7 completed, 2 recruiting, 2 terminated, 1 unknown. 6 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 4, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Chronic Daily Headache: new trials by email Literature Review of Chronic Daily Headache trials Research Report on Chronic Daily Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multi-center RCT of IV Ketamine Efficacy and Safety in Chronic Daily Headaches Ketamine, 0.9% Saline - Chronic Daily Headache | Phase 3 | Recruiting | University Health Network, Toronto | 56 | 2022-06-01 | 2026-06-08 |
| Assessment of the Efficacy of the Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Daily Headache in Children and Adolescents. Sphenopalatine ganglion block with 0.5% bupivacaine, Sphenopalatine ganglion block with saline - Chronic Daily Headache, Post-Traumatic Headache | Not applicable | Unknown | Pablo Ingelmo | 120 | 2022-02-05 | 2022-01-28 |
| Offset Analgesia as a Measure of Central Sensitization in Children Offset analgesia - Chronic Pain Syndrome, Chronic Daily Headache | Not applicable | Completed | Boston Children's Hospital | 15 | 2018-04-01 | 2021-02-21 |
| Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics Chronic Daily Headache, Chronic Migraine | Recruiting | Stanford University | 700 | 2014-12-12 | 2025-07-23 | |
| Sphenopalatine Ganglion Nerve Block vs. Elavil for Treatment of Transformed Migraines SPG Block with 5% Lidocaine gel, Amitriptyline - Transformed Migraine, Chronic Daily Headache | Phase 4 | Terminated | Rutgers, The State University of New Jersey | 10 | 2014-05-01 | 2026-06-23 |
| Yoga Training for Returning Veterans With Headache Iyengar-based Yoga Training - Post Traumatic Headache, Chronic Daily Headache | Not applicable | Terminated | University of California, Los Angeles | 20 | 2013-10-01 | 2017-05-02 |
| Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache Syntocinon, Sterile water - Chronic Daily Headache | Not applicable | Completed | MedVadis Research Corporation | 60 | 2009-11-01 | 2023-06-15 |
| Nutrition for Chronic Daily Headache Diet A, Diet B - Chronic Daily Headache | Not applicable | Completed | University of North Carolina, Chapel Hill | 67 | 2009-07-01 | 2017-02-23 |
| Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief? Chronic Daily Headache | Completed | Thomas Jefferson University | 45 | 2009-04-01 | 2025-02-28 | |
| Intensive Meditation and Migraines: Effects on Health and Well Being Vipassana Meditation - Chronic Daily Headache | Not applicable | Completed | Johns Hopkins University | 36 | 2008-04-01 | 2016-07-29 |
| Atkins Diet for Difficult-to-Control Headaches in Teenagers Modified Atkins diet - Chronic Daily Headache | Phase 1 | Completed | Johns Hopkins University | 10 | 2005-09-01 | 2009-07-02 |
| Propofol Injection for Daily Headache Propofol - Chronic Headache, Analgesic Rebound Headache | Phase 2 | Completed | University of Alberta | 28 | 2004-09-01 | 2017-05-04 |
Headache Disorders (12) · Headache (4) · Migraine Disorders (4) · Chronic Pain (2) · Post-Traumatic Headache (2) · Collagen Diseases (1) · Complex Regional Pain Syndromes (1) · Epilepsy, Temporal Lobe (1) · Headache Disorders, Secondary (1) · Inflammation (1) · Ketosis (1) · Tension-Type Headache (1) · Vascular Headaches (1)
Brain Diseases (12) · Central Nervous System Diseases (12) · Nervous System Diseases (12) · Neurologic Manifestations (5) · Pain (5) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (5) · Headache Disorders, Primary (4) · Headache Disorders, Secondary (3) · Acid-Base Imbalance (1) · Acidosis (1) · Autonomic Nervous System Diseases (1) · Cardiovascular Diseases (1) · Cerebrovascular Disorders (1) · Connective Tissue Diseases (1)
Amitriptyline (1) · Bupivacaine (1) · Ketamine (1) · Nutritional Status (1) · Oxytocin (1) · Propofol (1) · Saline Solution (1) · Sodium Chloride (1) · Sphenopalatine Ganglion Block (1)
Johns Hopkins University (2) · Boston Children's Hospital (1) · MedVadis Research Corporation (1) · Pablo Ingelmo (1) · Rutgers, The State University of New Jersey (1) · Stanford University (1) · Thomas Jefferson University (1) · University Health Network, Toronto (1) · University of Alberta (1) · University of California, Los Angeles (1) · University of North Carolina, Chapel Hill (1)
United States (9) · Canada (3)
Anuj Bhatia, MD, PhD (1) · Bruce Naliboff, PhD (1) · Egilius LH Spierings, MD, PhD (1) · Eric H Kossoff, MD (1) · John Douglas Mann, MD (1) · Madhav Goyal, MD, MPH (1) · Mark K Simmonds, MD (1) · Milena Zirovich, MD (1) · Pablo Ingelmo, MD (1) · Robert Cowan, MD, FAAN (1) · Stephen D Silberstein, MD (1)
PMID 19923528, PMID 21496264, PMID 23886520, PMID 25790451, PMID 25958314, PMID 28025837, PMID 29923953, PMID 31082965, PMID 36855160, PMID 38282695, PMID 39314676, PMID 39428602