152 completed, 48 unknown, 34 recruiting, 15 not yet recruiting. 164 Not applicable, 33 Phase 2, 20 Phase 1, 11 Phase 3, 11 Phase 4.
Follow Ketosis: new trials by email Literature Review of Ketosis trials Research Report on Ketosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM) | Phase 2 | Not yet recruiting | HealthPartners Institute | 80 | 2027-01-01 | 2026-10-23 |
| The BRIGHT Study (Device Name: HALO System) The HALO System - Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2 | Not applicable | Not yet recruiting | Indigo Diabetes NV | 12 | 2026-12-01 | 2026-08-04 |
| Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder Kenetik, magnetic resonance imaging scan, Alcohol bar lab - Alcohol Use Disorder, Ketosis | Phase 2 / Phase 3 | Recruiting | University of Pennsylvania | 60 | 2026-12-01 | 2026-10-21 |
| Acute Effects of Ketone Monoester Co-Ingestion With Dietary Protein on Whole-Body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Older Males Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Ketosis, Resistance Exercise | Not applicable | Not yet recruiting | McGill University | 18 | 2026-11-01 | 2026-10-20 |
| Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes PAL-119, Placebo - Healthy Volunteers and Diabetes Participants | Phase 1 / Phase 2 | Not yet recruiting | Paulex Bio Inc. | 147 | 2026-11-01 | 2026-10-28 |
| LIfestyle MEtabotype Study B (LIME-B) βHB drink (ketone ester), Carbohydrate drink - Nutritional and Metabolic Diseases, Prediabetes | Not applicable | Recruiting | German Institute of Human Nutrition | 300 | 2026-10-26 | 2026-10-28 |
| Acute Effects of Ketone Monoester Co-ingestion With Dietary Protein on Whole-body Phenylalanine Oxidation, Phenylalanine Retention, and Myofibrillar Protein Breakdown Following Resistance Exercise in Young Males. Ketone Monoester + Dietary Protein (KET+PRO), Dietary Protein (PRO), Resistance Exercise - Post-exercise Period, Ketosis | Not applicable | Recruiting | McGill University | 18 | 2026-10-23 | 2026-10-23 |
| Perfusion Index for Predicting Diabetic Ketoacidosis Severity in the Emergency Department Diabetic Ketoacidosis | Recruiting | Ankara Etlik City Hospital | 140 | 2026-09-15 | 2026-09-16 | |
| Leukocyte Glucose Index and Severity of Diabetic Ketoacidosis Diabetic Ketoacidosis, Diabetes Mellitus | Not yet recruiting | Assiut University | 120 | 2026-09-10 | 2026-09-16 | |
| Ketosis, Immune Function and Metabolic Adaptation in Response to Short-term Fasting in Critical Illness Delayed nutrition, Standard nutrition, Fasting - Critical Illness, Fasting State | Not applicable | Not yet recruiting | Karolinska University Hospital | 200 | 2026-08-31 | 2026-09-01 |
| Combining Fasting and Fibre Interventions to Optimise Their Gut Microbiome-mediated Health Benefits Fibre Arm, Control Arm - Fasting, Dietary Fibre | Not applicable | Recruiting | Buchinger Wilhelmi Development & Holding GmbH | 75 | 2026-08-31 | 2026-09-30 |
| Ketones for Opioid Craving Treatment with Ketone Supplement, Treatment with Placebo - Opioid Use Disorder | Phase 2 | Recruiting | University of Maryland, Baltimore | 50 | 2026-07-16 | 2026-08-25 |
| Exogenous Ketone Supplementation in ICU Delirium Ketone monoester, Placebo - ICU Delirium, Critical Illness | Phase 2 | Recruiting | Vanderbilt University Medical Center | 40 | 2026-06-09 | 2026-08-24 |
| Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies Metabolic Diseases, Diabetes Mellitus (Type 2) | Not yet recruiting | Centre Hospitalier Universitaire de la Guadeloupe | 118 | 2026-06-01 | 2026-05-08 | |
| Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure Ketone Monoester (KE) - Acute Heart Failure (AHF), Cardiogenic Shock | Phase 4 | Recruiting | Institute for Clinical and Experimental Medicine | 12 | 2026-04-04 | 2026-04-14 |
| Ketogenic Diet for Post-Traumatic Stress Disorder (PTSD) Ketogenic diet - Post-Traumatic Stress Disorder, PTSD | Not applicable | Completed | Bundeswehr University Munich | 6 | 2026-03-12 | 2026-08-13 |
