Acid-Base Imbalance: Clinical Trials

262 completed, 77 unknown, 54 recruiting, 29 terminated. 233 Not applicable, 63 Phase 2, 35 Phase 3, 33 Phase 1, 28 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	233	Completed 146, Unknown 36, Recruiting 20, Not yet recruiting 10, Terminated 10, Withdrawn 8, Active not recruiting 3
Phase 2	63	Completed 24, Recruiting 12, Unknown 9, Terminated 6, Not yet recruiting 4, Withdrawn 4, Active not recruiting 2, Enrolling by invitation 2
Phase 3	35	Completed 16, Terminated 5, Recruiting 4, Unknown 4, Active not recruiting 3, Withdrawn 2, Enrolling by invitation 1
Phase 1	33	Completed 16, Recruiting 4, Terminated 4, Not yet recruiting 3, Unknown 2, Withdrawn 2, Active not recruiting 1, Suspended 1
Phase 4	28	Completed 16, Recruiting 5, Terminated 3, Unknown 2, Not yet recruiting 1, Withdrawn 1
Early Phase 1	4	Completed 2, Recruiting 2

Follow Acid-Base Imbalance: new trials by email Literature Review of Acid-Base Imbalance trials Research Report on Acid-Base Imbalance

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)	Phase 1 / Phase 2	Not yet recruiting	George Washington University	24	2027-03-01	2026-10-05
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)	Phase 2	Not yet recruiting	HealthPartners Institute	80	2027-01-01	2026-10-23
The BRIGHT Study (Device Name: HALO System) The HALO System - Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2	Not applicable	Not yet recruiting	Indigo Diabetes NV	12	2026-12-01	2026-08-04
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis	Phase 2 / Phase 3	Recruiting	University of Pennsylvania	60	2026-12-01	2026-10-21
Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Ketosis, Resistance Exercise	Not applicable	Not yet recruiting	McGill University	18	2026-11-01	2026-10-20
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes PAL-119, Placebo - Healthy Volunteers and Diabetes Participants	Phase 1 / Phase 2	Not yet recruiting	Paulex Bio Inc.	147	2026-11-01	2026-10-28
LIfestyle MEtabotype Study B (LIME-B) βHB drink (ketone ester), Carbohydrate drink - Nutritional and Metabolic Diseases, Prediabetes	Not applicable	Recruiting	German Institute of Human Nutrition	300	2026-10-26	2026-10-28
Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males. Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Post-exercise Period, Ketosis	Not applicable	Recruiting	McGill University	18	2026-10-23	2026-10-23
Frequency of Metabolic Acidosis in the Pediatric Intensive Care Unit Metabolic Acidosis, Acid-Base Imbalance		Not yet recruiting	Assiut University	140	2026-10-01	2026-09-03
Central Venous vs Arterial Blood Gas and CO2 Gap in Critically Ill Patients With and Without Diabetes Critical Illness, Diabetes Mellitus		Not yet recruiting	Assiut University	100	2026-10-01	2026-09-02
Perfusion Index for Predicting Diabetic Ketoacidosis Severity in the Emergency Department Diabetic Ketoacidosis		Recruiting	Ankara Etlik City Hospital	140	2026-09-15	2026-09-16
A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients Sodium bicarbonate, Tris-hydroxymethyl Aminomethane - Metabolic Acidosis	Phase 4	Recruiting	Mayo Clinic	250	2026-09-14	2026-09-21
Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis Diabetic Ketoacidosis, Diabetes Mellitus		Not yet recruiting	Assiut University	120	2026-09-10	2026-09-16
Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for Intubation Extracorporeal Carbon Dioxide Removal, Noninvasive Ventilation - Acute Exacerbation of Chronic Obstructive Pulmonary Disease	Not applicable	Not yet recruiting	Hospital del Mar Research Institute (IMIM)	14	2026-09-01	2026-08-25
Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness Delayed nutrition, Standard nutrition, Fasting - Critical Illness, Fasting State	Not applicable	Not yet recruiting	Karolinska University Hospital	200	2026-08-31	2026-09-01
Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits Fibre Arm, Control Arm - Fasting, Dietary Fibre	Not applicable	Recruiting	Buchinger Wilhelmi Development & Holding GmbH	75	2026-08-31	2026-09-30
Ketones for Opioid Craving Treatment with Ketone Supplement, Treatment with Placebo - Opioid Use Disorder	Phase 2	Recruiting	University of Maryland, Baltimore	50	2026-07-16	2026-08-25
Pilot Trial of Oral Sodium Bicarbonate Versus Higher Dialysate Bicarbonate in Hemodialysis Patients With Metabolic Acidosis Oral sodium bicarbonate, Increased Dialysate Bicarbonate - End-stage Renal Disease (ESRD), Chronic Hemodialysis	Not applicable	Not yet recruiting	University of Sfax	37	2026-07-01	2026-07-21
Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis Ventilatory support via nasal high flow, Ventilatory support via NIV - Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Hypercapnic Acidosis	Not applicable	Recruiting	University Hospital, Montpellier	174	2026-06-16	2026-06-22
Exogenous Ketone Supplementation in ICU Delirium Ketone monoester, Placebo - ICU Delirium, Critical Illness	Phase 2	Recruiting	Vanderbilt University Medical Center	40	2026-06-09	2026-08-24

Showing 20 of 478. Sign in to see all of them.

