120 completed. 120 Phase 2, 27 Phase 1, 15 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 120 | Completed 120 |
| Phase 1 | 27 | Completed 27 |
| Phase 3 | 15 | Completed 15 |
Follow Craniocerebral Trauma: new trials by email Literature Review of Craniocerebral Trauma trials Research Report on Craniocerebral Trauma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BCAAs in Concussion 2.0 BCAA, Placebo - Concussion, Brain, Concussion, Mild | Phase 2 | Completed | Akiva Cohen | 17 | 2025-04-01 | 2026-09-03 |
| Cannabinoids and Traumatic Brain Injury: A Randomized, Placebo Controlled Trial Cannabidiol, Placebo - Brain Injuries, Traumatic | Phase 2 | Completed | University of Colorado, Denver | 43 | 2023-04-11 | 2025-12-17 |
| Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin melatonin, placebo - Traumatic Brain Injury, Critical Illness | Phase 2 | Completed | Oregon Health and Science University | 21 | 2023-01-02 | 2025-08-20 |
| Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms Hyperbaric oxygen at 1.5 ATA, Sham treatment - Persistent Post-concussive Syndrome, Concussion Post Syndrome | Phase 2 | Completed | Essentia Health | 20 | 2022-06-28 | 2026-10-15 |
| The Role of OmniLenz® in the Treatment of Small Corneal Perforations Secondary to Exposure Keratitis in ICU Patients OmniLenz® - Corneal Perforation, Exposure Keratitis | Phase 2 / Phase 3 | Completed | Farwaniya Hospital | 5 | 2022-04-10 | 2024-08-06 |
| Cold-stored Platelet Early Intervention in TBI Cold Stored Platelets, Standard Care - Traumatic Brain Injury | Phase 2 | Completed | Jason Sperry | 100 | 2022-03-21 | 2025-05-11 |
| Outcomes of Autologous Bone Marrow-derived Mononuclear Cell Transplantation in the Management of Neurological Sequelae autologous bone marrow-derived mononuclear cell transplantation, Rehabilitation therapy - Sequelae of Injuries of Head | Phase 1 / Phase 2 | Completed | Vinmec Research Institute of Stem Cell and Gene Technology | 50 | 2021-04-01 | 2024-10-01 |
| Ghrelin (OXE--103) for Acute Concussion Management Ghrelin (OXE-103), Placebo - Concussion, Brain, Traumatic Brain Injury | Phase 2 | Completed | Michael Rippee | 23 | 2020-10-20 | 2024-05-21 |
| A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy HB-adMSCs - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Hope Biosciences LLC | 24 | 2020-01-01 | 2026-01-15 |
| Prospective Analysis of the Use of N-Acetylcysteine and Vitamins in the Treatment of TBI in Geriatric Patients N-Acetyl cysteine - Traumatic Brain Injury | Phase 2 | Completed | HonorHealth Research Institute | 92 | 2019-09-01 | 2026-05-01 |
| RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD) Reconsolidation of Traumatic Memories (RTM), Prolonged Exposure (PE) - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 / Phase 3 | Completed | Uniformed Services University of the Health Sciences | 94 | 2019-06-12 | 2025-07-15 |
| Evaluation the Effects of French Maritime Pine Bark Extract on the Clinical Status in Traumatic Brain Injury Patients Dietary Supplement (OLIGOPIN), Placebo - Traumatic Brain Injury | Phase 1 / Phase 2 | Completed | Mashhad University of Medical Sciences | 67 | 2019-04-14 | 2020-05-21 |
| Efficacy and Tolerability of Erenumab in the Prophylactic Treatment of Persistent Post-Traumatic Headache AMG 334 - Post-Traumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Completed | Danish Headache Center | 100 | 2019-04-05 | 2020-02-10 |
| Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study Tranexamic Acid, Placebo - Brain Injuries, Wounds and Injuries | Phase 2 | Completed | Daniel Nishijima, MD, MAS | 31 | 2019-03-04 | 2021-09-05 |
| Magnesium Sulphate Versus Fentanyl Sedation During Burr-hole Surgery Magnesium Sulphate, Fentanyl, Propofol - Monitored Anesthesia Care | Phase 2 | Completed | Kasr El Aini Hospital | 32 | 2019-03-01 | 2021-04-13 |