| Hemodynamic Effects of Ketone Esters in Patients With Sepsis Induced Cardiomyopathy Ketone ester, Placebo - Sepsis Induced Cardiomyopathy | Not applicable | Not yet recruiting | Tor Biering-Sørensen | 12 | 2026-03-10 | 2026-03-04 |
| Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes CIR-0602K, Placebo - Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus | Phase 2 | Recruiting | University of Virginia | 40 | 2026-02-22 | 2026-02-25 |
| Undiluted and Diluted Nutrition Enteral fluid, Intravenous fluid - Critical Illness, Gastro Intestinal Surgery | Not applicable | Not yet recruiting | John Paul II Catholic University of Lublin | 80 | 2026-02-02 | 2026-01-20 |
| Evaluating Safe Ketone Thresholds To Minimise Ketosis in People With Type 1 Diabetes Using Dapagliflozin FORXIGA - Type 1 Diabetes Mellitus | Phase 2 | Not yet recruiting | St Vincent's Hospital Melbourne | 115 | 2026-02-01 | 2025-11-06 |
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Diabetic Ketoacidosis (73) · Diabetes Mellitus, Type 1 (31) · Diabetes Mellitus (21) · Diabetes Mellitus, Type 2 (19) · Motor Activity (19) · Obesity (13) · Hyperglycemia (12) · Insulin Resistance (12) · Hypoglycemia (9) · Heart Failure (8) · Alzheimer Disease (7) · Epilepsy (7) · Fasting (7) · Hypoxia (6)
Acid-Base Imbalance (281) · Nutritional and Metabolic Diseases (280) · Acidosis (277) · Metabolic Diseases (275) · Endocrine System Diseases (106) · Diabetes Mellitus (83) · Glucose Metabolism Disorders (76) · Diabetes Complications (72) · Pathological Conditions, Signs and Symptoms (64) · Signs and Symptoms (42) · Behavior (37) · Nervous System Diseases (36) · Immune System Diseases (35) · Autoimmune Diseases (31)
formic acid 4-(3-oxobutyl)phenyl ester (16) · Diet, Ketogenic (14) · Ketones (8) · Insulin (7) · Insulin Glargine (7) · dapagliflozin (7) · 3-Hydroxybutyric Acid (6) · Blood Specimen Collection (6) · Sodium Chloride (6) · Continuous Glucose Monitoring (5) · Resistance Training (4) · Ringer's Lactate (4) · 1,3-butylene glycol (3) · Angptl4 protein, mouse (3) · Diet (3)
Université de Sherbrooke (18) · University of Aarhus (16) · University of British Columbia (12) · Johns Hopkins University (8) · KU Leuven (7) · McGill University (5) · Ohio State University (5) · University of Pennsylvania (5) · Emory University (4) · Western University, Canada (4) · Assistance Publique - Hôpitaux de Paris (3) · Assiut University (3) · Boston Children's Hospital (3) · Duke University (3) · Gødstrup Hospital (3)
United States (94) · Canada (42) · Denmark (27) · Belgium (12) · United Kingdom (11) · Germany (10) · Egypt (5) · France (5) · Italy (5) · Turkey (Türkiye) (5) · Spain (4) · Australia (3) · Czechia (3) · Poland (3) · Argentina (2)
Corinde Wiers, Ph.D. (4) · Eric H Kossoff, MD (4) · Stephen Cunnane, PhD (4) · Jonathan Jun, MD (3) · Antonio Paoli, MD (2) · Christophe De Block, MD, PhD (2) · Guillermo Umpierrez, MD (2) · Jacob T Mey, PhD, RD (2) · Jeff Volek, PhD (2) · Jonathan Little, PhD (2) · Kevin Zemmour, MD (2) · Niels Jessen, Professor (2)
PMID 42458538, PMID 33074729, PMID 39804761, PMID 40043832, PMID 41315088, PMID 10064682, PMID 11604980, PMID 15636651, PMID 15840076, PMID 17508198, PMID 19366972, PMID 19664276, PMID 20492042, PMID 20492047, PMID 20621273, PMID 21323778, PMID 21992747, PMID 22685233, PMID 22931483, PMID 23245705, PMID 23689789, PMID 24035670, PMID 24963569, PMID 25275931, PMID 25346490, PMID 25758624, PMID 25905280, PMID 26013711, PMID 26057287, PMID 26064113, PMID 26855664, PMID 27385608, PMID 27912960, PMID 28389705, PMID 28434475, PMID 29716903, PMID 29735284, PMID 29761785, PMID 29897851, PMID 29955713, PMID 30057058, PMID 30506451, PMID 30600227, PMID 31028699, PMID 31067015, PMID 31599919, PMID 31862758, PMID 31918761, PMID 32383792, PMID 32475838
K23HL161348 (2), R21AA031088 (2), 2018 (1), 2023 (1), K01HL169491 (1), P30AG028740 (1), P30AG059297 (1), R01AA031570 (1), R01DK072433 (1), R01DK107680 (1), R01DK112886 (1), R01DK138309 (1), R01NS052592 (1), R01NS052619 (1), R21AA031337 (1)