Narrower conditions

Ketosis (213)  ·  Acidosis (102)  ·  Diabetic Ketoacidosis (73)  ·  Acidosis, Lactic (47)  ·  Diabetes Mellitus, Type 1 (31)  ·  Diabetes Mellitus (27)  ·  Diabetes Mellitus, Type 2 (22)  ·  Renal Insufficiency, Chronic (21)  ·  Acidosis, Respiratory (20)  ·  Motor Activity (20)  ·  Obesity (15)  ·  Hypoxia (14)  ·  Insulin Resistance (13)  ·  Acute Kidney Injury (12)

Broader conditions

Nutritional and Metabolic Diseases (477)  ·  Metabolic Diseases (469)  ·  Acidosis (347)  ·  Pathological Conditions, Signs and Symptoms (160)  ·  Endocrine System Diseases (117)  ·  Pathologic Processes (93)  ·  Signs and Symptoms (88)  ·  Diabetes Mellitus (86)  ·  Glucose Metabolism Disorders (85)  ·  Diabetes Complications (72)  ·  Ketosis (68)  ·  Urogenital Diseases (64)  ·  Female Urogenital Diseases and Pregnancy Complications (62)  ·  Nervous System Diseases (62)

Interventions

Sodium Bicarbonate (23)  ·  formic acid 4-(3-oxobutyl)phenyl ester (16)  ·  Diet, Ketogenic (14)  ·  Sodium Chloride (14)  ·  Ringer's Lactate (10)  ·  Saline Solution (9)  ·  Ketones (8)  ·  Blood Specimen Collection (7)  ·  Insulin (7)  ·  Insulin Glargine (7)  ·  dapagliflozin (7)  ·  3-Hydroxybutyric Acid (6)  ·  Dichloroacetic Acid (6)  ·  Metformin (6)  ·  Acetazolamide (5)

Sponsors

Université de Sherbrooke (18)  ·  University of Aarhus (17)  ·  University of British Columbia (13)  ·  Johns Hopkins University (8)  ·  University of Colorado, Denver (8)  ·  KU Leuven (7)  ·  Assiut University (6)  ·  University of Florida (6)  ·  Albert Einstein College of Medicine (5)  ·  Duke University (5)  ·  McGill University (5)  ·  Ohio State University (5)  ·  Sohag University (5)  ·  University of Pennsylvania (5)  ·  Emory University (4)

Countries

United States (151)  ·  Canada (57)  ·  Denmark (34)  ·  United Kingdom (28)  ·  France (26)  ·  Germany (25)  ·  Italy (23)  ·  Belgium (19)  ·  Spain (13)  ·  Turkey (Türkiye) (11)  ·  Australia (10)  ·  Brazil (9)  ·  Egypt (9)  ·  Switzerland (8)  ·  Czechia (7)

Top investigators

Corinde Wiers, Ph.D. (4)  ·  Eric H Kossoff, MD (4)  ·  Stephen Cunnane, PhD (4)  ·  Jonathan Jun, MD (3)  ·  Karim Brohi, MD (3)  ·  Thomas Langer, MD (3)  ·  Antonio Paoli, MD (2)  ·  Antonio Pesenti, MD (2)  ·  Christophe De Block, MD, PhD (2)  ·  Giacomo Grasselli, MD (2)  ·  Guillermo Umpierrez, MD (2)  ·  Jacob T Mey, PhD, RD (2)

Results publications

PMID 42458538, PMID 32071135, PMID 33074729, PMID 37889573, PMID 39804761, PMID 40043832, PMID 41315088, PMID 10064682, PMID 10102718, PMID 10189326, PMID 10218526, PMID 10371175, PMID 10546860, PMID 10563713, PMID 10634199, PMID 10789605, PMID 10971863, PMID 10988097, PMID 11046201, PMID 11071184, PMID 11188837, PMID 11216928, PMID 11262215, PMID 11366976, PMID 11399982, PMID 11604980, PMID 11719381, PMID 11722270, PMID 11737323, PMID 11740189, PMID 11807691, PMID 12008784, PMID 12126821, PMID 12134254, PMID 12172088, PMID 12186514, PMID 12243433, PMID 12534953, PMID 12553482, PMID 12558340, PMID 12640206, PMID 12741625, PMID 12819520, PMID 12853195, PMID 12859325, PMID 12891060, PMID 12957089, PMID 14518432, PMID 14581998, PMID 14627784

NIH funding

2018 (2), 2023 (2), 2025 (2), K23HL161348 (2), R21AA031088 (2), 2008 (1), 2009 (1), 2015 (1), 2016 (1), K01HL169491 (1), K23HL128814 (1), P30AG028740 (1), P30AG059297 (1), R01AA031570 (1), R01CA125618 (1)