| 3MDR to Treat PTSD With mTBI (3MDR) Motion-assisted, Multi-modular Memory Desensitization and Reconsolidation (3MDR) Therapy - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 | Completed | Walter Reed National Military Medical Center | 20 | 2019-01-11 | 2025-07-18 |
| Effects of Peer Mentoring on Caregivers of Patients With Acquired Brain Injury one-to-one peer mentoring - Acquired Brain Injury, Family Members | Phase 2 | Completed | Shepherd Center, Atlanta GA | 41 | 2019-01-08 | 2021-04-20 |
| Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury Bromocriptine 5 MG, Acetaminophen 650 MG - Subarachnoid Hemorrhage, Subdural Hematoma | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 47 | 2018-11-30 | 2021-06-24 |
| Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) Temozolomide - Gastrointestinal Stromal Tumors, Sdh | Phase 2 | Completed | Adam Burgoyne, MD, PhD | 23 | 2018-09-12 | 2026-07-28 |
| Magnesium Sulphate Versus Fentanyl for Conscious Sedation in CSDH Magnesium sulphate, Fentanyl, Propofol - Conscious Sedation | Phase 2 | Completed | Kasr El Aini Hospital | 34 | 2018-04-10 | 2018-12-04 |
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Brain Injuries, Traumatic (68) · Brain Injuries (33) · Brain Concussion (10) · Stroke (10) · Post-Concussion Syndrome (9) · Post-Traumatic Headache (5) · Stress Disorders, Post-Traumatic (5) · Wounds and Injuries (5) · Cerebral Palsy (4) · Headache (4) · Chronic Traumatic Encephalopathy (3) · Consciousness Disorders (3) · Corneal Injuries (3) · Hematoma, Subdural, Chronic (3)
Nervous System Diseases (120) · Trauma, Nervous System (117) · Wounds and Injuries (115) · Brain Diseases (108) · Central Nervous System Diseases (107) · Brain Injuries (68) · Pathological Conditions, Signs and Symptoms (47) · Signs and Symptoms (32) · Cardiovascular Diseases (23) · Neurologic Manifestations (22) · Pathologic Processes (22) · Vascular Diseases (22) · Cerebrovascular Disorders (21) · Mental Disorders (19)
Sodium Chloride (6) · Hyperbaric Oxygenation (5) · Acetylcysteine (4) · Saline Solution (4) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3) · Propofol (3) · Acetaminophen (2) · Fentanyl (2) · Magnesium Sulfate (2) · Magnetic Resonance Spectroscopy (2) · Melatonin (2) · Methylphenidate (2) · Oxyhemoglobins (2) · Rosuvastatin Calcium (2) · Sertraline (2)
University of Washington (4) · National Institutes of Health Clinical Center (CC) (3) · The University of Texas Health Science Center, Houston (3) · University of Pennsylvania (3) · Avid Radiopharmaceuticals (2) · Kasr El Aini Hospital (2) · Neuren Pharmaceuticals Limited (2) · U.S. Army Medical Research and Development Command (2) · Uniformed Services University of the Health Sciences (2) · Universidad Autonoma de San Luis Potosí (2) · University of British Columbia (2) · University of Calgary (2) · University of California, San Francisco (2) · University of Magdeburg (2) · University of Pittsburgh (2)
United States (77) · Canada (8) · United Kingdom (5) · Germany (4) · Denmark (3) · France (3) · Iran (3) · Australia (2) · Belgium (2) · Brazil (2) · China (2) · Egypt (2) · Israel (2) · Mexico (2) · New Zealand (2)
Charles S Cox, Jr., M.D. (2) · Charles S Cox, MD (2) · Eric M Wassermann, M.D. (2) · Jeanne M Hoffman, PhD (2) · Leighton Chan, M.D. (2) · Lindell K. Weaver, MD (2) · Ramon R. Diaz-Arrastia, MD, PhD (2) · Ross R Bullock, M.D., PhD (2) · Adam Burgoyne, MD, PhD (1) · Alexander A Ostanin, MD, PhD (1) · Alice Rose (1) · Allen Lamb, DO (1) · Allen Thornton (1) · Allen W Brown, MD (1)
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1IK2RX001136-01A2 (1), 2009 (1), 2018 (1), K23HD049626 (1), K23HL150229 (1), K23NS048152 (1), K23NS065132 (1), P01NS038660 (1), R01HD036075 (1), R01HD070792 (1), R01NS039097 (1), R01NS052448 (1), R01NS055827 (1), R01NS061860 (1), R01NS069247 (1)