |
| Efficacy of a 14-Day Bismuth-Containing Quadruple Therapy Guided by Drug Susceptibility Testing in Patients with Extremely Refractory Helicobacter Pylori Infection: an Exploratory Study Bismuth, Vonoprazan, Amoxicillin - HELICOBACTER PYLORI INFECTIONS | Not yet recruiting | Xiuli Zuo | 30 | 2025-01-01 | 2024-12-19 | |
| Triple Versus Quadruple Therapy for the Eradication of Helicobacter Pylori Vonoprazan-Amoxicillin-Tetracycline-Bismuth quadruple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 14 days, Vonoprazan-Amoxicillin-Tetracycline triple regimen for 7 days - Helicobacter Pylori Infection | Not applicable | Unknown | Shandong University | 375 | 2024-11-27 | 2024-12-03 |
| Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line Eradication Berberine, Vonoprazan, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 558 | 2024-09-20 | 2025-07-03 |
| Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori. esomeprazole, Bismuth, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Unknown | Xijing Hospital of Digestive Diseases | 548 | 2023-11-20 | 2024-09-19 |
| Efficacy of 7-day Versus 14-day Bismuth Quadruple Therapy for the Eradication of Helicobacter Pylori（SHARE2302) 7days bismuth quadruple, 14 days bismuth quadruple - Helicobacter Pylori Infection | Not applicable | Unknown | Shandong University | 254 | 2023-09-02 | 2024-01-11 |
| Helicobacter Rescue Therapy With Vonorazon and Amoxicillin Dual Therapy Versus Bismuth-containing Quadruple Therapy Vonoprazan, amoxicillin, Bismuth - Gastritis Dyspepsia Helicobacter Pylori Infection Gastric Cancer Peptic Ulcer | Phase 4 | Completed | Yongquan Shi | 688 | 2023-06-06 | 2025-07-03 |
| Efficacy and Safety of Rifasutenizol (TNP 2198), Rabeprazole and Amoxicillin in Participants With H. Pylori Infection Rifasutenizol capsules, Rabeprazole sodium enteric-coated tablets, Amoxicillin Capsules - H.Pylori Infection | Phase 3 | Completed | TenNor Therapeutics (Suzhou) Limited | 700 | 2023-05-18 | 2025-08-17 |
| Drug Interaction Study Between Tegoprazan, Bismuth, Amoxicillin and Clarithromycin Tegoprazan, Bismuth, Amoxicilli - Healthy | Phase 1 | Completed | Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. | 22 | 2023-03-23 | 2023-06-23 |
| Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies. Tetracycline 500mg tid, Tetracycline 500mg qid - Helicobacter Pylori Infection | Phase 4 | Unknown | Shandong University | 260 | 2023-03-12 | 2023-04-07 |
| Effects of High-dose Dual Therapy and Bismuth Quadruple Therapy for Helicobacter Pylori Eradication on Intestinal Microecology Esomeprazole, Amoxicillin, Bismuth - Gastritis, Dyspepsia | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 124 | 2022-12-01 | 2025-07-03 |
| The Effect of Time Intervals for Rescue Treatment on Eradication Effect of Helicobacter Pylori Infection Amoxicillin + Tetracycline + Bismuth + Esomeprazole, Amoxicillin + Tetracycline + Bismuth + Vonoprazan, Amoxicillin + Tetracycline + Bismuth + Tegoprazan - Helicobacter Pylori Infection | Unknown | Shandong University | 626 | 2022-11-11 | 2022-11-17 | |
| Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies. Tetracyclin - Helicobacter Pylori Infection | Phase 4 | Unknown | Shandong University | 407 | 2022-06-25 | 2023-01-31 |
| Helicobacter Pylori Eradication Therapy in Portugal H. pylori eradication scheme A, H. pylori eradication scheme B, H. pylori eradication scheme C - Helicobacter Pylori, Gut Microbiota | Not applicable | Unknown | Unidade Local de Saúde de Coimbra, EPE | 230 | 2022-05-01 | 2022-07-08 |
| Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line Eradication Berberine, Vonoprazan, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 300 | 2021-12-01 | 2023-01-31 |
| Efficacy and Safety Study of Egg Yolk Antibody in Adjuvant Treatment of Helicobacter Pylori Infection Yolk antibody and IIaprazole, Amoxicillin/ Clarithromycin/Furazolidone, Doxycycline, Bismuth, IIaprazole, Amoxicillin/Clarithromycin/Furazolidone, Doxycycline, Bismuth, Yolk antibody and IIaprazole, Amoxicillin/ Clarithromycin/Furazolidone, Doxycycline - Helicobacter Pylori Infection | Not applicable | Unknown | The Third Xiangya Hospital of Central South University | 100 | 2021-04-06 | 2022-12-09 |
| Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple Therapy Berberine, Amoxicillin, Rabeprazole - Dyspepsia, Chronic Gastritis | Phase 4 | Completed | Xijing Hospital of Digestive Diseases | 524 | 2021-01-07 | 2023-01-31 |
Showing 20 of 41. Sign in to see all of them.
Peptic Ulcer (10) · Dyspepsia (9) · Gastritis (8) · Stomach Neoplasms (6) · Colitis (1) · Colitis, Microscopic (1) · Diarrhea (1) · Helicobacter Infections (1) · Hematologic Diseases (1) · Hematologic Neoplasms (1) · Leukemia (1) · Lymphoma (1) · Multiple Myeloma (1) · Neoplasms (1) · Neoplasms, Plasma Cell (1)
Xijing Hospital of Digestive Diseases (10) · Shandong University (5) · Shanghai Jiao Tong University School of Medicine (5) · National Taiwan University Hospital (3) · Yongquan Shi (3) · Asan Medical Center (1) · Chih-An Shih, MD (1) · Copenhagen University Hospital at Herlev (1) · HK inno.N Corporation (1) · Kaohsiung Veterans General Hospital. (1) · Norwegian University of Science and Technology (1) · Seoul National University Bundang Hospital (1) · Shandong Luoxin Pharmaceutical Group Stock Co., Ltd. (1) · Sihuan Pharmaceutical Holdings Group Ltd. (1) · TenNor Therapeutics (Suzhou) Limited (1)
China (28) · Taiwan (5) · South Korea (3) · Denmark (1) · Italy (1) · Norway (1) · Portugal (1)
Yongquan Shi, Ph. D (4) · Hong Lu, M.D. (3) · Yanqing Li, Ph.D (2) · Chih-An Shih, Doctor of Medicine (1) · Elisa Gravito-Soares, MD (1) · Hong Lu (1) · Hwoon-Yong Jung, M.D (1) · Jyh-Chin Yang, M.D.Ph.D. (1) · Jyh-Ming Liou, MD, PhD (1) · Min-Gul Kim, MD (1) · Per B Hansen, MD (1) · Per G Farup, PhD (1) · Ping-I Hsu (1)
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